Basic Tumor Immunology

Cancer-associated foam cells hamper protective T cell immunity and favor tumor progression in human colon carcinogenesis
Elena Daveri, Barbara Vergani, Luca Lalli, Giulio Ferrero, Elena Casiraghi, Agata Cova, Marta Zorza, Veronica Huber, Manuela Gariboldi, Patrizia Pasanisi, Simonetta Guarrera, Daniele Morelli, Flavio Arienti, Marco Vitellaro, Paola A Corsetto, Angela M Rizzo, Martina Stroscia, Paola Frati, Vincenzo Lagano, Laura Cattaneo, Giovanna Sabella, Biagio E Leone, Massimo Milione, Luca Sorrentino, Licia Rivoltini

Journal for ImmunoTherapy of Cancer Oct 2024, 12 (10) e009720; DOI: 10.1136/jitc-2024-009720
HDAC inhibitor SAHA enhances antitumor immunity via the HDAC1/JAK1/FGL1 axis in lung adenocarcinoma
Tingting Xu, Yuan Fang, Yunru Gu, Duo Xu, Tong Hu, Tao Yu, Yang-Yue Xu, Hao-Yang Shen, Pei Ma, Yongqian Shu

Journal for ImmunoTherapy of Cancer Oct 2024, 12 (10) e010077; DOI: 10.1136/jitc-2024-010077
Novel H-2D^b-restricted CD8 epitope derived from mouse MAGE-type antigen P1A mediates antitumor immunity in C57BL/6 mice
James McAuliffe, Silvia Panetti, Emily Steffke, Amanda Wicki, Vinnycius Pereira-Almeida, Laurine Noblecourt, Yushu Hu, Shi Yu William Guo, Julie Lesenfants, Ramiro Andrei Ramirez-Valdez, Vineethkrishna Chandrasekar, Maryam Ahmad, Vincent Stroobant, Nathalie Vigneron, Benoit J Van den Eynde, Carol Sze Ki Leung

Journal for ImmunoTherapy of Cancer Oct 2024, 12 (10) e008998; DOI: 10.1136/jitc-2024-008998
Vaccination generates functional progenitor tumor-specific CD8 T cells and long-term tumor control
Carlos R Detrés Román, Megan M Erwin, Michael W Rudloff, Frank Revetta, Kristen A Murray, Natalie R Favret, Jessica J Roetman, Joseph T Roland, Mary K Washington, Mary Philip

Journal for ImmunoTherapy of Cancer Oct 2024, 12 (10) e009129; DOI: 10.1136/jitc-2024-009129
Novel bispecific antibody-drug conjugate targeting PD-L1 and B7-H3 enhances antitumor efficacy and promotes immune-mediated antitumor responses
Yijun Dong, Zongliang Zhang, Siyuan Luan, Meijun Zheng, Zeng Wang, Yongdong Chen, Xiaoting Chen, Aiping Tong, Hui Yang

Journal for ImmunoTherapy of Cancer Oct 2024, 12 (10) e009710; DOI: 10.1136/jitc-2024-009710
Anti-metabolite chemotherapy increases LAG-3 expressing tumor-infiltrating lymphocytes which can be targeted by combination immune checkpoint blockade
Nicola Principe, Amber-Lee Phung, Kofi L P Stevens, Omar Elaskalani, Ben Wylie, Caitlin M Tilsed, Fezaan Sheikh, M Lizeth Orozco Morales, Joel Kidman, Elly Marcq, Scott A Fisher, Anna K Nowak, Alison M McDonnell, W Joost Lesterhuis, Jonathan Chee

Journal for ImmunoTherapy of Cancer Sep 2024, 12 (9) e008568; DOI: 10.1136/jitc-2023-008568
Inhibition of the NF-κB/HIF-1α signaling pathway in colorectal cancer by tyrosol: a gut microbiota-derived metabolite
Jian Guo, Fanqi Meng, Ruixue Hu, Lei Chen, Jiang Chang, Ke Zhao, Honglin Ren, Zengshan Liu, Pan Hu, Guangyi Wang, Jiandong Tai

Journal for ImmunoTherapy of Cancer Sep 2024, 12 (9) e008831; DOI: 10.1136/jitc-2024-008831
Metabolic reprogramming of hypoxic tumor-associated macrophages through CSF-1R targeting favors treatment efficiency in colorectal cancers
Khaldoun Gharzeddine, Cristina Gonzalez Prieto, Marie Malier, Clara Hennot, Renata Grespan, Yoshiki Yamaryo-Botté, Cyrille Y Botté, Fabienne Thomas, Marie-Hélène Laverriere, Edouard Girard, Gael Roth, Arnaud Millet

Journal for ImmunoTherapy of Cancer Sep 2024, 12 (9) e009602; DOI: 10.1136/jitc-2024-009602
Spatial colocalization and combined survival benefit of natural killer and CD8 T cells despite profound MHC class I loss in non-small cell lung cancer
Remziye E Wessel, Nardin Ageeb, Joseph M Obeid, Ileana S Mauldin, Kate A Goundry, Gabriel F Hanson, Mahdin Hossain, Chad Lehman, Ryan D Gentzler, Nolan A Wages, Craig L Slingluff, Timothy N J Bullock, Sepideh Dolatshahi, Michael G Brown

Journal for ImmunoTherapy of Cancer Sep 2024, 12 (9) e009126; DOI: 10.1136/jitc-2024-009126
S100A9 and HMGB1 orchestrate MDSC-mediated immunosuppression in melanoma through TLR4 signaling
Feyza Gül Özbay Kurt, Beatrice-Ana Cicortas, Bianca M Balzasch, Carolina De la Torre, Volker Ast, Ece Tavukcuoglu, Cagla Ak, Sebastian A Wohlfeil, Adelheid Cerwenka, Jochen Utikal, Viktor Umansky

Journal for ImmunoTherapy of Cancer Aug 2024, 12 (9) e009552; DOI: 10.1136/jitc-2024-009552

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