Clinical/Translational Cancer Immunotherapy

First-in-human study of SBRT and adenosine pathway blockade to potentiate the benefit of immunochemotherapy in early-stage luminal B breast cancer: results of the safety run-in phase of the Neo-CheckRay trial
Alex De Caluwe, Emanuela Romano, Philip Poortmans, Andrea Gombos, Elisa Agostinetto, Guilherme Nader Marta, Zoe Denis, Stylianos Drisis, Christophe Vandekerkhove, Antoine Desmet, Catherine Philippson, Ligia Craciun, Isabelle Veys, Denis Larsimont, Marianne Paesmans, Dirk Van Gestel, Roberto Salgado, Christos Sotiriou, Martine Piccart-Gebhart, Michail Ignatiadis, Laurence Buisseret

Journal for ImmunoTherapy of Cancer Dec 2023, 11 (12) e007279; DOI: 10.1136/jitc-2023-007279
Differential requirements for CD4+ T cells in the efficacy of the anti-PD-1+LAG-3 and anti-PD-1+CTLA-4 combinations in melanoma flank and brain metastasis models
Manali S Phadke, Jiannong Li, Zhihua Chen, Paulo C Rodriguez, Jessica K Mandula, Lilit Karapetyan, Peter A Forsyth, Y Ann Chen, Keiran S M Smalley

Journal for ImmunoTherapy of Cancer Dec 2023, 11 (12) e007239; DOI: 10.1136/jitc-2023-007239
Multicenter randomized controlled trial of neoadjuvant chemoradiotherapy alone or in combination with pembrolizumab in patients with resectable or borderline resectable pancreatic adenocarcinoma
Matthew H G Katz, Gina R Petroni, Todd Bauer, Matthew J Reilley, Brian M Wolpin, Chee-Chee Stucky, Tanios S Bekaii-Saab, Rawad Elias, Nipun Merchant, Andressa Dias Costa, Patrick Lenehan, Victoire Cardot-Ruffino, Scott Rodig, Kathleen Pfaff, Stephanie K Dougan, Jonathan Andrew Nowak, Gauri R Varadhachary, Craig L Slingluff, Osama Rahma

Journal for ImmunoTherapy of Cancer Dec 2023, 11 (12) e007586; DOI: 10.1136/jitc-2023-007586
Methylglyoxal from gut microbes boosts radiosensitivity and radioimmunotherapy in rectal cancer by triggering endoplasmic reticulum stress and cGAS-STING activation
Han Zhou, Lei Wang, Zhiwen Lin, Chenwei Jiang, Xingte Chen, Kai Wang, Libin Liu, Lingdong Shao, Jianji Pan, Jinluan Li, Da Zhang, Junxin Wu

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (11) e007840; DOI: 10.1136/jitc-2023-007840
Phase I/Ib, open-label, multicenter, dose-escalation study of the anti-TGF-β monoclonal antibody, NIS793, in combination with spartalizumab in adult patients with advanced tumors
Todd M Bauer, Armando Santoro, Chia-Chi Lin, Ignacio Garrido-Laguna, Markus Joerger, Richard Greil, Anna Spreafico, Thomas Yau, Maria-Elisabeth Goebeler, Marie Luise Hütter-Krönke, Antonella Perotti, Pierre-Eric Juif, Darlene Lu, Louise Barys, Viviana Cremasco, Marc Pelletier, Helen Evans, Claire Fabre, Toshikiko Doi

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (11) e007353; DOI: 10.1136/jitc-2023-007353
High-dimensional single-cell proteomics analysis of esophageal squamous cell carcinoma reveals dynamic alterations of the tumor immune microenvironment after neoadjuvant therapy
Dingpei Han, Yichao Han, Wei Guo, Wei Wei, Su Yang, Jie Xiang, Jiaming Che, Lianggang Zhu, Junbiao Hang, Tom van den Ende, Hanneke W M van Laarhoven, Bin Li, Youqiong Ye, Hecheng Li

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (11) e007847; DOI: 10.1136/jitc-2023-007847
Randomized, open-label, phase II, biomarker study of immune-mediated mechanism of action of neoadjuvant subcutaneous trastuzumab in patients with locally advanced, inflammatory, or early HER2-positive breast cancer—Immun-HER trial (GOIRC-01-2016)
Benedetta Pellegrino, Chiara Tommasi, Olga Serra, Stefania Gori, Elisabetta Cretella, Massimo Ambroggi, Antonio Frassoldati, Giancarlo Bisagni, Chiara Casarini, Emilio Bria, Luisa Carbognin, Elena Fiorio, Antonella Mura, Claudio Zamagni, Lorenzo Gianni, Alberto Zambelli, Filippo Montemurro, Michele Tognetto, Renata Todeschini, Gabriele Missale, Nicoletta Campanini, Enrico Maria Silini, Giuseppe Maglietta, Antonino Musolino

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (11) e007667; DOI: 10.1136/jitc-2023-007667
CDK5 destabilizes PD-L1 via chaperon-mediated autophagy to control cancer immune surveillance in hepatocellular carcinoma
Ruonan Zhang, Jie Wang, Yu Du, Ze Yu, Yihan Wang, Yixiao Jiang, Yixin Wu, Ting Le, Ziqi Li, Guoqiang Zhang, Lei Lv, Haijie Ma

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (11) e007529; DOI: 10.1136/jitc-2023-007529
Phase 1 first-in-human dose-escalation study of ANV419 in patients with relapsed/refractory advanced solid tumors
Markus Joerger, Emiliano Calvo, Heinz Laubli, Juanita Lopez, Guzmán Alonso, Elena Corral de la Fuente, Dagmar Hess, David König, Vicky Sanchez Perez, Christoph Bucher, Sangeeta Jethwa, Elena Garralda

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (11) e007784; DOI: 10.1136/jitc-2023-007784
Polycomb repressor complex 2 suppresses interferon-responsive MHC-II expression in melanoma cells and is associated with anti-PD-1 resistance
Jamaal L James, Brandie C Taylor, Margaret L Axelrod, Xiaopeng Sun, Lindsey N Guerin, Paula I Gonzalez-Ericsson, Yu Wang, Violeta Sanchez, Catherine C Fahey, Melinda E Sanders, Yaomin Xu, Emily Hodges, Douglas B Johnson, Justin M Balko

Journal for ImmunoTherapy of Cancer Nov 2023, 11 (11) e007736; DOI: 10.1136/jitc-2023-007736

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