Clinical/Translational Cancer Immunotherapy

Immune adverse events (irAEs) with adjuvant ipilimumab in melanoma, use of immunosuppressants and association with outcome: ECOG-ACRIN E1609 study analysis
Ahmad A Tarhini, Ni Kang, Sandra J Lee, F Stephen Hodi, Gary I Cohen, Omid Hamid, Laura F Hutchins, Jeffrey A Sosman, Harriet M Kluger, Zeynep Eroglu, Henry B Koon, Donald P Lawrence, Kari L Kendra, David R Minor, Carrie B Lee, Mark R Albertini, Lawrence E Flaherty, Teresa M Petrella, Howard Streicher, Vernon K Sondak, John M Kirkwood

Journal for ImmunoTherapy of Cancer May 2021, 9 (5) e002535; DOI: 10.1136/jitc-2021-002535
Neoadjuvant immunoradiotherapy results in high rate of complete pathological response and clinical to pathological downstaging in locally advanced head and neck squamous cell carcinoma
Rom Leidner, Marka Crittenden, Kristina Young, Hong Xiao, Yaping Wu, Marcus A Couey, Ashish A Patel, Allen C Cheng, Amber L Watters, Carlo Bifulco, George Morris, Lessli Rushforth, Shorin Nemeth, Walter J Urba, Michael Gough, R Bryan Bell

Journal for ImmunoTherapy of Cancer May 2021, 9 (5) e002485; DOI: 10.1136/jitc-2021-002485
Combination anti-PD1 and ipilimumab therapy in patients with advanced melanoma and pre-existing autoimmune disorders
Lauren J Brown, Alison Weppler, Prachi Bhave, Clara Allayous, J. Randall Patrinely Jr, Patrick Ott, Shahneen Sandhu, Andrew Haydon, Celeste Lebbe, Douglas B Johnson, Georgina V Long, Alexander A Menzies, Matteo S Carlino

Journal for ImmunoTherapy of Cancer May 2021, 9 (5) e002121; DOI: 10.1136/jitc-2020-002121
Tumor hypoxia is associated with resistance to PD-1 blockade in squamous cell carcinoma of the head and neck
Dan P Zandberg, Ashley V Menk, Maria Velez, Daniel Normolle, Kristin DePeaux, Angen Liu, Robert L Ferris, Greg M Delgoffe

Journal for ImmunoTherapy of Cancer May 2021, 9 (5) e002088; DOI: 10.1136/jitc-2020-002088
Pre-existing immune status associated with response to combination of sipuleucel-T and ipilimumab in patients with metastatic castration-resistant prostate cancer
Meenal Sinha, Li Zhang, Sumit Subudhi, Brandon Chen, Jaqueline Marquez, Eric V Liu, Kate Allaire, Alexander Cheung, Sharon Ng, Christopher Nguyen, Terence W Friedlander, Rahul Aggarwal, Matthew Spitzer, James P Allison, Eric J Small, Padmanee Sharma, Lawrence Fong

Journal for ImmunoTherapy of Cancer May 2021, 9 (5) e002254; DOI: 10.1136/jitc-2020-002254
NKTR-255, a novel polymer-conjugated rhIL-15 with potent antitumor efficacy
Takahiro Miyazaki, Mekhala Maiti, Marlene Hennessy, Thomas Chang, Peiwen Kuo, Murali Addepalli, Palakshi Obalapur, Sara Sheibani, Joanna Wilczek, Rhoneil Pena, Phi Quach, Janet Cetz, Andrew Moffett, Yinyan Tang, Peter Kirk, Jicai Huang, Dawei Sheng, Ping Zhang, Werner Rubas, Loui Madakamutil, Saul Kivimäe, Jonathan Zalevsky

Journal for ImmunoTherapy of Cancer May 2021, 9 (5) e002024; DOI: 10.1136/jitc-2020-002024
Dichotomous and stable gamma delta T-cell number and function in healthy individuals
Lingling Ou, Huaishan Wang, Qin Liu, Jie Zhang, Hezhe Lu, Liangping Luo, Changzheng Shi, Shaoqiang Lin, Liyun Dong, Yeye Guo, Lili Huang, Jinjin Zhu, Xiangfan Yin, Alexander C Huang, Giorgos Karakousis, Lynn Schuchter, Ravi Amaravadi, Cathy Zheng, Yi Fan, Wei Guo, Xiaowei Xu

Journal for ImmunoTherapy of Cancer May 2021, 9 (5) e002274; DOI: 10.1136/jitc-2020-002274
INfluenza Vaccine Indication During therapy with Immune checkpoint inhibitors: a multicenter prospective observational study (INVIDIa-2)
Melissa Bersanelli, Diana Giannarelli, Ugo De Giorgi, Sandro Pignata, Massimo Di Maio, Alberto Clemente, Elena Verzoni, Raffaele Giusti, Marilena Di Napoli, Giuseppe Aprile, Paola Ermacora, Annamaria Catino, Vieri Scotti, Francesca Mazzoni, Pamela Francesca Guglielmini, Antonello Veccia, Marco Maruzzo, Ernesto Rossi, Francesco Grossi, Chiara Casadei, Corrado Ficorella, Vincenzo Montesarchio, Francesco Verderame, Mimma Rizzo, Giorgia Guaitoli, Lucia Fratino, Caterina Accettura, Manlio Mencoboni, Fable Zustovich, Cinzia Baldessari, Saverio Cinieri, Andrea Camerini, Letizia Laera, Mariella Sorarù, Paolo Andrea Zucali, Valentina Guadalupi, Francesco Leonardi, Marcello Tiseo, Michele Tognetto, Francesco Di Costanzo, Carmine Pinto, Giorgia Negrini, Antonio Russo, Maria R Migliorino, Marco Filetti, Sebastiano Buti

Journal for ImmunoTherapy of Cancer May 2021, 9 (5) e002619; DOI: 10.1136/jitc-2021-002619
Randomized phase II trial of lymphodepletion plus adoptive cell transfer of tumor-infiltrating lymphocytes, with or without dendritic cell vaccination, in patients with metastatic melanoma
Chantal Saberian, Rodabe N. Amaria, Amer M. Najjar, Laszlo G. Radvanyi, Cara L. Haymaker, Marie-Andrée Forget, Roland L. Bassett, Silvana C. Faria, Isabella C. Glitza, Enrique Alvarez, Sapna Parshottam, Victor Prieto, Gregory Lizée, Michael K. Wong, Jennifer L. McQuade, Adi Diab, Cassian Yee, Hussein A. Tawbi, Sapna Patel, Elizabeth J. Shpall, Michael A. Davies, Patrick Hwu, Chantale Bernatchez

Journal for ImmunoTherapy of Cancer May 2021, 9 (5) e002449; DOI: 10.1136/jitc-2021-002449
T cell engaging bispecific antibodies targeting CD33 IgV and IgC domains for the treatment of acute myeloid leukemia
Sayed Shahabuddin Hoseini, Mallika Vadlamudi, Madelyn Espinosa-Cotton, Hoa Tran, Yi Feng, Hong-fen Guo, Hong Xu, Irene Cheung, Nai-Kong V Cheung

Journal for ImmunoTherapy of Cancer May 2021, 9 (5) e002509; DOI: 10.1136/jitc-2021-002509

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