Immune Cell Therapies and Immune Cell Engineering

Integrating binding affinity and tonic signaling enables a rational CAR design for augmented T cell function
Markus Barden, Patrick Ronan Elsenbroich, Vivian Haas, Moritz Ertelt, Philip Pervan, Lukas Velas, Bence Gergely, Árpád Szöőr, Dennis Christoph Harrer, Valerie Bezler, Astrid Holzinger, Rasmus Ulslev Wegener Friis, Gyorgy Vereb, Gerhard J Schütz, Clara T Schoeder, Andreas A Hombach, Hinrich Abken

Journal for ImmunoTherapy of Cancer Dec 2024, 12 (12) e010208; DOI: 10.1136/jitc-2024-010208
MAGE-A4 pMHC-targeted CAR-T cells exploiting TCR machinery exhibit significantly improved in vivo function while retaining antigen specificity
Meiou Liu, Yasushi Akahori, Naoko Imai, Linan Wang, Kohei Negishi, Takuma Kato, Hiroshi Fujiwara, Hiroshi Miwa, Hiroshi Shiku, Yoshihiro Miyahara

Journal for ImmunoTherapy of Cancer Nov 2024, 12 (11) e010248; DOI: 10.1136/jitc-2024-010248
IL-18R supported CAR T cells targeting oncofetal tenascin C for the immunotherapy of pediatric sarcoma and brain tumors
Elizabeth Wickman, Shannon Lange, Jessica Wagner, Jorge Ibanez, Liqing Tian, Meifen Lu, Heather Sheppard, Jason Chiang, Selene C Koo, Peter Vogel, Deanna Langfitt, S Scott Perry, Raghuvaran Shanmugam, Matthew Bell, Timothy I Shaw, Giedre Krenciute, Jinghui Zhang, Stephen Gottschalk

Journal for ImmunoTherapy of Cancer Nov 2024, 12 (11) e009743; DOI: 10.1136/jitc-2024-009743
Preclinical evaluation of antigen-sensitive B7-H3-targeting nanobody-based CAR-T cells in glioblastoma cautions for on-target, off-tumor toxicity
Fien Meeus, Cyprine Neba Funeh, Robin Maximilian Awad, Katty Zeven, Dorien Autaers, Ann De Becker, Ivan Van Riet, Cleo Goyvaerts, Sandra Tuyaerts, Bart Neyns, Nick Devoogdt, Yannick De Vlaeminck, Karine Breckpot

Journal for ImmunoTherapy of Cancer Nov 2024, 12 (11) e009110; DOI: 10.1136/jitc-2024-009110
Adoptive transfer of membrane-restricted IL-12-TCR T cells promotes antigen spreading and elimination of antigen-negative tumor variants
Ling Zhang, Scott M Norberg, Farrah Karimipour, John S Davies, Alex Kuznetsov, Wiem Lassoued, Daniel Burnett, Philip Homan, Margaret Cam, Andrew Sinkoe, Ping Xue, James L Gulley, Christian S Hinrichs

Journal for ImmunoTherapy of Cancer Nov 2024, 12 (11) e009868; DOI: 10.1136/jitc-2024-009868
Afatinib boosts CAR-T cell antitumor therapeutic efficacy via metabolism and fate reprogramming
Yueyu Dai, Yue Liu, Lingna An, Fangyuan Zhong, Xi Zhang, Shifeng Lou

Journal for ImmunoTherapy of Cancer Nov 2024, 12 (11) e009949; DOI: 10.1136/jitc-2024-009949
Comparison of CAR T-cell and bispecific antibody as third-line or later-line treatments for multiple myeloma: a meta-analysis
Xiaojie Liang, Yufan Wang, Baiwei Luo, Bingyu Lin, WeiXiang Lu, Shengyu Tian, Dan Liu, Liang Wang

Journal for ImmunoTherapy of Cancer Nov 2024, 12 (11) e010064; DOI: 10.1136/jitc-2024-010064
DLL4-targeted CAR-T therapy sensitizes neoadjuvant chemotherapy via eliminating cancer stem cells and reshaping immune microenvironment in HER2⁺ breast cancer
Jingrui Yan, Yongjie Xie, Ziyun Liu, Yanfang Yang, Tianxing Zhou

Journal for ImmunoTherapy of Cancer Nov 2024, 12 (11) e009636; DOI: 10.1136/jitc-2024-009636
ICOS-expressing CAR-T cells mediate durable eradication of triple-negative breast cancer and metastasis
Lixue Cao, Haojie Peng, Yanzhen Chen, Baijin Xia, Tao Zeng, Jialing Guo, Fei Yu, Haiyan Ye, Hui Zhang, Xinxin Chen

Journal for ImmunoTherapy of Cancer Nov 2024, 12 (11) e010028; DOI: 10.1136/jitc-2024-010028
In situ endoscopic photodynamic therapy combined with immature DC vaccination induces a robust T cell response against peritoneal carcinomatosis
Charline Degavre, Anouk Lepez, Sebastien Ibanez, Clémence François, Katarzyna Głowacka, Céline Guilbaud, Florine Laloux-Morris, Hrag Esfahani, Davide Brusa, Caroline Bouzin, Olivier Feron

Journal for ImmunoTherapy of Cancer Nov 2024, 12 (11) e009752; DOI: 10.1136/jitc-2024-009752

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