Immunotherapy Biomarkers

Novel role of microphthalmia-associated transcription factor in modulating the differentiation and immunosuppressive functions of myeloid-derived suppressor cells
Aram Lee, Haesun Park, Soyoung Lim, Jihyun Lim, Jaemoon Koh, Yoon Kyung Jeon, Young Yang, Myeong-Sok Lee, Jong-Seok Lim

Journal for ImmunoTherapy of Cancer Jan 2023, 11 (1) e005699; DOI: 10.1136/jitc-2022-005699
Human soft tissue sarcomas harbor an intratumoral viral microbiome which is linked with natural killer cell infiltrate and prognosis
Lauren M Perry, Sylvia M Cruz, Kara T Kleber, Sean J Judge, Morgan A Darrow, Louis B Jones, Ugur N Basmaci, Nikhil Joshi, Matthew L Settles, Blythe P Durbin-Johnson, Alicia A Gingrich, Arta Monir Monjazeb, Janai Carr-Ascher, Steve W Thorpe, William J Murphy, Jonathan A Eisen, Robert J Canter

Journal for ImmunoTherapy of Cancer Jan 2023, 11 (1) e004285; DOI: 10.1136/jitc-2021-004285
Association of immune-related adverse events with the outcomes of immune checkpoint inhibitors in patients with dMMR/MSI-H metastatic colorectal cancer
Vincenzo Nasca, Francesco Barretta, Francesca Corti, Sara Lonardi, Monica Niger, Maria Elena Elez, Marwan Fakih, Priya Jayachandran, Aakash Tushar Shah, Massimiliano Salati, Elisabetta Fenocchio, Lisa Salvatore, Chiara Cremolini, Javier Ros, Margherita Ambrosini, Giacomo Mazzoli, Rossana Intini, Michael J Overman, Rosalba Miceli, Filippo Pietrantonio

Journal for ImmunoTherapy of Cancer Jan 2023, 11 (1) e005493; DOI: 10.1136/jitc-2022-005493
Modification of PLAC8 by UFM1 affects tumorous proliferation and immune response by impacting PD-L1 levels in triple-negative breast cancer
Misha Mao, Yongxia Chen, Jingjing Yang, Yifan Cheng, Ling Xu, Feiyang Ji, Jichun Zhou, Xun Zhang, Zhaoqing Li, Cong Chen, Siwei Ju, Jiahang Zhang, Linbo Wang

Journal for ImmunoTherapy of Cancer Dec 2022, 10 (12) e005668; DOI: 10.1136/jitc-2022-005668
Macrophage GSK3β-deficiency inhibits the progression of hepatocellular carcinoma and enhances the sensitivity of anti-PD1 immunotherapy
Guangshun Sun, Hanyuan Liu, Jie Zhao, Jinyu Zhang, Tian Huang, Guoqiang Sun, Siqi Zhao, Zihao Zhang, Hengsong Cao, Dawei Rong, Xiangyi Kong, Qinghua Ji, Li Liu, Xuehao Wang, Weiwei Tang, Yongxiang Xia

Journal for ImmunoTherapy of Cancer Dec 2022, 10 (12) e005655; DOI: 10.1136/jitc-2022-005655
SP140 inhibits STAT1 signaling, induces IFN-γ in tumor-associated macrophages, and is a predictive biomarker of immunotherapy response
Kranthi Kiran Kishore Tanagala, Joshua Morin-Baxter, Richard Carvajal, Maryum Cheema, Sunil Dubey, Hiroshi Nakagawa, Angela Yoon, Yi-Shing L Cheng, Alison Taylor, Jeffrey Nickerson, Akiva Mintz, Fatemeh Momen-Heravi

Journal for ImmunoTherapy of Cancer Dec 2022, 10 (12) e005088; DOI: 10.1136/jitc-2022-005088
Short-term dynamics of circulating tumor DNA predicting efficacy of sintilimab plus docetaxel in second-line treatment of advanced NSCLC: biomarker analysis from a single-arm, phase 2 trial
Xiao Han, Xiaoyong Tang, Hui Zhu, Dongyuan Zhu, Xiqin Zhang, Xiangjiao Meng, Ying Hua, Zhongtang Wang, Yan Zhang, Wei Huang, Linlin Wang, Shuanghu Yuan, Pinliang Zhang, Heyi Gong, Yulan Sun, Yingjie Zhang, Zengjun Liu, Xiaomeng Dong, Fei Gai, Zhan Huang, Changbin Zhu, Jun Guo, Zhehai Wang

Journal for ImmunoTherapy of Cancer Dec 2022, 10 (12) e004952; DOI: 10.1136/jitc-2022-004952
Development of ⁸⁹Zr-anti-CD103 PET imaging for non-invasive assessment of cancer reactive T cell infiltration
Arjan Kol, Xiaoyu Fan, Marta A. Wazynska, Sander M.J. van Duijnhoven, Danique Giesen, Annechien Plat, Hans Van Eenennaam, Philip H. Elsinga, Hans W. Nijman, Marco de Bruyn

Journal for ImmunoTherapy of Cancer Dec 2022, 10 (12) e004877; DOI: 10.1136/jitc-2022-004877
Nivolumab serum concentration in metastatic melanoma patients could be related to outcome and enhanced immune activity: a gene profiling retrospective analysis
Domenico Mallardo, Diana Giannarelli, Maria Grazia Vitale, Domenico Galati, Giusy Trillò, Assunta Esposito, Maria Antonietta Isgrò, Grazia D'Angelo, Lucia Festino, Vito Vanella, Claudia Trojaniello, Andrew White, Teresa De Cristofaro, Michael Bailey, Sandro Pignata, Corrado Caracò, Antonella Petrillo, Paolo Muto, Piera Maiolino, Alfredo Budillon, Sarah Warren, Ernesta Cavalcanti, Paolo Antonio Ascierto

Journal for ImmunoTherapy of Cancer Nov 2022, 10 (11) e005132; DOI: 10.1136/jitc-2022-005132
Maturation and abundance of tertiary lymphoid structures are associated with the efficacy of neoadjuvant chemoimmunotherapy in resectable non-small cell lung cancer
Xiaoyan Sun, Weiran Liu, Leina Sun, Huilan Mo, Yingnan Feng, Xinyi Wu, Chenguang Li, Chen Chen, Jingjing Li, Ying Xin, Zhenfa Zhang, Changli Wang, Bin Zhang, Dongsheng Yue

Journal for ImmunoTherapy of Cancer Nov 2022, 10 (11) e005531; DOI: 10.1136/jitc-2022-005531

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