Oncolytic and Local Immunotherapy

Intratumoral combination therapy with poly(I:C) and resiquimod synergistically triggers tumor-associated macrophages for effective systemic antitumoral immunity
Clément Anfray, Francesco Mainini, Elisabeth Digifico, Akihiro Maeda, Marina Sironi, Marco Erreni, Achille Anselmo, Aldo Ummarino, Sara Gandoy, Francisco Expósito, Miriam Redrado, Diego Serrano, Alfonso Calvo, Marvin Martens, Susana Bravo, Alberto Mantovani, Paola Allavena, Fernando Torres Andón

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e002408; DOI: 10.1136/jitc-2021-002408
Simple and effective bacterial-based intratumoral cancer immunotherapy
Christina S E Carroll, Erin R Andrew, Laeeq Malik, Kathryn F Elliott, Moira Brennan, James Meyer, Alexander Hintze, Andrew A Almonte, Cassandra Lappin, Philip MacPherson, Klaus-Martin Schulte, Jane E Dahlstrom, Rohit Tamhane, Teresa Neeman, Elizabeth W Herbert, Maurice Orange, Desmond Yip, Rachel Allavena, Aude M Fahrer

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e002688; DOI: 10.1136/jitc-2021-002688
Recombinant Mycobacterium smegmatis delivering a fusion protein of human macrophage migration inhibitory factor (MIF) and IL-7 exerts an anticancer effect by inducing an immune response against MIF in a tumor-bearing mouse model
Hyein Jeong, So-Young Lee, Hyejun Seo, Bum-Joon Kim

Journal for ImmunoTherapy of Cancer Aug 2021, 9 (8) e003180; DOI: 10.1136/jitc-2021-003180
Novel oncolytic adenovirus expressing enhanced cross-hybrid IgGA Fc PD-L1 inhibitor activates multiple immune effector populations leading to enhanced tumor killing in vitro, in vivo and with patient-derived tumor organoids
Firas Hamdan, Erkko Ylösmäki, Jacopo Chiaro, Yvonne Giannoula, Maeve Long, Manlio Fusciello, Sara Feola, Beatriz Martins, Michaela Feodoroff, Gabriella Antignani, Salvatore Russo, Otto Kari, Moon Hee Lee, Petrus Järvinen, Harry Nisen, Anna Kreutzman, Jeanette Leusen, Satu Mustjoki, Thomas G McWilliams, Mikaela Grönholm, Vincenzo Cerullo

Journal for ImmunoTherapy of Cancer Aug 2021, 9 (8) e003000; DOI: 10.1136/jitc-2021-003000
High potency STING agonists engage unique myeloid pathways to reverse pancreatic cancer immune privilege
Casey R Ager, Akash Boda, Kimal Rajapakshe, Spencer Thomas Lea, Maria Emilia Di Francesco, Priyamvada Jayaprakash, Ravaen B Slay, Brittany Morrow, Rishika Prasad, Meghan A Dean, Colm R Duffy, Cristian Coarfa, Philip Jones, Michael A Curran

Journal for ImmunoTherapy of Cancer Aug 2021, 9 (8) e003246; DOI: 10.1136/jitc-2021-003246
Intratumoral talimogene laherparepvec injection with concurrent preoperative radiation in patients with locally advanced soft-tissue sarcoma of the trunk and extremities: phase IB/II trial
Varun Monga, Benjamin J Miller, Munir Tanas, Sarag Boukhar, Bryan Allen, Carryn Anderson, Laura Stephens, Stacey Hartwig, Steven Varga, Jon Houtman, Lei Wang, Weizhou Zhang, Omar Jaber, Jon Thomason, David Kuehn, Maheen Rajput, Catherine Metz, K.D. Zamba, Sarah Mott, Chinemerem Abanonu, Sudershan Bhatia, Mohammed Milhem

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e003119; DOI: 10.1136/jitc-2021-003119
Statins act as transient type I interferon inhibitors to enable the antitumor activity of modified vaccinia Ankara viral vectors
Shirley Tenesaca, Marcos Vasquez, Maite Alvarez, Itziar Otano, Myriam Fernandez-Sendin, Claudia Augusta Di Trani, Nuria Ardaiz, Celia Gomar, Angela Bella, Fernando Aranda, José Medina-Echeverz, Ignacio Melero, Pedro Berraondo

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e001587; DOI: 10.1136/jitc-2020-001587
Antiviral antibody responses to systemic administration of an oncolytic RNA virus: the impact of standard concomitant anticancer chemotherapies
Victoria Roulstone, David Mansfield, Robert J Harris, Katie Twigger, Christine White, Johann de Bono, James Spicer, Sophia N Karagiannis, Richard Vile, Hardev Pandha, Alan Melcher, Kevin Harrington

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002673; DOI: 10.1136/jitc-2021-002673
GD2-directed bispecific trifunctional antibody outperforms dinutuximab beta in a murine model for aggressive metastasized neuroblastoma
Felix Zirngibl, Sara M Ivasko, Laura Grunewald, Anika Klaus, Silke Schwiebert, Peter Ruf, Horst Lindhofer, Kathy Astrahantseff, Lena Andersch, Johannes H Schulte, Holger N Lode, Angelika Eggert, Kathleen Anders, Patrick Hundsdoerfer, Annette Künkele

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002923; DOI: 10.1136/jitc-2021-002923
CD137 and PD-L1 targeting with immunovirotherapy induces a potent and durable antitumor immune response in glioblastoma models
Montserrat Puigdelloses, Marc Garcia-Moure, Sara Labiano, Virginia Laspidea, Marisol Gonzalez-Huarriz, Marta Zalacain, Lucia Marrodan, Naiara Martinez-Velez, Daniel De la Nava, Iker Ausejo, Sandra Hervás-Stubbs, Guillermo Herrador, ZhiHong Chen, Dolores Hambardzumyan, Ana Patino Garcia, Hong Jiang, Candelaria Gomez-Manzano, Juan Fueyo, Jaime Gállego Pérez-Larraya, Marta Alonso

Journal for ImmunoTherapy of Cancer Jul 2021, 9 (7) e002644; DOI: 10.1136/jitc-2021-002644

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