Oncolytic and Local Immunotherapy

Short-course neoadjuvant in situ vaccination for murine melanoma
Taylor J Aiken, David Komjathy, Matthew Rodriguez, Ashley Stuckwisch, Arika Feils, Vladimir Subbotin, Jen Birstler, Stephen D Gillies, Alexander L Rakhmilevich, Amy K Erbe, Paul M Sondel

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003586; DOI: 10.1136/jitc-2021-003586
Systemic high-dose dexamethasone treatment may modulate the efficacy of intratumoral viral oncolytic immunotherapy in glioblastoma models
Marilin S Koch, Mykola Zdioruk, Michal O Nowicki, Alec M Griffith, Estuardo Aguilar, Laura K Aguilar, Brian W Guzik, Francesca Barone, Paul P Tak, Ghazaleh Tabatabai, James A Lederer, E Antonio Chiocca, Sean Lawler

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003368; DOI: 10.1136/jitc-2021-003368
Live attenuated bacterium limits cancer resistance to CAR-T therapy by remodeling the tumor microenvironment
Fengguang Guo, Jugal K Das, Koichi S Kobayashi, Qing-Ming Qin, Thomas A Ficht, Robert C Alaniz, Jianxun Song, Paul De Figueiredo

Journal for ImmunoTherapy of Cancer Jan 2022, 10 (1) e003760; DOI: 10.1136/jitc-2021-003760
An engineered oncolytic vaccinia virus encoding a single-chain variable fragment against TIGIT induces effective antitumor immunity and synergizes with PD-1 or LAG-3 blockade
Shuguang Zuo, Min Wei, Tiancheng Xu, Lingkai Kong, Bohao He, Shiqun Wang, Shibing Wang, Junhua Wu, Jie Dong, Jiwu Wei

Journal for ImmunoTherapy of Cancer Dec 2021, 9 (12) e002843; DOI: 10.1136/jitc-2021-002843
Safety and efficacy of the tumor-selective adenovirus enadenotucirev with or without paclitaxel in platinum-resistant ovarian cancer: a phase 1 clinical trial
Victor Moreno, Maria-Pilar Barretina-Ginesta, Jesús García-Donas, Gordon C Jayson, Patricia Roxburgh, Raúl Márquez Vázquez, Agnieszka Michael, Antonio Antón-Torres, Richard Brown, David Krige, Brian Champion, Iain McNeish

Journal for ImmunoTherapy of Cancer Dec 2021, 9 (12) e003645; DOI: 10.1136/jitc-2021-003645
Intratumoral co-injection of the poly I:C-derivative BO-112 and a STING agonist synergize to achieve local and distant anti-tumor efficacy
Maite Alvarez, Carmen Molina, Carlos E De Andrea, Myriam Fernandez-Sendin, Maria Villalba, Jose Gonzalez-Gomariz, Maria Carmen Ochoa, Alvaro Teijeira, Javier Glez-Vaz, Fernando Aranda, Miguel F Sanmamed, Maria E Rodriguez-Ruiz, Xinyi Fan, Wen H Shen, Pedro Berraondo, Marisol Quintero, Ignacio Melero

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e002953; DOI: 10.1136/jitc-2021-002953
Metformin reduces PD-L1 on tumor cells and enhances the anti-tumor immune response generated by vaccine immunotherapy
Luis Enrique Munoz, Lei Huang, Ramireddy Bommireddy, Richa Sharma, Lenore Monterroza, Rohini N. Guin, Sarah G. Samaranayake, Christopher D. Pack, Sampath Ramachandiran, Shaker J.C. Reddy, Mala Shanmugam, Periasamy Selvaraj

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e002614; DOI: 10.1136/jitc-2021-002614
VCN-01 disrupts pancreatic cancer stroma and exerts antitumor effects
Miriam Bazan-Peregrino, Rocio Garcia-Carbonero, Berta Laquente, Rafael Álvarez, Ana Mato-Berciano, Marta Gimenez-Alejandre, Sara Morgado, Alba Rodríguez-García, Maria V Maliandi, M Carmen Riesco, Rafael Moreno, Mireia M Ginestà, Mercedes Perez-Carreras, Joan B Gornals, Susana Prados, Sofía Perea, Gabriel Capella, Ramon Alemany, Ramon Salazar, Emma Blasi, Carmen Blasco, Manel Cascallo, Manuel Hidalgo

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e003254; DOI: 10.1136/jitc-2021-003254
Synergy between Toxoplasma gondii type I ΔGRA17 immunotherapy and PD-L1 checkpoint inhibition triggers the regression of targeted and distal tumors
Yu-Chao Zhu, Hany M Elsheikha, Jian-Hua Wang, Shuai Fang, Jun-Jun He, Xing-Quan Zhu, Jia Chen

Journal for ImmunoTherapy of Cancer Nov 2021, 9 (11) e002970; DOI: 10.1136/jitc-2021-002970
Spatiotemporal depletion of tumor-associated immune checkpoint PD-L1 with near-infrared photoimmunotherapy promotes antitumor immunity
Shunichi Taki, Kohei Matsuoka, Yuko Nishinaga, Kazuomi Takahashi, Hirotoshi Yasui, Chiaki Koike, Misae Shimizu, Mitsuo Sato, Kazuhide Sato

Journal for ImmunoTherapy of Cancer Oct 2021, 9 (11) e003036; DOI: 10.1136/jitc-2021-003036

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