Oncolytic and Local Immunotherapy

Nanoparticles targeting immune checkpoint protein VISTA induce potent antitumor immunity
Taylor J Moon, Hieu Minh Ta, Anubhuti Bhalotia, Kai E Paulsen, Diarmuid W Hutchinson, Gabrielle M Arkema, Andrew S Choi, Michiko G Haynie, Laolu Ogunnaike, Margee Dever, Li Lily Wang, Efstathios Karathanasis

Journal for ImmunoTherapy of Cancer Aug 2024, 12 (8) e008977; DOI: 10.1136/jitc-2024-008977
Adenovirus vaccine targeting kinases induces potent antitumor immunity in solid tumors
Fei Zhu, Zheng Lu, Wenjing Tang, Guangya Zhao, Yingxiang Shao, Bowen Lu, Jiage Ding, Yanyan Zheng, Lin Fang, Huizhong Li, Gang Wang, Renjin Chen, Junnian Zheng, Dafei Chai

Journal for ImmunoTherapy of Cancer Aug 2024, 12 (8) e009869; DOI: 10.1136/jitc-2024-009869
Treatment with oncolytic vaccinia virus infects tumor-infiltrating regulatory and exhausted T cells
Kristin DePeaux, William G Gunn, Dayana B Rivadeneira, Greg M Delgoffe

Journal for ImmunoTherapy of Cancer Aug 2024, 12 (8) e009062; DOI: 10.1136/jitc-2024-009062
Combination of oncolytic Maraba virus with immune checkpoint blockade overcomes therapy resistance in an immunologically cold model of advanced melanoma with dysfunctional T-cell receptor signalling
Edward Armstrong, Matthew K L Chiu, Shane Foo, Lizzie Appleton, Pablo Nenclares, Anton Patrikeev, Nitya Mohan, Martin Mclaughlin, Galabina Bozhanova, Julia Hoebart, Victoria Roulstone, Emmanuel Patin, Malin Pedersen, Joan Kyula, Masahiro Ono, Fiona Errington-Mais, John Bell, Kevin J Harrington, Alan Melcher, Victoria Jennings

Journal for ImmunoTherapy of Cancer Jul 2024, 12 (7) e009443; DOI: 10.1136/jitc-2024-009443
TG6050, an oncolytic vaccinia virus encoding interleukin-12 and anti-CTLA-4 antibody, favors tumor regression via profound immune remodeling of the tumor microenvironment
Fadi Azar, Jules Deforges, Christelle Demeusoit, Patricia Kleinpeter, Christelle Remy, Nathalie Silvestre, Johann Foloppe, Laetitia Fend, Clémentine Spring-Giusti, Eric Quéméneur, Jean-Baptiste Marchand

Journal for ImmunoTherapy of Cancer Jul 2024, 12 (7) e009302; DOI: 10.1136/jitc-2024-009302
Targeting NKG2D ligands in glioblastoma with a bispecific T-cell engager is augmented with conventional therapy and enhances oncolytic virotherapy of glioma stem-like cells
Richard Baugh, Hena Khalique, Emma Page, Janet Lei-Rossmann, Peter Kok-Ting Wan, Timothy Johanssen, Daniel Ebner, Olaf Ansorge, Leonard W Seymour

Journal for ImmunoTherapy of Cancer May 2024, 12 (5) e008460; DOI: 10.1136/jitc-2023-008460
Preliminary efficacy and safety of YSCH-01 in patients with advanced solid tumors: an investigator-initiated trial
Yandong He, Xuhong Huang, Xiaoxia Li, Hongwei Liu, Min Liu, Junjia Tao, Yuanzhou Shan, Hafiz Khuram Raza, Yanqiu Liu, Wenting Zhong, Xue-ping Cao, Yuan-yuan Yang, Ruimei Li, Xian-long Fang, Kang-jian Zhang, Rong Zhang, Feng Liu

Journal for ImmunoTherapy of Cancer May 2024, 12 (5) e008999; DOI: 10.1136/jitc-2024-008999
Tigilanol tiglate is an oncolytic small molecule that induces immunogenic cell death and enhances the response of both target and non-injected tumors to immune checkpoint blockade
Jason K Cullen, Pei-Yi Yap, Blake Ferguson, Zara C Bruce, Motoko Koyama, Herlina Handoko, Kevin Hendrawan, Jacinta L Simmons, Kelly M Brooks, Jenny Johns, Emily S Wilson, Marjorie M A de Souza, Natasa Broit, Praphaporn Stewart, Daniel Shelley, Tracey McMahon, Steven M Ogbourne, Tam Hong Nguyen, Yi Chieh Lim, Alberto Pagani, Giovanni Appendino, Victoria A Gordon, Paul W Reddell, Glen M Boyle, Peter G Parsons

Journal for ImmunoTherapy of Cancer Apr 2024, 12 (4) e006602; DOI: 10.1136/jitc-2022-006602
Oncolytic herpes simplex virus expressing IL-2 controls glioblastoma growth and improves survival
Praveen K Bommareddy, Hiroaki Wakimoto, Robert L Martuza, Howard L Kaufman, Samuel D Rabkin, Dipongkor Saha

Journal for ImmunoTherapy of Cancer Apr 2024, 12 (4) e008880; DOI: 10.1136/jitc-2024-008880
RCAd-LTH-shPD-L1, a double-gene recombinant oncolytic adenovirus with enhanced antitumor immunity, increases lymphocyte infiltration and reshapes the tumor microenvironment
Yuan Meng, Haotian Liu, Haoran Zhu, Wanrong Zhang, Dong Sun, Xuefei Han, Ying Liu, Guangzuo Luo

Journal for ImmunoTherapy of Cancer Jan 2024, 12 (1) e007171; DOI: 10.1136/jitc-2023-007171

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