Oncolytic and Local Immunotherapy

Immunologically programming the tumor microenvironment induces the pattern recognition receptor NLRC4-dependent antitumor immunity
Xiaofei Yu, Wenjie Liu, Shixian Chen, Xueqian Cheng, Patrick A Paez, Tuanwei Sun, Fang Yuan, Chunyan Wei, Joseph W Landry, Andrew S Poklepovic, Harry D Bear, John R Subjeck, Elizabeth Repasky, Chunqing Guo, Xiang-Yang Wang

Journal for ImmunoTherapy of Cancer Jan 2021, 9 (1) e001595; DOI: 10.1136/jitc-2020-001595
Safety of immune checkpoint inhibitor rechallenge after discontinuation for grade ≥2 immune-related adverse events in patients with cancer
Marion Allouchery, Thomas Lombard, Mickael Martin, Franck Rouby, Marion Sassier, Celia Bertin, Marina Atzenhoffer, Ghada Miremont-Salame, Marie-Christine Perault-Pochat, Mathieu Puyade

Journal for ImmunoTherapy of Cancer Dec 2020, 8 (2) e001622; DOI: 10.1136/jitc-2020-001622
Neospora caninum: a new class of biopharmaceuticals in the therapeutic arsenal against cancer
Louis Lantier, Agathe Poupée-Beaugé, Anne di Tommaso, Céline Ducournau, Mathieu Epardaud, Zineb Lakhrif, Stéphanie Germon, Françoise Debierre-Grockiego, Marie-Noëlle Mévélec, Arthur Battistoni, Loïs Coënon, Nora Deluce-Kakwata-Nkor, Florence Velge-Roussel, Céline Beauvillain, Thomas Baranek, Gordon Scott Lee, Thibault Kervarrec, Antoine Touzé, Nathalie Moiré, Isabelle Dimier-Poisson

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (2) e001242; DOI: 10.1136/jitc-2020-001242
Oncolytic vaccinia virus reinvigorates peritoneal immunity and cooperates with immune checkpoint inhibitor to suppress peritoneal carcinomatosis in colon cancer
Yu Seong Lee, Won Suk Lee, Chang Woo Kim, Seung Joon Lee, Hannah Yang, So Jung Kong, John Ning, Kyung-Mee Yang, Beodeul Kang, Woo Ram Kim, Hong Jae Chon, Chan Kim

Journal for ImmunoTherapy of Cancer Nov 2020, 8 (2) e000857; DOI: 10.1136/jitc-2020-000857
Preconditioning of the tumor microenvironment with oncolytic reovirus converts CD3-bispecific antibody treatment into effective immunotherapy
Christianne Groeneveldt, Priscilla Kinderman, Diana J M van den Wollenberg, Ruben L van den Oever, Jim Middelburg, Dana A M Mustafa, Rob C Hoeben, Sjoerd H van der Burg, Thorbald van Hall, Nadine van Montfoort

Journal for ImmunoTherapy of Cancer Oct 2020, 8 (2) e001191; DOI: 10.1136/jitc-2020-001191
In situ immunization of a TLR9 agonist virus-like particle enhances anti-PD1 therapy
Yinwen Cheng, Caitlin D Lemke-Miltner, Wattawan Wongpattaraworakul, Zhaoming Wang, Carlos H F Chan, Aliasger K Salem, George J Weiner, Andrean L Simons

Journal for ImmunoTherapy of Cancer Oct 2020, 8 (2) e000940; DOI: 10.1136/jitc-2020-000940
Nanoemulsion adjuvantation strategy of tumor-associated antigen therapy rephrases mucosal and immunotherapeutic signatures following intranasal vaccination
Chung-Hsiung Huang, Chiung-Yi Huang, Hui-Min Ho, Ching-Hung Lee, Pang-Ti Lai, Suh-Chin Wu, Shih-Jen Liu, Ming-Hsi Huang

Journal for ImmunoTherapy of Cancer Oct 2020, 8 (2) e001022; DOI: 10.1136/jitc-2020-001022
Safety and clinical activity of intratumoral MEDI9197 alone and in combination with durvalumab and/or palliative radiation therapy in patients with advanced solid tumors
Lillian Siu, Joshua Brody, Shilpa Gupta, Aurélien Marabelle, Antonio Jimeno, Pamela Munster, Juneko Grilley-Olson, Alain H Rook, Antoine Hollebecque, Rebecca K S Wong, James W Welsh, Yuling Wu, Christopher Morehouse, Oday Hamid, Farzana Walcott, Zachary A Cooper, Rakesh Kumar, Charles Ferté, David S Hong

Journal for ImmunoTherapy of Cancer Oct 2020, 8 (2) e001095; DOI: 10.1136/jitc-2020-001095
Therapeutic efficacy and safety of a human fusion construct targeting the TWEAK receptor Fn14 and containing a modified granzyme B
Ana Alvarez de Cienfuegos, Lawrence H Cheung, Khalid A Mohamedali, Timothy G Whitsett, Jeffrey A Winkles, Walter N Hittelman, Michael G Rosenblum

Journal for ImmunoTherapy of Cancer Sep 2020, 8 (2) e001138; DOI: 10.1136/jitc-2020-001138
Combining BRAF inhibition with oncolytic herpes simplex virus enhances the immune-mediated antitumor therapy of BRAF-mutant thyroid cancer
Eva Crespo-Rodriguez, Katharina Bergerhoff, Galabina Bozhanova, Shane Foo, Emmanuel C Patin, Harriet Whittock, Richard Buus, Syed Haider, Gareth Muirhead, Khin Thway, Kate Newbold, Robert S Coffin, Richard G Vile, Dae Kim, Martin McLaughlin, Alan A Melcher, Kevin J Harrington, Malin Pedersen

Journal for ImmunoTherapy of Cancer Aug 2020, 8 (2) e000698; DOI: 10.1136/jitc-2020-000698

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