Oncolytic and Local Immunotherapy

STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer
Seung Joon Lee, Hannah Yang, Woo Ram Kim, Yu Seong Lee, Won Suk Lee, So Jung Kong, Hye Jin Lee, Jeong Hun Kim, Jaekyung Cheon, Beodeul Kang, Hong Jae Chon, Chan Kim

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002195; DOI: 10.1136/jitc-2020-002195
Direct and indirect immune effects of CMP-001, a virus-like particle containing a TLR9 agonist
Shakoora A Sabree, Andrew P Voigt, Sue E Blackwell, Ajaykumar Vishwakarma, Michael S Chimenti, Aliasger K Salem, George J Weiner

Journal for ImmunoTherapy of Cancer Jun 2021, 9 (6) e002484; DOI: 10.1136/jitc-2021-002484
In situ delivery of iPSC-derived dendritic cells with local radiotherapy generates systemic antitumor immunity and potentiates PD-L1 blockade in preclinical poorly immunogenic tumor models
Takaaki Oba, Kenichi Makino, Ryutaro Kajihara, Toshihiro Yokoi, Ryoko Araki, Masumi Abe, Hans Minderman, Alfred E Chang, Kunle Odunsi, Fumito Ito

Journal for ImmunoTherapy of Cancer May 2021, 9 (5) e002432; DOI: 10.1136/jitc-2021-002432
Oncolytic adenovirus and gene therapy with EphA2-BiTE for the treatment of pediatric high-grade gliomas
Claudia Manuela Arnone, Vinicia Assunta Polito, Angela Mastronuzzi, Andrea Carai, Francesca Camassei Diomedi, Laura Antonucci, Lucia Lisa Petrilli, Maria Vinci, Francesco Ferrari, Elisa Salviato, Marco Scarsella, Cristiano De Stefanis, Gerrit Weber, Concetta Quintarelli, Biagio De Angelis, Malcolm K Brenner, Stephen Gottschalk, Valentina Hoyos, Franco Locatelli, Ignazio Caruana, Francesca Del Bufalo

Journal for ImmunoTherapy of Cancer May 2021, 9 (5) e001930; DOI: 10.1136/jitc-2020-001930
Phase I trial of intratumoral PVSRIPO in patients with unresectable, treatment-refractory melanoma
Georgia M Beasley, Smita K Nair, Norma E Farrow, Karenia Landa, Maria Angelica Selim, Carol Ann Wiggs, Sin-Ho Jung, Darell D Bigner, Andrea True Kelly, Matthias Gromeier, April KS Salama

Journal for ImmunoTherapy of Cancer Apr 2021, 9 (4) e002203; DOI: 10.1136/jitc-2020-002203
Intratumoral OH2, an oncolytic herpes simplex virus 2, in patients with advanced solid tumors: a multicenter, phase I/II clinical trial
Bo Zhang, Jing Huang, Jialin Tang, Sheng Hu, Suxia Luo, Zhiguo Luo, Fuxiang Zhou, Shiyun Tan, Jieer Ying, Qing Chang, Rui Zhang, Chengyun Geng, Dawei Wu, Xiangyong Gu, Binlei Liu

Journal for ImmunoTherapy of Cancer Apr 2021, 9 (4) e002224; DOI: 10.1136/jitc-2020-002224
Oncolytic herpesvirus expressing PD-L1 BiTE for cancer therapy: exploiting tumor immune suppression as an opportunity for targeted immunotherapy
Hena Khalique, Richard Baugh, Arthur Dyer, Eleanor M. Scott, Sally Frost, Sarah Larkin, Janet Lei-Rossmann, Leonard W. Seymour

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (4) e001292; DOI: 10.1136/jitc-2020-001292
New generation of DNA-based immunotherapy induces a potent immune response and increases the survival in different tumor models
Alessandra Lopes, Chiara Bastiancich, Mathilde Bausart, Sophie Ligot, Laure Lambricht, Kevin Vanvarenberg, Bernard Ucakar, Bernard Gallez, Véronique Préat, Gaëlle Vandermeulen

Journal for ImmunoTherapy of Cancer Apr 2021, 9 (4) e001243; DOI: 10.1136/jitc-2020-001243
Talimogene laherparepvec upregulates immune-cell populations in non-injected lesions: findings from a phase II, multicenter, open-label study in patients with stage IIIB–IVM1c melanoma
Josep Malvehy, Igor Samoylenko, Dirk Schadendorf, Ralf Gutzmer, Jean-Jacques Grob, Joseph J Sacco, Kevin S Gorski, Abraham Anderson, Cheryl A Pickett, Kate Liu, Helen Gogas

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e001621; DOI: 10.1136/jitc-2020-001621
Reovirus-induced cell-mediated immunity for the treatment of multiple myeloma within the resistant bone marrow niche
Louise M E Müller, Gemma Migneco, Gina B Scott, Jenny Down, Sancha King, Basem Askar, Victoria Jennings, Babatunde Oyajobi, Karen Scott, Emma West, Christy Ralph, Adel Samson, Elizabeth J Ilett, Munitta Muthana, Matt Coffey, Alan Melcher, Christopher Parrish, Gordon Cook, Michelle Lawson, Fiona Errington-Mais

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e001803; DOI: 10.1136/jitc-2020-001803

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