Oncolytic and Local Immunotherapy

Preconditioning of the tumor microenvironment with oncolytic reovirus converts CD3-bispecific antibody treatment into effective immunotherapy
Christianne Groeneveldt, Priscilla Kinderman, Diana J M van den Wollenberg, Ruben L van den Oever, Jim Middelburg, Dana A M Mustafa, Rob C Hoeben, Sjoerd H van der Burg, Thorbald van Hall, Nadine van Montfoort

Journal for ImmunoTherapy of Cancer Oct 2020, 8 (2) e001191; DOI: 10.1136/jitc-2020-001191
In situ immunization of a TLR9 agonist virus-like particle enhances anti-PD1 therapy
Yinwen Cheng, Caitlin D Lemke-Miltner, Wattawan Wongpattaraworakul, Zhaoming Wang, Carlos H F Chan, Aliasger K Salem, George J Weiner, Andrean L Simons

Journal for ImmunoTherapy of Cancer Oct 2020, 8 (2) e000940; DOI: 10.1136/jitc-2020-000940
Safety and clinical activity of intratumoral MEDI9197 alone and in combination with durvalumab and/or palliative radiation therapy in patients with advanced solid tumors
Lillian Siu, Joshua Brody, Shilpa Gupta, Aurélien Marabelle, Antonio Jimeno, Pamela Munster, Juneko Grilley-Olson, Alain H Rook, Antoine Hollebecque, Rebecca K S Wong, James W Welsh, Yuling Wu, Christopher Morehouse, Oday Hamid, Farzana Walcott, Zachary A Cooper, Rakesh Kumar, Charles Ferté, David S Hong

Journal for ImmunoTherapy of Cancer Oct 2020, 8 (2) e001095; DOI: 10.1136/jitc-2020-001095
Nanoemulsion adjuvantation strategy of tumor-associated antigen therapy rephrases mucosal and immunotherapeutic signatures following intranasal vaccination
Chung-Hsiung Huang, Chiung-Yi Huang, Hui-Min Ho, Ching-Hung Lee, Pang-Ti Lai, Suh-Chin Wu, Shih-Jen Liu, Ming-Hsi Huang

Journal for ImmunoTherapy of Cancer Oct 2020, 8 (2) e001022; DOI: 10.1136/jitc-2020-001022
Therapeutic efficacy and safety of a human fusion construct targeting the TWEAK receptor Fn14 and containing a modified granzyme B
Ana Alvarez de Cienfuegos, Lawrence H Cheung, Khalid A Mohamedali, Timothy G Whitsett, Jeffrey A Winkles, Walter N Hittelman, Michael G Rosenblum

Journal for ImmunoTherapy of Cancer Sep 2020, 8 (2) e001138; DOI: 10.1136/jitc-2020-001138
A recombinant oncolytic Newcastle virus expressing MIP-3α promotes systemic antitumor immunity
Feng-Ying Huang, Jin-Yan Wang, Shu-Zhen Dai, Ying-Ying Lin, Yan Sun, Liming Zhang, Zhuoxuan Lu, Rong Cao, Guang-Hong Tan

Journal for ImmunoTherapy of Cancer Aug 2020, 8 (2) e000330; DOI: 10.1136/jitc-2019-000330
Combining BRAF inhibition with oncolytic herpes simplex virus enhances the immune-mediated antitumor therapy of BRAF-mutant thyroid cancer
Eva Crespo-Rodriguez, Katharina Bergerhoff, Galabina Bozhanova, Shane Foo, Emmanuel C Patin, Harriet Whittock, Richard Buus, Syed Haider, Gareth Muirhead, Khin Thway, Kate Newbold, Robert S Coffin, Richard G Vile, Dae Kim, Martin McLaughlin, Alan A Melcher, Kevin J Harrington, Malin Pedersen

Journal for ImmunoTherapy of Cancer Aug 2020, 8 (2) e000698; DOI: 10.1136/jitc-2020-000698
Relaxin-expressing oncolytic adenovirus induces remodeling of physical and immunological aspects of cold tumor to potentiate PD-1 blockade
Bo-Kyeong Jung, Hae Young Ko, Hyunji Kang, JinWoo Hong, Hyo Min Ahn, Youjin Na, Hyeongi Kim, Jin Su Kim, Chae-Ok Yun

Journal for ImmunoTherapy of Cancer Aug 2020, 8 (2) e000763; DOI: 10.1136/jitc-2020-000763
A heat-shocked melanoma cell lysate vaccine enhances tumor infiltration by prototypic effector T cells inhibiting tumor growth
María Alejandra Gleisner, Cristián Pereda, Andrés Tittarelli, Mariela Navarrete, Camila Fuentes, Ignacio Ávalos, Fabian Tempio, Juan Pablo Araya, María Inés Becker, Fermín Eduardo González, Mercedes Natalia López, Flavio Salazar-Onfray

Journal for ImmunoTherapy of Cancer Jul 2020, 8 (2) e000999; DOI: 10.1136/jitc-2020-000999
Initial dose of oncolytic myxoma virus programs durable antitumor immunity independent of in vivo viral replication
Erica B Flores, Bulent A Aksoy, Eric Bartee

Journal for ImmunoTherapy of Cancer Jun 2020, 8 (1) e000804; DOI: 10.1136/jitc-2020-000804

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