Oncolytic and Local Immunotherapy

BCG hydrogel promotes CTSS-mediated antigen processing and presentation, thereby suppressing metastasis and prolonging survival in melanoma
Mirela Kremenovic, Alfred A Chan, Bing Feng, Lukas Bäriswyl, Steve Robatel, Thomas Gruber, Li Tang, Delphine J Lee, Mirjam Schenk

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004133; DOI: 10.1136/jitc-2021-004133
Innate immune receptor signaling induces transient melanoma dedifferentiation while preserving immunogenicity
Beatrice Thier, Fang Zhao, Simone Stupia, Alicia Brüggemann, Johannes Koch, Nina Schulze, Susanne Horn, Christoph Coch, Gunther Hartmann, Antje Sucker, Dirk Schadendorf, Annette Paschen

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e003863; DOI: 10.1136/jitc-2021-003863
Oncolytic virus expressing PD-1 inhibitors activates a collaborative intratumoral immune response to control tumor and synergizes with CTLA-4 or TIM-3 blockade
Fei Ju, Yong Luo, Chaolong Lin, Xian Jia, Zilong Xu, Rui Tian, Yanhua Lin, Min Zhao, Yating Chang, Xiaoxuan Huang, Shaopeng Li, Wenfeng Ren, Yaning Qin, Mengqin Yu, Jizong Jia, Jinle Han, Wenxin Luo, Jun Zhang, Guo Fu, Xiangzhong Ye, Chenghao Huang, Ningshao Xia

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004762; DOI: 10.1136/jitc-2022-004762
Intratumoral administration of STING-activating nanovaccine enhances T cell immunotherapy
Xiaoyi Jiang, Jian Wang, Xichen Zheng, Zhida Liu, Xinyu Zhang, Yuwei Li, Jonathan Wilhelm, Jun Cao, Gang Huang, Jinlan Zhang, Baran Sumer, Jayanthi Lea, Zhigang Lu, Jinming Gao, Min Luo

Journal for ImmunoTherapy of Cancer May 2022, 10 (5) e003960; DOI: 10.1136/jitc-2021-003960
Triple-serotype chimeric oncolytic adenovirus exerts multiple synergistic mechanisms against solid tumors
Yinghan Su, Jiang Li, Weidan Ji, Gang Wang, Lin Fang, Qin Zhang, Lin Ang, Min Zhao, Yuan Sen, Lei Chen, Junnian Zheng, Changqing Su, Lunxiu Qin

Journal for ImmunoTherapy of Cancer May 2022, 10 (5) e004691; DOI: 10.1136/jitc-2022-004691
Mechanism of effective combination radio-immunotherapy against 9464D-GD2, an immunologically cold murine neuroblastoma
Taylor J Aiken, Amy K Erbe, Lauren Zebertavage, David Komjathy, Arika S Feils, Matthew Rodriguez, Ashley Stuckwisch, Stephen D Gillies, Zachary S Morris, Jen Birstler, Alexander L Rakhmilevich, Paul M Sondel

Journal for ImmunoTherapy of Cancer May 2022, 10 (5) e004834; DOI: 10.1136/jitc-2022-004834
TNF blockade enhances the efficacy of myxoma virus-based oncolytic virotherapy
Miriam Valenzuela-Cardenas, Cody Gowan, Parker Dryja, Mee Y Bartee, Eric Bartee

Journal for ImmunoTherapy of Cancer May 2022, 10 (5) e004770; DOI: 10.1136/jitc-2022-004770
OrienX010, an oncolytic virus, in patients with unresectable stage IIIC–IV melanoma: a phase Ib study
ChuanLiang Cui, Xuan Wang, Bin Lian, Qing Ji, Li Zhou, Zhihong Chi, Lu Si, Xinan Sheng, Yan Kong, Jiayi Yu, Siming Li, Lili Mao, Bixia Tang, Jie Dai, Xieqiao Yan, Xue Bai, Robert Andtbacka, Jun Guo

Journal for ImmunoTherapy of Cancer Apr 2022, 10 (4) e004307; DOI: 10.1136/jitc-2021-004307
Sensitizing immune unresponsive colorectal cancers to immune checkpoint inhibitors through MAVS overexpression
Bin-Jin Hwang, Li-Chung Tsao, Chaitanya R Acharya, Timothy Trotter, Pankaj Agarwal, Junping Wei, Tao Wang, Xiao-Yi Yang, Gangjun Lei, Takuya Osada, Herbert Kim Lyerly, Michael A Morse, Zachary Conrad Hartman

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e003721; DOI: 10.1136/jitc-2021-003721
CD4 T cell dynamics shape the immune response to combination oncolytic herpes virus and BRAF inhibitor therapy for melanoma
Galabina Bozhanova, Jehanne Hassan, Lizzie Appleton, Victoria Jennings, Shane Foo, Martin McLaughlin, Charleen ML Chan Wah Hak, Emmanuel C Patin, Eva Crespo-Rodriguez, Gabby Baker, Edward Armstrong, Matthew Chiu, Hardev Pandha, Adel Samson, Victoria Roulstone, Joan Kyula, Richard Vile, Fiona Errington-Mais, Malin Pedersen, Kevin Harrington, Masahiro Ono, Alan Melcher

Journal for ImmunoTherapy of Cancer Mar 2022, 10 (3) e004410; DOI: 10.1136/jitc-2021-004410

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