Oncolytic and Local Immunotherapy

Intratumoral OH2, an oncolytic herpes simplex virus 2, in patients with advanced solid tumors: a multicenter, phase I/II clinical trial
Bo Zhang, Jing Huang, Jialin Tang, Sheng Hu, Suxia Luo, Zhiguo Luo, Fuxiang Zhou, Shiyun Tan, Jieer Ying, Qing Chang, Rui Zhang, Chengyun Geng, Dawei Wu, Xiangyong Gu, Binlei Liu

Journal for ImmunoTherapy of Cancer Apr 2021, 9 (4) e002224; DOI: 10.1136/jitc-2020-002224
Oncolytic herpesvirus expressing PD-L1 BiTE for cancer therapy: exploiting tumor immune suppression as an opportunity for targeted immunotherapy
Hena Khalique, Richard Baugh, Arthur Dyer, Eleanor M. Scott, Sally Frost, Sarah Larkin, Janet Lei-Rossmann, Leonard W. Seymour

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (4) e001292; DOI: 10.1136/jitc-2020-001292
New generation of DNA-based immunotherapy induces a potent immune response and increases the survival in different tumor models
Alessandra Lopes, Chiara Bastiancich, Mathilde Bausart, Sophie Ligot, Laure Lambricht, Kevin Vanvarenberg, Bernard Ucakar, Bernard Gallez, Véronique Préat, Gaëlle Vandermeulen

Journal for ImmunoTherapy of Cancer Apr 2021, 9 (4) e001243; DOI: 10.1136/jitc-2020-001243
Talimogene laherparepvec upregulates immune-cell populations in non-injected lesions: findings from a phase II, multicenter, open-label study in patients with stage IIIB–IVM1c melanoma
Josep Malvehy, Igor Samoylenko, Dirk Schadendorf, Ralf Gutzmer, Jean-Jacques Grob, Joseph J Sacco, Kevin S Gorski, Abraham Anderson, Cheryl A Pickett, Kate Liu, Helen Gogas

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e001621; DOI: 10.1136/jitc-2020-001621
Reovirus-induced cell-mediated immunity for the treatment of multiple myeloma within the resistant bone marrow niche
Louise M E Müller, Gemma Migneco, Gina B Scott, Jenny Down, Sancha King, Basem Askar, Victoria Jennings, Babatunde Oyajobi, Karen Scott, Emma West, Christy Ralph, Adel Samson, Elizabeth J Ilett, Munitta Muthana, Matt Coffey, Alan Melcher, Christopher Parrish, Gordon Cook, Michelle Lawson, Fiona Errington-Mais

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e001803; DOI: 10.1136/jitc-2020-001803
Combination immunotherapy using G-CSF and oncolytic virotherapy reduces tumor growth in osteosarcoma
Alvaro Morales-Molina, Stefano Gambera, Angela Leo, Javier García-Castro

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e001703; DOI: 10.1136/jitc-2020-001703
T cell infiltration on local CpG-B delivery in early-stage melanoma is predominantly related to CLEC9A⁺CD141⁺ cDC1 and CD14⁺ antigen-presenting cell recruitment
Bas D Koster, Marta López González, Mari FCM van den Hout, Annelies W Turksma, Berbel JR Sluijter, Barbara G Molenkamp, Paul AM van Leeuwen, Saskia Vosslamber, Rik J Scheper, Alfons JM van den Eertwegh, M Petrousjka van den Tol, Ekaterina J Jordanova, Tanja D de Gruijl

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e001962; DOI: 10.1136/jitc-2020-001962
Natural killer T cell immunotherapy combined with oncolytic vesicular stomatitis virus or reovirus treatments differentially increases survival in mouse models of ovarian and breast cancer metastasis
Simon Gebremeskel, Adam Nelson, Brynn Walker, Tora Oliphant, Lynnea Lobert, Douglas Mahoney, Brent Johnston

Journal for ImmunoTherapy of Cancer Mar 2021, 9 (3) e002096; DOI: 10.1136/jitc-2020-002096
Real-life use of talimogene laherparepvec (T-VEC) in melanoma patients in centers in Austria, Switzerland and Germany
Julia Maria Ressler, Matthias Karasek, Lukas Koch, Rita Silmbrod, Joanna Mangana, Sofiya Latifyan, Veronica Aedo-Lopez, Helmut Kehrer, Felix Weihsengruber, Peter Koelblinger, Christian Posch, Julian Kofler, Olivier Michielin, Erika Richtig, Christine Hafner, Christoph Hoeller

Journal for ImmunoTherapy of Cancer Feb 2021, 9 (2) e001701; DOI: 10.1136/jitc-2020-001701
Influence of injection technique, drug formulation and tumor microenvironment on intratumoral immunotherapy delivery and efficacy
Nina M. Muñoz, Malea Williams, Katherine Dixon, Crystal Dupuis, Amanda McWatters, Rony Avritscher, Soraya Zorro Manrique, Kevin McHugh, Ravi Murthy, Alda Tam, Aung Naing, Sapna P. Patel, David Leach, Jeffrey D. Hartgerink, Simon Young, Punit Prakash, Patrick Hwu, Rahul A. Sheth

Journal for ImmunoTherapy of Cancer Feb 2021, 9 (2) e001800; DOI: 10.1136/jitc-2020-001800

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