Oncolytic and Local Immunotherapy

Multimodality analysis confers a prognostic benefit of a T-cell infiltrated tumor microenvironment and peripheral immune status in patients with melanoma
Georgia M Beasley, Michael C Brown, Norma E Farrow, Karenia Landa, Rami N Al-Rohil, Maria Angelica Selim, Aaron D Therien, Sin-Ho Jung, Junheng Gao, David Boczkowski, Eda K Holl, April K S Salama, Darell D Bigner, Matthias Gromeier, Smita K Nair

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e005052; DOI: 10.1136/jitc-2022-005052
Intratumoral administration of CD1c (BDCA-1)⁺ and CD141 (BDCA-3)⁺ myeloid dendritic cells in combination with talimogene laherparepvec in immune checkpoint blockade refractory advanced melanoma patients: a phase I clinical trial
Julia Katharina Schwarze, Jens Tijtgat, Gil Awada, Louise Cras, Angela Vasaturo, Christopher Bagnall, Ramses Forsyth, Inès Dufait, Sandra Tuyaerts, Ivan Van Riet, Bart Neyns

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e005141; DOI: 10.1136/jitc-2022-005141
Restoration of p53 activity via intracellular protein delivery sensitizes triple negative breast cancer to anti-PD-1 immunotherapy
Zaofeng Yang, Jacquelyne Ka-Li Sun, Marianne M Lee, Michael K Chan

Journal for ImmunoTherapy of Cancer Sep 2022, 10 (9) e005068; DOI: 10.1136/jitc-2022-005068
Reshaping the tumor microenvironment with oncolytic viruses, positive regulation of the immune synapse, and blockade of the immunosuppressive oncometabolic circuitry
Teresa T Nguyen, Dong Ho Shin, Sagar Sohoni, Sanjay K Singh, Yisel Rivera-Molina, Hong Jiang, Xuejun Fan, Joy Gumin, Frederick F Lang, Christopher Alvarez-Breckenridge, Filipa Godoy-Vitorino, Lisha Zhu, W Jim Zheng, Lijie Zhai, Erik Ladomersky, Kristen L Lauing, Marta M Alonso, Derek A Wainwright, Candelaria Gomez-Manzano, Juan Fueyo

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e004935; DOI: 10.1136/jitc-2022-004935
Preinduced reovirus-specific T-cell immunity enhances the anticancer efficacy of reovirus therapy
Christianne Groeneveldt, Priscilla Kinderman, Jordi J C van Stigt Thans, Camilla Labrie, Lisa Griffioen, Marjolein Sluijter, Diana J M van den Wollenberg, Rob C Hoeben, Joke M M den Haan, Sjoerd H van der Burg, Thorbald van Hall, Nadine van Montfoort

Journal for ImmunoTherapy of Cancer Jul 2022, 10 (7) e004464; DOI: 10.1136/jitc-2021-004464
Intratumoral immunotherapy using a TLR2/3 agonist, L-pampo, induces robust antitumor immune responses and enhances immune checkpoint blockade
Won Suk Lee, Dong Sung Kim, Jeong Hun Kim, Yoonki Heo, Hannah Yang, Eun-Jin Go, Jin Hyoung Kim, Seung Joon Lee, Byung Cheol Ahn, Jung Sun Yum, Hong Jae Chon, Chan Kim

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004799; DOI: 10.1136/jitc-2022-004799
BCG hydrogel promotes CTSS-mediated antigen processing and presentation, thereby suppressing metastasis and prolonging survival in melanoma
Mirela Kremenovic, Alfred A Chan, Bing Feng, Lukas Bäriswyl, Steve Robatel, Thomas Gruber, Li Tang, Delphine J Lee, Mirjam Schenk

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004133; DOI: 10.1136/jitc-2021-004133
Innate immune receptor signaling induces transient melanoma dedifferentiation while preserving immunogenicity
Beatrice Thier, Fang Zhao, Simone Stupia, Alicia Brüggemann, Johannes Koch, Nina Schulze, Susanne Horn, Christoph Coch, Gunther Hartmann, Antje Sucker, Dirk Schadendorf, Annette Paschen

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e003863; DOI: 10.1136/jitc-2021-003863
Oncolytic virus expressing PD-1 inhibitors activates a collaborative intratumoral immune response to control tumor and synergizes with CTLA-4 or TIM-3 blockade
Fei Ju, Yong Luo, Chaolong Lin, Xian Jia, Zilong Xu, Rui Tian, Yanhua Lin, Min Zhao, Yating Chang, Xiaoxuan Huang, Shaopeng Li, Wenfeng Ren, Yaning Qin, Mengqin Yu, Jizong Jia, Jinle Han, Wenxin Luo, Jun Zhang, Guo Fu, Xiangzhong Ye, Chenghao Huang, Ningshao Xia

Journal for ImmunoTherapy of Cancer Jun 2022, 10 (6) e004762; DOI: 10.1136/jitc-2022-004762
Intratumoral administration of STING-activating nanovaccine enhances T cell immunotherapy
Xiaoyi Jiang, Jian Wang, Xichen Zheng, Zhida Liu, Xinyu Zhang, Yuwei Li, Jonathan Wilhelm, Jun Cao, Gang Huang, Jinlan Zhang, Baran Sumer, Jayanthi Lea, Zhigang Lu, Jinming Gao, Min Luo

Journal for ImmunoTherapy of Cancer May 2022, 10 (5) e003960; DOI: 10.1136/jitc-2021-003960

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