Oncolytic and Local Immunotherapy

Trojan-horse silk fibroin nanocarriers loaded with a re-call antigen to redirect immunity against cancer
Elia Bari, Francesca Ferrera, Tiziana Altosole, Sara Perteghella, Pierluigi Mauri, Rossana Rossi, Giulia Passignani, Luca Mastracci, Martina Galati, Giuseppina Iliana Astone, Maddalena Mastrogiacomo, Patrizio Castagnola, Daniela Fenoglio, Dario Di Silvestre, Maria Luisa Torre, Gilberto Filaci

Journal for ImmunoTherapy of Cancer Jan 2023, 11 (1) e005916; DOI: 10.1136/jitc-2022-005916
Phase 1, open-label, dose-escalation study on the safety, pharmacokinetics, and preliminary efficacy of intravenous Coxsackievirus A21 (V937), with or without pembrolizumab, in patients with advanced solid tumors
Charles M Rudin, Hardev S Pandha, Matthew Zibelman, Wallace L Akerley, Kevin J Harrington, Daphne Day, Andrew G Hill, Steven J O'Day, Timothy D Clay, Gavin M Wright, Ross R Jennens, David E Gerber, Jonathan E Rosenberg, Christy Ralph, David C Campbell, Brendan D Curti, Jaime R Merchan, Yixin Ren, Emmett V Schmidt, Lisa Guttman, Sumati Gupta

Journal for ImmunoTherapy of Cancer Jan 2023, 11 (1) e005007; DOI: 10.1136/jitc-2022-005007
Novel combination strategy of high intensity focused ultrasound (HIFU) and checkpoint blockade boosted by bioinspired and oxygen-supplied nanoprobe for multimodal imaging-guided cancer therapy
Rui Tang, Hongye He, Xiaohong Lin, Nianhong Wu, Li Wan, Qiaoqi Chen, Yaqin Hu, Chen Cheng, Yuting Cao, Xun Guo, Ying Zhou, Xialin Xiong, Min Zheng, Qi Wang, Faqi Li, Yang Zhou, Pan Li

Journal for ImmunoTherapy of Cancer Jan 2023, 11 (1) e006226; DOI: 10.1136/jitc-2022-006226
Radiation to all macroscopic sites of tumor permits greater systemic antitumor response to in situ vaccination
Peter M Carlson, Ravi B Patel, Jen Birstler, Matthew Rodriquez, Claire Sun, Amy K Erbe, Amber M Bates, Ian Marsh, Joseph Grudzinski, Reinier Hernandez, Alexander A Pieper, Arika S Feils, Alexander L Rakhmilevich, Jamey P Weichert, Bryan P Bednarz, Paul M Sondel, Zachary S Morris

Journal for ImmunoTherapy of Cancer Jan 2023, 11 (1) e005463; DOI: 10.1136/jitc-2022-005463
Treatment of pancreatic cancer with irreversible electroporation and intratumoral CD40 antibody stimulates systemic immune responses that inhibit liver metastasis in an orthotopic model
Jayanth S Shankara Narayanan, Tomoko Hayashi, Suna Erdem, Sara McArdle, Herve Tiriac, Partha Ray, Minya Pu, Zbigniew Mikulski, Aaron Miller, Karen Messer, Dennis Carson, Stephen Schoenberger, Rebekah R White

Journal for ImmunoTherapy of Cancer Jan 2023, 11 (1) e006133; DOI: 10.1136/jitc-2022-006133
Intratumoral BO-112 in combination with radiotherapy synergizes to achieve CD8 T-cell-mediated local tumor control
Maria E Rodriguez-Ruiz, Irantzu Serrano-Mendioroz, Eneko Garate-Soraluze, Paloma Sánchez-Mateos, Celia Barrio-Alonso, Inmaculada Rodríguez López, Victor Diaz Pascual, Leire Arbea Moreno, Maite Alvarez, Miguel F Sanmamed, Jose Luis Perez-Gracia, Helena Escuin-Ordinas, Marisol Quintero, Ignacio Melero

Journal for ImmunoTherapy of Cancer Jan 2023, 11 (1) e005011; DOI: 10.1136/jitc-2022-005011
Intratumoral oncolytic virus V937 plus ipilimumab in patients with advanced melanoma: the phase 1b MITCI study
Brendan D Curti, Jon Richards, John R Hyngstrom, Gregory A Daniels, Mark Faries, Lynn Feun, Kim A Margolin, Sigrun Hallmeyer, Mark Grose, Yiwei Zhang, Anlong Li, Robert H I Andtbacka

Journal for ImmunoTherapy of Cancer Dec 2022, 10 (12) e005224; DOI: 10.1136/jitc-2022-005224
Systemic cellular viroimmunotherapy for canine high-grade gliomas
Ana Cloquell, Isidro Mateo, Stefano Gambera, Martí Pumarola, Ramon Alemany, Javier García-Castro, Ana Judith Perisé-Barrios

Journal for ImmunoTherapy of Cancer Dec 2022, 10 (12) e005669; DOI: 10.1136/jitc-2022-005669
In situ vaccination with cowpea mosaic virus elicits systemic antitumor immunity and potentiates immune checkpoint blockade
Chenkai Mao, Veronique Beiss, Gregory W Ho, Jennifer Fields, Nicole F Steinmetz, Steven Fiering

Journal for ImmunoTherapy of Cancer Dec 2022, 10 (12) e005834; DOI: 10.1136/jitc-2022-005834
Enhanced efficacy of direct immunochemotherapy for hepatic cancer with image-guided intratumoral radiofrequency hyperthermia
Xuefeng Kan, Guanhui Zhou, Feng Zhang, Hongxiu Ji, David S Shin, Wayne Monsky, Chuansheng Zheng, Xiaoming Yang

Journal for ImmunoTherapy of Cancer Nov 2022, 10 (11) e005619; DOI: 10.1136/jitc-2022-005619

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