Open access

Multiparametric MRI of early tumor response to immune checkpoint blockade in metastatic melanoma
Doreen Lau, Mary A McLean, Andrew N Priest, Andrew B Gill, Francis Scott, Ilse Patterson, Bruno Carmo, Frank Riemer, Joshua D Kaggie, Amy Frary, Doreen Milne, Catherine Booth, Arthur Lewis, Michal Sulikowski, Lee Brown, Jean-Martin Lapointe, Luigi Aloj, Martin J Graves, Kevin M Brindle, Pippa G Corrie, Ferdia A Gallagher

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e003125; DOI: 10.1136/jitc-2021-003125
DNA methylation-based signature of CD8+ tumor-infiltrating lymphocytes enables evaluation of immune response and prognosis in colorectal cancer
Qi Zou, Xiaolin Wang, Donglin Ren, Bang Hu, Guannan Tang, Yu Zhang, Meijin Huang, Rish K Pai, Daniel D Buchanan, Aung Ko Win, Polly A Newcomb, William M Grady, Huichuan Yu, Yanxin Luo

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e002671; DOI: 10.1136/jitc-2021-002671
Effect of a multidisciplinary Severe Immunotherapy Complications Service on outcomes for patients receiving immune checkpoint inhibitor therapy for cancer
Leyre Zubiri, Gabriel E Molina, Meghan J Mooradian, Justine Cohen, Sienna M Durbin, Laura Petrillo, Genevieve M Boland, Dejan Juric, Michael Dougan, Molly F Thomas, Alex T Faje, Michelle Rengarajan, Amanda C Guidon, Steven T Chen, Daniel Okin, Benjamin D Medoff, Mazen Nasrallah, Minna J Kohler, Sara R Schoenfeld, Rebecca S Karp-Leaf, Meghan E Sise, Tomas G Neilan, Daniel A Zlotoff, Jocelyn R Farmer, Aditya Bardia, Ryan J Sullivan, Steven M Blum, Yevgeniy R Semenov, Alexandra-Chloé Villani, Kerry L Reynolds

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e002886; DOI: 10.1136/jitc-2021-002886
Intratumoral combination therapy with poly(I:C) and resiquimod synergistically triggers tumor-associated macrophages for effective systemic antitumoral immunity
Clément Anfray, Francesco Mainini, Elisabeth Digifico, Akihiro Maeda, Marina Sironi, Marco Erreni, Achille Anselmo, Aldo Ummarino, Sara Gandoy, Francisco Expósito, Miriam Redrado, Diego Serrano, Alfonso Calvo, Marvin Martens, Susana Bravo, Alberto Mantovani, Paola Allavena, Fernando Torres Andón

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e002408; DOI: 10.1136/jitc-2021-002408
Simple and effective bacterial-based intratumoral cancer immunotherapy
Christina S E Carroll, Erin R Andrew, Laeeq Malik, Kathryn F Elliott, Moira Brennan, James Meyer, Alexander Hintze, Andrew A Almonte, Cassandra Lappin, Philip MacPherson, Klaus-Martin Schulte, Jane E Dahlstrom, Rohit Tamhane, Teresa Neeman, Elizabeth W Herbert, Maurice Orange, Desmond Yip, Rachel Allavena, Aude M Fahrer

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e002688; DOI: 10.1136/jitc-2021-002688
Pembrolizumab with low-dose carboplatin for recurrent platinum-resistant ovarian, fallopian tube, and primary peritoneal cancer: survival and immune correlates
John B Liao, William R Gwin, Renata R Urban, Katie M Hitchcock-Bernhardt, Andrew L Coveler, Doreen M Higgins, Jennifer S Childs, Hania N Shakalia, Ron E Swensen, Sasha E Stanton, Anna V Tinker, Tanya A Wahl, Richard G Ancheta, Kathryn F McGonigle, James Y Dai, Mary L Disis, Barbara A Goff

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e003122; DOI: 10.1136/jitc-2021-003122
Systematic preclinical evaluation of CD33-directed chimeric antigen receptor T cell immunotherapy for acute myeloid leukemia defines optimized construct design
Haiying Qin, Lila Yang, John A Chukinas, Nirali Shah, Samiksha Tarun, Marie Pouzolles, Christopher D Chien, Lisa M Niswander, Anthony R Welch, Naomi Taylor, Sarah K Tasian, Terry J Fry

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e003149; DOI: 10.1136/jitc-2021-003149
Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes
Mikako Nishida, Nahoko Yamashita, Taisaku Ogawa, Keita Koseki, Eiji Warabi, Tomoyuki Ohue, Masaaki Komatsu, Hirokazu Matsushita, Kazuhiro Kakimi, Eiryo Kawakami, Katsuyuki Shiroguchi, Heiichiro Udono

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e002954; DOI: 10.1136/jitc-2021-002954
Activated osteoarthritis following immune checkpoint inhibitor treatment: an observational study
Pankti Reid, David FL Liew, Rajshi Akruwala, Anne R Bass, Karmela K Chan

Journal for ImmunoTherapy of Cancer Sep 2021, 9 (9) e003260; DOI: 10.1136/jitc-2021-003260
Correction: CD3xCD19 DART molecule treatment induces non-apoptotic killing and is efficient against high-risk chemotherapy and venetoclax-resistant chronic lymphocytic leukemia cells
Journal for ImmunoTherapy of Cancer Aug 2021, 9 (8) 1; DOI: 10.1136/jitc-2019-000218corr1

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