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  • CD40L-armed oncolytic herpes simplex virus suppresses pancreatic ductal adenocarcinoma by facilitating the tumor microenvironment favorable to cytotoxic T cell response in the syngeneic mouse model

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Oncolytic and local immunotherapy
Original research
CD40L-armed oncolytic herpes simplex virus suppresses pancreatic ductal adenocarcinoma by facilitating the tumor microenvironment favorable to cytotoxic T cell response in the syngeneic mouse model

Authors

  • Ruikun Wang Tianjin Key Laboratory of Protein Sciences, Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, ChinaFrontier Science Center for Cell Responses, College of Life Sciences, Nankai University, Tianjin, China PubMed articlesGoogle scholar articles
  • Jingru Chen Tianjin Key Laboratory of Protein Sciences, Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, ChinaNankai International Advanced Research Institute (Shenzhen Futian), Nankai University, Shenzhen, China PubMed articlesGoogle scholar articles
  • Wei Wang Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China PubMed articlesGoogle scholar articles
  • Zhuoqian Zhao Tianjin Key Laboratory of Protein Sciences, Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, China PubMed articlesGoogle scholar articles
  • Haoran Wang Tianjin Key Laboratory of Protein Sciences, Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, China PubMed articlesGoogle scholar articles
  • Shiyu Liu Tianjin Key Laboratory of Protein Sciences, Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, ChinaState Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, China PubMed articlesGoogle scholar articles
  • Fan Li Tianjin Key Laboratory of Protein Sciences, Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, ChinaState Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, China PubMed articlesGoogle scholar articles
  • Yajuan Wan Tianjin Key Laboratory of Protein Sciences, Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, China PubMed articlesGoogle scholar articles
  • Jie Yin Department of Immunology, Tianjin Medical University, Tianjin, China PubMed articlesGoogle scholar articles
  • Rui Wang Tianjin Key Laboratory of Protein Sciences, Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, China PubMed articlesGoogle scholar articles
  • Yuanke Li State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, China PubMed articlesGoogle scholar articles
  • Cuizhu Zhang Tianjin Key Laboratory of Protein Sciences, Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, ChinaNankai International Advanced Research Institute (Shenzhen Futian), Nankai University, Shenzhen, China PubMed articlesGoogle scholar articles
  • Hongkai Zhang Tianjin Key Laboratory of Protein Sciences, Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, ChinaFrontier Science Center for Cell Responses, College of Life Sciences, Nankai University, Tianjin, ChinaShanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, ChinaState Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, ChinaCNBG-NKU Joint R&D Center, Beijing Institute of Biological Products Co., Ltd., China National Biotec Group, Beijing, China PubMed articlesGoogle scholar articles
  • Youjia Cao Tianjin Key Laboratory of Protein Sciences, Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin, ChinaFrontier Science Center for Cell Responses, College of Life Sciences, Nankai University, Tianjin, ChinaNankai International Advanced Research Institute (Shenzhen Futian), Nankai University, Shenzhen, China PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Youjia Cao; caoyj{at}nankai.edu.cn; Dr Hongkai Zhang; hongkai{at}nankai.edu.cn; Dr Cuizhu Zhang; cz912{at}nankai.edu.cn
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Citation

Wang R, Chen J, Wang W, et al
CD40L-armed oncolytic herpes simplex virus suppresses pancreatic ductal adenocarcinoma by facilitating the tumor microenvironment favorable to cytotoxic T cell response in the syngeneic mouse model
Journal for ImmunoTherapy of Cancer 2022;10:e003809. doi: 10.1136/jitc-2021-003809

Publication history

  • Accepted December 28, 2021
  • First published January 27, 2022.
Online issue publication 
October 18, 2023

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.