Article info

Original research
Targeting cathepsin B by cycloastragenol enhances antitumor immunity of CD8 T cells via inhibiting MHC-I degradation

Authors

  • Guoliang Deng State Key Laboratory of Pharmaceutical Biotechnology, Chemistry and Biomedicine Innovation Center (ChemBIC), Department of Biotechnology and Pharmaceutical Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China PubMed articlesGoogle scholar articles
  • Lisha Zhou State Key Laboratory of Pharmaceutical Biotechnology, Chemistry and Biomedicine Innovation Center (ChemBIC), Department of Biotechnology and Pharmaceutical Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China PubMed articlesGoogle scholar articles
  • Binglin Wang State Key Laboratory of Pharmaceutical Biotechnology, Chemistry and Biomedicine Innovation Center (ChemBIC), Department of Biotechnology and Pharmaceutical Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, ChinaBioinformatics Department of Predictive Medicine, Institute of Biomedical Informatics, Cell Signal Transduction Laboratory, School of Basic Medical Sciences, Henan University, Kaifeng, Henan, People's Republic of China PubMed articlesGoogle scholar articles
  • Xiaofan Sun State Key Laboratory of Pharmaceutical Biotechnology, Chemistry and Biomedicine Innovation Center (ChemBIC), Department of Biotechnology and Pharmaceutical Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China PubMed articlesGoogle scholar articles
  • Qinchang Zhang Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor, The First Clinical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China PubMed articlesGoogle scholar articles
  • Hongqi Chen Department of General Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, People's Republic of China PubMed articlesGoogle scholar articles
  • Ning Wan Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, China PubMed articlesGoogle scholar articles
  • Hui Ye Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, China PubMed articlesGoogle scholar articles
  • Xiaoqi Wu Genergy Bio-technology (Shanghai) Co. Ltd, Shanghai, China PubMed articlesGoogle scholar articles
  • Dongdong Sun Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor, The First Clinical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China PubMed articlesGoogle scholar articles
  • Yang Sun State Key Laboratory of Pharmaceutical Biotechnology, Chemistry and Biomedicine Innovation Center (ChemBIC), Department of Biotechnology and Pharmaceutical Sciences, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, ChinaJiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, China PubMed articlesGoogle scholar articles
  • Haibo Cheng Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor, The First Clinical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China PubMed articlesGoogle scholar articles
  1. Correspondence to Professor Yang Sun; yangsun{at}nju.edu.cn; Dr Dongdong Sun; sundd{at}njucm.edu.cn; Haibo Cheng; haibocheng{at}njucm.edu.cn
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Citation

Deng G, Zhou L, Wang B, et al
Targeting cathepsin B by cycloastragenol enhances antitumor immunity of CD8 T cells via inhibiting MHC-I degradation

Publication history

  • Accepted September 22, 2022
  • First published October 28, 2022.
Online issue publication 
December 07, 2023

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