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Basic tumor immunology
Original research
Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity

Authors

  • Khalid W Kalim Division of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Jun-Qi Yang Division of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Mark Wunderlich Division of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Vishnu Modur Division of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Phuong Nguyen Division of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Yuan Li Division of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Ting Wen Division of Allergy and Immunology, Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Ashley Kuenzi Davis Division of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Ravinder Verma Division of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Qing Richard Lu Division of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Anil G Jegga Division of Biomedical Informatics, Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Yi Zheng Division of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  • Fukun Guo Division of Experimental Hematology and Cancer Biology, Children's Hospital Medical Center, and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Fukun Guo; fukun.guo{at}cchmc.org; Professor Yi Zheng; yi.zheng{at}cchmc.org
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Citation

Kalim KW, Yang J, Wunderlich M, et al
Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity
Journal for ImmunoTherapy of Cancer 2022;10:e004806. doi: 10.1136/jitc-2022-004806

Publication history

  • Accepted October 11, 2022
  • First published November 25, 2022.
Online issue publication 
October 18, 2023

  • Supplementary Data

    This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.