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  • Inhibiting DNA methylation and RNA editing upregulates immunogenic RNA to transform the tumor microenvironment and prolong survival in ovarian cancer

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Clinical/translational cancer immunotherapy
Original research
Inhibiting DNA methylation and RNA editing upregulates immunogenic RNA to transform the tumor microenvironment and prolong survival in ovarian cancer

Authors

  • Stephanie Gomez Department of Microbiology, Immunology and Tropical Medicine, The George Washington University Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA PubMed articlesGoogle scholar articles
  • Olivia L Cox Department of Microbiology, Immunology and Tropical Medicine, The George Washington University Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA PubMed articlesGoogle scholar articles
  • Reddick R Walker Department of Microbiology, Immunology and Tropical Medicine, The George Washington University Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA PubMed articlesGoogle scholar articles
  • Uzma Rentia Department of Microbiology, Immunology and Tropical Medicine, The George Washington University Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA PubMed articlesGoogle scholar articles
  • Melissa Hadley Department of Microbiology, Immunology and Tropical Medicine, The George Washington University Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA PubMed articlesGoogle scholar articles
  • Elisa Arthofer Department of Microbiology, Immunology and Tropical Medicine, The George Washington University Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA PubMed articlesGoogle scholar articles
  • Noor Diab Department of Microbiology, Immunology and Tropical Medicine, The George Washington University Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA PubMed articlesGoogle scholar articles
  • Erin E Grundy Department of Microbiology, Immunology and Tropical Medicine, The George Washington University Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA PubMed articlesGoogle scholar articles
  • Tomas Kanholm Department of Microbiology, Immunology and Tropical Medicine, The George Washington University Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA PubMed articlesGoogle scholar articles
  • James I McDonald Department of Microbiology, Immunology and Tropical Medicine, The George Washington University Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA PubMed articlesGoogle scholar articles
  • Julie Kobyra Department of Microbiology, Immunology and Tropical Medicine, The George Washington University Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA PubMed articlesGoogle scholar articles
  • Erica Palmer Department of Biochemistry, The George Washington University Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA PubMed articlesGoogle scholar articles
  • Satish Noonepalle Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia, USA PubMed articlesGoogle scholar articles
  • Alejandro Villagra Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia, USA PubMed articlesGoogle scholar articles
  • David Leitenberg Department of Microbiology, Immunology and Tropical Medicine, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA Department of Pediatrics, Division of Pathology and Laboratory Medicine, Children's National Hospital, Washington, District of Columbia, USA PubMed articlesGoogle scholar articles
  • Catherine M Bollard Department of Microbiology, Immunology and Tropical Medicine, The George Washington University Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA Department of Pediatrics, Children's National Hospital, Washington, District of Columbia, USA PubMed articlesGoogle scholar articles
  • Yogen Saunthararajah Department of Hematology and Medical Oncology, Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, USA PubMed articlesGoogle scholar articles
  • Katherine B Chiappinelli Department of Microbiology, Immunology and Tropical Medicine, The George Washington University Cancer Center, The George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Katherine B Chiappinelli; kchiapp1{at}gwu.edu
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Citation

Gomez S, Cox OL, Walker RR, et al
Inhibiting DNA methylation and RNA editing upregulates immunogenic RNA to transform the tumor microenvironment and prolong survival in ovarian cancer
Journal for ImmunoTherapy of Cancer 2022;10:e004974. doi: 10.1136/jitc-2022-004974

Publication history

  • Accepted October 8, 2022
  • First published November 7, 2022.
Online issue publication 
October 18, 2023

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.