Metformin increases natural killer cell functions in head and neck squamous cell carcinoma through CXCL1 inhibition

McKenzie Crist; Benyamin Yaniv; Sarah Palackdharry; Maria A Lehn; Mario Medvedovic; Timothy Stone; Shuchi Gulati; Vidhya Karivedu; Michael Borchers; Bethany Fuhrman; Audrey Crago; Joseph Curry; Ubaldo Martinez-Outschoorn; Vinita Takiar; Trisha M Wise-Draper

doi:10.1136/jitc-2022-005632

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Clinical/translational cancer immunotherapy

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Metformin increases natural killer cell functions in head and neck squamous cell carcinoma through CXCL1 inhibition

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McKenzie Crist Department of Internal Medicine; Division of Hematology/Oncology, University of Cincinnati, Cincinnati, Ohio, USA PubMed articles Google scholar articles
Benyamin Yaniv Department of Medicine, UMass Memorial Medical Center, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA PubMed articles Google scholar articles
Sarah Palackdharry University of Cincinnati Cancer Center, University of Cincinnati, Cincinnati, Ohio, USA PubMed articles Google scholar articles
Maria A Lehn Department of Internal Medicine; Division of Hematology/Oncology, University of Cincinnati, Cincinnati, Ohio, USADivision of Radiation Oncology, University of Cincinnati, Cincinnati, Ohio, USA PubMed articles Google scholar articles
Mario Medvedovic Department of Environmental Health; Division of Biostatistics and Bioinformatics, University of Cincinnati, Cincinnati, Ohio, USA PubMed articles Google scholar articles
Timothy Stone Department of Environmental Health; Division of Biostatistics and Bioinformatics, University of Cincinnati, Cincinnati, Ohio, USA PubMed articles Google scholar articles
Shuchi Gulati Department of Internal Medicine; Division of Hematology/Oncology, University of Cincinnati, Cincinnati, Ohio, USA PubMed articles Google scholar articles
Vidhya Karivedu Department of Medical Oncology Head and Neck Oncology, The Ohio State University, Columbus, Ohio, USA PubMed articles Google scholar articles
Michael Borchers Division of Biostatistics and Bioinformatics, University of Cincinnati, Cincinnati, Ohio, USACincinnati VA Medical Center, Cincinnati, Ohio, USA PubMed articles Google scholar articles
Bethany Fuhrman University of Cincinnati Cancer Center, University of Cincinnati, Cincinnati, Ohio, USA PubMed articles Google scholar articles
Audrey Crago University of Cincinnati Cancer Center, University of Cincinnati, Cincinnati, Ohio, USA PubMed articles Google scholar articles
Joseph Curry Department of Otolaryngology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA PubMed articles Google scholar articles
Ubaldo Martinez-Outschoorn Department of Medical Oncology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA PubMed articles Google scholar articles
Vinita Takiar Division of Radiation Oncology, University of Cincinnati, Cincinnati, Ohio, USACincinnati VA Medical Center, Cincinnati, Ohio, USA PubMed articles Google scholar articles
Trisha M Wise-Draper Department of Internal Medicine; Division of Hematology/Oncology, University of Cincinnati, Cincinnati, Ohio, USA PubMed articles Google scholar articles

Correspondence to Dr Trisha M Wise-Draper; wiseth{at}ucmail.uc.edu

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Citation

Crist M, Yaniv B, Palackdharry S, et al

Metformin increases natural killer cell functions in head and neck squamous cell carcinoma through CXCL1 inhibition

Journal for ImmunoTherapy of Cancer 2022;10:e005632. doi: 10.1136/jitc-2022-005632

Publication history

Accepted September 30, 2022
First published November 3, 2022.

Online issue publication

October 18, 2023

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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