Table of contents

Basic tumor immunology

• Original research: PP4 inhibition sensitizes ovarian cancer to NK cell-mediated cytotoxicity via STAT1 activation and inflammatory signaling (23 December, 2022)

  Remya Raja, Christopher Wu, Esen Yonca Bassoy, Thomas E Rubino, Emma C Utagawa, Paul M Magtibay, Kristina A Butler, Marion Curtis
• Original research: Targeting of colorectal cancer organoids with zoledronic acid conjugated to the anti-EGFR antibody cetuximab (21 December, 2022)

  Roberto Benelli, Delfina Costa, Laura Salvini, Samuele Tardito, Francesca Tosetti, Federico Villa, Maria Raffaella Zocchi, Alessandro Poggi
• Original research: Tumor-associated neutrophils and macrophages exacerbate antidrug IgG-mediated anaphylactic reaction against an immune checkpoint inhibitor (21 December, 2022)

  Takahiro Arai, Tomomi Kokubo, Ruiheng Tang, Hirohito Abo, Ayu Terui, Jotaro Hirakawa, Hidetaka Akita, Hiroto Kawashima, Akihiro Hisaka, Hiroto Hatakeyama
• Original research: Activated B cells suppress T-cell function through metabolic competition (21 December, 2022)

  Nobuhiko Imahashi, Rafet Basar, Yuefan Huang, Fang Wang, Natalia Baran, Pinaki Prosad Banerjee, Junjun Lu, Ana Karen Nunez Cortes, Nadima Uprety, Emily Ensley, Luis Muniz-Feliciano, Tamara J Laskowski, Judy S Moyes, May Daher, Mayela Mendt, Lucila N Kerbauy, Mayra Shanley, Li Li, Francesca Lorraine Wei Inng Lim, Hila Shaim, Ye Li, Marina Konopleva, Michael Green, Jennifer Wargo, Elizabeth J Shpall, Ken Chen, Katayoun Rezvani
• Original research: Impact of CD4 T cells on intratumoral CD8 T-cell exhaustion and responsiveness to PD-1 blockade therapy in mouse brain tumors (21 December, 2022)

  Saad M Khan, Rupen Desai, Andrew Coxon, Alexandra Livingstone, Gavin P Dunn, Allegra Petti, Tanner M Johanns
• Original research: Activated NK cells reprogram MDSCs via NKG2D-NKG2DL and IFN-γ to modulate antitumor T-cell response after cryo-thermal therapy (15 December, 2022)

  Peng Peng, Yue Lou, Shicheng Wang, Junjun Wang, Zelu Zhang, Peishan Du, Jiamin Zheng, Ping Liu, Lisa X Xu
• Original research: Preconditioning of the immune system modulates the response of papillary thyroid cancer to immune checkpoint inhibitors (15 December, 2022)

  Fabiana Pani, Yoshinori Yasuda, Sylvie T Rousseau, Kevin C Bermea, Solmaz Roshanmehr, Rulin Wang, Srinivasan Yegnasubramanian, Patrizio Caturegli, Luigi Adamo
• Original research: Epigenetic modulation of neuroblastoma enhances T cell and NK cell immunogenicity by inducing a tumor-cell lineage switch (15 December, 2022)

  Annelisa M Cornel, Ester Dunnebach, Damon A Hofman, Sanjukta Das, Satyaki Sengupta, Femke van den Ham, Judith Wienke, Josephine G M Strijker, Denise A M H van den Beemt, Anke H W Essing, Bianca Koopmans, Sem A G Engels, Vania Lo Presti, Celina S Szanto, Rani E George, Jan J Molenaar, Sebastiaan van Heesch, Miranda P Dierselhuis, S Nierkens
• Original research: Immune responses against shared antigens are common in esophago-gastric cancer and can be enhanced using CD40-activated B cells (9 December, 2022)

  Martin Thelen, Diandra Keller, Jonas Lehmann, Kerstin Wennhold, Hendrik Weitz, Eugen Bauer, Birgit Gathof, Monika Brüggemann, Michaela Kotrova, Alexander Quaas, Christoph Mallmann, Seung-Hun Chon, Axel M Hillmer, Christiane Bruns, Michael von Bergwelt-Baildon, Maria Alejandra Garcia-Marquez, Hans Anton Schlößer
• Original research: Silence of a dependence receptor CSF1R in colorectal cancer cells activates tumor-associated macrophages (6 December, 2022)

  Mingxuan Zhu, Liangliang Bai, Xiaoxia Liu, Shaoyong Peng, Yumo Xie, Hong Bai, Huichuan Yu, Xiaolin Wang, Ping Yuan, Rui Ma, Jinxin Lin, Linping Wu, Meijin Huang, Yingjie Li, Yanxin Luo
• Original research: TGFβ-derived immune modulatory vaccine: targeting the immunosuppressive and fibrotic tumor microenvironment in a murine model of pancreatic cancer (6 December, 2022)

  Maria Perez-Penco, Stine Emilie Weis-Banke, Aimilia Schina, Majken Siersbæk, Mie Linder Hübbe, Mia Aaboe Jørgensen, Inés Lecoq, Lucia Lara de la Torre, Simone Kloch Bendtsen, Evelina Martinenaite, Morten Orebo Holmström, Daniel Hargbøl Madsen, Marco Donia, Niels Ødum, Lars Grøntved, Mads Hald Andersen
• Original research: T cells of colorectal cancer patients’ stimulated by neoantigenic and cryptic peptides better recognize autologous tumor cells (2 December, 2022)

  Sandra Schwarz, Johanna Schmitz, Markus W Löffler, Michael Ghosh, Hans-Georg Rammensee, Evgenia Olshvang, Marvin Markel, Nadine Mockel-Tenbrinck, Andrzej Dzionek, Susann Krake, Basak Arslan, Kapil Dev Kampe, Anne Wendt, Peter Bauer, Christina S Mullins, Andreas Schlosser, Michael Linnebacher
• Update in the treatment of non-melanoma skin cancers: the use of PD-1 inhibitors in basal cell carcinoma and cutaneous squamous-cell carcinoma (1 December, 2022)

  Paolo A Ascierto, Dirk Schadendorf