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Original research
TIGIT blockade repolarizes AML-associated TIGIT+ M2 macrophages to an M1 phenotype and increases CD47-mediated phagocytosis

Authors

  • Franziska Brauneck Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyMildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, Hamburg, Germany PubMed articlesGoogle scholar articles
  • Brit Fischer Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany PubMed articlesGoogle scholar articles
  • Marius Witt Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany PubMed articlesGoogle scholar articles
  • Jana Muschhammer Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany PubMed articlesGoogle scholar articles
  • Jennyfer Oelrich Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany PubMed articlesGoogle scholar articles
  • Pedro Henrique da Costa Avelar Department of Informatics, Faculty of Natural and Mathematical Sciences, King's College London, London, UK PubMed articlesGoogle scholar articles
  • Sophia Tsoka Department of Informatics, Faculty of Natural and Mathematical Sciences, King's College London, London, UK PubMed articlesGoogle scholar articles
  • Lars Bullinger Department of Hematology, Oncology and Tumor Immunology, Charite Universitatsmedizin Berlin, Berlin, Germany PubMed articlesGoogle scholar articles
  • Elisa Seubert Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany PubMed articlesGoogle scholar articles
  • Daniel J Smit Institute of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Hamburg, Germany PubMed articlesGoogle scholar articles
  • Carsten Bokemeyer Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany PubMed articlesGoogle scholar articles
  • Christin Ackermann Infectious Diseases Unit, I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany PubMed articlesGoogle scholar articles
  • Jasmin Wellbrock Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany PubMed articlesGoogle scholar articles
  • Friedrich Haag Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany PubMed articlesGoogle scholar articles
  • Walter Fiedler Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Franziska Brauneck; f.brauneck{at}uke.de
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Citation

Brauneck F, Fischer B, Witt M, et al
TIGIT blockade repolarizes AML-associated TIGIT+ M2 macrophages to an M1 phenotype and increases CD47-mediated phagocytosis

Publication history

  • Accepted October 27, 2022
  • First published December 22, 2022.
Online issue publication 
October 18, 2023
  • Supplementary Data

    This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

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