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Clinical/translational cancer immunotherapy
Original research
1α,25(OH)2D3 reverses exhaustion and enhances antitumor immunity of human cytotoxic T cells

Authors

  • Peng Li Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, Guangdong, ChinaThe Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Xinhai Zhu Department of Oncology, First Affiliated Hospital, Jinan University, Jinan University, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Guangchao Cao Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, Guangdong, ChinaThe Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Ruan Wu Anhui Provincial Center for Disease Control and Prevention, Hefei, Anhui, China PubMed articlesGoogle scholar articles
  • Ke Li Department of Infectious Disease, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Wenhui Yuan Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, Guangdong, ChinaThe Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Biyun Chen Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Guodong Sun Department of Orthopedics, First Affiliated Hospital, Jinan University, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Xichun Xia Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, Guangdong, ChinaThe Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Hua Zhang Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, Guangdong, ChinaThe Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Xiao Wang Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, Guangdong, ChinaThe Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Zhinan Yin Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, Guangdong, ChinaThe Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Ligong Lu Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, Guangdong, China PubMed articlesGoogle scholar articles
  • Yunfei Gao Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People's Hospital Affiliated with Jinan University, Jinan University, Zhuhai, Guangdong, ChinaThe Biomedical Translational Research Institute, Faculty of Medical Science, Jinan University, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Yunfei Gao; tyunfeigao{at}jnu.edu.cn
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Citation

Li P, Zhu X, Cao G, et al
1α,25(OH)2D3 reverses exhaustion and enhances antitumor immunity of human cytotoxic T cells
Journal for ImmunoTherapy of Cancer 2022;10:e003477. doi: 10.1136/jitc-2021-003477

Publication history

  • Accepted February 1, 2022
  • First published March 22, 2022.
Online issue publication 
March 22, 2022

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.