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Oncolytic and local immunotherapy
Original research
Oncolytic peptide LTX-315 induces anti-pancreatic cancer immunity by targeting the ATP11B-PD-L1 axis

Authors

  • Tianyu Tang Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of ChinaZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of ChinaZhejiang Clinical Research Center of Hepatobiliary and Pancreatic Diseases, Hangzhou, People's Republic of ChinaThe Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, Hangzhou, People's Republic of ChinaCancer Center, Zhejiang University, Hangzhou, People's Republic of China PubMed articlesGoogle scholar articles
  • Xing Huang Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of ChinaZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of ChinaZhejiang Clinical Research Center of Hepatobiliary and Pancreatic Diseases, Hangzhou, People's Republic of ChinaThe Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, Hangzhou, People's Republic of ChinaCancer Center, Zhejiang University, Hangzhou, People's Republic of China PubMed articlesGoogle scholar articles
  • Gang Zhang Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of ChinaZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of ChinaZhejiang Clinical Research Center of Hepatobiliary and Pancreatic Diseases, Hangzhou, People's Republic of ChinaThe Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, Hangzhou, People's Republic of ChinaCancer Center, Zhejiang University, Hangzhou, People's Republic of China PubMed articlesGoogle scholar articles
  • Minghao Lu Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of ChinaZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of ChinaZhejiang Clinical Research Center of Hepatobiliary and Pancreatic Diseases, Hangzhou, People's Republic of ChinaThe Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, Hangzhou, People's Republic of ChinaCancer Center, Zhejiang University, Hangzhou, People's Republic of China PubMed articlesGoogle scholar articles
  • Zhengtao Hong Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of ChinaZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of ChinaZhejiang Clinical Research Center of Hepatobiliary and Pancreatic Diseases, Hangzhou, People's Republic of ChinaThe Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, Hangzhou, People's Republic of ChinaCancer Center, Zhejiang University, Hangzhou, People's Republic of China PubMed articlesGoogle scholar articles
  • Meng Wang Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of ChinaZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of ChinaZhejiang Clinical Research Center of Hepatobiliary and Pancreatic Diseases, Hangzhou, People's Republic of ChinaThe Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, Hangzhou, People's Republic of ChinaCancer Center, Zhejiang University, Hangzhou, People's Republic of China PubMed articlesGoogle scholar articles
  • Junming Huang Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of ChinaZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of ChinaZhejiang Clinical Research Center of Hepatobiliary and Pancreatic Diseases, Hangzhou, People's Republic of ChinaThe Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, Hangzhou, People's Republic of ChinaCancer Center, Zhejiang University, Hangzhou, People's Republic of China PubMed articlesGoogle scholar articles
  • Xiao Zhi Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of ChinaZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of ChinaZhejiang Clinical Research Center of Hepatobiliary and Pancreatic Diseases, Hangzhou, People's Republic of ChinaThe Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, Hangzhou, People's Republic of ChinaCancer Center, Zhejiang University, Hangzhou, People's Republic of China PubMed articlesGoogle scholar articles
  • Tingbo Liang Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of ChinaZhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of ChinaZhejiang Clinical Research Center of Hepatobiliary and Pancreatic Diseases, Hangzhou, People's Republic of ChinaThe Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, Hangzhou, People's Republic of ChinaCancer Center, Zhejiang University, Hangzhou, People's Republic of China PubMed articlesGoogle scholar articles
  1. Correspondence to Dr. Xing Huang; dr.huangxing{at}foxmail.com; Prof. Tingbo Liang; liangtingbo{at}zju.edu.cn
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Citation

Tang T, Huang X, Zhang G, et al
Oncolytic peptide LTX-315 induces anti-pancreatic cancer immunity by targeting the ATP11B-PD-L1 axis
Journal for ImmunoTherapy of Cancer 2022;10:e004129. doi: 10.1136/jitc-2021-004129

Publication history

  • Accepted February 5, 2022
  • First published March 14, 2022.
Online issue publication 
March 14, 2022

  • Supplementary Data

    This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.