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Clinical/translational cancer immunotherapy
Original research
L-5-hydroxytryptophan promotes antitumor immunity by inhibiting PD-L1 inducible expression

Authors

  • Jing Huang Drug Discovery and Design Center, The Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai, ChinaUniversity of Chinese Academy of Sciences, Beijing, China PubMed articlesGoogle scholar articles
  • Xiaobo Wang Key Laboratory of Metabolism and Molecular Medicine, The Ministry of Education, Department of Biochemistry and Molecular Biology, Fudan University School of Basic Medical Sciences, Shanghai, China PubMed articlesGoogle scholar articles
  • Bing Li Drug Discovery and Design Center, The Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai, ChinaUniversity of Chinese Academy of Sciences, Beijing, China PubMed articlesGoogle scholar articles
  • Shiyu Shen Department of Integrative Medicine and Neurobiology, State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences, Institutes of Brain Science, Brain Science Collaborative Innovation Center, Shanghai Medical College of Fudan University, Shanghai, China PubMed articlesGoogle scholar articles
  • Ruina Wang Key Laboratory of Metabolism and Molecular Medicine, The Ministry of Education, Department of Biochemistry and Molecular Biology, Fudan University School of Basic Medical Sciences, Shanghai, China PubMed articlesGoogle scholar articles
  • Hongru Tao Drug Discovery and Design Center, The Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai, ChinaSchool of Life Science and Technology, Harbin Institute of Technology, Harbin, China PubMed articlesGoogle scholar articles
  • Junchi Hu Center for Novel Target and Therapeutic Intervention, Chongqing Medical University, Chongqing, China PubMed articlesGoogle scholar articles
  • Jin Yu Department of Integrative Medicine and Neurobiology, State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences, Institutes of Brain Science, Brain Science Collaborative Innovation Center, Shanghai Medical College of Fudan University, Shanghai, China PubMed articlesGoogle scholar articles
  • Hualiang Jiang Drug Discovery and Design Center, The Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai, ChinaUniversity of Chinese Academy of Sciences, Beijing, China PubMed articlesGoogle scholar articles
  • Kaixian Chen Drug Discovery and Design Center, The Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai, ChinaUniversity of Chinese Academy of Sciences, Beijing, China PubMed articlesGoogle scholar articles
  • Cheng Luo Drug Discovery and Design Center, The Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai, ChinaUniversity of Chinese Academy of Sciences, Beijing, China PubMed articlesGoogle scholar articles
  • Yongjun Dang Key Laboratory of Metabolism and Molecular Medicine, The Ministry of Education, Department of Biochemistry and Molecular Biology, Fudan University School of Basic Medical Sciences, Shanghai, ChinaCenter for Novel Target and Therapeutic Intervention, Chongqing Medical University, Chongqing, China PubMed articlesGoogle scholar articles
  • Yuanyuan Zhang Drug Discovery and Design Center, The Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai, ChinaUniversity of Chinese Academy of Sciences, Beijing, China PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Yuanyuan Zhang; zhangyy{at}simm.ac.cn; Professor Yongjun Dang; yjdang{at}cqmu.edu; Professor Cheng Luo; cluo{at}simm.ac.cn
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Citation

Huang J, Wang X, Li B, et al
L-5-hydroxytryptophan promotes antitumor immunity by inhibiting PD-L1 inducible expression
Journal for ImmunoTherapy of Cancer 2022;10:e003957. doi: 10.1136/jitc-2021-003957

Publication history

  • Accepted March 22, 2022
  • First published June 21, 2022.
Online issue publication 
January 24, 2024

  • Supplementary Data

    This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.