Inhaled recombinant human IL-15 in dogs with naturally occurring pulmonary metastases from osteosarcoma or melanoma: a phase 1 study of clinical activity and correlates of response

Robert B Rebhun; Daniel York; Sylvia Margret Cruz; Sean J Judge; Aryana M Razmara; Lauren E Farley; Rachel V Brady; Eric G Johnson; Jenna H Burton; Jennifer Willcox; Luke A Wittenburg; Kevin Woolard; Cordelia Dunai; Susan L Stewart; Ellen E Sparger; Sita S Withers; Alicia A Gingrich; Katherine A Skorupski; Sami Al-Nadaf; Amandine T LeJeune; William TN Culp; William J Murphy; Michael S Kent; Robert J Canter

doi:10.1136/jitc-2022-004493

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Clinical/translational cancer immunotherapy

Original research

Inhaled recombinant human IL-15 in dogs with naturally occurring pulmonary metastases from osteosarcoma or melanoma: a phase 1 study of clinical activity and correlates of response

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Robert B Rebhun Department of Surgical and Radiological Sciences, University of California, Davis, California, USA PubMed articles Google scholar articles
Daniel York Department of Surgical and Radiological Sciences, University of California, Davis, California, USA PubMed articles Google scholar articles
Sylvia Margret Cruz Division of Surgical Oncology, Department of Surgery, University of California Davis Medical Center, Sacramento, California, USA PubMed articles Google scholar articles
Sean J Judge Division of Surgical Oncology, Department of Surgery, University of California Davis Medical Center, Sacramento, California, USA PubMed articles Google scholar articles
Aryana M Razmara Division of Surgical Oncology, Department of Surgery, University of California Davis Medical Center, Sacramento, California, USA PubMed articles Google scholar articles
Lauren E Farley Division of Surgical Oncology, Department of Surgery, University of California Davis Medical Center, Sacramento, California, USA PubMed articles Google scholar articles
Rachel V Brady College of Veterinary Medicine, Colorado State University, Fort Collins, Colorado, USA PubMed articles Google scholar articles
Eric G Johnson Department of Surgical and Radiological Sciences, University of California, Davis, California, USA PubMed articles Google scholar articles
Jenna H Burton Department of Clinical Sciences, Colorado State University College of Veterinary Medicine, Fort Collins, Colorado, USA PubMed articles Google scholar articles
Jennifer Willcox Department of Surgical and Radiological Sciences, University of California, Davis, California, USA PubMed articles Google scholar articles
Luke A Wittenburg Department of Surgical and Radiological Sciences, University of California, Davis, California, USA PubMed articles Google scholar articles
Kevin Woolard Department of Pathology, University of California, Davis, California, USA PubMed articles Google scholar articles
Cordelia Dunai Department of Dermatology, University of California, Davis, California, USA PubMed articles Google scholar articles
Susan L Stewart Department of Public Health Sciences, University of California, Davis, California, USA PubMed articles Google scholar articles
Ellen E Sparger Department of Medicine and Epidemiology, University of California, Davis, California, USA PubMed articles Google scholar articles
Sita S Withers Department of Veterinary Clinical Sciences, Louisiana State University, Baton Rouge, Louisiana, USA PubMed articles Google scholar articles
Alicia A Gingrich Division of Surgical Oncology, Department of Surgery, University of California Davis Medical Center, Sacramento, California, USA PubMed articles Google scholar articles
Katherine A Skorupski Department of Surgical and Radiological Sciences, University of California, Davis, California, USA PubMed articles Google scholar articles
Sami Al-Nadaf Department of Surgical and Radiological Sciences, University of California, Davis, California, USA PubMed articles Google scholar articles
Amandine T LeJeune Department of Surgical and Radiological Sciences, University of California, Davis, California, USA PubMed articles Google scholar articles
William TN Culp Department of Surgical and Radiological Sciences, University of California, Davis, California, USA PubMed articles Google scholar articles
William J Murphy Department of Dermatology, University of California Davis Medical Center, Sacramento, California, USADivision of Hematology and Oncology, Department of Medicine, University of California Davis Medical Center, Sacramento, California, USA PubMed articles Google scholar articles
Michael S Kent Department of Surgical and Radiological Sciences, University of California, Davis, California, USA PubMed articles Google scholar articles
Robert J Canter Division of Surgical Oncology, Department of Surgery, University of California, Davis, California, USA PubMed articles Google scholar articles

Correspondence to Dr Robert B Rebhun; rbrebhun{at}ucdavis.edu; Dr Robert J Canter; rjcanter{at}ucdavis.edu

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Rebhun RB, York D, Cruz SM, et al

Inhaled recombinant human IL-15 in dogs with naturally occurring pulmonary metastases from osteosarcoma or melanoma: a phase 1 study of clinical activity and correlates of response

Journal for ImmunoTherapy of Cancer 2022;10:e004493. doi: 10.1136/jitc-2022-004493

Publication history

Accepted May 3, 2022
First published June 9, 2022.

Online issue publication

January 24, 2024

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This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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