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Original research
Oncolytic virus expressing PD-1 inhibitors activates a collaborative intratumoral immune response to control tumor and synergizes with CTLA-4 or TIM-3 blockade

Authors

  • Fei Ju State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, China PubMed articlesGoogle scholar articles
  • Yong Luo Yangshengtang Co., Ltd, Hangzhou, ChinaHangzhou Yangshengtang Biopharmaceutical Co., Ltd, Hangzhou, China PubMed articlesGoogle scholar articles
  • Chaolong Lin State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, China PubMed articlesGoogle scholar articles
  • Xian Jia School of Life Sciences, Xiamen University, Xiamen, Fujian, China PubMed articlesGoogle scholar articles
  • Zilong Xu State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, China PubMed articlesGoogle scholar articles
  • Rui Tian State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, China PubMed articlesGoogle scholar articles
  • Yanhua Lin State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, China PubMed articlesGoogle scholar articles
  • Min Zhao State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, ChinaSchool of Life Sciences, Xiamen University, Xiamen, Fujian, China PubMed articlesGoogle scholar articles
  • Yating Chang State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, ChinaSchool of Life Sciences, Xiamen University, Xiamen, Fujian, China PubMed articlesGoogle scholar articles
  • Xiaoxuan Huang State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, China PubMed articlesGoogle scholar articles
  • Shaopeng Li State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, China PubMed articlesGoogle scholar articles
  • Wenfeng Ren State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, China PubMed articlesGoogle scholar articles
  • Yaning Qin State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, China PubMed articlesGoogle scholar articles
  • Mengqin Yu State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, China PubMed articlesGoogle scholar articles
  • Jizong Jia Beijing Wantai Biological Pharmacy, Beijing, China PubMed articlesGoogle scholar articles
  • Jinle Han Beijing Wantai Biological Pharmacy, Beijing, China PubMed articlesGoogle scholar articles
  • Wenxin Luo State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, China PubMed articlesGoogle scholar articles
  • Jun Zhang State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, China PubMed articlesGoogle scholar articles
  • Guo Fu School of Medicine, Xiamen University, Xiamen, Fujian, China PubMed articlesGoogle scholar articles
  • Xiangzhong Ye Beijing Wantai Biological Pharmacy, Beijing, China PubMed articlesGoogle scholar articles
  • Chenghao Huang State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, China PubMed articlesGoogle scholar articles
  • Ningshao Xia State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Xiamen University, Xiamen, Fujian, ChinaSchool of Life Sciences, Xiamen University, Xiamen, Fujian, China PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Chenghao Huang; huangchenghao{at}xmu.edu.cn; Professor Ningshao Xia; nsxia{at}xmu.edu.cn; Mr Xiangzhong Ye; yexiangzhong{at}ystwt.com; Dr Guo Fu; guofu{at}xmu.edu.cn
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Citation

Ju F, Luo Y, Lin C, et al
Oncolytic virus expressing PD-1 inhibitors activates a collaborative intratumoral immune response to control tumor and synergizes with CTLA-4 or TIM-3 blockade

Publication history

  • Accepted May 6, 2022
  • First published June 10, 2022.
Online issue publication 
March 20, 2024
  • Supplementary Data

    This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

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