Journal for ImmunoTherapy of Cancer: 10 (7)

Basic tumor immunology

Original research:
Intrahepatic CD69⁺Vδ1 T cells re-circulate in the blood of patients with metastatic colorectal cancer and limit tumor progression
(21 July, 2022)
Elena Bruni, Matteo Maria Cimino, Matteo Donadon, Roberta Carriero, Sara Terzoli, Rocco Piazza, Sarina Ravens, Immo Prinz, Valentina Cazzetta, Paolo Marzano, Paolo Kunderfranco, Clelia Peano, Cristiana Soldani, Barbara Franceschini, Federico Simone Colombo, Cecilia Garlanda, Alberto Mantovani, Guido Torzilli, Joanna Mikulak, Domenico Mavilio
Original research: ELK3 modulates the antitumor efficacy of natural killer cells against triple negative breast cancer by regulating mitochondrial dynamics (20 July, 2022)
Joo Dong Park, Kwang-Soo Kim, Seung Hee Choi, Gae Hoon Jo, Jin-Ho Choi, Si-Won Park, Eun-Su Ko, Minwook Lee, Dae-Keum Lee, Hye Jung Jang, Sohyun Hwang, Hae-Yun Jung, Kyung-Soon Park
Original research: CD40×HER2 bispecific antibody overcomes the CCL2-induced trastuzumab resistance in HER2-positive gastric cancer (17 July, 2022)
Weilin Sun, Xi Wang, Daohan Wang, Li Lu, Hai Lin, Zhaoxiong Zhang, Yangpu Jia, Xinyang Nie, Tong Liu, Weihua Fu
Original research: Dendritic cell-mediated cross presentation of tumor-derived peptides is biased against plasma membrane proteins (12 July, 2022)
Tim B Fessenden, Lauren E Stopfer, Fiona Chatterjee, Julian Zulueta, Josh Mesfin, Therese Cordero Dumit, Irene Reijers, Esmee P Hoefsmit, Christian Blank, Forest White, Stefani Spranger
Original research:
Gallic acid induces T-helper-1-like T_reg cells and strengthens immune checkpoint blockade efficacy
(11 July, 2022)
Biaolong Deng, Biaolong Yang, Jieqiong Chen, Shuaiwei Wang, Weiqi Zhang, Yixian Guo, Yichao Han, Hecheng Li, Yongjun Dang, Yaqin Yuan, Xueyu Dai, Yuansheng Zang, Yangyang Li, Bin Li
Original research: Local and systemic immune profiles of human pancreatic ductal adenocarcinoma revealed by single-cell mass cytometry (6 July, 2022)
Thomas P Brouwer, Natasja L de Vries, Tamim Abdelaal, Ricki T Krog, Zheng Li, Dina Ruano, Arantza Fariña, Boudewijn P F Lelieveldt, Hans Morreau, Bert A Bonsing, Alexander L Vahrmeijer, Frits Koning, Noel F C C de Miranda
Original research: Inhibition of stearoyl-CoA desaturase 1 (SCD1) enhances the antitumor T cell response through regulating β-catenin signaling in cancer cells and ER stress in T cells and synergizes with anti-PD-1 antibody (6 July, 2022)
Yuki Katoh, Tomonori Yaguchi, Akiko Kubo, Takashi Iwata, Kenji Morii, Daiki Kato, Shigeki Ohta, Ryosuke Satomi, Yasuhiro Yamamoto, Yoshitaka Oyamada, Kota Ouchi, Shin Takahashi, Chikashi Ishioka, Ryo Matoba, Makoto Suematsu, Yutaka Kawakami

Case report

T cell responses against SARS-CoV-2 and its Omicron variant in a patient with B cell lymphoma after multiple doses of a COVID-19 mRNA vaccine (17 July, 2022)
Djordje Atanackovic, Robert J Kreitman, Jeffrey Cohen, Nancy M Hardy, Destiny Omili, Thierry Iraguha, Peter D Burbelo, Etse Gebru, Xiaoxuan Fan, John Baddley, Tim Luetkens, Saurabh Dahiya, Aaron P Rapoport

Clinical/translational cancer immunotherapy

Original research: Overcoming resistance to αPD-1 of MMR-deficient tumors with high tumor-induced neutrophils levels by combination of αCTLA-4 and αPD-1 blockers (27 July, 2022)
Laetitia Nebot-Bral, Antoine Hollebecque, Andrey A Yurchenko, Louise de Forceville, Mathieu Danjou, Jean-Mehdi Jouniaux, Reginaldo C A Rosa, Caroline Pouvelle, Said Aoufouchi, Perrine Vuagnat, Cristina Smolenschi, Emeline Colomba, Alexandra Leary, Aurelien Marabelle, Jean-Yves Scoazec, Lydie Cassard, Sergey Nikolaev, Nathalie Chaput, Patricia Kannouche
Original research: Tumor cell SYK expression modulates the tumor immune microenvironment composition in human cancer via TNF-α dependent signaling (22 July, 2022)
Adam Aguirre-Ducler, Nicole Gianino, Franz Villarroel-Espindola, Shruti Desai, Daiwei Tang, Hongyu Zhao, Konstantinos Syrigos, William L Trepicchio, Karuppiah Kannan, Richard C Gregory, Kurt A Schalper
Original research: Colocalized targeting of TGF-β and PD-L1 by bintrafusp alfa elicits distinct antitumor responses (20 July, 2022)
Yan Lan, Tsz-Lun Yeung, Hui Huang, Ansgar A Wegener, Somdutta Saha, Mira Toister-Achituv, Molly H Jenkins, Li-Ya Chiu, Adam Lazorchak, Ohad Tarcic, Hong Wang, Jin Qi, George Locke, Doron Kalimi, Guozhong Qin, Bo Marelli, Huakui Yu, Alec W Gross, Melissa G Derner, Maria Soloviev, Mathieu Botte, Aroop Sircar, Hong Ma, Vanita D Sood, Dong Zhang, Feng Jiang, Kin-Ming Lo
Original research: Toll-like receptor 7/8 agonist R848 alters the immune tumor microenvironment and enhances SBRT-induced antitumor efficacy in murine models of pancreatic cancer (17 July, 2022)
Jian Ye, Bradley N Mills, Shuyang S Qin, Jesse Garrett-Larsen, Joseph D Murphy, Taylor P Uccello, Booyeon J Han, Tara G Vrooman, Carl J Johnston, Edith M Lord, Brian A Belt, David C Linehan, Scott A Gerber
Original research: TransCon IL-2 β/γ: a novel long-acting prodrug with sustained release of an IL-2Rβ/γ-selective IL-2 variant with improved pharmacokinetics and potent activation of cytotoxic immune cells for the treatment of cancer (11 July, 2022)
David B Rosen, Anne Månsson Kvarnhammar, Burkhardt Laufer, Thomas Knappe, Jens Jakob Karlsson, Enping Hong, Yu-Chi Lee, Dhruv Thakar, Luis Alejandro Zúñiga, Kathy Bang, Simran Singh Sabharwal, Karan Uppal, Janne Damm Olling, Kristian Kjaergaard, Thomas Kurpiers, Meike Schnabel, Diana Reich, Philipp Glock, Joachim Zettler, Mathias Krusch, Ana Bernhard, Stefan Heinig, Valentino Konjik, Thomas Wegge, Yvonne Hehn, Steffen Killian, Laura Viet, Josefine Runz, Frank Faltinger, Mohammad Tabrizi, Kristin Laura Abel, Vibeke Miller Breinholt, Stina M Singel, Kennett Sprogøe, Juha Punnonen
Original research: Efficacy and safety of anti-PD1 monotherapy or in combination with ipilimumab after BRAF/MEK inhibitors in patients with BRAF mutant metastatic melanoma (7 July, 2022)
Ines Pires da Silva, Danny Zakria, Tasnia Ahmed, Claudia Trojanello, Florentia Dimitriou, Clara Allayous, Camille Gerard, Lisa Zimmer, Serigne Lo, Olivier Michielin, Celeste Lebbe, Johanna Mangana, Paolo Antonio Ascierto, Douglas B Johnson, Matteo Carlino, Alexander Menzies, Georgina Long
Original research: Quantitative tissue analysis and role of myeloid cells in non-small cell lung cancer (6 July, 2022)
Brian S Henick, Franz Villarroel-Espindola, Ila Datar, Miguel F Sanmamed, Jovian Yu, Shruti Desai, Alice Li, Adam Aguirre-Ducler, Konstantinos Syrigos, David L Rimm, Lieping Chen, Roy S Herbst, Kurt A Schalper
Original research: Efficacy of anti-PD-1 and ipilimumab alone or in combination in acral melanoma (6 July, 2022)
Prachi Bhave, Tasnia Ahmed, Serigne N Lo, Alexander Shoushtari, Anne Zaremba, Judith M Versluis, Joanna Mangana, Michael Weichenthal, Lu Si, Thierry Lesimple, Caroline Robert, Claudia Trojanello, Alexandre Wicky, Richard Heywood, Lena Tran, Kathleen Batty, Florentia Dimitriou, Anna Stansfeld, Clara Allayous, Julia K Schwarze, Meghan J Mooradian, Oliver Klein, Inderjit Mehmi, Rachel Roberts-Thomson, Andrea Maurichi, Hui-Ling Yeoh, Adnan Khattak, Lisa Zimmer, Christian U Blank, Egle Ramelyte, Katharina C Kähler, Severine Roy, Paolo A Ascierto, Olivier Michielin, Paul C Lorigan, Douglas B Johnson, Ruth Plummer, Celeste Lebbe, Bart Neyns, Ryan Sullivan, Omid Hamid, Mario Santinami, Grant A McArthur, Andrew M Haydon, Georgina V Long, Alexander M Menzies, Matteo S Carlino
Original research: Phase II study of ceralasertib (AZD6738) in combination with durvalumab in patients with advanced gastric cancer (5 July, 2022)
Minsuk Kwon, Gahyun Kim, Ryul Kim, Kyu-Tae Kim, Seung Tae Kim, Simon Smith, Peter G S Mortimer, Jung Yong Hong, Arsene-Bienvenu Loembé, Itziar Irurzun-Arana, Loumpiana Koulai, Kyoung-Mee Kim, Won Ki Kang, Emma Dean, Woong-Yang Park, Jeeyun Lee
Original research: Novel intravesical bacterial immunotherapy induces rejection of BCG-unresponsive established bladder tumors (3 July, 2022)
Eduardo Moreo, Santiago Uranga, Ana Picó, Ana Belén Gómez, Denise Nardelli-Haefliger, Carlos del Fresno, Ingrid Murillo, Eugenia Puentes, Esteban Rodríguez, Mar Vales-Gómez, Julian Pardo, David Sancho, Carlos Martín, Nacho Aguilo

Commentary

Oncolytic immunotherapy: multiple mechanisms of oncolytic peptides to confer anticancer immunity (17 July, 2022)
Tianyu Tang, Xing Huang, Gang Zhang, Tingbo Liang
Low-dose irradiation for reversing immunotherapy resistance: how to translate? (14 July, 2022)
Maria Ochoa-de-Olza, Jean Bourhis, George Coukos, Fernanda G Herrera

Hypothesis

Rethinking the immunotherapy numbers game (6 July, 2022)
Rebecca A Bekker, Mohammad U Zahid, Jennifer M Binning, Bryan Q Spring, Patrick Hwu, Shari Pilon-Thomas, Heiko Enderling

Immunotherapy biomarkers

Original research: Multimodule characterization of immune subgroups in intrahepatic cholangiocarcinoma reveals distinct therapeutic vulnerabilities (21 July, 2022)
Jian Lin, Yuting Dai, Chen Sang, Guohe Song, Bin Xiang, Mao Zhang, Liangqing Dong, Xiaoli Xia, Jiaqiang Ma, Xia Shen, Shuyi Ji, Shu Zhang, Mingjie Wang, Hai Fang, Xiaoming Zhang, Xiangdong Wang, Bing Zhang, Jian Zhou, Jia Fan, Hu Zhou, Daming Gao, Qiang Gao
Original research: Clinical outcome following checkpoint therapy in renal cell carcinoma is associated with a burst of activated CD8 T cells in blood (21 July, 2022)
Jennifer Wilkinson Carlisle, Caroline S Jansen, Maria Andrea Cardenas, Ewelina Sobierajska, Adriana Moon Reyes, Rachel Greenwald, Luke Del Balzo, Nataliya Prokhnevska, Omer Kucuk, Bradley C Carthon, Patrick Connor Mullane, Adeboye Osunkoya, Deborah Baumgarten, Fares Hosseinzadeh, Scott Wilkinson, Ross Lake, Adam G Sowalsky, Yuan Liu, Viraj A Master, Mehmet A Bilen, Haydn Kissick
Original research: Therapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors recruits cytotoxic T cells into solid tumor microenvironment (21 July, 2022)
Rita C. Acúrcio, Sabina Pozzi, Barbara Carreira, Marta Pojo, Nuria Gómez-Cebrián, Sandra Casimiro, Adelaide Fernandes, Andreia Barateiro, Vitor Farricha, Joaquim Brito, Ana Paula Leandro, Jorge A R Salvador, Luís Graça, Leonor Puchades-Carrasco, Luís Costa, Ronit Satchi-Fainaro, Rita C. Guedes, Helena F. Florindo
Original research: Mutation burden-orthogonal tumor genomic subtypes delineate responses to immune checkpoint therapy (22 July, 2022)
Shiro Takamatsu, Junzo Hamanishi, J B Brown, Ken Yamaguchi, Koji Yamanoi, Kosuke Murakami, Osamu Gotoh, Seiichi Mori, Masaki Mandai, Noriomi Matsumura
Original research: Baseline and post-treatment biomarkers of resistance to anti-PD-1 therapy in acral and mucosal melanoma: an observational study (6 July, 2022)
Irene M. Shui, Xiao Qiao Liu, Qing Zhao, Seung Tae Kim, Yuan Sun, Jennifer H. Yearley, Tasmiah Choudhury, Andrea L. Webber, Clemens Krepler, Razvan Cristescu, Jeeyun Lee
Original research: Spatial meta-transcriptomics reveal associations of intratumor bacteria burden with lung cancer cells showing a distinct oncogenic signature (6 July, 2022)
Abigail Wong-Rolle, Qiang Dong, Yunhua Zhu, Prajan Divakar, Jyh Liang Hor, Noemi Kedei, Madeline Wong, Desiree Tillo, Elizabeth A Conner, Arun Rajan, David S Schrump, Chengcheng Jin, Ronald N Germain, Chen Zhao
Pathological complete response to immune checkpoint inhibitor in patients with colorectal cancer liver metastases harboring POLE exonuclease domain mutation
(6 July, 2022)
Lei Wen, Zhigang Chen, Xiaomeng Ji, William Pat Fong, Qiong Shao, Chao Ren, Yanyu Cai, Binkui Li, Yunfei Yuan, Deshen Wang, Yuhong Li

Immune cell therapies and immune cell engineering

Original research: Chimeric antigen receptor T cells engineered to recognize the P329G-mutated Fc part of effector-silenced tumor antigen-targeting human IgG1 antibodies enable modular targeting of solid tumors (28 July, 2022)
Sophia Stock, Mohamed-Reda Benmebarek, Anna-Kristina Kluever, Diana Darowski, Christian Jost, Kay-Gunnar Stubenrauch, Joerg Benz, Anne Freimoser-Grundschober, Ekkehard Moessner, Pablo Umana, Marion Subklewe, Stefan Endres, Christian Klein, Sebastian Kobold
Original research: Indomethacin-induced oxidative stress enhances death receptor 5 signaling and sensitizes tumor cells to adoptive T-cell therapy (26 July, 2022)
Nada S Aboelella, Caitlin Brandle, Ogacheko Okoko, Md Yeashin Gazi, Zhi-Chun Ding, Hongyan Xu, Gregory Gorman, Roni Bollag, Marco L Davila, Locke J Bryan, David H Munn, Gary A Piazza, Gang Zhou
CRISPR-mediated TGFBR2 knockout renders human ovarian cancer tumor-infiltrating lymphocytes resistant to TGF-β signaling (26 July, 2022)
Samantha M Fix, Marie-Andrée Forget, Donastas Sakellariou-Thompson, Yunfei Wang, Tamara M Griffiths, Minjung Lee, Cara L Haymaker, Ana Lucía Dominguez, Rafet Basar, Christopher Reyes, Sanjay Kumar, Larissa A Meyer, Patrick Hwu, Chantale Bernatchez, Amir A Jazaeri
Original research: Structural insights into engineering a T-cell receptor targeting MAGE-A10 with higher affinity and specificity for cancer immunotherapy (17 July, 2022)
Philip C Simister, Ellen C Border, João F Vieira, Nicholas J Pumphrey
Original research: Chimeric antigen receptor T-cells targeting IL-1RAP: a promising new cellular immunotherapy to treat acute myeloid leukemia (8 July, 2022)
Rim Trad, Walid Warda, Vincent Alcazer, Mathieu Neto da Rocha, Ana Berceanu, Clémentine Nicod, Rafik Haderbache, Xavier Roussel, Yohan Desbrosses, Etienne Daguindau, Florain Renosi, Christophe Roumier, Lucie Bouquet, Sabeha Biichle, Melanie Guiot, Evan Seffar, Denis Caillot, Stephane Depil, Eric Robinet, Yahya Salma, Eric Deconinck, Marina Deschamps, Christophe Ferrand
Original research: Natural high-avidity T-cell receptor efficiently mediates regression of cancer/testis antigen 83 positive common solid cancers (7 July, 2022)
Qingyang Li, Wei Hu, Baoyi Liao, Chanchan Song, Liangping Li
Original research: Non-synergy of PD-1 blockade with T-cell therapy in solid tumors (6 July, 2022)
John S Davies, Farrah Karimipour, Ling Zhang, Nisha Nagarsheth, Scott Norberg, Carylinda Serna, Julius Strauss, Shinheng Chiou, James L Gulley, Christian S Hinrichs

Oncolytic and local immunotherapy

Original research: Reshaping the tumor microenvironment with oncolytic viruses, positive regulation of the immune synapse, and blockade of the immunosuppressive oncometabolic circuitry (28 July, 2022)
Teresa T Nguyen, Dong Ho Shin, Sagar Sohoni, Sanjay K Singh, Yisel Rivera-Molina, Hong Jiang, Xuejun Fan, Joy Gumin, Frederick F Lang, Christopher Alvarez-Breckenridge, Filipa Godoy-Vitorino, Lisha Zhu, W Jim Zheng, Lijie Zhai, Erik Ladomersky, Kristen L Lauing, Marta M Alonso, Derek A Wainwright, Candelaria Gomez-Manzano, Juan Fueyo
Original research: Preinduced reovirus-specific T-cell immunity enhances the anticancer efficacy of reovirus therapy (19 July, 2022)
Christianne Groeneveldt, Priscilla Kinderman, Jordi J C van Stigt Thans, Camilla Labrie, Lisa Griffioen, Marjolein Sluijter, Diana J M van den Wollenberg, Rob C Hoeben, Joke M M den Haan, Sjoerd H van der Burg, Thorbald van Hall, Nadine van Montfoort

Position article and guidelines

Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of nonmelanoma skin cancer (28 July, 2022)
Ann W Silk, Christopher A Barker, Shailender Bhatia, Kathryn B Bollin, Sunandana Chandra, Zeynep Eroglu, Brian R Gastman, Kari L Kendra, Harriet Kluger, Evan J Lipson, Kathleen Madden, David M Miller, Paul Nghiem, Anna C Pavlick, Igor Puzanov, Guilherme Rabinowits, Emily S Ruiz, Vernon K Sondak, Edward A Tavss, Michael T Tetzlaff, Isaac Brownell

Review

Microbial short-chain fatty acids: a strategy to tune adoptive T cell therapy (26 July, 2022)
Priya Rangan, Anna Mondino
NIR fluorescence imaging and treatment for cancer immunotherapy (20 July, 2022)
Homan Kang, Min-Woong Kang, Satoshi Kashiwagi, Hak Soo Choi
Addressing CPI resistance in NSCLC: targeting TAM receptors to modulate the tumor microenvironment and future prospects (20 July, 2022)
Solange Peters, Luis Paz-Ares, Roy S Herbst, Martin Reck
CD47/SIRPα axis: bridging innate and adaptive immunity (13 July, 2022)
Anneloes van Duijn, Sjoerd H Van der Burg, Ferenc A Scheeren
Lipid-loaded macrophages as new therapeutic target in cancer (7 July, 2022)
Giulia Marelli, Nicolò Morina, Federica Portale, Marta Pandini, Marta Iovino, Giusy Di Conza, Ping-Chih Ho, Diletta Di Mitri
Imaging approaches and radiomics: toward a new era of ultraprecision radioimmunotherapy? (6 July, 2022)
Roger Sun, Théophraste Henry, Adrien Laville, Alexandre Carré, Anthony Hamaoui, Sophie Bockel, Ines Chaffai, Antonin Levy, Cyrus Chargari, Charlotte Robert, Eric Deutsch

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Table of contents

July 2022 - Volume 10 - 7

Basic tumor immunology

Case report

Clinical/translational cancer immunotherapy

Commentary

Hypothesis

Immunotherapy biomarkers

Immune cell therapies and immune cell engineering

Oncolytic and local immunotherapy

Position article and guidelines

Review

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Table of contents

July 2022 - Volume 10 - 7

Basic tumor immunology

Case report

Clinical/translational cancer immunotherapy

Commentary

Hypothesis

Immunotherapy biomarkers

Immune cell therapies and immune cell engineering

Oncolytic and local immunotherapy

Position article and guidelines

Review