Article info

Original research
Spatially resolved proteomic profiling identifies tumor cell CD44 as a biomarker associated with sensitivity to PD-1 axis blockade in advanced non-small-cell lung cancer

Authors

  • Myrto K Moutafi Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA PubMed articlesGoogle scholar articles
  • Magdalena Molero Tumor Microenvironment and Immunotherapy Research Group, 12 de Octubre Research Institute (i+12), Madrid, SpainH12O-CNIO Lung Cancer Clinical Research Unit, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Spanish National Cancer Research Center (CNIO), Madrid, Spain PubMed articlesGoogle scholar articles
  • Sandra Martinez Morilla Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA PubMed articlesGoogle scholar articles
  • Javier Baena Tumor Microenvironment and Immunotherapy Research Group, 12 de Octubre Research Institute (i+12), Madrid, SpainDepartment of Medical Oncology, 12 de Octubre Hospital, Madrid, Spain PubMed articlesGoogle scholar articles
  • Ioannis A Vathiotis Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA PubMed articlesGoogle scholar articles
  • Niki Gavrielatou Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA PubMed articlesGoogle scholar articles
  • Laura Castro-Labrador Tumor Microenvironment and Immunotherapy Research Group, 12 de Octubre Research Institute (i+12), Madrid, Spain PubMed articlesGoogle scholar articles
  • Gorka Ruiz de Garibay Tumor Microenvironment and Immunotherapy Research Group, 12 de Octubre Research Institute (i+12), Madrid, SpainH12O-CNIO Lung Cancer Clinical Research Unit, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Spanish National Cancer Research Center (CNIO), Madrid, Spain PubMed articlesGoogle scholar articles
  • Vera Adradas Tumor Microenvironment and Immunotherapy Research Group, 12 de Octubre Research Institute (i+12), Madrid, Spain PubMed articlesGoogle scholar articles
  • Daniel Orive Program in Solid Tumors, CIMA-University of Navarra, Pamplona, SpainDepartment of Pathology, University of Navarra, Pamplona, Spain PubMed articlesGoogle scholar articles
  • Karmele Valencia Program in Solid Tumors, CIMA-University of Navarra, Pamplona, SpainSpanish Center for Biomedical Research Network in Oncology, CIBERONC, Madrid, SpainHealth Research Institute of Navarra, IdiSNA, Pamplona, Spain PubMed articlesGoogle scholar articles
  • Alfonso Calvo Program in Solid Tumors, CIMA-University of Navarra, Pamplona, SpainDepartment of Pathology, University of Navarra, Pamplona, SpainSpanish Center for Biomedical Research Network in Oncology, CIBERONC, Madrid, SpainHealth Research Institute of Navarra, IdiSNA, Pamplona, Spain PubMed articlesGoogle scholar articles
  • Luis M Montuenga Program in Solid Tumors, CIMA-University of Navarra, Pamplona, SpainDepartment of Pathology, University of Navarra, Pamplona, SpainSpanish Center for Biomedical Research Network in Oncology, CIBERONC, Madrid, SpainHealth Research Institute of Navarra, IdiSNA, Pamplona, Spain PubMed articlesGoogle scholar articles
  • S Ponce Aix Tumor Microenvironment and Immunotherapy Research Group, 12 de Octubre Research Institute (i+12), Madrid, SpainH12O-CNIO Lung Cancer Clinical Research Unit, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Spanish National Cancer Research Center (CNIO), Madrid, SpainDepartment of Medical Oncology, 12 de Octubre Hospital, Madrid, SpainSpanish Center for Biomedical Research Network in Oncology, CIBERONC, Madrid, Spain PubMed articlesGoogle scholar articles
  • Kurt A Schalper Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USADepartment of Medicine (Oncology), Yale University School of Medicine, New Haven, Connecticut, USA PubMed articlesGoogle scholar articles
  • Roy S Herbst Department of Medicine (Oncology), Yale University School of Medicine, New Haven, Connecticut, USA PubMed articlesGoogle scholar articles
  • Luis Paz-Ares Tumor Microenvironment and Immunotherapy Research Group, 12 de Octubre Research Institute (i+12), Madrid, SpainH12O-CNIO Lung Cancer Clinical Research Unit, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Spanish National Cancer Research Center (CNIO), Madrid, SpainDepartment of Medical Oncology, 12 de Octubre Hospital, Madrid, SpainSpanish Center for Biomedical Research Network in Oncology, CIBERONC, Madrid, SpainDepartment of Medicine, Complutense University, Madrid, Spain PubMed articlesGoogle scholar articles
  • David L Rimm Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USADepartment of Medicine (Oncology), Yale University School of Medicine, New Haven, Connecticut, USA PubMed articlesGoogle scholar articles
  • Jon Zugazagoitia Tumor Microenvironment and Immunotherapy Research Group, 12 de Octubre Research Institute (i+12), Madrid, SpainH12O-CNIO Lung Cancer Clinical Research Unit, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Spanish National Cancer Research Center (CNIO), Madrid, SpainDepartment of Medical Oncology, 12 de Octubre Hospital, Madrid, SpainSpanish Center for Biomedical Research Network in Oncology, CIBERONC, Madrid, Spain PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Jon Zugazagoitia; j.zugazagoitia.imas12{at}h12o.es
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Citation

Moutafi MK, Molero M, Martinez Morilla S, et al
Spatially resolved proteomic profiling identifies tumor cell CD44 as a biomarker associated with sensitivity to PD-1 axis blockade in advanced non-small-cell lung cancer

Publication history

  • Accepted July 17, 2022
  • First published August 24, 2022.
Online issue publication 
November 15, 2022
  • Supplementary Data

    This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

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