Table of contents

Clinical/translational cancer immunotherapy

• Original research: Single-cell transcriptomics identifies pathogenic T-helper 17.1 cells and pro-inflammatory monocytes in immune checkpoint inhibitor-related pneumonitis (28 September, 2022)

  Amelie Franken, Pierre Van Mol, Sam Vanmassenhove, Elena Donders, Rogier Schepers, Thomas Van Brussel, Christophe Dooms, Jonas Yserbyt, Nico De Crem, Dries Testelmans, Walter De Wever, Kristiaan Nackaerts, Johan Vansteenkiste, Robin Vos, Stéphanie Humblet-Baron, Diether Lambrechts, Els Wauters
• Original research: Combination of a novel heat shock protein 90-targeted photodynamic therapy with PD-1/PD-L1 blockade induces potent systemic antitumor efficacy and abscopal effect against breast cancers (28 September, 2022)

  Kensuke Kaneko, Chaitanya R Acharya, Hiroshi Nagata, Xiao Yang, Zachary Conrad Hartman, Amy Hobeika, Philip F Hughes, Timothy A J Haystead, Michael A Morse, Herbert Kim Lyerly, Takuya Osada
• Original research: Generation and proof-of-concept for allogeneic CD123 CAR-Delta One T (DOT) cells in acute myeloid leukemia (26 September, 2022)

  Diego Sánchez Martínez, Néstor Tirado, Sofia Mensurado, Alba Martínez-Moreno, Paola Romecín, Francisco Gutiérrez Agüera, Daniel V Correia, Bruno Silva-Santos, Pablo Menéndez
• Original research: TEM8 Tri-specific Killer Engager binds both tumor and tumor stroma to specifically engage natural killer cell anti-tumor activity (26 September, 2022)

  Michael F Kaminski, Laura Bendzick, Rachel Hopps, Marissa Kauffman, Behiye Kodal, Yvette Soignier, Peter Hinderlie, Joshua T Walker, Todd R Lenvik, Melissa A Geller, Jeffrey S Miller, Martin Felices
• Original research: Mitigating the prevalence and function of myeloid-derived suppressor cells by redirecting myeloid differentiation using a novel immune modulator (23 September, 2022)

  Liliana Oliver, Rydell Alvarez, Raquel Diaz, Anet Valdés, Sean H Colligan, Michael J Nemeth, Danielle Y F Twum, Audry Fernández, Olivia Fernández-Medina, Louise M Carlson, Han Yu, Kevin H Eng, Mary L Hensen, Maura L Rábade-Chediak, Luis Enrique Fernández, Kelvin P Lee, Leslie Perez, Jason B Muhitch, Circe Mesa, Scott I Abrams
• Shorter versus longer corticosteroid duration and recurrent immune checkpoint inhibitor-associated AKI (22 September, 2022)

  Shruti Gupta, Clara Garcia-Carro, Jason M Prosek, Ilya Glezerman, Sandra M Herrmann, Pablo Garcia, Ala Abudayyeh, Nuttha Lumlertgul, A Bilal Malik, Sebastian Loew, Pazit Beckerman, Amanda D Renaghan, Christopher A Carlos, Arash Rashidi, Zain Mithani, Priya Deshpande, Sunil Rangarajan, Chintan V Shah, Sophie De Seigneux, Luca Campedel, Abhijat Kitchlu, Daniel Sanghoon Shin, Gaia Coppock, David I Ortiz-Melo, Ben Sprangers, Vikram Aggarwal, Karolina Benesova, Rimda Wanchoo, Naoka Murakami, Frank B Cortazar, Kerry L Reynolds, Meghan E Sise, Maria Jose Soler, David E Leaf
• Original research: Oral beclomethasone dipropionate is an effective treatment for immune checkpoint inhibitor induced colitis (16 September, 2022)

  James L Alexander, Hajir Ibraheim, Camellia Richards, Ben Shum, Polychronis Pavlidis, Nikki Hunter, Julian P Teare, Andrew Wotherspoon, Andrew Furness, Samra Turajlic, Lisa Pickering, James Larkin, Ally Speight, Sophie Papa, Nick Powell
• Original research:

  Personalized neoantigen vaccine combined with PD-1 blockade increases CD8⁺ tissue-resident memory T-cell infiltration in preclinical hepatocellular carcinoma models

  (16 September, 2022)

  Hengkai Chen, Zhenli Li, Liman Qiu, Xiuqing Dong, Geng Chen, Yingjun Shi, Linsheng Cai, Wenhan Liu, Honghao Ye, Yang Zhou, Jiahe Ouyang, Zhixiong Cai, Xiaolong Liu
• Original research:

  Generation and in vivo validation of an IL-12 fusion protein based on a novel anti-human FAP monoclonal antibody

  (14 September, 2022)

  Lisa Nadal, Frederik Peissert, Abdullah Elsayed, Tobias Weiss, Thomas Look, Michael Weller, Geny Piro, Carmine Carbone, Giampaolo Tortora, Mattia Matasci, Nicholas Favalli, Riccardo Corbellari, Cesare Di Nitto, Eleonora Prodi, Chiara Libbra, Simone Galeazzi, Claudiopietro Carotenuto, Cornelia Halin, Emanuele Puca, Dario Neri, Roberto De Luca
• Original research: Phase I/II clinical trial of a helper peptide vaccine plus PD-1 blockade in PD-1 antibody-naïve and PD-1 antibody-experienced patients with melanoma (MEL64) (13 September, 2022)

  Rick D Vavolizza, Gina R Petroni, Ileana S Mauldin, Kimberly A Chianese-Bullock, Walter C Olson, Kelly T Smith, Lynn T Dengel, Kathleen Haden, William W Grosh, Varinder Kaur, Nikole Varhegyi, Elizabeth M Gaughan, Craig L Slingluff
• Original research: Phase 1 study of C-CAR088, a novel humanized anti-BCMA CAR T-cell therapy in relapsed/refractory multiple myeloma (13 September, 2022)

  Xiaoyan Qu, Gang An, Weiwei Sui, Tingyu Wang, Xian Zhang, Junfang Yang, Yan Zhang, Lu Zhang, Dan Zhu, Jiaqi Huang, Shigui Zhu, Xin Yao, Jing Li, Chengxiao Zheng, Kevin Zhu, Yutian Wei, Xiaoteng Lv, Liping Lan, Yihong Yao, Daobin Zhou, Peihua Lu, Lugui Qiu, Jianyong Li
• Original research:

  Elicitation of stem-like CD8⁺ T cell responses via lymph node-targeted chemoimmunotherapy evokes systemic tumor control

  (13 September, 2022)

  Margaret P Manspeaker, Meghan J O'Melia, Susan N Thomas
• Original research: Preclinical characterization and clinical translation of pharmacodynamic markers for MK-5890: a human CD27 activating antibody for cancer immunotherapy (13 September, 2022)

  Lars Guelen, Thierry O Fischmann, Jerelyn Wong, Smita Mauze, Marco Guadagnoli, Nikolina Bąbała, Jozef Wagenaars, Veronica Juan, David Rosen, Winnie Prosise, Maurice Habraken, Imke Lodewijks, Danling Gu, Judith Stammen-Vogelzangs, Ying Yu, Jeanne Baker, David Lutje Hulsik, Lilian Driessen-Engels, Dan Malashock, Joost Kreijtz, Astrid Bertens, Evert de Vries, Astrid Bovens, Arne Bramer, Yiwei Zhang, Richard Wnek, Sean Troth, Elliot Chartash, Konstantin Dobrenkov, Svetlana Sadekova, Andrea van Elsas, Jason K Cheung, Laurence Fayadat-Dilman, Jannie Borst, Amy M Beebe, Hans Van Eenennaam
• Original research: In situ delivery of nanoparticles formulated with micron-sized crystals protects from murine melanoma (13 September, 2022)

  Mona O Mohsen, Matthew Heath, Matthias F Kramer, Thalia Carreno Velazquez, Alan Bullimore, Murray A Skinner, Daniel E Speiser, Martin F Bachmann
• Original research:

  Selective targeting of GARP-LTGFβ axis in the tumor microenvironment augments PD-1 blockade via enhancing CD8⁺ T cell antitumor immunity

  (12 September, 2022)

  Anqi Li, Yuzhou Chang, No-Joon Song, Xingjun Wu, Dongjun Chung, Brian P Riesenberg, Maria Velegraki, Giuseppe D Giuliani, Komal Das, Tamio Okimoto, Hyunwoo Kwon, Karthik B Chakravarthy, Chelsea Bolyard, Yi Wang, Kai He, Margaret Gatti-Mays, Jayajit Das, Yiping Yang, Daniel T Gewirth, Qin Ma, David Carbone, Zihai Li
• Original research: COLAR: open-label clinical study of IL-6 blockade with tocilizumab for the treatment of immune checkpoint inhibitor-induced colitis and arthritis (12 September, 2022)

  Rikke Boedker Holmstroem, Ole Haagen Nielsen, Søren Jacobsen, Lene Buhl Riis, Susann Theile, Jacob Tveiten Bjerrum, Peter Vilmann, Julia Sidenius Johansen, Mogens Karsbøl Boisen, Rikke Helene Løvendahl Eefsen, Inge Marie Svane, Dorte Lisbet Nielsen, Inna Markovna Chen
• Original research: Unveiling the tumor immune microenvironment of organ-specific melanoma metastatic sites (12 September, 2022)

  Jordan W Conway, Robert V Rawson, Serigne Lo, Tasnia Ahmed, Ismael A Vergara, Tuba N Gide, Grace Heloise Attrill, Matteo S Carlino, Robyn P M Saw, John F Thompson, Andrew J Spillane, Kerwin F Shannon, Brindha Shivalingam, Alexander Maxwell Menzies, James S Wilmott, Georgina V Long, Richard A Scolyer, Ines Pires da Silva
• Original research: BND-22, a first-in-class humanized ILT2-blocking antibody, promotes antitumor immunity and tumor regression (12 September, 2022)

  Ilana Mandel, Dana Haves Ziv, Ilana Goldshtein, Tsuri Peretz, Dror Alishekevitz, Anna Fridman Dror, Motti Hakim, Sharon Hashmueli, Itay Friedman, Yair Sapir, Rita Greco, Hongjing Qu, Frank Nestle, Dmitri Wiederschain, Lily Pao, Sharad Sharma, Tehila Ben Moshe
• Original research: Nemvaleukin alfa, a novel engineered IL-2 fusion protein, drives antitumor immunity and inhibits tumor growth in small cell lung cancer (8 September, 2022)

  Yuanwang Pan, Yuan Hao, Han Han, Ting Chen, Hailin Ding, Kristen E Labbe, Elaine Shum, Kayla Guidry, Hai Hu, Fiona Sherman, Ke Geng, Janaye Stephens, Alison Chafitz, Sittinon Tang, Hsin-Yi Huang, Chengwei Peng, Christina Almonte, Jared E Lopes, Heather C Losey, Raymond J Winquist, Vamsidhar Velcheti, Hua Zhang, Kwok-Kin Wong
• Original research: Effect of CD4+ T cell count on treatment-emergent adverse events among patients with and without HIV receiving immunotherapy for advanced cancer (2 September, 2022)

  Thomas A Odeny, Kathryn Lurain, Julius Strauss, Steven P Fling, Elad Sharon, Anna Wright, Javier Martinez-Picado, Teresa Moran, James L Gulley, Maria Gonzalez-Cao, Thomas S Uldrick, Robert Yarchoan, Ramya Ramaswami