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Immune cell therapies and immune cell engineering
Original research
Production and characterization of virus-free, CRISPR-CAR T cells capable of inducing solid tumor regression

Authors

  • Katherine P Mueller Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USAWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, Wisconsin, USA PubMed articlesGoogle scholar articles
  • Nicole J Piscopo Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USAWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, Wisconsin, USA PubMed articlesGoogle scholar articles
  • Matthew H Forsberg Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA PubMed articlesGoogle scholar articles
  • Louise A Saraspe Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, Wisconsin, USA PubMed articlesGoogle scholar articles
  • Amritava Das Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, Wisconsin, USA PubMed articlesGoogle scholar articles
  • Brittany Russell Wisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, Wisconsin, USA PubMed articlesGoogle scholar articles
  • Madeline Smerchansky Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USAWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, Wisconsin, USA PubMed articlesGoogle scholar articles
  • Dan Cappabianca Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USAWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, Wisconsin, USA PubMed articlesGoogle scholar articles
  • Lei Shi Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA PubMed articlesGoogle scholar articles
  • Keerthana Shankar Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USAWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, Wisconsin, USA PubMed articlesGoogle scholar articles
  • Lauren Sarko Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USAWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, Wisconsin, USA PubMed articlesGoogle scholar articles
  • Namita Khajanchi Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USAWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, Wisconsin, USA PubMed articlesGoogle scholar articles
  • Nina La Vonne Denne Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USAWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, Wisconsin, USA PubMed articlesGoogle scholar articles
  • Apoorva Ramamurthy Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USAWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, Wisconsin, USA PubMed articlesGoogle scholar articles
  • Adeela Ali Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA PubMed articlesGoogle scholar articles
  • Cicera R Lazzarotto Department of Hematology, St Jude Children’s Research Hospital, Memphis, Tennessee, USA PubMed articlesGoogle scholar articles
  • Shengdar Q Tsai Department of Hematology, St Jude Children’s Research Hospital, Memphis, Tennessee, USA PubMed articlesGoogle scholar articles
  • Christian M Capitini Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA PubMed articlesGoogle scholar articles
  • Krishanu Saha Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, Wisconsin, USAWisconsin Institute for Discovery, University of Wisconsin-Madison, Madison, Wisconsin, USA PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Krishanu Saha; ksaha{at}wisc.edu; Dr Christian M Capitini, Wisconsin Institute for Medical Research, Madison, WI 53705, USA; ccapitini{at}pediatrics.wisc.edu
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Citation

Mueller KP, Piscopo NJ, Forsberg MH, et al
Production and characterization of virus-free, CRISPR-CAR T cells capable of inducing solid tumor regression
Journal for ImmunoTherapy of Cancer 2022;10:e004446. doi: 10.1136/jitc-2021-004446

Publication history

  • Accepted August 4, 2022
  • First published September 7, 2022.
Online issue publication 
September 07, 2022

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.