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Basic tumor immunology
Original research
Complement downregulation promotes an inflammatory signature that renders colorectal cancer susceptible to immunotherapy

Authors

  • Carsten Krieg Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USAHollings Cancer Center Charleston, Medical University of South Carolina, Charleston, South Carolina, USA PubMed articlesGoogle scholar articles
  • Lukas M Weber Institute of Molecular Life Sciences, University of Zurich, Zurich, SwitzerlandSIB Swiss Institute of Bioinformatics, University of Zurich, Zurich, Switzerland PubMed articlesGoogle scholar articles
  • Bruno Fosso Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, Consiglio Nazionale delle Ricerche, Bari, Italy PubMed articlesGoogle scholar articles
  • Marinella Marzano Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, Consiglio Nazionale delle Ricerche, Bari, Italy PubMed articlesGoogle scholar articles
  • Gary Hardiman School of Biological Sciences and Institute for Global Food Security, Queens University of Belfast, Belfast, UK PubMed articlesGoogle scholar articles
  • Monica M Olcina Institute of Radiation Oncology, Medical Research Council Oxford Institute for Radiation Oncology, Oxford, UK PubMed articlesGoogle scholar articles
  • Enric Domingo Institute of Radiation Oncology, Medical Research Council Oxford Institute for Radiation Oncology, Oxford, UK PubMed articlesGoogle scholar articles
  • Sahar El Aidy Host-microbe Metabolic Interactions, Microbiology, University of Groningen, Groningen, The Netherlands PubMed articlesGoogle scholar articles
  • Khalil Mallah Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA PubMed articlesGoogle scholar articles
  • Mark D Robinson Institute of Molecular Life Sciences, University of Zurich, Zurich, SwitzerlandSIB Swiss Institute of Bioinformatics, University of Zurich, Zurich, Switzerland PubMed articlesGoogle scholar articles
  • Silvia Guglietta Hollings Cancer Center Charleston, Medical University of South Carolina, Charleston, South Carolina, USARegenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, South Carolina, USADepartment of Experimental Oncology, IEO European Institute of Oncology IRCCS, Milan, Italy PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Silvia Guglietta; gugliett{at}musc.edu
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Citation

Krieg C, Weber LM, Fosso B, et al
Complement downregulation promotes an inflammatory signature that renders colorectal cancer susceptible to immunotherapy
Journal for ImmunoTherapy of Cancer 2022;10:e004717. doi: 10.1136/jitc-2022-004717

Publication history

  • Accepted August 29, 2022
  • First published September 22, 2022.
Online issue publication 
March 12, 2024

  • Supplementary Data

    This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

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Copyright information

© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.