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  • Transcriptional and functional analyses of neoantigen-specific CD4 T cells during a profound response to anti-PD-L1 in metastatic Merkel cell carcinoma

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Basic tumor immunology
Original research
Transcriptional and functional analyses of neoantigen-specific CD4 T cells during a profound response to anti-PD-L1 in metastatic Merkel cell carcinoma

Authors

  • Candice Church Division of Dermatology, Department of Medicine, University of Washington, Seattle, WA, USA PubMed articlesGoogle scholar articles
  • Thomas Pulliam Division of Dermatology, Department of Medicine, University of Washington, Seattle, WA, USA PubMed articlesGoogle scholar articles
  • Natalie Longino Division of Dermatology, Department of Medicine, University of Washington, Seattle, WA, USA PubMed articlesGoogle scholar articles
  • Song Y Park Division of Dermatology, Department of Medicine, University of Washington, Seattle, WA, USA PubMed articlesGoogle scholar articles
  • Kimberly S Smythe Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA PubMed articlesGoogle scholar articles
  • Vladimir Makarov Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USACenter for Immunotherapy and Precision Immuno-oncology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA PubMed articlesGoogle scholar articles
  • Nadeem Riaz Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA PubMed articlesGoogle scholar articles
  • Lichen Jing Department of Medicine, University of Washington, Seattle, Washington, USA PubMed articlesGoogle scholar articles
  • Robert Amezquita Biostatistics Bioinformatics and Epidemiology Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA PubMed articlesGoogle scholar articles
  • Jean S Campbell Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA PubMed articlesGoogle scholar articles
  • Raphael Gottardo Biostatistics Bioinformatics and Epidemiology Division, Fred Hutchinson Cancer Center, Seattle, Washington, USALausanne University Hospital, Lausanne, Vaud, SwitzerlandSwiss Institute of Bioinformatics, Lausanne, Switzerland PubMed articlesGoogle scholar articles
  • Robert H Pierce Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA PubMed articlesGoogle scholar articles
  • Jaehyuk Choi Department of Dermatology, Biochemistry & Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA PubMed articlesGoogle scholar articles
  • Timothy A Chan Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USACenter for Immunotherapy and Precision Immuno-oncology, Cleveland Clinic, Cleveland, Ohio, USA PubMed articlesGoogle scholar articles
  • David M Koelle Department of Medicine, University of Washington, Seattle, Washington, USAVaccine and Infectious Diseases Division, Fred Hutchinson Cancer Center, Seattle, Washington, USADepartment of Global Health, University of Washington, Seattle, WA, USADepartment of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USABenaroya Research Institute, Seattle, WA, USA PubMed articlesGoogle scholar articles
  • Paul Nghiem Division of Dermatology, Department of Medicine, University of Washington, Seattle, WA, USAClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Paul Nghiem; pnghiem{at}uw.edu
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Citation

Church C, Pulliam T, Longino N, et al
Transcriptional and functional analyses of neoantigen-specific CD4 T cells during a profound response to anti-PD-L1 in metastatic Merkel cell carcinoma
Journal for ImmunoTherapy of Cancer 2022;10:e005328. doi: 10.1136/jitc-2022-005328

Publication history

  • Accepted August 14, 2022
  • First published September 9, 2022.
Online issue publication 
September 09, 2022

  • Supplementary Data

    This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.