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Basic tumor immunology
Original research
HSP90α induces immunosuppressive myeloid cells in melanoma via TLR4 signaling

Authors

  • Ihor Arkhypov Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, GermanyDepartment of Dermatology, Venereology and Allergology, University Medical Centre, Ruprecht-Karl University of Heidelberg, Mannheim, GermanyDFKZ-Hector Cancer Institute, University Medical Center Mannheim, Mannheim, GermanyMannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany PubMed articlesGoogle scholar articles
  • Feyza Gül Özbay Kurt Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, GermanyDepartment of Dermatology, Venereology and Allergology, University Medical Centre, Ruprecht-Karl University of Heidelberg, Mannheim, GermanyDFKZ-Hector Cancer Institute, University Medical Center Mannheim, Mannheim, GermanyMannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany PubMed articlesGoogle scholar articles
  • Rebekka Bitsch Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, GermanyDepartment of Dermatology, Venereology and Allergology, University Medical Centre, Ruprecht-Karl University of Heidelberg, Mannheim, GermanyDFKZ-Hector Cancer Institute, University Medical Center Mannheim, Mannheim, GermanyMannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany PubMed articlesGoogle scholar articles
  • Daniel Novak Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, GermanyDepartment of Dermatology, Venereology and Allergology, University Medical Centre, Ruprecht-Karl University of Heidelberg, Mannheim, GermanyDFKZ-Hector Cancer Institute, University Medical Center Mannheim, Mannheim, GermanyMannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany PubMed articlesGoogle scholar articles
  • Vera Petrova Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, GermanyDepartment of Dermatology, Venereology and Allergology, University Medical Centre, Ruprecht-Karl University of Heidelberg, Mannheim, GermanyDFKZ-Hector Cancer Institute, University Medical Center Mannheim, Mannheim, GermanyMannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany PubMed articlesGoogle scholar articles
  • Samantha Lasser Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, GermanyDepartment of Dermatology, Venereology and Allergology, University Medical Centre, Ruprecht-Karl University of Heidelberg, Mannheim, GermanyDFKZ-Hector Cancer Institute, University Medical Center Mannheim, Mannheim, GermanyMannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany PubMed articlesGoogle scholar articles
  • Thomas Hielscher Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany PubMed articlesGoogle scholar articles
  • Christopher Groth Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, GermanyDepartment of Dermatology, Venereology and Allergology, University Medical Centre, Ruprecht-Karl University of Heidelberg, Mannheim, GermanyDFKZ-Hector Cancer Institute, University Medical Center Mannheim, Mannheim, GermanyMannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany PubMed articlesGoogle scholar articles
  • Alisa Lepper Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, GermanyDepartment of Dermatology, Venereology and Allergology, University Medical Centre, Ruprecht-Karl University of Heidelberg, Mannheim, GermanyDFKZ-Hector Cancer Institute, University Medical Center Mannheim, Mannheim, GermanyMannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany PubMed articlesGoogle scholar articles
  • Xiaoying Hu Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, GermanyDepartment of Dermatology, Venereology and Allergology, University Medical Centre, Ruprecht-Karl University of Heidelberg, Mannheim, GermanyDFKZ-Hector Cancer Institute, University Medical Center Mannheim, Mannheim, GermanyMannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany PubMed articlesGoogle scholar articles
  • Wei Li Department of Dermatology and the USC-Norris Comprehensive Cancer Centre, University of Southern California Keck Medical Center, Los Angeles, California, USA PubMed articlesGoogle scholar articles
  • Jochen Utikal Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, GermanyDepartment of Dermatology, Venereology and Allergology, University Medical Centre, Ruprecht-Karl University of Heidelberg, Mannheim, GermanyDFKZ-Hector Cancer Institute, University Medical Center Mannheim, Mannheim, GermanyMannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany PubMed articlesGoogle scholar articles
  • Peter Altevogt Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, GermanyDepartment of Dermatology, Venereology and Allergology, University Medical Centre, Ruprecht-Karl University of Heidelberg, Mannheim, GermanyDFKZ-Hector Cancer Institute, University Medical Center Mannheim, Mannheim, GermanyMannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany PubMed articlesGoogle scholar articles
  • Viktor Umansky Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg, GermanyDepartment of Dermatology, Venereology and Allergology, University Medical Centre, Ruprecht-Karl University of Heidelberg, Mannheim, GermanyDFKZ-Hector Cancer Institute, University Medical Center Mannheim, Mannheim, GermanyMannheim Institute for Innate Immunoscience (MI3), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Viktor Umansky; V.Umansky{at}dkfz-heidelberg.de
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Citation

Arkhypov I, Özbay Kurt FG, Bitsch R, et al
HSP90α induces immunosuppressive myeloid cells in melanoma via TLR4 signaling
Journal for ImmunoTherapy of Cancer 2022;10:e005551. doi: 10.1136/jitc-2022-005551

Publication history

  • Accepted September 1, 2022
  • First published September 16, 2022.
Online issue publication 
March 12, 2024

  • Supplementary Data

    This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.