1307 The microbiome-derived metabolite TMAO drives immune activation and boosts response to immune checkpoint blockade in pancreatic cancer

Gauri Mirji; Alison Worth; Sajad Bhat; Mohamed El Sayed; Toshitha Kannan; Aaron Goldman; Hsin Yao Tang; Qin Liu; Noam Auslander; Chi Dang; Mohamed Abdel-Mohsen; Andrew Kossenkov; Ben Stanger; Rahul Shinde

doi:10.1136/jitc-2022-SITC2022.1307

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Regular and Young Investigator Award Abstracts

Microbiome and Other Environmental Factors

1307 The microbiome-derived metabolite TMAO drives immune activation and boosts response to immune checkpoint blockade in pancreatic cancer

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Gauri Mirji Wistar Institute, Philadelphia, PA, USA PubMed articles Google scholar articles
Alison Worth Wistar Institute, Philadelphia, PA, USA PubMed articles Google scholar articles
Sajad Bhat Wistar Institute, Philadelphia, PA, USA PubMed articles Google scholar articles
Mohamed El Sayed Wistar Institute, Philadelphia, PA, USA PubMed articles Google scholar articles
Toshitha Kannan Wistar Institute, Philadelphia, PA, USA PubMed articles Google scholar articles
Aaron Goldman Wistar Institute, Philadelphia, PA, USA PubMed articles Google scholar articles
Hsin Yao Tang Wistar Institute, Philadelphia, PA, USA PubMed articles Google scholar articles
Qin Liu Wistar Institute, Philadelphia, PA, USA PubMed articles Google scholar articles
Noam Auslander Wistar Institute, Philadelphia, PA, USA PubMed articles Google scholar articles
Chi Dang Wistar Institute, Philadelphia, PA, USA PubMed articles Google scholar articles
Mohamed Abdel-Mohsen Wistar Institute, Philadelphia, PA, USA PubMed articles Google scholar articles
Andrew Kossenkov Wistar Institute, Philadelphia, PA, USA PubMed articles Google scholar articles
Ben Stanger University of Pennsylvania, Philadelphia, PA, USA PubMed articles Google scholar articles
Rahul Shinde Wistar Institute, Philadelphia, PA, USA PubMed articles Google scholar articles

Citation

Mirji G, Worth A, Bhat S, et al

1307 The microbiome-derived metabolite TMAO drives immune activation and boosts response to immune checkpoint blockade in pancreatic cancer

Journal for ImmunoTherapy of Cancer 2022;10:doi: 10.1136/jitc-2022-SITC2022.1307

Publication history

First published November 7, 2022.

Online issue publication

April 26, 2023

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