Modulation of myeloid and T cells in vivo by Bruton’s tyrosine kinase inhibitor ibrutinib in patients with metastatic pancreatic ductal adenocarcinoma

Meenal Sinha; Courtney Betts; Li Zhang; Madeline J Griffith; Isabelle Solman; Brandon Chen; Eric Liu; Whitney Tamaki; Jacob Stultz; Jaqueline Marquez; Shamilene Sivagnanam; Alexander Cheung; Denise Pener; Anne Fahlman; Erin Taber; Kimberly Lerner; Matthew Crocker; Kendra Todd; Brindha Rajagopalan; Clarisha Ware; Mark Bridge; Johnson Vo; Hannah Dragomanovich; Julie Sudduth-Klinger; Gina Vaccaro; Charles D Lopez; Margaret Tempero; Lisa M Coussens; Lawrence Fong

doi:10.1136/jitc-2022-005425

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Clinical/translational cancer immunotherapy

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Modulation of myeloid and T cells in vivo by Bruton’s tyrosine kinase inhibitor ibrutinib in patients with metastatic pancreatic ductal adenocarcinoma

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Meenal Sinha Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, California, USA PubMed articles Google scholar articles
Courtney Betts Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, Oregon, USA PubMed articles Google scholar articles
Li Zhang Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, California, USADepartment of Biostatistics, University of California, San Francisco, California, USA PubMed articles Google scholar articles
Madeline J Griffith Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, California, USA PubMed articles Google scholar articles
Isabelle Solman AbbVie, Irvine, California, USA PubMed articles Google scholar articles
Brandon Chen Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, California, USA PubMed articles Google scholar articles
Eric Liu Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, California, USA PubMed articles Google scholar articles
Whitney Tamaki Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, California, USA PubMed articles Google scholar articles
Jacob Stultz Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, California, USA PubMed articles Google scholar articles
Jaqueline Marquez Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, California, USA PubMed articles Google scholar articles
Shamilene Sivagnanam Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, Oregon, USA PubMed articles Google scholar articles
Alexander Cheung Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, California, USA PubMed articles Google scholar articles
Denise Pener Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA PubMed articles Google scholar articles
Anne Fahlman Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA PubMed articles Google scholar articles
Erin Taber Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA PubMed articles Google scholar articles
Kimberly Lerner Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA PubMed articles Google scholar articles
Matthew Crocker Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA PubMed articles Google scholar articles
Kendra Todd Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA PubMed articles Google scholar articles
Brindha Rajagopalan Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA PubMed articles Google scholar articles
Clarisha Ware Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, California, USA PubMed articles Google scholar articles
Mark Bridge Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, California, USA PubMed articles Google scholar articles
Johnson Vo Department of Medicine, Oregon Health & Science University, Portland, Oregon, USA PubMed articles Google scholar articles
Hannah Dragomanovich Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, California, USA PubMed articles Google scholar articles
Julie Sudduth-Klinger Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, California, USA PubMed articles Google scholar articles
Gina Vaccaro Medical Oncology, Providence Portland Medical Center, Portland, Oregon, USA PubMed articles Google scholar articles
Charles D Lopez Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, Oregon, USADepartment of Medicine, Oregon Health & Science University, Portland, Oregon, USA PubMed articles Google scholar articles
Margaret Tempero Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, California, USA PubMed articles Google scholar articles
Lisa M Coussens Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, Oregon, USA PubMed articles Google scholar articles
Lawrence Fong Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, California, USAParker Institute for Cancer Immunotherapy, San Francisco, California, USA PubMed articles Google scholar articles

Correspondence to Dr Lawrence Fong; lawrence.fong{at}ucsf.edu

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Sinha M, Betts C, Zhang L, et al

Modulation of myeloid and T cells in vivo by Bruton’s tyrosine kinase inhibitor ibrutinib in patients with metastatic pancreatic ductal adenocarcinoma

Journal for ImmunoTherapy of Cancer 2023;11:e005425. doi: 10.1136/jitc-2022-005425

Publication history

Accepted December 7, 2022
First published January 2, 2023.

Online issue publication

December 07, 2023

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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