Journal for ImmunoTherapy of Cancer: 11 (12)

Basic tumor immunology

Original research: ASCC3 promotes the immunosuppression and progression of non-small cell lung cancer by impairing the type I interferon response via CAND1-mediated ubiquitination inhibition of STAT3 (26 December, 2023)
Yong-Qiang Ao, Jian Gao, Chun Jin, Shuai Wang, Li-Cheng Zhang, Jie Deng, Zong-wei Chen, Hai-Kun Wang, Jia-Hao Jiang, Jian-Yong Ding
Original research:
M1 macrophages induce PD-L1^hi cell-led collective invasion in HPV-positive head and neck squamous cell carcinoma via TNF-α/CDK4/UPS14
(26 December, 2023)
Jiashun Wu, Xin Pang, Xiao Yang, Mei Zhang, Bingjun Chen, Huayang Fan, Haofan Wang, Xianghua Yu, Yaling Tang, Xinhua Liang
Original research: Identification of pan-cancer/testis genes and validation of therapeutic targeting in triple-negative breast cancer: Lin28a-based and Siglece-based vaccination induces antitumor immunity and inhibits metastasis (22 December, 2023)
Jason A Carter, Bharati Matta, Jenna Battaglia, Carter Somerville, Benjamin D Harris, Margaret LaPan, Gurinder S Atwal, Betsy J Barnes
Original research: Aldehyde dehydrogenase 2-mediated aldehyde metabolism promotes tumor immune evasion by regulating the NOD/VISTA axis (7 December, 2023)
Yuru Chen, Jiazheng Sun, Jiazhou Liu, Yuxian Wei, Xiaoyu Wang, Huiying Fang, Huimin Du, Jing Huang, Qin Li, Guosheng Ren, Xiaoyi Wang, Hongzhong Li
Original research: Fibrinogen-like protein 2 promotes tumor immune suppression by regulating cholesterol metabolism in myeloid-derived suppressor cells (6 December, 2023)
Lei Wu, Xudong Liu, Juan Lei, Nan Zhang, Huakan Zhao, Jiangang Zhang, Huan Deng, Yongsheng Li
Original research: Tumor cell-intrinsic SETD2 inactivation sensitizes cancer cells to immune checkpoint blockade through the NR2F1-STAT1 pathway (6 December, 2023)
Xufen Zheng, Yuxiang Luo, Yangjie Xiong, Xiaoxiao Liu, Chunling Zeng, Xiaojing Lu, Xiaofang Wang, Yumei Cheng, Simin Wang, Haoqi Lan, Kai Wang, Zhonghui Weng, Wenbo Bi, Xinxin Gan, Xiaona Jia, Linhui Wang, Yuexiang Wang
Original research: Caspase-9 inhibition triggers Hsp90-based chemotherapy-mediated tumor intrinsic innate sensing and enhances antitumor immunity (6 December, 2023)
Jingyang Li, Xiaoyu Han, Mayu Sun, Weida Li, Guanghuan Yang, Huiyi Chen, Bao Guo, Jingquan Li, Xiaoguang Li, Hui Wang
Original research: Enhanced CD1d phosphatidylserine presentation using a single-domain antibody promotes immunomodulatory CD1d-TIM-3 interactions (1 December, 2023)
Roeland Lameris, Adam Shahine, Myrthe Veth, Bart Westerman, Dale I Godfrey, David Lutje Hulsik, Patricia Brouwer, Jamie Rossjohn, Tanja D de Gruijl, Hans J van der Vliet

Case report

Immune microenvironment of basal cell carcinoma and tumor regression following combined PD-1/LAG-3 blockade (14 December, 2023)
Julie Stein Deutsch, Jonathan Lai, Kara M Schenk, Abha Soni, Elizabeth M Will, Logan L Engle, Haiying Xu, Alexandra Ogurtsova, Vrinda Madan, Jennifer K Chong, Daphne Wang, Benjamin F Green, Peter Nguyen, Megan D Schollenberger, Evan J Lipson, Janis M Taube

Clinical/translational cancer immunotherapy

Original research: Phase 2 trial of a DNA vaccine (pTVG-HP) and nivolumab in patients with castration-sensitive non-metastatic (M0) prostate cancer (14 December, 2023)
Douglas G McNeel, Hamid Emamekhoo, Jens C Eickhoff, Christos E Kyriakopoulos, Ellen Wargowski, Tommaso P Tonelli, Laura E Johnson, Glenn Liu
Original research: Intravesical Ty21a treatment of non-muscle invasive bladder cancer induces immune responses that correlate with safety and may be associated to therapy potential (14 December, 2023)
Laurent Derré, Ilaria Lucca, Valérie Cesson, Perrine Bohner, Francois Crettenand, Sonia-Cristina Rodrigues-Dias, Florence Dartiguenave, Audrey Masnada, Carla Teixeira-Pereira, Sulayman Benmerzoug, Mathieu F Chevalier, Sonia Domingos-Pereira, Sylvain Nguyen, Lenka Polak, Anna K Schneider, Patrice Jichlinski, Beat Roth, Denise Nardelli-Haefliger
Original research: First-in-human study of SBRT and adenosine pathway blockade to potentiate the benefit of immunochemotherapy in early-stage luminal B breast cancer: results of the safety run-in phase of the Neo-CheckRay trial (6 December, 2023)
Alex De Caluwe, Emanuela Romano, Philip Poortmans, Andrea Gombos, Elisa Agostinetto, Guilherme Nader Marta, Zoe Denis, Stylianos Drisis, Christophe Vandekerkhove, Antoine Desmet, Catherine Philippson, Ligia Craciun, Isabelle Veys, Denis Larsimont, Marianne Paesmans, Dirk Van Gestel, Roberto Salgado, Christos Sotiriou, Martine Piccart-Gebhart, Michail Ignatiadis, Laurence Buisseret
Original research: Differential requirements for CD4+ T cells in the efficacy of the anti-PD-1+LAG-3 and anti-PD-1+CTLA-4 combinations in melanoma flank and brain metastasis models (6 December, 2023)
Manali S Phadke, Jiannong Li, Zhihua Chen, Paulo C Rodriguez, Jessica K Mandula, Lilit Karapetyan, Peter A Forsyth, Y Ann Chen, Keiran S M Smalley
Original research: Multicenter randomized controlled trial of neoadjuvant chemoradiotherapy alone or in combination with pembrolizumab in patients with resectable or borderline resectable pancreatic adenocarcinoma (1 December, 2023)
Matthew H G Katz, Gina R Petroni, Todd Bauer, Matthew J Reilley, Brian M Wolpin, Chee-Chee Stucky, Tanios S Bekaii-Saab, Rawad Elias, Nipun Merchant, Andressa Dias Costa, Patrick Lenehan, Victoire Cardot-Ruffino, Scott Rodig, Kathleen Pfaff, Stephanie K Dougan, Jonathan Andrew Nowak, Gauri R Varadhachary, Craig L Slingluff, Osama Rahma

Commentary

Commentary on oncolytic viruses: past, present, and future (21 December, 2023)
Christopher Larson, Bryan Oronsky, Tony R Reid

Immunotherapy biomarkers

Original research: Early kinetics of C reactive protein for cancer-agnostic prediction of therapy response and mortality in patients treated with immune checkpoint inhibitors: a multicenter cohort study (14 December, 2023)
Dominik A Barth, Florian Moik, Sarah Steinlechner, Florian Posch, Marie-Christina Mayer, Amelie M Sandner, Franziska Berton, Verena Schlintl, Lukas Koch, Nikolaus John, Robert Wurm, Martin Pichler, Thomas Bauernhofer, Patrick Reimann, Christoph Wohlkönig, Erika Richtig, Thomas Winder, Matthias Preusser, Philipp J Jost, Cihan Ay, Armin Gerger, Angelika Terbuch, Jakob Michael Riedl
Original research: Targeting integrin α5 in fibroblasts potentiates colorectal cancer response to PD-L1 blockade by affecting extracellular-matrix deposition (1 December, 2023)
Ling Lu, Yaohui Gao, Dengfeng Huang, Hu Liu, Dingzi Yin, Man Li, Jiayi Zheng, Shufei Wang, Weijun Wu, Li Zhao, Dexi Bi, Youhua Zhang, Feifei Song, Ruting Xie, Jifeng Wang, Huanlong Qin, Qing Wei
Original research: Hsa-LINC02418/mmu-4930573I07Rik regulated by METTL3 dictates anti-PD-L1 immunotherapeutic efficacy via enhancement of Trim21-mediated PD-L1 ubiquitination (1 December, 2023)
Zhijia Sun, Haixing Mai, Chunyuan Xue, Zhongyi Fan, Jiangbo Li, Hairui Chen, Nan Huo, Xiaofeng Kang, Chuanhao Tang, Liaoxin Fang, Hui Zhao, Yuchen Han, Chao Sun, Huanyan Peng, Yimeng Du, Jing Yang, Nan Du, Xiaojie Xu
Original research: Heterogeneity in tertiary lymphoid structures predicts distinct prognosis and immune microenvironment characterizations of clear cell renal cell carcinoma (1 December, 2023)
Wenhao Xu, Jiahe Lu, Wang-Rui Liu, Aihetaimujiang Anwaier, Yuhao Wu, Xi Tian, Jia-Qi Su, Yuan-Yuan Qu, Jianfeng Yang, Hailiang Zhang, Dingwei Ye

Immune cell therapies and immune cell engineering

Original research: Scalable generation of functional human iPSC-derived CAR-macrophages that efficiently eradicate CD19-positive leukemia (22 December, 2023)
Shifaa M. Abdin, Daniela Paasch, Arnold Kloos, Marco Carvalho Oliveira, Mi-Sun Jang, Mania Ackermann, Andriana Stamopoulou, Philipp J Mroch, Christine S Falk, Constantin S von Kaisenberg, Axel Schambach, Michael Heuser, Thomas Moritz, Gesine Hansen, Michael Morgan, Nico Lachmann
Original research: HER2 and HLA-A*02 dual CAR-T cells utilize LOH in a NOT logic gate to address on-target off-tumor toxicity (14 December, 2023)
David Bassan, Leehee Weinberger, Jason Yi, Tanya Kim, Michael R Weist, Gregor B Adams, Orit Foord, Neta Chaim, Sarit Tabak, Nir Bujanover, Yael Lopesco, Kristina Vucci, Caitlin Schnair, Limor Levy-Knafo, Richard L Kendall, Frank J Calzone, Adi Sharbi-Yunger
Original research: Discovery of U2AF1 neoantigens in myeloid neoplasms (12 December, 2023)
Melinda Ann Biernacki, Jessica Lok, Ralph Graeme Black, Kimberly A Foster, Carrie Cummings, Kyle B Woodward, Tim Monahan, Vivian G Oehler, Derek L Stirewalt, David Wu, Anthony Rongvaux, Hans Joachim Deeg, Marie Bleakley
Original research: Knockout of the inhibitory receptor TIGIT enhances the antitumor response of ex vivo expanded NK cells and prevents fratricide with therapeutic Fc-active TIGIT antibodies (11 December, 2023)
Md Faqrul Hasan, Amanda R Campbell, Tayler J Croom-Perez, Jeremiah L Oyer, Thomas A Dieffenthaller, Liza D Robles-Carrillo, Catherine A Cash, Jonathan E Eloriaga, Sanjana Kumar, Brendan W Andersen, Meisam Naeimi Kararoudi, Brian P Tullius, Dean A Lee, Alicja J Copik
Original research: Deletion of the protein tyrosine phosphatase PTPN22 for adoptive T cell therapy facilitates CTL effector function but promotes T cell exhaustion (6 December, 2023)
Alexandra Rose Teagle, Patricia Castro-Sanchez, Rebecca J Brownlie, Nicola Logan, Simran S Kapoor, David Wright, Robert J Salmond, Rose Zamoyska
Original research: Allogeneic NK cells induce monocyte-to-dendritic cell conversion, control tumor growth, and trigger a pro-inflammatory shift in patient-derived cultures of primary and metastatic colorectal cancer (6 December, 2023)
Elisa C Toffoli, Amanda A van Vliet, Henk W M Verheul, Hans J van der Vliet, Jurriaan Tuynman, Jan Spanholtz, Tanja D de Gruijl
Original research: CXCL10 and Nrf2-upregulated mesenchymal stem cells reinvigorate T lymphocytes for combating glioblastoma (6 December, 2023)
Jiaji Mao, Jianing Li, Junwei Chen, Qin Wen, Minghui Cao, Fang Zhang, Baoxun Li, Qinyuan Zhang, Zhe Wang, Jingzhong Zhang, Jun Shen
Original research: iPSC-derived natural killer cells expressing the FcγR fusion CD64/16A can be armed with antibodies for multitumor antigen targeting (6 December, 2023)
Kristin M Snyder, Kate J Dixon, Zachary Davis, Martin Hosking, Geoffrey Hart, Melissa Khaw, Anders Matson, Ryan Bjordahl, Bryan Hancock, Soheila Shirinbak, Jeffrey S Miller, Bahram Valamehr, Jianming Wu, Bruce Walcheck

Oncolytic and local immunotherapy

Original research: XTX101, a tumor-activated, Fc-enhanced anti-CTLA-4 monoclonal antibody, demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer (12 December, 2023)
Kurt A Jenkins, Miso Park, Magali Pederzoli-Ribeil, Ugur Eskiocak, Parker Johnson, Wilson Guzman, Megan McLaughlin, Deborah Moore-Lai, Caitlin O’Toole, Zhen Liu, Benjamin Nicholson, Veronica Flesch, Huawei Qiu, Tim Clackson, Ronan C O’Hagan, Ulrich Rodeck, Margaret Karow, Jennifer O’Neil, John C Williams

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Table of contents

December 2023 - Volume 11 - 12

Basic tumor immunology

Case report

Clinical/translational cancer immunotherapy

Commentary

Immunotherapy biomarkers

Immune cell therapies and immune cell engineering

Oncolytic and local immunotherapy

Correction

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Table of contents

December 2023 - Volume 11 - 12

Basic tumor immunology

Case report

Clinical/translational cancer immunotherapy

Commentary

Immunotherapy biomarkers

Immune cell therapies and immune cell engineering

Oncolytic and local immunotherapy

Correction