Journal for ImmunoTherapy of Cancer: 11 (2)

Case report

Role of peripheral blood MRD and 18F-FDG PET in the post-CAR relapse setting: a case study of discordant peripheral blood and bone marrow MRD (27 February, 2023)
Liora Schultz, Kara Lynn Davis, Ann Walkush, Christina Baggott, Courtney Erickson, Sneha Ramakrishna, Catherine Aftandilian, Norman Lacayo, Helen Ruth Nadel, Jean Oak, Crystal L Mackall

Basic tumor immunology

Original research: Venetoclax improves CD20 immunotherapy in a mouse model of MYC/BCL2 double-expressor diffuse large B-cell lymphoma (28 February, 2023)
Javier Melchor, Marcos Garcia-Lacarte, Sara C. Grijalba, Adrián Arnaiz-Leché, Marién Pascual, Carlos Panizo, Oscar Blanco, Victor Segura, Francisco J. Novo, Juan Garcia Valero, Patricia Pérez-Galán, Jose A. Martinez-Climent, Sergio Roa
Original research: Downregulation of phosphoserine phosphatase potentiates tumor immune environments to enhance immune checkpoint blockade therapy (27 February, 2023)
Zhi-Peng Peng, Xing-Chen Liu, Yong-Hao Ruan, Da Jiang, Ai-Qi Huang, Wan-Ru Ning, Ze-Zhou Jiang, Limin Zheng, Yan Wu
Original research: Treg-selective IL-2 starvation synergizes with CD40 activation to sustain durable responses in lymphoma models (23 February, 2023)
Kristin Stirm, Peter Leary, Daria Wüst, Dominique Stark, Nicole Joller, Ufuk Karakus, Onur Boyman, Alexandar Tzankov, Anne Müller
Original research: Inhibition of myeloperoxidase enhances immune checkpoint therapy for melanoma (17 February, 2023)
Tracy W Liu, Seth T Gammon, Ping Yang, Wencai Ma, Jing Wang, David Piwnica-Worms
Original research: CD103 and CD39 coexpression identifies neoantigen-specific cytotoxic T cells in colorectal cancers with low mutation burden (15 February, 2023)
Jitske van den Bulk, Manon van der Ploeg, Marieke E Ijsselsteijn, Dina Ruano, Ruud van der Breggen, Rebekka Duhen, Koen C M J Peeters, Arantza Fariña-Sarasqueta, Els M E Verdegaal, Sjoerd H van der Burg, Thomas Duhen, Noel F C C de Miranda
Original research: GLIS1 intervention enhances anti-PD1 therapy for hepatocellular carcinoma by targeting SGK1-STAT3-PD1 pathway (14 February, 2023)
Dawei Rong, Yuliang Wang, Li Liu, Hengsong Cao, Tian Huang, Hanyuan Liu, Xiaopei Hao, Guangshun Sun, Guoqiang Sun, Zhiying Zheng, Junwei Kang, Yongxiang Xia, Ziyi Chen, Weiwei Tang, Xuehao Wang
BRCA1 deficiency in mature CD8⁺ T lymphocytes impairs antitumor immunity
(2 February, 2023)
Bogang Wu, Leilei Qi, Huai-Chin Chiang, Haihui Pan, Xiaowen Zhang, Alexandra Greenbaum, Elizabeth Stark, Li-Ju Wang, Yidong Chen, Bassem R. Haddad, Dionyssia Clagett, Claudine Isaacs, Richard Elledge, Anelia Horvath, Yanfen Hu, Rong Li

Clinical/translational cancer immunotherapy

Original research: Spatial multi-omics revealed the impact of tumor ecosystem heterogeneity on immunotherapy efficacy in patients with advanced non-small cell lung cancer treated with bispecific antibody (28 February, 2023)
Xinyu Song, Anwen Xiong, Fengying Wu, Xuefei Li, Jing Wang, Tao Jiang, Peixin Chen, Xiaoshen Zhang, Zhikai Zhao, Huifang Liu, Lei Cheng, Chao Zhao, Zhehai Wang, Chaohu Pan, Xiaoli Cui, Ting Xu, Haitao Luo, Caicun Zhou
Original research: Concurrent durvalumab and radiation therapy (DUART) followed by adjuvant durvalumab in patients with localized urothelial cancer of bladder: results from phase II study, BTCRC-GU15-023 (23 February, 2023)
Monika Joshi, Leonard Tuanquin, Junjia Zhu, Vonn Walter, Todd Schell, Matthew Kaag, Deepak Kilari, Jiangang Liao, Sheldon L Holder, Hamid Emamekhoo, Alexander Sankin, Suzzane Merrill, Hong Zheng, Joshua Warrick, Ralph Hauke, Benjamin Gartrel, Mark Stein, Joseph Drabick, David J Degraff, Yousef Zakharia
Original research: T cell-mediated targeted delivery of tadalafil regulates immunosuppression and polyamine metabolism to overcome immune checkpoint blockade resistance in hepatocellular carcinoma (22 February, 2023)
Xiaobin Wang, Qiaoyun Zhang, Jingwen Zhou, Zecong Xiao, Jianxin Liu, Shaohui Deng, Xiaoyang Hong, Wensou Huang, Mingyue Cai, Yongjian Guo, Jingjun Huang, Yong Wang, Liteng Lin, Kangshun Zhu
Original research: SAFFRON-103: a phase 1b study of the safety and efficacy of sitravatinib combined with tislelizumab in patients with locally advanced or metastatic non-small cell lung cancer (20 February, 2023)
Jun Zhao, Xinmin Yu, Dingzhi Huang, Zhiyong Ma, Bo Gao, Jiuwei Cui, Qian Chu, Qing Zhou, Meili Sun, Daphne Day, Jingxun Wu, Hongming Pan, Lifeng Wang, Mark Voskoboynik, Zhehai Wang, Yunpeng Liu, Hui Li, Juan Zhang, Yanyan Peng, Yi-Long Wu
Original research: Safety and efficacy of autologous and allogeneic humanized CD19-targeted CAR-T cell therapy for patients with relapsed/refractory B-ALL (20 February, 2023)
Fengmei Song, Yongxian Hu, Yanlei Zhang, Mingming Zhang, Tingting Yang, Wenjun Wu, Simao Huang, Huijun Xu, Alex H Chang, He Huang, Guoqing Wei
Original research: Senescent cancer cell vaccines induce cytotoxic T cell responses targeting primary tumors and disseminated tumor cells (15 February, 2023)
Yue Liu, Joanna Pagacz, Donald J Wolfgeher, Kenneth D Bromerg, Jacob V Gorman, Stephen J Kron
Original research: Neoadjuvant sintilimab and chemotherapy in patients with potentially resectable esophageal squamous cell carcinoma (KEEP-G 03): an open-label, single-arm, phase 2 trial (9 February, 2023)
Xiaofeng Chen, Xiang Xu, Danping Wang, Jinyuan Liu, Jing Sun, Mingjie Lu, Rui Wang, Bingqing Hui, Xiaofei Li, Chenchen Zhou, Min Wang, Tianzhu Qiu, Shiyun Cui, Nana Sun, Yang Li, Fufeng Wang, Cuicui Liu, Yang Shao, Jinhua Luo, Yanhong Gu
Original research: Pharmacological tumor PDL1 depletion with chlorambucil treats ovarian cancer and melanoma: improves antitumor immunity and renders anti-PDL1-resistant tumors anti-PDL1-sensitive through NK cell effects (9 February, 2023)
Haiyan Bai, Alvaro S Padron, Yilun Deng, Yiji J Liao, Clare J Murray, Carlos Ontiveros, Suresh J Kari, Aravind Kancharla, Anand V R Kornepati, Myrna Garcia, Ryan Michael Reyes, Harshita B Gupta, Jose R Conejo-Garcia, Tyler Curiel
Original research: MUC1-C is a master regulator of MICA/B NKG2D ligand and exosome secretion in human cancer cells (8 February, 2023)
Yoshihiro Morimoto, Nami Yamashita, Tatsuaki Daimon, Haruka Hirose, Shizuka Yamano, Naoki Haratake, Satoshi Ishikawa, Atrayee Bhattacharya, Atsushi Fushimi, Rehan Ahmad, Hidekazu Takahashi, Olga Dashevsky, Constantine Mitsiades, Donald Kufe
Original research: COVID-19 vaccination in patients with cancer receiving immune checkpoint inhibitors: a systematic review and meta-analysis (6 February, 2023)
Juan Ignacio Ruiz, Maria Angeles Lopez-Olivo, Yimin Geng, Maria E Suarez-Almazor
Original research: Intratumoral IFN-γ or topical TLR7 agonist promotes infiltration of melanoma metastases by T lymphocytes expanded in the blood after cancer vaccine (6 February, 2023)
Christine A Tran, Kevin T Lynch, Max O Meneveau, Priya Katyal, Walter C Olson, Craig L Slingluff,
Original research: Phase 1 first-in-human study of dalutrafusp alfa, an anti–CD73-TGF-β-trap bifunctional antibody, in patients with advanced solid tumors (6 February, 2023)
Anthony W Tolcher, Michael Gordon, Kathleen M Mahoney, Anna Seto, Marianna Zavodovskaya, Chia-Hsiang Hsueh, Shuyan Zhai, Thomas Tarnowski, Juliane M Jürgensmeier, Susanna Stinson, Ahmed A Othman, Tianling Chen, James Strauss
Original research: First-line nivolumab plus ipilimumab for metastatic non-small cell lung cancer, including patients with ECOG performance status 2 and other special populations: CheckMate 817 (1 February, 2023)
Neal E Ready, Clarisse Audigier-Valette, Jonathan W Goldman, Enriqueta Felip, Tudor-Eliade Ciuleanu, María Rosario García Campelo, Kevin Jao, Fabrice Barlesi, Stéphanie Bordenave, Erika Rijavec, Laszlo Urban, Jean-Sébastien Aucoin, Cristina Zannori, Karim Vermaelen, Osvaldo Arén Frontera, Alessandra Curioni Fontecedro, Amparo Sánchez-Gastaldo, Oscar Juan-Vidal, Helena Linardou, Elena Poddubskaya, David R Spigel, Samreen Ahmed, Michele Maio, Sunney Li, Han Chang, Joseph Fiore, Angelic Acevedo, Luis Paz-Ares

Immunotherapy biomarkers

PD-L1 gene amplification and focality: relationship with protein expression (27 February, 2023)
Denis Leonardo Jardim, Karthikeyan Murugesan, Julia A. Elvin, Richard S. P. Huang, Razelle Kurzrock
Original research: KIR/KIR-ligand genotypes and clinical outcomes following chemoimmunotherapy in patients with relapsed or refractory neuroblastoma: a report from the Children’s Oncology Group (23 February, 2023)
Amy K Erbe, Mitch B Diccianni, Rajen Mody, Arlene Naranjo, Fan F Zhang, Jen Birstler, KyungMann Kim, Arika S Feils, Jung-Tung Hung, Wendy B London, Barry L Shulkin, Varsha Mathew, Marguerite T Parisi, Sabah Servaes, Shahab Asgharzadeh, John M Maris, Julie Park, Alice L Yu, Paul M Sondel, Rochelle Bagatell
Original research: Predictive biomarkers for PD-1/PD-L1 checkpoint inhibitor response in NSCLC: an analysis of clinical trial and real-world data (23 February, 2023)
WeiQing Venus So, David Dejardin, Eva Rossmann, Jehad Charo
Original research: ANKRD22 is a potential novel target for reversing the immunosuppressive effects of PMN-MDSCs in ovarian cancer (23 February, 2023)
Huanhuan Chen, Keqing Yang, Lingxiao Pang, Jing Fei, Yongliang Zhu, Jianwei Zhou
Original research: Changes in circulating tumor DNA and outcomes in solid tumors treated with immune checkpoint inhibitors: a systematic review (15 February, 2023)
Laith Al-Showbaki, Brooke Wilson, Faris Tamimi, Consolacion Molto, Abhenil Mittal, David W Cescon, Eitan Amir
Original research: Clonal expansion of resident memory T cells in peripheral blood of patients with non-small cell lung cancer during immune checkpoint inhibitor treatment (14 February, 2023)
Hyunsu Kim, Sehhoon Park, Kyoung-Yeon Han, Naeun Lee, Hyemin Kim, Hyun Ae Jung, Jong-Mu Sun, Jin Seok Ahn, Myung-Ju Ahn, Se-Hoon Lee, Woong-Yang Park
Original research: Localization and density of tertiary lymphoid structures associate with molecular subtype and clinical outcome in colorectal cancer liver metastases (9 February, 2023)
Chong Zhang, Xiang-Yu Wang, Jie-Liang Zuo, Xue-Fu Wang, Xiao-Wen Feng, Bo Zhang, Yi-Tong Li, Chen-He Yi, Peng Zhang, Xiao-Chen Ma, Zhen-Mei Chen, Yue Ma, Jia-Hao Han, Bao-Rui Tao, Rui Zhang, Tian-Qi Wang, Li Tong, Wang Gu, Si-Yu Wang, Xiao-Fei Zheng, Wen-Kang Yuan, Zi-Jie Kan, Jie Fan, Xiang-Yang Hu, Jun Li, Chao Zhang, Jin-Hong Chen
Suitability of tumor-associated antibodies as predictive biomarker for response to immune checkpoint inhibitors in patients with melanoma: a short report (7 February, 2023)
Karlijn de Joode, Sharon Veenbergen, Claudia Kransse, Dian Kortleve, Reno Debets, Ron H J Mathijssen, Arjen Joosse, Marco W J Schreurs, Astrid A M Van der Veldt
Original research: Single-cell spatial landscape of immunotherapy response reveals mechanisms of CXCL13 enhanced antitumor immunity (1 February, 2023)
Mark Sorin, Elham Karimi, Morteza Rezanejad, Miranda W Yu, Lysanne Desharnais, Sheri A C McDowell, Samuel Doré, Azadeh Arabzadeh, Valerie Breton, Benoit Fiset, Yuhong Wei, Roni Rayes, Michele Orain, Francois Coulombe, Venkata S K Manem, Andreanne Gagne, Daniela F Quail, Philippe Joubert, Jonathan D Spicer, Logan A Walsh

Immune cell therapies and immune cell engineering

Original research: Synergistic therapeutic combination with a CAF inhibitor enhances CAR-NK-mediated cytotoxicity via reduction of CAF-released IL-6 (27 February, 2023)
Young Eun Lee, Ga-Yeon Go, Eun-Young Koh, Han-Na Yoon, Minkoo Seo, Seung-Mo Hong, Ji Hye Jeong, Jin-Chul Kim, Duck Cho, Tae Sung Kim, Song Cheol Kim, Eunsung Jun, Mihue Jang
Original research: Runx3-overexpression cooperates with ex vivo AKT inhibition to generate receptor-engineered T cells with better persistence, tumor-residency, and antitumor ability (27 February, 2023)
Jianghui Tang, Jianpeng Sheng, Qi Zhang, Yongtao Ji, Xun Wang, Junlei Zhang, Jiangchao Wu, Jinyuan Song, Xueli Bai, Tingbo Liang
Original research: Generation of TGFβR2(-1) neoantigen-specific HLA-DR4-restricted T cell receptors for cancer therapy (23 February, 2023)
Natalia Plewa, Lucia Poncette, Thomas Blankenstein
Original research: TCR-engineered adoptive cell therapy effectively treats intracranial murine glioblastoma (20 February, 2023)
Maximilian O Schaettler, Rupen Desai, Anthony Z Wang, Alexandra J Livingstone, Dale K Kobayashi, Andrew T Coxon, Jay A Bowman-Kirigin, Connor J Liu, Mao Li, Diane E Bender, Michael J White, David M Kranz, Tanner M Johanns, Gavin P Dunn
Original research: IL15 modification enables CAR T cells to act as a dual targeting agent against tumor cells and myeloid-derived suppressor cells in GBM (9 February, 2023)
Markella Zannikou, Joseph T Duffy, Rebecca N Levine, Maggie Seblani, Qianli Liu, Aaron Presser, Victor A Arrieta, Christopher J Chen, Adam M Sonabend, Craig M Horbinski, Catalina Lee-Chang, Jason Miska, Maciej S Lesniak, Stephen Gottschalk, Irina V Balyasnikova
Original research: Immunotherapy reverses glioma-driven dysfunction of immune system homeostasis (7 February, 2023)
Bayli DiVita Dean, Tyler Wildes, Joseph Dean, Oleg Yegorov, Changlin Yang, David Shin, Connor Francis, John W Figg, Mathew Sebastian, Laura Falceto Font, Dan Jin, Alexandra Reid, Ginger Moore, Brandon Fernandez, Brandon Wummer, Carmelle Kuizon, Duane Mitchell, Catherine T Flores
Original research:
TIPE2 deletion improves the therapeutic potential of adoptively transferred NK cells
(1 February, 2023)
Jiacheng Bi, Chen Huang, Xiaomeng Jin, Chaoyue Zheng, Yingying Huang, Xiaohu Zheng, Zhigang Tian, Haoyu Sun
Original research: Tuned activation of MSLN-CAR T cells induces superior antitumor responses in ovarian cancer models (6 February, 2023)
Esther Schoutrop, Thomas Poiret, Ibrahim El-Serafi, Ying Zhao, Rui He, Alina Moter, Johan Henriksson, Moustapha Hassan, Isabelle Magalhaes, Jonas Mattsson

Letter

Response to a letter to the editor: a better understanding of Immune Checkpoint Inhibitor-induced cholangitis for better management (27 February, 2023)
Alexander Coukos, Julien Vionnet, Christine Sempoux, Montserrat Fraga
Better understanding of ICI-induced cholangitis for better management (27 February, 2023)
Lucy Meunier, Alexandre Maria
Liquid biopsies, are we ready for prime time? (16 February, 2023)
Nicola Normanno, Kathi Apostolidis, Mark Stewart

Oncolytic and local immunotherapy

Original research: PKR induces TGF-β and limits oncolytic immune therapy (16 February, 2023)
Bangxing Hong, Upasana Sahu, Matthew P Mullarkey, Evan Hong, Guangsheng Pei, Yuanqing Yan, Yoshihiro Otani, Yeshavanth Banasavadi-Siddegowda, Huihui Fan, Zhongming Zhao, Jianhua Yu, Michael A Caligiuri, Balveen Kaur
Original research: Phase I/II study of PexaVec in combination with immune checkpoint inhibition in refractory metastatic colorectal cancer (8 February, 2023)
Cecilia Monge, Changqing Xie, Yuta Myojin, Kelley Coffman, Donna Mabry Hrones, Sophie Wang, Jonathan M Hernandez, Bradford J Wood, Elliot B Levy, Israa Juburi, Stephen M Hewitt, David E Kleiner, Seth M Steinberg, William D Figg, Bernadette Redd, Philip Homan, Maggie Cam, Benjamin Ruf, Austin G Duffy, Tim F Greten

Review

Targeting tumor-associated macrophages for successful immunotherapy of ovarian carcinoma (23 February, 2023)
Iva Truxova, David Cibula, Radek Spisek, Jitka Fucikova
Regulatory implications of ctDNA in immuno-oncology for solid tumors (16 February, 2023)
Paz J Vellanki, Soma Ghosh, Anand Pathak, Michael J Fusco, Erik W Bloomquist, Shenghui Tang, Harpreet Singh, Reena Philip, Richard Pazdur, Julia A Beaver
Targeting Cbl-b in cancer immunotherapy (7 February, 2023)
Ryan C. Augustin, Riyue Bao, Jason J. Luke

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Table of contents

February 2023 - Volume 11 - 2

Case report

Basic tumor immunology

Clinical/translational cancer immunotherapy

Immunotherapy biomarkers

Immune cell therapies and immune cell engineering

Letter

Oncolytic and local immunotherapy

Review

Correction

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Table of contents

February 2023 - Volume 11 - 2

Case report

Basic tumor immunology

Clinical/translational cancer immunotherapy

Immunotherapy biomarkers

Immune cell therapies and immune cell engineering

Letter

Oncolytic and local immunotherapy

Review

Correction