Table of contents

Clinical/translational cancer immunotherapy

• Original research: Inhibition of lactate transport by MCT-1 blockade improves chimeric antigen receptor T-cell therapy against B-cell malignancies (30 June, 2023)

  Ernesto Lopez, Rajesh Karattil, Francesco Nannini, Gordon Weng-Kit Cheung, Lilian Denzler, Felipe Galvez-Cancino, Sergio Quezada, Martin A Pule
• Original research: Association between gene expression signatures and clinical outcomes of pembrolizumab versus paclitaxel in advanced gastric cancer: exploratory analysis from the randomized, controlled, phase III KEYNOTE-061 trial (30 June, 2023)

  Kohei Shitara, Maria Di Bartolomeo, Mario Mandala, Min-Hee Ryu, Christian Caglevic, Tomasz Olesinski, Hyun Cheol Chung, Kei Muro, Eray Goekkurt, Raymond S McDermott, Wasat Mansoor, Zev A Wainberg, Chie-Schin Shih, Julie Kobie, Michael Nebozhyn, Razvan Cristescu, Z Alexander Cao, Andrey Loboda, Mustafa Özgüroğlu
• Original research: Carbohydrate ligand engagement with CD11b enhances differentiation of tumor-associated myeloid cells for immunotherapy of solid cancers (30 June, 2023)

  Veronique Roche, Victor Sandoval, Claire Wolford, Zachary Senders, Julian Anthony Kim, Susan Pereira Ribeiro, Alex Yicheng Huang, Rafick-Pierre Sekaly, Joshua Lyons, Mei Zhang
• Original research: Phase 1 dose-escalation study of SEA-CD40: a non-fucosylated CD40 agonist, in advanced solid tumors and lymphomas (29 June, 2023)

  Andrew L Coveler, David C Smith, Tycel Phillips, Brendan D Curti, Sanjay Goel, Amitkumar N Mehta, Timothy M Kuzel, Svetomir N Markovic, Olivier Rixe, David L Bajor, Thomas F Gajewski, Martin Gutierrez, Hun Ju Lee, Ajay K Gopal, Paolo Caimi, Elisabeth I Heath, John A Thompson, Sahar Ansari, Celine Jacquemont, Ariel Topletz-Erickson, Peigen Zhou, Michael W Schmitt, Juneko E Grilley-Olson
• Original research: PRMT5 reduces immunotherapy efficacy in triple-negative breast cancer by methylating KEAP1 and inhibiting ferroptosis (28 June, 2023)

  Zhe Wang, Ruolei Li, Niuniu Hou, Juliang Zhang, Ting Wang, Pengyu Fan, Cheng Ji, Bo Zhang, Liuyin Liu, Yaping Wang, Jing Kong, Qing Yao, Jie Duan, Ge Zhao, Rui Ling, Jian Zhang
• Original research: CLDN18.2 and 4-1BB bispecific antibody givastomig exerts antitumor activity through CLDN18.2-expressing tumor-directed T-cell activation (26 June, 2023)

  Jing Gao, Zhengyi Wang, Wenqing Jiang, Yanni Zhang, Zhen Meng, Yanling Niu, Zhen Sheng, Chan Chen, Xuejun Liu, Xi Chen, Chanjuan Liu, Keren Jia, Cheng Zhang, Haiyan Liao, Jaeho Jung, Eunsil Sung, Hyejin Chung, Jingwu Z. Zhang, Andrew X. Zhu, Lin Shen
• Original research: TIGIT is a key inhibitory checkpoint receptor in lymphoma (26 June, 2023)

  James Godfrey, Xiufen Chen, Nicole Sunseri, Alan Cooper, Jovian Yu, Arina Varlamova, Dmitry Zarubin, Yuriy Popov, Connor Jacobson, Ekaterina Postovalova, Zhongmin Xiang, Krystle Nomie, Aleksander Bagaev, Girish Venkataraman, Yuanyuan Zha, Sravya Tumuluru, Sonali M Smith, Justin P Kline
• Original research: Concurrent immune checkpoint inhibition and selective immunosuppressive therapy in patients with immune-related enterocolitis (22 June, 2023)

  Yousef R Badran, Fangwen Zou, Sienna M Durbin, Barbara E Dutra, Hamzah Abu-Sbeih, Anusha S Thomas, Mehmet Altan, John A Thompson, Wei Qiao, Donna E Leet, Po-Ying Lai, Nora K Horick, Michael A Postow, David M Faleck, Yinghong Wang, Michael Dougan
• Organ-specific heterogeneity in tumor-infiltrating immune cells and cancer antigen expression in primary and autologous metastatic lung adenocarcinoma (22 June, 2023)

  David Restle, Joseph Dux, Xiaoyu Li, Alexander J Byun, Jennie K Choe, Yan Li, Raj G Vaghjiani, Carlos Thomas, Kyohei Misawa, Kay See Tan, David R Jones, Navin K Chintala, Prasad S Adusumilli
• Original research: G-CSF rescue of FOLFIRINOX-induced neutropenia leads to systemic immune suppression in mice and humans (21 June, 2023)

  Victoire Cardot-Ruffino, Naima Bollenrucher, Luisa Delius, S Jennifer Wang, Lauren K Brais, Joshua Remland, C Elizabeth Keheler, Keri M Sullivan, Thomas A Abrams, Leah H Biller, Peter C Enzinger, Nadine J McCleary, Anuj K Patel, Douglas A Rubinson, Benjamin Schlechter, Sarah Slater, Matthew B Yurgelun, James M Cleary, Kimberly Perez, Michael Dougan, Kimmie Ng, Brian M Wolpin, Harshabad Singh, Stephanie K Dougan
• Original research: Selective immune suppression using interleukin-6 receptor inhibitors for management of immune-related adverse events (16 June, 2023)

  Faisal Fa'ak, Maryam Buni, Adewunmi Falohun, Huifang Lu, Juhee Song, Daniel H Johnson, Chrystia M Zobniw, Van A Trinh, Muhammad Osama Awiwi, Nourel Hoda Tahon, Khaled M Elsayes, Kaysia Ludford, Emma J Montazari, Julia Chernis, Maya Dimitrova, Sabina Sandigursky, Jeffrey A Sparks, Osama Abu-Shawer, Osama Rahma, Uma Thanarajasingam, Ashley M Zeman, Rafee Talukder, Namrata Singh, Sarah H Chung, Petros Grivas, May Daher, Ala Abudayyeh, Iman Osman, Jeffrey Weber, Jean H Tayar, Maria E Suarez-Almazor, Noha Abdel-Wahab, Adi Diab
• Original research: First-line treatment of unresectable or metastatic HER2 positive esophagogastric adenocarcinoma: liquid biomarker analysis of the phase 2 INTEGA trial (16 June, 2023)

  Lisa Paschold, Alexander Stein, Benjamin Thiele, Joseph Tintelnot, Svenja-Sibylla Henkes, Cornelia Coith, Christoph Schultheiß, Klaus Pantel, Sabine Riethdorf, Mascha Binder
• Original research: Zoledronic acid and thymosin α1 elicit antitumor immunity against prostate cancer by enhancing tumor inflammation and cytotoxic T cells (9 June, 2023)

  Sheng Wang, Maohua Huang, Minfeng Chen, Zhiting Sun, Yubo Jiao, Geni Ye, Jinghua Pan, Wencai Ye, Jianfu Zhao, Dongmei Zhang
• Original research: Risk factors and immunomodulators use in steroid-refractory checkpoint inhibitor pneumonitis (8 June, 2023)

  Yanlin Li, Xiaohui Jia, Yajuan Zhang, Yonghao Du, Yuzhu Chang, Yuan Shen, Ziyang Mao, Mengjie Liu, Hong Sun, Hui Guo
• Original research: Tebentafusp in combination with durvalumab and/or tremelimumab in patients with metastatic cutaneous melanoma: a phase 1 study (7 June, 2023)

  Omid Hamid, Jessica C Hassel, Alexander N Shoushtari, Friedegund Meier, Todd M Bauer, April K S Salama, John M Kirkwood, Paolo A Ascierto, Paul C Lorigan, Cornelia Mauch, Marlana Orloff, Thomas R Jeffry Evans, Chris Holland, Ramakrishna Edukulla, Shaad E Abedin, Mark R Middleton
• Original research: Dynamics and survival associations of T cell receptor clusters in patients with pleural mesothelioma treated with immunotherapy (6 June, 2023)

  Aakash P Desai, Farhad Kosari, Maria Disselhorst, Jun Yin, Alireza Agahi, Tobias Peikert, Julia Udell, Sarah H Johnson, James Smadbeck, Stephen Murphy, Giannoula Karagouga, Alexa McCune, Janet Schaefer-Klein, Mitesh J Borad, John Cheville, George Vasmatzis, Paul Baas, Aaron Mansfield
• Original research: Outcomes and a prognostic classifier in patients with microsatellite instability-high metastatic gastric cancer receiving PD-1 blockade (5 June, 2023)

  Giovanni Randon, Yu Aoki, Romain Cohen, Leonardo Provenzano, Vincenzo Nasca, Samuel J Klempner, Steven B Maron, Riccardo Cerantola, Joseph Chao, Lorenzo Fornaro, Walter Ferrari Bravo, Filippo Ghelardi, Margherita Ambrosini, Paolo Manca, Massimiliano Salati, Akihito Kawazoe, Valerie Zhu, Darren Cowzer, Virginia Genovesi, Sara Lonardi, Kohei Shitara, Thierry André, Filippo Pietrantonio
• Management of immune-related cutaneous adverse events with dupilumab (2 June, 2023)

  Alyce Mei-Shiuan Kuo, Stephanie Gu, Joseph Stoll, Andrea P Moy, Stephen W Dusza, Allison Gordon, Elena C Haliasos, Yelena Janjigian, Lukas Kraehenbuehl, Elizabeth A Quigley, Paul Chapman, Mario E Lacouture, Alina Markova
• Original research: Optimal dosing regimen of CD73 blockade improves tumor response to radiotherapy through iCOS downregulation (2 June, 2023)

  Lydia Meziani, Marine Gerbé de Thoré, Céline Clémenson, Winchygn Liu, Pierre-Antoine Laurent, Michele Mondini, Marie-Catherine Vozenin, Eric Deutsch
• Original research: Phase I trial of KN046, a novel bispecific antibody targeting PD-L1 and CTLA-4 in patients with advanced solid tumors (1 June, 2023)

  Yuxiang Ma, Jinhui Xue, Yuanyuan Zhao, Yang Zhang, Yan Huang, Yunpeng Yang, Wenfeng Fang, Ye Guo, Qun Li, Xiaoxiao Ge, Jie Sun, Bangyong Zhang, Yuhan Zhang, Jinyuan Xiao, Li Zhang, Hongyun Zhao