Table of contents

Basic tumor immunology

• Original research: NKG2A gene variant predicts outcome of immunotherapy in AML and modulates the repertoire and function of NK cells (30 August, 2023)

  Brwa Ali Hussein, Linnea Kristenson, Silvia Pesce, Anne Wöhr, Yarong Tian, Alexander Hallner, Mats Brune, Kristoffer Hellstrand, Ka-Wei Tang, Elin Bernson, Fredrik B Thorén
• Original research: Inhibition of tumor intrinsic BANF1 activates antitumor immune responses via cGAS-STING and enhances the efficacy of PD-1 blockade (24 August, 2023)

  Minglei Wang, Yiheng Huang, Minxin Chen, Weiyan Wang, Fei Wu, Tao Zhong, Xiaozheng Chen, Fei Wang, Yang Li, Jinming Yu, Meng Wu, Dawei Chen
• Original research:

  Saponin-based adjuvants enhance antigen cross-presentation in human CD11c⁺ CD1c⁺ CD5⁻ CD163⁺ conventional type 2 dendritic cells

  (23 August, 2023)

  Nataschja I Ho, Lisa G M Huis in 't Veld, Jesper van Eck van der Sluijs, Branco M H Heuts, Maaike W G Looman, Esther D Kers-Rebel, Koen van den Dries, Harry Dolstra, Joost H A Martens, Willemijn Hobo, Gosse J Adema
• Original research:

  Id-neoantigen vaccine induces therapeutic CD8⁺ T cells against multiple myeloma: H chain-loss escapees cause FLC MM

  (22 August, 2023)

  Marita Westhrin, Jana Blazevski, Ana Textor, Pegah Abdollahi, Ramakrishna Prabhu Gopalakrishnan, Linda Thuy Ngo, Peter Olaf Hofgaard, Julia Heinzelbecker, Sonja Bobic, Even Fossum, Heidi Cecilie Larsen Spång, Ranveig Braathen, Bjarne Bogen
• Original research:

  C1q⁺ tumor-associated macrophages contribute to immunosuppression through fatty acid metabolic reprogramming in malignant pleural effusion

  (21 August, 2023)

  Siyu Zhang, Wenbei Peng, Haolei Wang, Xuan Xiang, Linlin Ye, Xiaoshan Wei, Zihao Wang, Qianqian Xue, Long Chen, Yuan Su, Qiong Zhou
• Original research:

  TP53 gain-of-function mutation modulates the immunosuppressive microenvironment in non-HPV-associated oral squamous cell carcinoma

  (21 August, 2023)

  Yewen Shi, Xiaoyong Ren, Shaolong Cao, Xi Chen, Bo Yuan, Fabio Henrique Brasil da Costa, Alanis E Rodriguez Rosario, Arnoldo Corona, Chieko Michikawa, Ratna Veeramachaneni, Abdullah A Osman, Tongxin Xie, Wenyi Wang, Andrew G Sikora, Jeffrey N Myers, Roberto Rangel
• Original research: Low molecular weight heparin synergistically enhances the efficacy of adoptive and anti-PD-1-based immunotherapy by increasing lymphocyte infiltration in colorectal cancer (18 August, 2023)

  Yibo Quan, Jie He, Qi Zou, Liuxi Zhang, Qihui Sun, Hongli Huang, Wanglin Li, Keping Xie, Fang Wei
• Original research:

  Reactivation of low avidity tumor-specific CD8⁺ T cells associates with immunotherapeutic efficacy of anti-PD-1

  (16 August, 2023)

  Gessa Sugiyarto, Doreen Lau, Samuel Luke Hill, David Arcia-Anaya, Denise S M Boulanger, Eileen E Parkes, Edward James, Tim Elliott
• Original research: PPARγ activation modulates the balance of peritoneal macrophage populations to suppress ovarian tumor growth and tumor-induced immunosuppression (16 August, 2023)

  Mélissa Prat, Kimberley Coulson, Clément Blot, Godefroy Jacquemin, Mathilde Romano, Marie-Laure Renoud, Mohamad AlaEddine, Augustin Le Naour, Hélène Authier, Mouna Chirine Rahabi, Khaddouj Benmoussa, Marie Salon, Mélissa Parny, Jean-Pierre Delord, Gwenaël Ferron, Lise Lefèvre, Bettina Couderc, Agnès Coste
• Original research: Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma (8 August, 2023)

  Vincenzo Graziano, Andreas Dannhorn, Heather Hulme, Kate Williamson, Hannah Buckley, Saadia A Karim, Matthew Wilson, Sheng Y Lee, Brajesh P Kaistha, Sabita Islam, James E D Thaventhiran, Frances M Richards, Richard Goodwin, Rebecca Brais, Jennifer P Morton, Simon J Dovedi, Alwin G Schuller, Jim Eyles, Duncan I Jodrell
• Original research:

  Single-cell sequencing on CD8⁺ TILs revealed the nature of exhausted T cells recognizing neoantigen and cancer/testis antigen in non-small cell lung cancer

  (6 August, 2023)

  Hiroyasu Komuro, Shuichi Shinohara, Yasunori Fukushima, Ayako Demachi-Okamura, Daisuke Muraoka, Katsuhiro Masago, Takuya Matsui, Yusuke Sugita, Yusuke Takahashi, Reina Nishida, Chieko Takashima, Takashi Ohki, Yoshiki Shigematsu, Fumiaki Watanabe, Katsutoshi Adachi, Takashi Fukuyama, Hiroshi Hamana, Hiroyuki Kishi, Daiki Miura, Yuki Tanaka, Kousuke Onoue, Kazuhide Onoguchi, Yoshiko Yamashita, Richard Stratford, Trevor Clancy, Rui Yamaguchi, Hiroaki Kuroda, Kiyoshi Doi, Hisashi Iwata, Hirokazu Matsushita