Article info

Original research
Antigen-independent activation is critical for the durable antitumor effect of GUCY2C-targeted CAR-T cells

Authors

  • Changsong Qi State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Early Drug Development Centre, Peking University Cancer Hospital, Beijing, China PubMed articlesGoogle scholar articles
  • Dongqun Liu Beijing Imunopharm Technology Co Ltd, Beijing, China PubMed articlesGoogle scholar articles
  • Chang Liu Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Early Drug Development Centre, Peking University Cancer Hospital, Beijing, China PubMed articlesGoogle scholar articles
  • Xiaofei Wei Beijing Imunopharm Technology Co Ltd, Beijing, China PubMed articlesGoogle scholar articles
  • Mingyang Ma Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital, Beijing, China PubMed articlesGoogle scholar articles
  • Xinan Lu Beijing Imunopharm Technology Co Ltd, Beijing, China PubMed articlesGoogle scholar articles
  • Min Tao Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital, Beijing, China PubMed articlesGoogle scholar articles
  • Cheng Zhang State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Gastrointestinal Oncology, Peking University Cancer Hospital, Beijing, China PubMed articlesGoogle scholar articles
  • Xicheng Wang Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Gastrointestinal Oncology, Peking University Cancer Hospital, Beijing, China PubMed articlesGoogle scholar articles
  • Ting He Beijing Imunopharm Technology Co Ltd, Beijing, China PubMed articlesGoogle scholar articles
  • Jian Li State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Gastrointestinal Oncology, Peking University Cancer Hospital, Beijing, China PubMed articlesGoogle scholar articles
  • Fei Dai Beijing Imunopharm Technology Co Ltd, Beijing, China PubMed articlesGoogle scholar articles
  • Yanping Ding Beijing Imunopharm Technology Co Ltd, Beijing, China PubMed articlesGoogle scholar articles
  • Lin Shen State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Beijing Key Laboratory of Carcinogenesis and Translational Research, Department of Gastrointestinal Oncology, Peking University Cancer Hospital, Beijing, China PubMed articlesGoogle scholar articles
  1. Correspondence to Professor Lin Shen; shenlin{at}bjmu.edu.cn; Dr Yanping Ding; dingyanping{at}imunopharm.com; Dr Changsong Qi; changsongqi{at}bjmu.edu.cn
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Citation

Qi C, Liu D, Liu C, et al
Antigen-independent activation is critical for the durable antitumor effect of GUCY2C-targeted CAR-T cells

Publication history

  • Accepted September 16, 2024
  • First published October 4, 2024.
Online issue publication 
October 04, 2024
  • Supplementary Data

    This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

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