Background Bacillus Calmette-Guérin (BCG) has been successfully used as immunotherapy to treat non-muscle invasive bladder cancer (NMIBC) for more than four decades. BCG is the only intravesical agent shown to reduce the risk of progression of NMIBC to muscle-invasive disease. Unfortunately, BCG therapy is not a universal panacea and it still fails in up to 40% of patients. Many of these patients, especially in the high-risk category (T1 high-grade disease, carcinoma in situ) will require aggressive therapy like cystectomy or in selected cases, bladder-sparing options like chemo-radiation. This prospective cohort study was designed to document efficacy and toxicity of half dose (40 mg) BCG.

Materials and Methods Eligibility criteria include intermediate and high-grade NMIBC and carcinoma in situ after 3 weeks of TURBT. Weekly BCG therapy (40 mg, half dose) was given for 6 weeks as induction and a weekly dose for 3 weeks at 3, 6, 9 and 12 months was given as maintenance therapy. The entire procedure was done as an outdoor procedure.

Results 18 patients were included in the study from 2018 to 2021. Cystitis is the most common symptom experienced by all patients to varied extent but fortunately all are self-limiting. 2 patients had fever which subsided with paracetamol. No serious adverse effect observed in any of the 18 patients, and all were discharged on the same day of admission. After 36 months of mean follow up period, 8 patients had recurrence, 1 patient died, and 1 patient had stuck foley catheter after BCG vaccine instillation which was managed conservatively.

Conclusions BCG therapy is an effective treatment in intermediate and high-grade NMIBC and carcinoma in situ after TURBT. With half dose of BCG toxicity is low and the cost of treatment is just over 20$ per dose.

S. Acharya: None.