Background Severe infections and febrile neutropenia FN due to the administration of conditioningregimens are common among patients undergoing Bone marrow transplantation orHematopoietic stem cell transplantation HSCT. Compliance with the standard antibioticsguidelines like IDSA and NCCN in these patients is crucial to minimise the risk of prolongedhospital stay, antibiotic resistance, increased pharmacoeconomic burden, morbidity andmortality. This study aimed to evaluate compliance with the FN clinical guidelines amongpatients undergoing HSCT.

Materials and Methods This is an ongoing prospective observational study is single-centre and was conducted at awell-known institute specialized for treating blood disorders and bone marrow transplantationfor 3 months. The recruited participants for inclusion criteria were those who at least had asingle episode of FN after post-HSCT. Antibiotics clinical guidelines compliance provided bythe Infectious Diseases Society of America (IDSA) and National Comprehensive CancerNetwork (NCCN) for FN treatment were assessed while reviewing patients‘ medical profiles.

Results The mean age of the patients was 15.09 years± 6.57, Till now in total 11 patients with 23episodes of FN were assessed. FN therapy with compliance-based guidelines (IDSA, NCCN)was examined in terms of selection, initial regimens and timing of antibiotics. Unfortunately,63% of recruited patients did not adhere to the IDSA and NCCN guidelines recommendationsfor initial regimen modification and antibiotic dosing. and only 27% of patients receivedtherapy as per the guidelines.

Conclusions Significant non-compliance to the clinical guidelines was determined, specifically in the useof vancomycin and initial regimen modification, which affect patient outcomes and hospitalstay. Conducting sessions to review IDSA and NCCN guidelines is essential for increasinghealthcare professionals’ awareness and encouraging the judicious utilization of antimicrobialagents.

K. Ali: None.