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  • Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8+ T cells directly within the tumor microenvironment

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Research Article
Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8+ T cells directly within the tumor microenvironment
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Authors

  1. ↵a sspranger{at}bsd.uchicago.edu
  2. ↵b hkoblish{at}incyte.com
  3. ↵c bleighhorton{at}gmail.com
  4. ↵d PScherle{at}incyte.com
  5. ↵e BNewton{at}incyte.com
  6. ↵f tgajewsk{at}medicine.bsd.uchicago.ed
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Citation

Spranger S, Koblish HK, Horton B, et al
Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8+ T cells directly within the tumor microenvironment
Journal for ImmunoTherapy of Cancer 2014;2:3. doi: 10.1186/2051-1426-2-3

Publication history

  • Received October 29, 2013
  • Accepted January 22, 2014
  • First published February 18, 2014.
Online issue publication 
February 09, 2021

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© The Author(s). 2014