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  • Paired tumor biopsy analysis and safety data from a pilot study evaluating Tremelimumab - a monoclonal antibody against CTLA-4 - in combination with ablative therapy in patients with hepatocellular carcinoma (HCC)

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Poster Presentation
Paired tumor biopsy analysis and safety data from a pilot study evaluating Tremelimumab - a monoclonal antibody against CTLA-4 - in combination with ablative therapy in patients with hepatocellular carcinoma (HCC)
  1. Austin Duffy1,
  2. Sid P Kerkar2,
  3. David E Kleiner1,
  4. Susanna Ulahannan3,
  5. Metin Kurtoglu3,
  6. Oxana Rusher3,
  7. Suzanne Fioravanti3,
  8. Melissa Walker3,
  9. William D Figg4,
  10. Kathryn Compton4,
  11. Aradhana Venkatesan5,
  12. Nadine Abi-Jaoudeh5,
  13. Brad Wood5 and
  14. Tim F Greten3
  1. Aff1 grid.94365.3d0000000122975165National Cancer InstituteNational Institutes of Health Bethesda MD USA
  2. Aff2 grid.48336.3a0000000419368075Laboratory of Pathology, Center for Cancer ResearchNational Cancer Institute, National Institutes of Health Bethesda MD USA
  3. Aff3 grid.48336.3a0000000419368075Gastrointestinal Malignancies Section, Center for Cancer ResearchNational Cancer Institute, National Institutes of Health Bethesda MD USA
  4. Aff4 grid.94365.3d0000000122975165Clinical Pharmacology Program, Center for Cancer Research, National Cancer InstituteNational Institutes of Health Bethesda MD USA
  5. Aff5 grid.94365.3d0000000122975165Radiology and Imaging Sciences, Center for Cancer ResearchNational Institutes of Health Bethesda MD USA

http://dx.doi.org/10.1186/2051-1426-2-S3-P98

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    Meeting abstracts

    Background

    Tremelimumab is a fully human monoclonal antibody that binds to CTLA-4 expressed on the surface of activated T lymphocytes and results in inhibition of B7-CTLA-4-mediated down regulation of T cell activation. Both transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA) have been shown to induce a peripheral immune response which may enhance the effect of anti-CTLA4 treatment in patients with advanced HCC.

    Methods

    Patients with HCC (Childs Pugh A/B7; Barcelona Clinic Liver Cancer Stage C; ECOG 0/1; previously progressed on Sorafenib) are being enrolled in a pilot study of Tremelimumab at 2 dose levels (DL1 and DL2) until disease progression (irRECIST). Subtotal TACE or RFA is performed during study week 6 with DLT evaluation period encompassing first 8 weeks of study. Tumor tissue is collected for analysis at baseline on all patients with optional on-treatment tumor biopsies performed at the time of the radiologic procedure.

    Results

    11 pts have been treated so far, 6 pts at DL1 and 5 pts at DL2; M:F 9:2; Median age = 54(range 42-75); Cirrhosis present in 7pts. Hepatitis B/C/neg: 3/6/2. 4 pts received TACE, 7 underwent RFA during week 6 of Tremelimumab therapy. Tumor tissue is being collected for analysis at baseline in all patients. Once DL1 was established as safe and feasible on-treatment tumor biopsies are being performed at the time of the radiologic procedure (Day 36 +/- 96hrs) on all patients. So far 2 of 5 patients treated at DL2 have shown extensive immune cell infiltration on tumor biopsies after 6 weeks of Tremelimumab. More in depth analysis are currently being conducted and will be presented together with safety data.

    Conclusions

    Tremelimumab in combination with TACE or RFA in patients with advanced HCC is feasible. Preliminary pathology data will be presented regarding all post-treatment tumor biopsies.