Journal for ImmunoTherapy of Cancer: 3 (1)

Basic Tumor Immunology

Designed ankyrin repeat proteins are effective targeting elements for chimeric antigen receptors (15 December, 2015)
Joanne A. Hammill, Heather VanSeggelen, Christopher W. Helsen, Galina F. Denisova, Carole Evelegh, Daniela G. M. Tantalo, Jennifer D. Bassett, Jonathan L. Bramson
Tasquinimod triggers an early change in the polarization of tumor associated macrophages in the tumor microenvironment (15 December, 2015)
Anders Olsson, Jessica Nakhlé, Anette Sundstedt, Pascale Plas, Anne-Laure Bauchet, Valérie Pierron, Luce Bruetschy, Adnan Deronic, Marie Törngren, David Liberg, Fabien Schmidlin, Tomas Leanderson
Characterization of the human T cell response to in vitro CD27 costimulation with varlilumab (18 August, 2015)
Venky Ramakrishna, Karuna Sundarapandiyan, Biwei Zhao, Max Bylesjo, Henry C. Marsh, Tibor Keler
Route of antigen delivery impacts the immunostimulatory activity of dendritic cell-based vaccines for hepatocellular carcinoma (21 July, 2015) Free
Angela D. Pardee, Hiroshi Yano, Aliyah M. Weinstein, Aaron A. K. Ponce, Alexander D. Ethridge, Daniel P. Normolle, Lazar Vujanovic, Gerald J. Mizejewski, Simon C. Watkins, Lisa H. Butterfield
Safety and efficacy of ipilimumab to treat advanced melanoma in the setting of liver transplantation (16 June, 2015) Free
Rita E Morales, Alexander N Shoushtari, Michelle M Walsh, Priya Grewal, Evan J Lipson, Richard D Carvajal
Immune modulating effects of cyclophosphamide and treatment with tumor lysate/CpG synergize to eliminate murine neuroblastoma (16 June, 2015) Free
Jill A. Gershan, Kristen M. Barr, James J. Weber, Weiqing Jing, Bryon D. Johnson
Survivin-specific CD4+ T cells are decreased in patients with survivin-positive myeloma (19 May, 2015)
Frederick L Locke, Meghan Menges, Anandharaman Veerapathran, Domenico Coppola, Dmitry Gabrilovich, Claudio Anasetti
Rapid complete response of metastatic melanoma in a patient undergoing ipilimumab immunotherapy in the setting of active ulcerative colitis (19 May, 2015) Free
A Doran Bostwick, April K Salama, Brent A Hanks
Preservation of tumor-host immune interactions with luciferase-tagged imaging in a murine model of ovarian cancer (19 May, 2015)
John B Liao, Kelsie J Ovenell, Erin E M Curtis, Denise L Cecil, Marlese R Koehnlein, Lauren R Rastetter, Ekram A Gad, Mary L Disis
NK cells and CD8+ T cells cooperate to improve therapeutic responses in melanoma treated with interleukin-2 (IL-2) and CTLA-4 blockade (19 May, 2015) Free
Frederick J Kohlhapp, Joseph R Broucek, Tasha Hughes, Erica J Huelsmann, Jevgenijs Lusciks, Janet P Zayas, Hubert Dolubizno, Vidyaratna A Fleetwood, Alisa Grin, Graham E Hill, Joseph L Poshepny, Arman Nabatiyan, Carl E Ruby, Joshua D Snook, Jai S Rudra, Jason M Schenkel, David Masopust, Andrew Zloza, Howard L Kaufman
Human tumor infiltrating lymphocytes cooperatively regulate prostate tumor growth in a humanized mouse model (21 April, 2015)
Michael D Roth, Airi Harui
Combined immune checkpoint protein blockade and low dose whole body irradiation as immunotherapy for myeloma (20 January, 2015) Free
Weiqing Jing, Jill A Gershan, James Weber, Dominique Tlomak, Laura McOlash, Catherine Sabatos-Peyton, Bryon D Johnson
T cell-NF-κB activation is required for tumor control in vivo
(20 January, 2015) Free
Sarah E Barnes, Ying Wang, Luqiu Chen, Luciana L Molinero, Thomas F Gajewski, Cesar Evaristo, Maria-Luisa Alegre

Case Report

Mismatch repair deficiency associated with complete remission to combination programmed cell death ligand immune therapy in a patient with sporadic urothelial carcinoma: immunotheranostic considerations (15 December, 2015)
Michael P. Castro, Neal Goldstein
Intrathecal trastuzumab: immunotherapy improves the prognosis of leptomeningeal metastases in HER-2+ breast cancer patient (15 September, 2015)
Nu T. Lu, Jeffrey Raizer, Erwin P. Gabor, Natalie M. Liu, James Q. Vu, Dennis J. Slamon, John L. Barstis
Acute heart failure due to autoimmune myocarditis under pembrolizumab treatment for metastatic melanoma (21 April, 2015) Free
Heinz Läubli, Cathrin Balmelli, Matthias Bossard, Otmar Pfister, Kathrin Glatz, Alfred Zippelius
Immune therapy of metastatic melanoma developing after allogeneic bone marrow transplant (24 March, 2015)
Michael Cecchini, Mario Sznol, Stuart Seropian
Apical ballooning and cardiomyopathy in a melanoma patient treated with ipilimumab: a case of takotsubo-like syndrome (17 February, 2015)
Benjamin P Geisler, Roy A Raad, Diana Esaian, Elad Sharon, David R Schwartz

Clinical/Translational Cancer Immunotherapy

Cetuximab ameliorates suppressive phenotypes of myeloid antigen presenting cells in head and neck cancer patients (17 November, 2015)
Jing Li, Raghvendra M. Srivastava, Abhinav Ettyreddy, Robert L. Ferris
Inhibition of the angiopoietin/Tie2 axis induces immunogenic modulation, which sensitizes human tumor cells to immune attack (17 November, 2015)
Italia Grenga, Anna R. Kwilas, Renee N. Donahue, Benedetto Farsaci, James W. Hodge
Self-adjuvanted mRNA vaccination in advanced prostate cancer patients: a first-in-man phase I/IIa study (16 June, 2015) Free
Hubert Kübler, Birgit Scheel, Ulrike Gnad-Vogt, Kurt Miller, Wolfgang Schultze-Seemann, Frank vom Dorp, Giorgio Parmiani, Christian Hampel, Steffen Wedel, Lutz Trojan, Dieter Jocham, Tobias Maurer, Gerd Rippin, Mariola Fotin-Mleczek, Florian von der Mülbe, Jochen Probst, Ingmar Hoerr, Karl-Josef Kallen, Thomas Lander, Arnulf Stenzl
Combination immunotherapy with α-CTLA-4 and α-PD-L1 antibody blockade prevents immune escape and leads to complete control of metastatic osteosarcoma (19 May, 2015) Free
Danielle M Lussier, John L Johnson, Pooja Hingorani, Joseph N Blattman
Survival with AGS-003, an autologous dendritic cell–based immunotherapy, in combination with sunitinib in unfavorable risk patients with advanced renal cell carcinoma (RCC): Phase 2 study results (21 April, 2015)
Asim Amin, Arkadiusz Z Dudek, Theodore F Logan, Raymond S Lance, Jeffrey M Holzbeierlein, Jennifer J Knox, Viraj A Master, Sumanta K Pal, Wilson H Miller, Lawrence I Karsh, Irina Y Tcherepanova, Mark A DeBenedette, W Lee Williams, Douglas C Plessinger, Charles A Nicolette, Robert A Figlin
Combination of IFNα and poly-I:C reprograms bladder cancer microenvironment for enhanced CTL attraction (24 March, 2015) Free
Ravikumar Muthuswamy, Liwen Wang, Jamie Pitteroff, Jeffrey R Gingrich, Pawel Kalinski
Early transduction produces highly functional chimeric antigen receptor-modified virus-specific T-cells with central memory markers: a Production Assistant for Cell Therapy (PACT) translational application (18 February, 2015) Free
Jiali Sun, Leslie E Huye, Natalia Lapteva, Maksim Mamonkin, Manasa Hiregange, Brandon Ballard, Olga Dakhova, Darshana Raghavan, April G Durett, Serena K Perna, Bilal Omer, Lisa A Rollins, Ann M Leen, Juan F Vera, Gianpietro Dotti, Adrian P Gee, Malcolm K Brenner, Douglas G Myers, Cliona M Rooney
Programmed death ligand-1 expression in adrenocortical carcinoma: an exploratory biomarker study (17 February, 2015) Free
André P Fay, Sabina Signoretti, Marcella Callea, Gabriela H Telό, Rana R McKay, Jiaxi Song, Ingrid Carvo, Megan E Lampron, Marina D Kaymakcalan, Carlos E Poli-de-Figueiredo, Joaquim Bellmunt, F Stephen Hodi, Gordon J Freeman, Aymen Elfiky, Toni K Choueiri

Commentary

The dark side of ID8-Luc2: pitfalls for luciferase tagged murine models for ovarian cancer (15 December, 2015)
Thaïs Baert, Tina Verschuere, Anaïs Van Hoylandt, Rik Gijsbers, Ignace Vergote, An Coosemans
A new paradigm for tumor immune escape: β-catenin-driven immune exclusion (15 September, 2015)
Stefani Spranger, Thomas F. Gajewski
Introducing the clinical trials monitor: a new section of the journal for immunotherapy of cancer (20 October, 2015)
Leisha A. Emens, Pedro Romero
Update on checkpoint blockade therapy for lymphoma (21 July, 2015)
Justin Kline, Michael R. Bishop
JITC launches a new section: commentary and editorials (24 June, 2015)
Christian M. Capitini, Pedro Romero
The therapeutic promise of disrupting the PD-1/PD-L1 immune checkpoint in cancer: unleashing the CD8 T cell mediated anti-tumor activity results in significant, unprecedented clinical efficacy in various solid tumors (21 April, 2015)
Emanuela Romano, Pedro Romero
Preamble to the 2015 SITC immunotherapy biomarkers taskforce (24 March, 2015)
Lisa H Butterfield, Mary L Disis, Bernard A Fox, Samir N Khleif, Francesco M Marincola

Immunotherapy Biomarkers

Multispectral imaging of formalin-fixed tissue predicts ability to generate tumor-infiltrating lymphocytes from melanoma (20 October, 2015)
Zipei Feng, Sachin Puri, Tarsem Moudgil, William Wood, Clifford C. Hoyt, Chichung Wang, Walter J. Urba, Brendan D. Curti, Carlo B. Bifulco, Bernard A. Fox
Prognostic impact of circulating Her-2-reactive T-cells producing pro- and/or anti-inflammatory cytokines in elderly breast cancer patients (20 October, 2015)
Jithendra Kini Bailur, Evelyna Derhovanessian, Brigitte Gueckel, Graham Pawelec
Baseline circulating IL-17 predicts toxicity while TGF-β1 and IL-10 are prognostic of relapse in ipilimumab neoadjuvant therapy of melanoma (15 September, 2015)
Ahmad A. Tarhini, Haris Zahoor, Yan Lin, Usha Malhotra, Cindy Sander, Lisa H. Butterfield, John M. Kirkwood
Increased CTLA-4⁺ T cells and an increased ratio of monocytes with loss of class II (CD14⁺ HLA-DR^lo/neg) found in aggressive pediatric sarcoma patients
(18 August, 2015) Free
Pooja Hingorani, Mary L. Maas, Michael P. Gustafson, Paul Dickman, Roberta H. Adams, Masayo Watanabe, Francis Eshun, James Williams, Matthew J. Seidel, Allan B. Dietz

Meeting Report

Combination immunotherapy: Where do we go from here? (18 August, 2015)
Abigail E. Overacre, Sema Kurtulus, Mario Sznol, Drew M. Pardoll, Ana Anderson, Dario A. A. Vignali
Target discovery for T cell therapy: next steps to advance Immunotherapies (21 July, 2015)
Adrian Bot, Joanna E Brewer, Zelig Eshhar, Stanley R Frankel, Emma Hickman, Achim A Jungbluth, Richard Morgan, Yoav Peretz, Laszlo Radvanyi, Carlos A Ramos, Paul F Robbins, Kai W Wucherpfennig
Tumor immunology and cancer immunotherapy: summary of the 2014 SITC primer (16 June, 2015)
David B. Page, Ariel Bulua Bourla, Anthony Daniyan, Jarushka Naidoo, Eric Smith, Melody Smith, Claire Friedman, Danny N. Khalil, Samuel Funt, Alexander N. Shoushtari, Willem W. Overwijk, Padmanee Sharma, Margaret K. Callahan
29^th Annual meeting of the Society for Immunotherapy of Cancer (SITC)
(19 May, 2015) Free
Arthur A Hurwitz, Sylvia Lee, Susan Knox, Holbrook Kohrt, Gregory Verdeil, Emanuela Romano, Kim Margolin, Walter J Urba, Daniel E Speiser

Review

Targeting the indoleamine 2,3-dioxygenase pathway in cancer (15 December, 2015)
Yong Wha Moon, Joud Hajjar, Patrick Hwu, Aung Naing
A quantitative analysis of therapeutic cancer vaccines in phase 2 or phase 3 trial (17 November, 2015)
Amabel CL Tan, Anne Goubier, Holbrook E. Kohrt
Pembrolizumab (18 August, 2015) Free
Leila Khoja, Marcus O. Butler, S. Peter Kang, Scot Ebbinghaus, Anthony M. Joshua
Enhancing the discovery and development of immunotherapies for cancer using quantitative and systems pharmacology: Interleukin-12 as a case study (16 June, 2015)
David J Klinke
Bridging infectious disease vaccines with cancer immunotherapy: a role for targeted RNA based immunotherapeutics (21 April, 2015) Free
Elias J Sayour, Luis Sanchez-Perez, Catherine Flores, Duane A Mitchell
New perspective on targeting the tumor suppressor p53 pathway in the tumor microenvironment to enhance the efficacy of immunotherapy (24 March, 2015)
Gang Guo, Yan Cui
Immunotherapeutic approaches to ovarian cancer treatment (24 March, 2015)
Cariad Chester, Oliver Dorigo, Jonathan S Berek, Holbrook Kohrt

Short Report

Ipilmumab and cranial radiation in metastatic melanoma patients: a case series and review (15 December, 2015)
Jonathan D. Schoenfeld, Anand Mahadevan, Scott R. Floyd, Michael A. Dyer, Paul J. Catalano, Brian M. Alexander, David F. McDermott, Irving D. Kaplan
nCounter^® PanCancer Immune Profiling Panel (NanoString Technologies, Inc., Seattle, WA)
(15 December, 2015)
Alessandra Cesano
Quantitative real-time PCR assisted cell counting (qPACC) for epigenetic - based immune cell quantification in blood and tissue (17 November, 2015)
Thomas Oliver Kleen, Jianda Yuan
Erratum to: Immune monitoring technology primer (17 November, 2015)
Kevin K. Dobbin
Immune monitoring technology primer: clinical validation for predictive markers (20 October, 2015)
Kevin K. Dobbin
Immune monitoring technology primer: flow and mass cytometry (15 September, 2015)
Holden T. Maecker, Alexandre Harari
Immune monitoring technology primer: Single Cell Network Profiling (SCNP) (18 August, 2015)
Rachael E. Hawtin, Alessandra Cesano
Immune monitoring technology primer: the enzyme-linked immunospot (Elispot) and Fluorospot assay (21 July, 2015)
Sylvia Janetzki
Immune monitoring technology primer: immunosequencing (25 June, 2015)
Ilan Kirsch
Peripheral T cell receptor diversity is associated with clinical outcomes following ipilimumab treatment in metastatic melanoma (16 June, 2015)
Michael A. Postow, Manuarii Manuel, Phillip Wong, Jianda Yuan, Zhiwan Dong, Cailian Liu, Solène Perez, Isabelle Tanneau, Marlène Noel, Anaïs Courtier, Nicolas Pasqual, Jedd D. Wolchok

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Table of contents

December 2015 - Volume 3 - 1

Basic Tumor Immunology

Case Report

Clinical/Translational Cancer Immunotherapy

Commentary

Immunotherapy Biomarkers

Meeting Report

Review

Short Report

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Table of contents

December 2015 - Volume 3 - 1

Basic Tumor Immunology

Case Report

Clinical/Translational Cancer Immunotherapy

Commentary

Immunotherapy Biomarkers

Meeting Report

Review

Short Report