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Circulating immune cells in patients with surgically resected nonfunctional pancreatic neuroendocrine tumors
  1. Zeljka Jutric1,
  2. Jan Grendar1,
  3. Benjamin Cottam1,2,
  4. Chet Hammill3,
  5. Ronald Wolf3,
  6. Paul Hansen3,
  7. Marka Crittenden1,2,3,
  8. Michael Gough1,2,3 and
  9. Pippa Newell1,2,3
  1. Aff1 grid.415337.7Providence Cancer Center Portland OR USA
  2. Aff2 grid.415286.c0000 0004 0463 5556Earle A. Chiles Research Institute Portland OR USA
  3. Aff3 grid.420050.30000 0004 0455 9389The Oregon Clinic Portland OR USA

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Meeting abstracts


There is debate regarding whether surgical resection and/or lymphadenectomy are indicated for small nonfunctional pancreatic neuroendocrine tumors (PNETs). Myeloid cell population expansion in peripheral blood has been correlated with clinical stage of patients with solid tumors. We aim to determine if blood sampling can be used as a predictor of malignant potential in nonfunctional PNETs.


We prospectively measured cell counts in 29 patients with PNET using flow cytometry of fresh whole blood before and after surgery, including CD3+, CD8+, and CD4+ T cells; monocytes; and granulocytes. Correlations were sought with known clinical markers of malignant potential such as tumor size, grade, number of positive lymph nodes, and TNM stage using t-test and one-way ANOVA analysis (STATA Inc).


In this small cohort of patients, there were no differences in circulating immune cell counts between patients with lymph node metastases versus those without, nor in patients with tumors > 2cm, nor in those patients with high grade tumors. Interestingly, patients with lymph node metastases had a significant decrease in number of circulating CD8+ T cells post operatively when compared to those with negative lymph nodes (p = 0.013). There was a similar decrease in monocyte count post operatively in patients with positive versus negative lymph nodes that did not reach significance (p = 0.056).


Our data do not provide evidence that circulating immune cell populations can be used as biomarkers of lymph node positivity or of malignant potential in PNET prior to resection.