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Core skin DC signatures control immune tolerance to skin cancer and limit anti-tumor immunity
  1. Christopher Nirschl1,
  2. Yong Liu1,
  3. Kavita Sarin2,
  4. Mayte Suarez-Farinas3,
  5. David Chau1,
  6. Peter Sage4,
  7. Arlene Sharpe4 and
  8. Niroshana Anandasabapathy1
  1. Aff1 grid.38142.3c000000041936754XBrigham and Women's Hospital, Department of DermatologyHarvard Medical School Boston MA USA
  2. Aff2 grid.168010.e0000000419368956Stanford University Stanford CA USA
  3. Aff3 grid.59734.3c0000000106702351Mount Sinai school of Medicine New York NY USA
  4. Aff4 grid.38142.3c000000041936754XHarvard Medical School Boston MA USA

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Meeting abstracts


Dendritic cells (DC) are gatekeepers of immunity, critical to both an initiate immune response upon infection and promote tolerance to self-antigens.


We have just established that DC subsets in the skin that constitutively migrate into LNs can individually and collectively temper an on-going immune response. Tissue DC originating in skin share a unique transcriptome signature geared towards immune dampening when compared to their lymphoid counterparts in both mouse and human.


Here we demonstrate expression of unique core skin DC transcripts are closely associated with increased clinical aggressiveness of BCC in humans and the stratify stage 4 melanoma outcomes. In mice, loss of signature genes in DC, which include but are not limited to PD-L1/PD-L2, lead to enhanced antigen-specific immunity, decreased tumor growth, and improved anti-tumor vaccine priming to melanoma skin cancer by distinguishable molecular control of T cell effector function and clonal proliferation.


These data suggest core skin DC signatures regulate the immune-epithelial interface.