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  • Feasibility of dc vaccine combined with low dose endoxan and high dose il-2 treatment associated with taurolidine for advanced, multi-resistant melanoma patients.

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Poster Presentation
Feasibility of dc vaccine combined with low dose endoxan and high dose il-2 treatment associated with taurolidine for advanced, multi-resistant melanoma patients.
  1. Gustavo A Moviglia1 and
  2. Ralf Kleef2
  1. Aff1 grid.440480.cMaimonides University Ciudad de Buenos Aires Argentina
  2. Aff2 Maimonides University Vienna Austria

https://doi.org/10.1186/2051-1426-3-S2-P209

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    Meeting abstracts

    Background

    2014 Dillman and coworkers reported 40% 5-year survival of advanced malignant melanoma (MM) patients treated with a combination of Tumor Vaccine in combination with High dose IL-2 versus 13% of similar patients treated only with High Dose of IL-2 (HD IL-2). In order to improve the efficacy of this approach and minimize the adverse effects of HD IL-2 therapy we have developed a protocol using a Dendritic Cell Vaccine challenged with autologous MM stem cells in combination with HD IL-2 and to Taurolidine (to diminish the vasculary leak syndrome).

    Methods

    5 advanced and rapidly progressive MM patients, resistant to any other standard therapy were treated. 1/5 with large brain metastasis was withdrawn from the treatment after the first cycle of treatment for rapid progression of his disease. 4/5 patients received three cycles. In brief, previous to vaccination with a patient specific autologous dendritic cell vaccine patients underwent low dose endoxan 300m/m2, and were subsequently treated for 5 days with high-dose IL-2 in combination with Taurolidine as described by O'Brian et.al. 2006.

    Results

    Major side effects were high temperature 4/4 and hypereosinophilia associated with itching (2/5). No other signs like severe edema, renal failure or any other life threatening condition was observed. 4/5 patients did not show any progression of their condition during the 2-3 months of observation.

    Conclusions

    DC-vaccine associated to HD IL-2 + Taurolidine vaccine seems to be a feasible and low toxic treatment. Longer observation time as well as increment of the number of patients treated is necessary to confirm these preliminary findings.