Article info
Research Article
CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids
- ↵a reyes.gonzalezexposito{at}icr.ac.uk
- ↵b maria.semiannikova{at}icr.ac.uk
- ↵c beatrice.griffiths{at}icr.ac.uk
- ↵d khurum.khan{at}rmh.nhs.uk
- ↵e louise.barber01{at}icr.ac.uk
- ↵f andrew.woolston{at}icr.ac.uk
- ↵g georgia.spain{at}icr.ac.uk
- ↵h katharina.vonloga{at}icr.ac.uk
- ↵i ben.challoner{at}icr.ac.uk
- ↵j radhika.patel{at}icr.ac.uk
- ↵k michael.ranes{at}icr.ac.uk
- ↵l amanda.swain{at}icr.ac.uk
- ↵m janet.thomas{at}rmh.nhs.uk
- ↵n annette.bryant{at}rmh.nhs.uk
- ↵o claire.saffery{at}rmh.nhs.uk
- ↵p nicos.fotiadis{at}rmh.nhs.uk
- ↵q sebastian.guettler{at}icr.ac.uk
- ↵r david.mansfield{at}icr.ac.uk
- ↵s alan.melcher{at}icr.ac.uk
- ↵t thomas.powles{at}bartshealth.nhs.uk
- ↵u sheela.rao{at}rmh.nhs.uk
- ↵v david.watkins{at}rmh.nhs.uk
- ↵w ian.chau{at}rmh.nhs.uk
- ↵x nik.matthews{at}icr.ac.uk
- ↵y fredrik.wallberg{at}icr.ac.uk
- ↵z naureen.starling{at}rmh.nhs.uk
- ↵{ david.cunningham{at}rmh.nhs.uk
- ↵| +44 207 153 5234 marco.gerlinger{at}icr.ac.uk
Citation
CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer organoids
Publication history
- Received December 18, 2018
- Accepted March 22, 2019
- First published April 15, 2019.
Online issue publication
April 15, 2019
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© The Author(s).
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.