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Metastatic breast cancers have reduced immune cell recruitment but harbor increased macrophages relative to their matched primary tumors

Authors

  • Li Zhu Department of BiostatisticsUniversity of Pittsburgh Pittsburgh PA USA PubMed articlesGoogle scholar articles
  • Jessica L. Narloch Clinical Research Training ProgramDuke University Medical Center (DUMC) Durham NC USA Breast Cancer Program, Duke Cancer Institute, DUMC Durham NC USA PubMed articlesGoogle scholar articles
  • Sayali Onkar Department of ImmunologyUniversity of Pittsburgh Pittsburgh PA USA Tumor Microenvironment Center, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center Pittsburgh PA USA PubMed articlesGoogle scholar articles
  • Marion Joy National Surgical Adjuvant Breast and Bowel Project (NSABP) Pittsburgh PA USA PubMed articlesGoogle scholar articles
  • Gloria Broadwater Duke Clinical Research Institute Durham NC USA PubMed articlesGoogle scholar articles
  • Catherine Luedke Department of PathologyDUMC Durham NC USA PubMed articlesGoogle scholar articles
  • Allison Hall Department of PathologyDUMC Durham NC USA PubMed articlesGoogle scholar articles
  • Rim Kim National Surgical Adjuvant Breast and Bowel Project (NSABP) Pittsburgh PA USA PubMed articlesGoogle scholar articles
  • Katherine Pogue-Geile National Surgical Adjuvant Breast and Bowel Project (NSABP) Pittsburgh PA USA PubMed articlesGoogle scholar articles
  • Sarah Sammons Breast Cancer Program, Duke Cancer Institute, DUMC Durham NC USA Division of Hematology/Oncology, Department of MedicineDUMC Durham NC USA PubMed articlesGoogle scholar articles
  • Naema Nayyar Division of Hematology & Oncology, Department of MedicineMassachusetts General Hospital, Harvard Medical School Boston MA USA Division of Neuro-Oncology, Department of NeurologyMassachusetts General Hospital, Harvard Medical School Boston MA USA PubMed articlesGoogle scholar articles
  • Ugonma Chukwueke Division of Hematology & Oncology, Department of MedicineMassachusetts General Hospital, Harvard Medical School Boston MA USA Division of Neuro-Oncology, Department of NeurologyMassachusetts General Hospital, Harvard Medical School Boston MA USA PubMed articlesGoogle scholar articles
  • Priscilla K. Brastianos Division of Hematology & Oncology, Department of MedicineMassachusetts General Hospital, Harvard Medical School Boston MA USA Division of Neuro-Oncology, Department of NeurologyMassachusetts General Hospital, Harvard Medical School Boston MA USA PubMed articlesGoogle scholar articles
  • Carey K. Anders Division of Medical Oncology, Department of MedicineUniversity of North Carolina at Chapel Hill Chapel Hill NC USA PubMed articlesGoogle scholar articles
  • Adam C. Soloff Department of Cardiothoracic SurgeryUniversity of Pittsburgh School of Medicine Pittsburgh PA USA PubMed articlesGoogle scholar articles
  • Dario A. A. Vignali Department of ImmunologyUniversity of Pittsburgh Pittsburgh PA USA Tumor Microenvironment Center, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center Pittsburgh PA USA PubMed articlesGoogle scholar articles
  • George C. Tseng Department of BiostatisticsUniversity of Pittsburgh Pittsburgh PA USA PubMed articlesGoogle scholar articles
  • Leisha A. Emens Tumor Microenvironment Center, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center Pittsburgh PA USA Department of MedicineUniversity of Pittsburgh Pittsburgh PA USA Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee Womens Research Institute Pittsburgh USA PubMed articlesGoogle scholar articles
  • Peter C. Lucas National Surgical Adjuvant Breast and Bowel Project (NSABP) Pittsburgh PA USA Department of PathologyUniversity of Pittsburgh School of Medicine Pittsburgh PA USA PubMed articlesGoogle scholar articles
  • Kimberly L. Blackwell Breast Cancer Program, Duke Cancer Institute, DUMC Durham NC USA Department of Radiation OncologyDUMC Durham NC USA PubMed articlesGoogle scholar articles
  • Steffi Oesterreich Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee Womens Research Institute Pittsburgh USA Department of Pharmacology & Chemical BiologyUniversity of Pittsburgh Pittsburgh USA PubMed articlesGoogle scholar articles
  • Adrian V. Lee Womens Cancer Research Center, UPMC Hillman Cancer Center, Magee Womens Research Institute Pittsburgh USA Department of Pharmacology & Chemical BiologyUniversity of Pittsburgh Pittsburgh USA PubMed articlesGoogle scholar articles
  1. v leeav{at}upmc.edu
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Citation

Zhu L, Narloch JL, Onkar S, et al
Metastatic breast cancers have reduced immune cell recruitment but harbor increased macrophages relative to their matched primary tumors

Publication history

  • Received June 23, 2019
  • Accepted September 20, 2019
  • First published October 18, 2019.
Online issue publication 
January 08, 2022

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