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Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1

Authors

  • Kellie N. Smith Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Nicolas J. Llosa Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Tricia R. Cottrell Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University Baltimore MD USA Department of PathologyJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Nicholas Siegel Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Hongni Fan Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Prerna Suri Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Hok Yee Chan Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Haidan Guo Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Teniola Oke Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Anas H. Awan Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Franco Verde Russell H. Morgan Department of Radiology and Radiological ScienceJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Ludmila Danilova Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University Baltimore MD USA Division of Biostatistics and BioinformaticsJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Valsamo Anagnostou Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Ada J. Tam Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Brandon S. Luber Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Division of Biostatistics and BioinformaticsJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Bjarne R. Bartlett Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA The Swim Across America Laboratory, John Hopkins University Baltimore MD USA Ludwig Center and Howard Hughes Medical InstituteJohns Hopkins University Baltimore MD USA Present address: B.R.B.,Bioinformatics Core, Department of Complementary & Integrative MedicineUniversity of Hawaii John A. Burns School of Medicine 96813 Honolulu HI USA PubMed articlesGoogle scholar articles
  • Laveet K. Aulakh Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA The Swim Across America Laboratory, John Hopkins University Baltimore MD USA Ludwig Center and Howard Hughes Medical InstituteJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • John-William Sidhom Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Qingfeng Zhu Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University Baltimore MD USA Department of PathologyJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Cynthia L. Sears Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Leslie Cope Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University Baltimore MD USA Division of Biostatistics and BioinformaticsJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • William H. Sharfman Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Elizabeth D. Thompson Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University Baltimore MD USA The Swim Across America Laboratory, John Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Joanne Riemer Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Kristen A. Marrone Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Jarushka Naidoo Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Victor E. Velculescu Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Patrick M. Forde Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Bert Vogelstein Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Ludwig Center and Howard Hughes Medical InstituteJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Kenneth W. Kinzler Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Ludwig Center and Howard Hughes Medical InstituteJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Nickolas Papadopoulos Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Ludwig Center and Howard Hughes Medical InstituteJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Jennifer N. Durham Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Hao Wang Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University Baltimore MD USA Division of Biostatistics and BioinformaticsJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Dung T. Le Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Sune Justesen Immunitrack Copenhagen Denmark PubMed articlesGoogle scholar articles
  • Janis M. Taube Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University Baltimore MD USA Department of PathologyJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Luis A. Diaz Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA The Swim Across America Laboratory, John Hopkins University Baltimore MD USA Ludwig Center and Howard Hughes Medical InstituteJohns Hopkins University Baltimore MD USA Department of Medicine, Division of Solid Tumor OncologyMemorial Sloan Kettering Cancer Center New York NY USA PubMed articlesGoogle scholar articles
  • Julie R. Brahmer Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Drew M. Pardoll Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Robert A. Anders Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University Baltimore MD USA Department of PathologyJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  • Franck Housseau Bloomberg-Kimmel Institute for Cancer ImmunotherapyJohns Hopkins University Baltimore MD USA Sidney Kimmel Comprehensive Cancer CenterJohns Hopkins University Baltimore MD USA PubMed articlesGoogle scholar articles
  1. a kellie{at}jhmi.edu
  2. b nllosa1{at}jhmi.edu
  3. c tcottre2{at}jhmi.edu
  4. d nsiegel4{at}jhmi.edu
  5. e hfan1{at}jhmi.edu
  6. f psuri1{at}jhu.edu
  7. g hchan14{at}jhu.edu
  8. h hguo8{at}jhmi.edu
  9. i toke1{at}jhmi.edu
  10. j aawan6{at}jhu.edu
  11. k fverde1{at}jhmi.edu
  12. l ludmila.danilova{at}gmail.com
  13. m vanagno1{at}jhmi.edu
  14. n adatam{at}jhmi.edu
  15. o bsluber{at}jhu.edu
  16. p bjarne{at}hawaii.edu
  17. q laulakh1{at}jhu.edu
  18. r jsidhom1{at}jhmi.edu
  19. s qzhu6{at}jhmi.edu
  20. t csears{at}jhmi.edu
  21. u lcope1{at}jhmi.edu
  22. v sharfwi{at}jhmi.edu
  23. w ethomp36{at}jhmi.edu
  24. x jriemer3{at}jhmi.edu
  25. y kmarron1{at}jhmi.edu
  26. z jnaidoo1{at}jhmi.edu
  27. { velculescu{at}jhmi.edu
  28. | pforde1{at}jhmi.edu
  29. } bertvog{at}gmail.com
  30. ~ kinzlke{at}jhmi.edu
  31.  npapado1{at}jhmi.edu
  32. € juram1{at}jhmi.edu
  33.  hwang76{at}jhmi.edu
  34. ‚ dle{at}jhmi.edu
  35. ƒ sjust{at}immunitrack.com
  36. „ jtaube1{at}jhmi.edu
  37. … ldiaz{at}mskcc.org
  38. † brahmju{at}jhmi.edu
  39. ‡ dpardol1{at}jhmi.edu
  40. ˆ rander54{at}jhmi.edu
  41. ‰ fhousse1{at}jhmi.edu
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Citation

Smith KN, Llosa NJ, Cottrell TR, et al
Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1

Publication history

  • Received September 14, 2018
  • Accepted December 20, 2018
  • First published February 11, 2019.
Online issue publication 
February 11, 2019

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