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Correction: HHLA2 and PD-L1 co-expression predicts poor prognosis in patients with clear cell renal cell carcinoma

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Zhou Q, Li K, Chen X, et al. HHLA2 and PD-L1 co-expression predicts poor prognosis in patients with clear cell renal cell carcinoma. J ImmunoTherap Cancer 2020;8:e000157. doi: 10.1136/jitc-2019-000157

In this article, the last panels in figure 3C and 3D incorrectly show the same image. The corrected figure 3 is shown below

Embedded ImageFigure 3. Representative micrographs of CD8 (A) and CD4 (B) expression and the corresponding negative controls within the tumor. Scatter plot depicted the correlation between HHLA2 and PD-L1 expression and classic subsets of T cells. (C) The correlation of HHLA2 expression and CD8+ T cells and CD4+ T cells in the training cohort and validation cohort. (D) The correlation of PD-L1 expression and CD8+ T cells and CD4+ T cells in the training cohort and validation cohort. (E) The correlation of the HHLA2/PD-L1 co-expression and CD8+ T cells and CD4+ T cells in the training cohort and validation cohort. Group I: HHLA2 (−)/PD-L1 (−); group II: HHLA2 (+)/PD-L1 (−) or HHLA2 (−)/PD-L1 (+); group III: HHLA2 (+)/PD-L1 (+). HHLA2, human endogenous retrovirus-H long terminal repeat-associating protein 2; PD-L1, programmed death 1 ligand 1.

Additionally, in the Results section titled ‘Immune classification for ccRCC’ the sentence “1.9% (4/206) and 2.5% (5/197) belong to type AIII, defined as negative TILs and both positive(HHLA2 (−)/PD-L1 (−)); 21.8% (45/206) and 22.3% (44/197) belong to type BI, defined as posi- tive TILs and both negative; 25.7% (53/206) and 22.3% (44/197) belong to type BII, defined as positive TILs and single positive; 18.0% (37/206) and 15.0% (31/197) belong to type BIII, defined as negative TILs and both positive (online supplementary table 4)” should read “1.9% (4/206) and 2.5% (5/197) belong to type AIII, defined as negative TILs and both positive(HHLA2 (+)/PD-L1 (+)); 21.8% (45/206) and 22.3% (44/197) belong to type BI, defined as posi- tive TILs and both negative; 25.7% (53/206) and 22.3% (44/197) belong to type BII, defined as positive TILs and single positive; 18.0% (37/206) and 15.0% (31/197) belong to type BIII, defined as positive TILs and both positive (online supplementary table 4).”

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