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Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

Authors

  • Lorenzo Galluzzi Department of Radiation Oncology, Weill Cornell Medical College, New York City, New York, USA Sandra and Edward Meyer Cancer Center, New York City, New York, USA Caryl and Israel Englander Institute for Precision Medicine, New York City, New York, USA Department of Dermatology, Yale School of Medicine, New Haven, Connecticut, USA Université de Paris, Paris, France PubMed articlesGoogle scholar articles
  • Ilio Vitale IIGM - Italian Institute for Genomic Medicine, c/o IRCSS, Candiolo, Torino, Italy Candiolo Cancer Institute, FPO - IRCCS, Candiolo, Italy PubMed articlesGoogle scholar articles
  • Sarah Warren NanoString Technologies, Seattle, Washington, USA PubMed articlesGoogle scholar articles
  • Sandy Adjemian VIB Center for Inflammation Research (IRC), Ghent, Belgium Department of Biomedical Molecular Biology (DBMB), Ghent University, Ghent, Belgium PubMed articlesGoogle scholar articles
  • Patrizia Agostinis Cell Death Research & Therapy (CDRT) Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium VIB-KU Leuven Center for Cancer Biology, KU Leuevn, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Aitziber Buqué Martinez Department of Radiation Oncology, Weill Cornell Medical College, New York City, New York, USA PubMed articlesGoogle scholar articles
  • Timothy A Chan Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York City, New York, USA Immunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer Center, New York City, New York, USA PubMed articlesGoogle scholar articles
  • George Coukos Ludwig Institute for Cancer Research and Department of Oncology, University of Lausanne, Lausanne, Switzerland PubMed articlesGoogle scholar articles
  • Sandra Demaria Department of Radiation Oncology, Weill Cornell Medical College, New York City, New York, USA Sandra and Edward Meyer Cancer Center, New York City, New York, USA Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York City, New York, USA PubMed articlesGoogle scholar articles
  • Eric Deutsch Department of Radiation Oncology, Gustave Roussy Cancer Campus, Villejuif, France INSERM "Molecular Radiotherapy and therapeutic innovation", U1030 Molecular Radiotherapy, Gustave Roussy Cancer Campus, Villejuif, France SIRIC SOCRATES, DHU Torino, Faculté de Medecine, Université Paris-Saclay, Kremlin-Bicêtre, France PubMed articlesGoogle scholar articles
  • Dobrin Draganov Calidi Biotherapeutics, San Diego, California, USA PubMed articlesGoogle scholar articles
  • Richard L Edelson Department of Dermatology, Yale School of Medicine, New Haven, Connecticut, USA Comprehensive Cancer Center, Yale University School of Medicine, New Haven, Connecticut, USA PubMed articlesGoogle scholar articles
  • Silvia C Formenti Department of Radiation Oncology, Weill Cornell Medical College, New York City, New York, USA Sandra and Edward Meyer Cancer Center, New York City, New York, USA PubMed articlesGoogle scholar articles
  • Jitka Fucikova Department of Immunology, Charles University, 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic Sotio, Prague, Czech Republic PubMed articlesGoogle scholar articles
  • Lucia Gabriele Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy PubMed articlesGoogle scholar articles
  • Udo S Gaipl Universitätsklinikum Erlangen, Erlangen, Germany PubMed articlesGoogle scholar articles
  • Sofia R Gameiro Laboratory of Tumor Immunology and Biology, National Cancer Institute/Center for Cancer Research, National Institutes of Health, Bethesda, Maryland, USA PubMed articlesGoogle scholar articles
  • Abhishek D Garg Cell Death Research & Therapy (CDRT) Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium PubMed articlesGoogle scholar articles
  • Encouse Golden Department of Radiation Oncology, Weill Cornell Medical College, New York City, New York, USA Sandra and Edward Meyer Cancer Center, New York City, New York, USA PubMed articlesGoogle scholar articles
  • Jian Han iRepertoire, Inc, Huntsville, Alabama, USA PubMed articlesGoogle scholar articles
  • Kevin J Harrington Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK The Royal Marsden Hospital/Institute of Cancer Research National Institute for Health Biomedical Research Centre, London, UK PubMed articlesGoogle scholar articles
  • Akseli Hemminki Cancer Gene Therapy Group, Translational Immunology Research Program, University of Helsinki, Helsinki, Finland Comprehensive Cancer Center, Helsinki University Hospital, Helsinki, Finland PubMed articlesGoogle scholar articles
  • James W Hodge Laboratory of Tumor Immunology and Biology, National Cancer Institute/Center for Cancer Research, National Institutes of Health, Bethesda, Maryland, USA PubMed articlesGoogle scholar articles
  • Dewan Md Sakib Hossain Merck & Co. Inc, Kenilworth, New Jersey, USA PubMed articlesGoogle scholar articles
  • Tim Illidge University of Manchester, NIHR Manchester Biomedical Research Centre, Christie Hospital, Manchester, UK PubMed articlesGoogle scholar articles
  • Michael Karin Department of Pharmacology and Pathology, University of California at San Diego (UCSD) School of Medicine, La Jolla, California, USA PubMed articlesGoogle scholar articles
  • Howard L Kaufman Division of Surgical Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA Replimune, Inc, Woburn, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Oliver Kepp Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Institute, Villejuif, France Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, Paris, France PubMed articlesGoogle scholar articles
  • Guido Kroemer Université de Paris, Paris, France Metabolomics and Cell Biology Platforms, Gustave Roussy Comprehensive Cancer Institute, Villejuif, France Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, Paris, France Gustave Roussy Comprehensive Cancer Institute, Villejuif, France INSERM, U1138, Paris, France Sorbonne Université, Paris, France Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France Karolinska Institute, Department of Women’s and Children’s Health, Karolinska University Hospital, Stockholm, Sweden Suzhou Institute for Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China PubMed articlesGoogle scholar articles
  • Juan Jose Lasarte Program of Immunology and Immunotherapy, Centro de Investigación Médica Aplicada (CIMA), University of Navarra, Pamplona, Spain PubMed articlesGoogle scholar articles
  • Sherene Loi Division of Research and Clinical Medicine, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia Department of Oncology, University of Melbourne, Parkville, Victoria, Australia PubMed articlesGoogle scholar articles
  • Michael T Lotze Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA Department of Bioengineering, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA PubMed articlesGoogle scholar articles
  • Gwenola Manic IIGM - Italian Institute for Genomic Medicine, c/o IRCSS, Candiolo, Torino, Italy Candiolo Cancer Institute, FPO - IRCCS, Candiolo, Italy PubMed articlesGoogle scholar articles
  • Taha Merghoub Ludwig Collaborative and Swim Across America Laboratory, MSKCC, New York City, New York, USA Weill Cornell Medical College, New York City, New York, USA Parker Institute for Cancer Immunotherapy, MSKCC, New York City, New York, USA PubMed articlesGoogle scholar articles
  • Alan A Melcher The Institute of Cancer Research, London, UK PubMed articlesGoogle scholar articles
  • Karen L Mossman McMaster University, Hamilton, Ontario, Canada PubMed articlesGoogle scholar articles
  • Felipe Prosper Hematology and Cell Therapy, Clinica Universidad de Navarra, Pamplona, Spain PubMed articlesGoogle scholar articles
  • Øystein Rekdal Lytix Biopharma, Oslo, Norway Department of Medical Biology, University of Tromsø, Tromsø, Norway PubMed articlesGoogle scholar articles
  • Maria Rescigno Humanitas Clinical and Research Center – IRCCS, Rozzano, Italy Humanitas University, Department of Biomedical Sciences, Pieve Emanuele, Milan, Italy PubMed articlesGoogle scholar articles
  • Chiara Riganti Department of Oncology, University of Torino, Torino, Italy Interdepartmental Research Center of Molecular Biotechnology, University of Torino, Torino, Italy PubMed articlesGoogle scholar articles
  • Antonella Sistigu UOSD Immunology and Immunotherapy Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy Istituto di Patologia Generale, Università Cattolica del Sacro Cuore, Rome, Italy PubMed articlesGoogle scholar articles
  • Mark J Smyth Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia PubMed articlesGoogle scholar articles
  • Radek Spisek Department of Immunology, Charles University, 2nd Faculty of Medicine and University Hospital Motol, Prague, Czech Republic Sotio, Prague, Czech Republic PubMed articlesGoogle scholar articles
  • John Stagg Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM), Montréal, Quebec City, Canada Institut du Cancer de Montréal, Montréal, Quebec City, Canada Faculté de Pharmacie de l’Université de Montréal, Montréal, Quebec City, Canada PubMed articlesGoogle scholar articles
  • Bryan E Strauss Centro de Investigação Translacional em Oncologia/LIM24, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brasil PubMed articlesGoogle scholar articles
  • Daolin Tang Department of Surgery, UT Southwestern Medical Center, Dallas, Texas, USA PubMed articlesGoogle scholar articles
  • Kazuki Tatsuno Department of Dermatology, Yale School of Medicine, New Haven, Connecticut, USA PubMed articlesGoogle scholar articles
  • Stefaan W van Gool Immun-Onkologisches Zentrum Köln, Cologne, Germany PubMed articlesGoogle scholar articles
  • Peter Vandenabeele VIB Center for Inflammation Research (IRC), Ghent, Belgium Department of Biomedical Molecular Biology (DBMB), Ghent University, Ghent, Belgium Methusalem program, Ghent University, Ghent, Belgium PubMed articlesGoogle scholar articles
  • Takahiro Yamazaki Department of Radiation Oncology, Weill Cornell Medical College, New York City, New York, USA PubMed articlesGoogle scholar articles
  • Dmitriy Zamarin Department of Medicine, Weill Cornell Medical College, New York City, New York, USA Department of Medicine, Memorial Sloan Kettering Cancer Center, New York City, New York, USA PubMed articlesGoogle scholar articles
  • Laurence Zitvogel Gustave Roussy Comprehensive Cancer Institute, Villejuif, France Equipe labellisée par la Ligue contre le cancer, Gustave Roussy, Villejuif, France Faculty of Medicine, University of Paris Sud/Paris Saclay, Le Kremlin-Bicêtre, France INSERM U1015, Villejuif, France Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 1428, Villejuif, France PubMed articlesGoogle scholar articles
  • Alessandra Cesano ESSA Pharmaceuticals, South San Francisco, California, USA PubMed articlesGoogle scholar articles
  • Francesco M Marincola Refuge Biotechnologies, Menlo Park, California, USA PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Lorenzo Galluzzi; deadoc80{at}gmail.com
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Citation

Galluzzi L, Vitale I, Warren S, et al
Consensus guidelines for the definition, detection and interpretation of immunogenic cell death
Journal for ImmunoTherapy of Cancer 2020;8:e000337. doi: 10.1136/jitc-2019-000337

Publication history

  • Accepted January 13, 2020
  • First published March 9, 2020.
Online issue publication 
March 09, 2020

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.