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  • Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-γ, CXCL9 and CXCL10

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Basic tumor immunology
Original research
Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-γ, CXCL9 and CXCL10

Authors

  • Cristina Bergamaschi Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland, USA PubMed articlesGoogle scholar articles
  • Hrishikesh Pandit Human Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland, USA PubMed articlesGoogle scholar articles
  • Bethany A Nagy Human Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland, USA PubMed articlesGoogle scholar articles
  • Dimitris Stellas Human Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland, USA PubMed articlesGoogle scholar articles
  • Shawn M Jensen Robert W Franz Cancer Research Center, Providence Portland Medical Center, Earle A Chiles Research Institute, Portland, Oregon, USA PubMed articlesGoogle scholar articles
  • Jenifer Bear Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland, USA PubMed articlesGoogle scholar articles
  • Maggie Cam Office of Science and Technology Resources, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, USA PubMed articlesGoogle scholar articles
  • Antonio Valentin Human Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland, USA PubMed articlesGoogle scholar articles
  • Bernard A Fox Robert W Franz Cancer Research Center, Providence Portland Medical Center, Earle A Chiles Research Institute, Portland, Oregon, USA PubMed articlesGoogle scholar articles
  • Barbara K Felber Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland, USA PubMed articlesGoogle scholar articles
  • George N Pavlakis Human Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland, USA PubMed articlesGoogle scholar articles
  1. Correspondence to Dr George N Pavlakis; george.pavlakis{at}nih.gov
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Citation

Bergamaschi C, Pandit H, Nagy BA, et al
Heterodimeric IL-15 delays tumor growth and promotes intratumoral CTL and dendritic cell accumulation by a cytokine network involving XCL1, IFN-γ, CXCL9 and CXCL10
Journal for ImmunoTherapy of Cancer 2020;8:e000599. doi: 10.1136/jitc-2020-000599

Publication history

  • Accepted April 9, 2020
  • First published May 26, 2020.
Online issue publication 
January 11, 2022

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.