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Oncolytic and local immunotherapy
Short report
Oncolytic vaccinia virus delivering tethered IL-12 enhances antitumor effects with improved safety

Authors

  • Yan Ge Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA UPMC Hillman Cancer Center, Pittsburgh, PA, USA Department of Immunology, School of Biology and Basic Medical Sciences, Medical College, Soochow University, Suzhou, Jiangsu Province, China PubMed articlesGoogle scholar articles
  • Haiyan Wang Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA UPMC Hillman Cancer Center, Pittsburgh, PA, USA Department of Immunology, School of Biology and Basic Medical Sciences, Medical College, Soochow University, Suzhou, Jiangsu Province, China PubMed articlesGoogle scholar articles
  • Jinghua Ren Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA UPMC Hillman Cancer Center, Pittsburgh, PA, USA Cancer Center, Union Hospital, Huazhong University of Science and Technology, Wuhan, Hubei Province, China PubMed articlesGoogle scholar articles
  • Weilin Liu Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA UPMC Hillman Cancer Center, Pittsburgh, PA, USA Xiangya School of Medicine, Central South University, Changsha, Hunan Province, China PubMed articlesGoogle scholar articles
  • Lingjuan Chen Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA UPMC Hillman Cancer Center, Pittsburgh, PA, USA Cancer Center, Union Hospital, Huazhong University of Science and Technology, Wuhan, Hubei Province, China PubMed articlesGoogle scholar articles
  • Hongqi Chen Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA UPMC Hillman Cancer Center, Pittsburgh, PA, USA Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China PubMed articlesGoogle scholar articles
  • Junjie Ye Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA UPMC Hillman Cancer Center, Pittsburgh, PA, USA Department of Cancer Center, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China PubMed articlesGoogle scholar articles
  • Enyong Dai Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA UPMC Hillman Cancer Center, Pittsburgh, PA, USA Department of Oncology and Hematology, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China PubMed articlesGoogle scholar articles
  • Congrong Ma Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA UPMC Hillman Cancer Center, Pittsburgh, PA, USA PubMed articlesGoogle scholar articles
  • Songguang Ju Department of Immunology, School of Biology and Basic Medical Sciences, Medical College, Soochow University, Suzhou, Jiangsu Province, China PubMed articlesGoogle scholar articles
  • Zong Sheng Guo Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA UPMC Hillman Cancer Center, Pittsburgh, PA, USA PubMed articlesGoogle scholar articles
  • Zuqiang Liu Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA UPMC Hillman Cancer Center, Pittsburgh, PA, USA PubMed articlesGoogle scholar articles
  • David L Bartlett Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA UPMC Hillman Cancer Center, Pittsburgh, PA, USA PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Zuqiang Liu; liuz{at}upmc.edu; Dr David L Bartlett; bartdl{at}UPMC.EDU
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Citation

Ge Y, Wang H, Ren J, et al
Oncolytic vaccinia virus delivering tethered IL-12 enhances antitumor effects with improved safety
Journal for ImmunoTherapy of Cancer 2020;8:e000710. doi: 10.1136/jitc-2020-000710

Publication history

  • Accepted February 26, 2020
  • First published March 24, 2020.
Online issue publication 
March 24, 2020

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.