Journal for ImmunoTherapy of Cancer: 8 (2)

December 2020 - Volume 8 - 2

Basic tumor immunology

Original research: 4-1BB co-stimulation further enhances anti-PD-1-mediated reinvigoration of exhausted CD39⁺ CD8 T cells from primary and metastatic sites of epithelial ovarian cancers (16 December, 2020)
Galam Leem, Junsik Park, Minwoo Jeon, Eui-Soon Kim, Sang Wun Kim, Yong Jae Lee, Seong Jin Choi, Baekgyu Choi, Seongyeol Park, Young Seok Ju, Inkyung Jung, Sunghoon Kim, Eui-Cheol Shin, Jung Yun Lee, Su-Hyung Park
Original research: A20 regulates the therapeutic effect of anti-PD-1 immunotherapy in melanoma (9 December, 2020)
Weinan Guo, Jinyuan Ma, Sen Guo, Huina Wang, Sijia Wang, Qiong Shi, Lin Liu, Tao Zhao, Fengfan Yang, Shuyang Chen, Jianru Chen, Jianhong Zhao, Chen Yu, Xiuli Yi, Yuqi Yang, Jingjing Ma, Qingrong Ni, Guannan Zhu, Tianwen Gao, Chunying Li
Original research: Combining inhibition of galectin-3 with and before a therapeutic vaccination is critical for the prostate-tumor-free outcome (8 December, 2020)
Carolina Tiraboschi, Lucas Gentilini, Carla Velazquez, Enrique Corapi, Felipe Martín Jaworski, José Daniel Garcia Garcia, Yorfer Rondón, Anne Chauchereau, Diego José Laderach, Daniel Compagno
Original research: Adenoviral vaccines promote protective tissue-resident memory T cell populations against cancer (8 December, 2020)
Esmé TI van der Gracht, Mark JA Schoonderwoerd, Suzanne van Duikeren, Ayse N Yilmaz, Felix M Behr, Julia M Colston, Lian N Lee, Hideo Yagita, Klaas PJM van Gisbergen, Lukas JAC Hawinkels, Frits Koning, Paul Klenerman, Ramon Arens
Original research: Antimetabolite pemetrexed primes a favorable tumor microenvironment for immune checkpoint blockade therapy (26 November, 2020)
Chia-Sing Lu, Ching-Wen Lin, Ya-Hsuan Chang, Hsuan-Yu Chen, Wei-Chia Chung, Wei-Yun Lai, Chao-Chi Ho, Tong-Hong Wang, Chi-Yuan Chen, Chen-Lin Yeh, Sean Wu, Shu-Ping Wang, Pan-Chyr Yang
Original research: Tumors establish resistance to immunotherapy by regulating T_reg recruitment via CCR4 (26 November, 2020)
Lisa A Marshall, Sachie Marubayashi, Aparna Jorapur, Scott Jacobson, Mikhail Zibinsky, Omar Robles, Dennis Xiaozhou Hu, Jeffrey J Jackson, Deepa Pookot, Jerick Sanchez, Martin Brovarney, Angela Wadsworth, David Chian, David Wustrow, Paul D Kassner, Gene Cutler, Brian Wong, Dirk G Brockstedt, Oezcan Talay
Original research: Overcoming leukemia heterogeneity by combining T cell engaging bispecific antibodies (25 November, 2020)
Sayed Shahabuddin Hoseini, Madelyn Espinosa-Cotton, Hong-fen Guo, Nai-Kong V Cheung
Original research: Preclinical platform for long-term evaluation of immuno-oncology drugs using hCD34+ humanized mouse model (25 November, 2020)
Nahee Park, Kamal Pandey, Sei Kyung Chang, Ah-Young Kwon, Young Bin Cho, Jin Hur, Nar Bahadur Katwal, Seung Ki Kim, Seung Ah Lee, Gun Woo Son, Jong Min Jo, Hee Jung Ahn, Yong Wha Moon
Original research: Local IFNα enhances the anti-tumoral efficacy of systemic anti-PD1 to prevent tumor relapse (25 November, 2020)
Marion v Guerin, Fabienne Regnier, Maxime Thoreau, Lene Vimeux, Matthieu Benard, Estelle Dransart, Hweixian L Penny, Ludger Johannes, Alain Trautmann, Nadege Bercovici
Original research: Wrinkle in the plan: miR-34a-5p impacts chemokine signaling by modulating CXCL10/CXCL11/CXCR3-axis in CD4⁺, CD8⁺ T cells, and M1 macrophages (23 November, 2020)
Martin Hart, Laura Nickl, Barbara Walch-Rueckheim, Lena Krammes, Stefanie Rheinheimer, Caroline Diener, Tanja Taenzer, Tim Kehl, Martina Sester, Hans-Peter Lenhof, Andreas Keller, Eckart Meese
Original research: Concomitant or delayed anti-TNF differentially impact on immune-related adverse events and antitumor efficacy after anti-CD40 therapy (16 November, 2020)
Celia Jacoberger-Foissac, Stephen J Blake, Jing Liu, Elizabeth McDonald, Hannah Triscott, Kyohei Nakamura, Mark J Smyth, Michele WL Teng
Original research: Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity (13 November, 2020)
Iuliia Efimova, Elena Catanzaro, Louis Van der Meeren, Victoria D Turubanova, Hamida Hammad, Tatiana A Mishchenko, Maria V Vedunova, Carmela Fimognari, Claus Bachert, Frauke Coppieters, Steve Lefever, Andre G Skirtach, Olga Krysko, Dmitri V Krysko
Original research: Combination of gemcitabine and anti-PD-1 antibody enhances the anticancer effect of M1 macrophages and the Th1 response in a murine model of pancreatic cancer liver metastasis (13 November, 2020)
Tuyen Thuy Bich Ho, Alessandro Nasti, Akihiro Seki, Takuya Komura, Hiiro Inui, Takashi Kozaka, Yoji Kitamura, Kazuhiro Shiba, Taro Yamashita, Tatsuya Yamashita, Eishiro Mizukoshi, Kazunori Kawaguchi, Takashi Wada, Masao Honda, Shuichi Kaneko, Yoshio Sakai
Original research: Fidelity of human ovarian cancer patient-derived xenografts in a partially humanized mouse model for preclinical testing of immunotherapies (11 November, 2020)
Adekunle Odunsi, A J Robert McGray, Anthony Miliotto, Yali Zhang, Jianming Wang, Adebukola Abiola, Cheryl Eppolito, Ruea-Yea Huang
Original research: Nicotinamide combined with gemcitabine is an immunomodulatory therapy that restrains pancreatic cancer in mice (5 November, 2020)
Benson Chellakkan Selvanesan, Kiran Meena, Amanda Beck, Lydie Meheus, Olaya Lara, Ilse Rooman, Claudia Gravekamp
Original research: Autoimmunity linked protein phosphatase PTPN22 as a target for cancer immunotherapy (30 October, 2020)
Rafael Cubas, Zia Khan, Qian Gong, Marina Moskalenko, Huizhong Xiong, Qinglin Ou, Christine Pai, Ryan Rodriguez, Jeanne Cheung, Andrew C Chan
Original research: EBV-EBNA1 constructs an immunosuppressive microenvironment for nasopharyngeal carcinoma by promoting the chemoattraction of Treg cells (29 October, 2020)
Shaofen Huo, Yunfan Luo, Rui Deng, Xiong Liu, Jie Wang, Lu Wang, Bao Zhang, Fan Wang, Juan Lu, Xiangping Li
Original research: Endogenous HLA-DQ8αβ programs superantigens (SEG/SEI) to silence toxicity and unleash a tumoricidal network with long-term melanoma survival (27 October, 2020)
Peter Knopick, David Terman, Nathan Riha, Travis Alvine, Riley Larson, Cedric Badiou, Gerard Lina, John Ballantyne, David Bradley
Original research: Combination of radiotherapy and suppression of Tregs enhances abscopal antitumor effect and inhibits metastasis in rectal cancer (26 October, 2020)
Dengbo Ji, Can Song, Yongheng Li, Jinhong Xia, Yanjing Wu, Jinying Jia, Xinxin Cui, Songmao Yu, Jin Gu
Original research: Deep immunophenotyping at the single-cell level identifies a combination of anti-IL-17 and checkpoint blockade as an effective treatment in a preclinical model of data-guided personalized immunotherapy (22 October, 2020)
Koji Nagaoka, Masataka Shirai, Kiyomi Taniguchi, Akihiro Hosoi, Changbo Sun, Yukari Kobayashi, Kazuhiro Maejima, Masashi Fujita, Hidewaki Nakagawa, Sachiyo Nomura, Kazuhiro Kakimi
Original research: Enhanced antitumor immunity through sequential targeting of PI3Kδ and LAG3 (22 October, 2020)
Sarah Nicol Lauder, Kathryn Smart, Veerle Kersemans, Danny Allen, Jake Scott, Ana Pires, Stefan Milutinovic, Michelle Somerville, Sean Smart, Paul Kinchesh, Elena Lopez-Guadamillas, Ellyn Hughes, Emma Jones, Martin Scurr, Andrew Godkin, Lori S Friedman, Bart Vanhaesebroeck, Awen Gallimore
Original research: Natural killer cells in the human lung tumor microenvironment display immune inhibitory functions (16 October, 2020)
Jules Russick, Pierre-Emmanuel Joubert, Mélanie Gillard-Bocquet, Carine Torset, Maxime Meylan, Florent Petitprez, Marie-Agnes Dragon-Durey, Solenne Marmier, Aditi Varthaman, Nathalie Josseaume, Claire Germain, Jérémy Goc, Marie-Caroline Dieu-Nosjean, Pierre Validire, Ludovic Fournel, Laurence Zitvogel, Gabriela Bindea, Audrey Lupo, Diane Damotte, Marco Alifano, Isabelle Cremer
Original research: Breast cancer-induced immune suppression in the sentinel lymph node is effectively countered by CpG-B in conjunction with inhibition of the JAK2/STAT3 pathway (12 October, 2020)
Kim M van Pul, Ronald J C L M Vuylsteke, Monique T A de Beijer, Rieneke van de Ven, M Petrousjka van den Tol, Hein B A C Stockmann, Tanja D de Gruijl
Original research: Analysis of the molecular nature associated with microsatellite status in colon cancer identifies clinical implications for immunotherapy (7 October, 2020)
Xuanwen Bao, Hangyu Zhang, Wei Wu, Shaobing Cheng, Xiaomeng Dai, Xudong Zhu, Qihan Fu, Zhou Tong, Lulu Liu, Yi Zheng, Peng Zhao, Weijia Fang, Fanglong Liu
Original research: 2,5-dimethylcelecoxib improves immune microenvironment of hepatocellular carcinoma by promoting ubiquitination of HBx-induced PD-L1 (7 October, 2020)
Zhanfei Chen, Yiyin Chen, Lirong Peng, Xiaoqian Wang, Nanhong Tang
Original research: Combining IL-2-based immunotherapy with commensal probiotics produces enhanced antitumor immune response and tumor clearance (7 October, 2020)
Linlin Shi, Jianyong Sheng, Guozhong Chen, Peng Zhu, Changping Shi, Bei Li, Chaiwoo Park, Jingyi Wang, Bixiang Zhang, Zhi Liu, Xiangliang Yang
Original research: Regulation of tumor growth by leukocyte-specific protein 1 in T cells (5 October, 2020)
Riri Kwon, Bong-Ki Hong, Kang-Gu Lee, Eunbyeol Choi, Laurent Sabbagh, Chul-Soo Cho, Naeun Lee, Wan-Uk Kim
Original research: CD47/SIRPα blocking peptide identification and synergistic effect with irradiation for cancer immunotherapy (5 October, 2020)
Hongfei Wang, Yixuan Sun, Xiuman Zhou, Chunxia Chen, Ling Jiao, Wanqiong Li, Shanshan Gou, Yanying Li, Jiangfeng Du, Guanyu Chen, Wenjie Zhai, Yahong Wu, Yuanming Qi, Yanfeng Gao
Original research: Host genetics and tumor environment determine the functional impact of neutrophils in mouse tumor models (30 September, 2020)
Marit van Elsas, Jan Willem Kleinovink, Matthijs Moerland, Gary Feiss, Guillaume Beyrend, Ramon Arens, Hailiang Mei, Peter H Nibbering, Silvana M Jirka, Thorbald van Hall, Sjoerd H van der Burg
Original research: Malignant cell-specific CXCL14 promotes tumor lymphocyte infiltration in oral cavity squamous cell carcinoma (21 September, 2020)
Anuraag Parikh, JuneHo Shin, William Faquin, Derrick T Lin, Itay Tirosh, John B Sunwoo, Sidharth V Puram
Original research: Differential gene expression of tumor-infiltrating CD8⁺ T cells in advanced versus early-stage colorectal cancer and identification of a gene signature of poor prognosis (18 September, 2020)
Reem Saleh, Varun Sasidharan Nair, Salman M Toor, Rowaida Z Taha, Khaled Murshed, Mahmood Al-Dhaheri, Mahwish Khawar, Mahir Abdulla Petkar, Mohamed Abu Nada, Fares Al-Ejeh, Eyad Elkord
Original research: Targeted delivery of miR-99b reprograms tumor-associated macrophage phenotype leading to tumor regression (18 September, 2020)
Liang Wang, Yi-Yang Hu, Jun-Long Zhao, Fei Huang, Shi-Qian Liang, Lei Dong, Yan Chen, Heng-Chao Yu, Jian Bai, Jia-Meng Yang, Jie-Yi Fan, Lei Feng, San-Zhong Li, Hua Han, Hong-Yan Qin
Original research: Enhanced lipid biosynthesis in human tumor-induced macrophages contributes to their protumoral characteristics (17 September, 2020)
Katrin Rabold, Anna Aschenbrenner, Christoph Thiele, Collins K Boahen, Alexander Schiltmans, Johannes W A Smit, Joachim L Schultze, Mihai G Netea, Gosse J Adema, Romana T Netea-Maier
Original research: CD25-targeted antibody–drug conjugate depletes regulatory T cells and eliminates established syngeneic tumors via antitumor immunity (10 September, 2020)
Francesca Zammarchi, Karin Havenith, Francois Bertelli, Balakumar Vijayakrishnan, Simon Chivers, Patrick H van Berkel
Original research: BRAF inhibitor resistance of melanoma cells triggers increased susceptibility to natural killer cell-mediated lysis (9 September, 2020)
Alexandra Frazao, Louise Rethacker, Géraldine Jeudy, Marina Colombo, Eric Pasmant, Marie-Françoise Avril, Antoine Toubert, Helene Moins-Teisserenc, Marie Roelens, Sophie Dalac, Eve Maubec, Anne Caignard
Original research: A new role for circulating T follicular helper cells in humoral response to anti-PD-1 therapy (7 September, 2020)
Santiago Sánchez-Alonso, Giulia Setti-Jerez, Montserrat Arroyo, Tathiana Hernández, Mª Inmaculada Martos, Jose Miguel Sánchez-Torres, Ramon Colomer, Almudena R Ramiro, Arantzazu Alfranca
Original research: A nomogram for predicting mortality in patients with COVID-19 and solid tumors: a multicenter retrospective cohort study (6 September, 2020)
Chao Liu, Li Li, Kehan Song, Zhi-Ying Zhan, Yi Yao, Hongyun Gong, Yuan Chen, Qun Wang, Xiaorong Dong, Zhibin Xie, Chun-Quan Ou, Qinyong Hu, Qibin Song
Original research: Lack of myeloid cell infiltration as an acquired resistance strategy to immunotherapy (1 September, 2020)
Elham Beyranvand Nejad, Camilla Labrie, Ziena Abdulrahman, Marit J van Elsas, Eva Rademaker, Jan Willem Kleinovink, Tetje C van der Sluis, Suzanne van Duikeren, Amina F A.S Teunisse, Aart G Jochemsen, Jan Oosting, Noel F C C de Miranda, Thorbald Van Hall, Ramon Arens, Sjoerd H van der Burg
Original research: IFN-γ treatment protocol for MHC-I^lo/PD-L1⁺ pancreatic tumor cells selectively restores their TAP-mediated presentation competence and CD8 T-cell priming potential (31 August, 2020)
Katja Stifter, Jana Krieger, Leonie Ruths, Johann Gout, Medhanie Mulaw, Andre Lechel, Alexander Kleger, Thomas Seufferlein, Martin Wagner, Reinhold Schirmbeck
Original research: Overcoming resistance to STING agonist therapy to incite durable protective antitumor immunity (26 August, 2020)
Henrique Lemos, Rong Ou, Caroline McCardle, Yijun Lin, Jessica Calver, Jack Minett, Ahmed Chadli, Lei Huang, Andrew L Mellor
Original research: Immunohistochemical scoring of CD38 in the tumor microenvironment predicts responsiveness to anti-PD-1/PD-L1 immunotherapy in hepatocellular carcinoma (26 August, 2020)
Harry Ho Man Ng, Ren Yuan Lee, Siting Goh, Isabel Shu Ying Tay, Xinru Lim, Bernett Lee, Valerie Chew, Huihua Li, Benedict Tan, Sherlly Lim, Jeffrey Chun Tatt Lim, Bijin Au, Josh Jie Hua Loh, Sahil Saraf, John Edward Connolly, Tracy Loh, Wei Qiang Leow, Joycelyn Jie Xin Lee, Han Chong Toh, Fabio Malavasi, Ser Yee Lee, Pierce Chow, Evan W Newell, Su Pin Choo, David Tai, Joe Yeong, Tony Kiat Hon Lim
Original research: IL-31 induces antitumor immunity in breast carcinoma (24 August, 2020)
Tal Kan, Erik Feldman, Michael Timaner, Ziv Raviv, Shai Shen-Orr, Ami Aronheim, Yuval Shaked
Original research: Anti-tumor effects of NK cells and anti-PD-L1 antibody with antibody-dependent cellular cytotoxicity in PD-L1-positive cancer cell lines (23 August, 2020)
Ji-Eun Park, Seong-Eun Kim, Bhumsuk Keam, Ha-Ram Park, Soyeon Kim, Miso Kim, Tae Min Kim, Junsang Doh, Dong-Wan Kim, Dae Seog Heo
Original research: An immune evasion mechanism with IgG4 playing an essential role in cancer and implication for immunotherapy (20 August, 2020)
Hui Wang, Qian Xu, Chanyuan Zhao, Ziqi Zhu, Xiaoqing Zhu, Junjie Zhou, Shuming Zhang, Tiqun Yang, Biying Zhang, Jun Li, Meiling Yan, Renming Liu, Changchun Ma, Yan Quan, Yongqu Zhang, Weifeng Zhang, Yiqun Geng, Chuangzhen Chen, Shaobin Chen, Ditian Liu, Yuping Chen, Dongping Tian, Min Su, Xueling Chen, Jiang Gu
Original research: Short-course radiotherapy promotes pro-inflammatory macrophages via extracellular vesicles in human rectal cancer (18 August, 2020)
Victoria Stary, Brigitte Wolf, Daniela Unterleuthner, Julia List, Merjem Talic, Johannes Laengle, Andrea Beer, Johanna Strobl, Georg Stary, Helmut Dolznig, Michael Bergmann
Original research: Remodeling tumor immune microenvironment (TIME) for glioma therapy using multi-targeting liposomal codelivery (17 August, 2020)
Zening Zheng, Jiaxin Zhang, Jizong Jiang, Yang He, Wenyuan Zhang, Xiaopeng Mo, Xuejia Kang, Qin Xu, Bing Wang, Yongzhuo Huang
Original research: Differential quantities of immune checkpoint-expressing CD8 T cells in soft tissue sarcoma subtypes (13 August, 2020)
Yarne Klaver, Maud Rijnders, Astrid Oostvogels, Rebecca Wijers, Marcel Smid, Dirk Grünhagen, Cornelis Verhoef, Stefan Sleijfer, Cor Lamers, Reno Debets
Original research: IL-6 regulates CCR5 expression and immunosuppressive capacity of MDSC in murine melanoma (11 August, 2020)
Rebekka Weber, Zeno Riester, Laura Hüser, Carsten Sticht, Alina Siebenmorgen, Christopher Groth, Xiaoying Hu, Peter Altevogt, Jochen S Utikal, Viktor Umansky
Original research: Antagonistic anti-LILRB1 monoclonal antibody regulates antitumor functions of natural killer cells (7 August, 2020)
Heyu Chen, Yuanzhi Chen, Mi Deng, Samuel John, Xun Gui, Ankit Kansagra, Weina Chen, Jaehyup Kim, Cheryl Lewis, Guojin Wu, Jingjing Xie, Lingbo Zhang, Ryan Huang, Xiaoye Liu, Hisashi Arase, Yang Huang, Hai Yu, Wenxin Luo, Ningshao Xia, Ningyan Zhang, Zhiqiang An, Cheng Cheng Zhang
Original research: PD-1 does not mark tumor-infiltrating CD8+ T cell dysfunction in human gastric cancer (4 August, 2020)
Yang Shen, Yongsheng Teng, Yipin Lv, Yongliang Zhao, Yuan Qiu, Weisan Chen, Lina Wang, Ying Wang, Fangyuan Mao, Ping Cheng, Daiyuan Ma, Yuan Zhuang, Quanming Zou, Liusheng Peng
Original research: Small molecule AZD4635 inhibitor of A_2AR signaling rescues immune cell function including CD103⁺ dendritic cells enhancing anti-tumor immunity (29 July, 2020)
Alexandra Borodovsky, Christine M Barbon, Yanjun Wang, Minwei Ye, Laura Prickett, Dinesh Chandra, Joseph Shaw, Nanhua Deng, Kris Sachsenmeier, James D Clarke, Bolan Linghu, Giles A Brown, James Brown, Miles Congreve, Robert KY Cheng, Andrew S Dore, Edward Hurrell, Wenlin Shao, Richard Woessner, Corinne Reimer, Lisa Drew, Stephen Fawell, Alwin G Schuller, Deanna A Mele
Original research: M1^hot tumor-associated macrophages boost tissue-resident memory T cells infiltration and survival in human lung cancer (21 July, 2020)
Eva M Garrido-Martin, Toby W P Mellows, James Clarke, Anusha-Preethi Ganesan, Oliver Wood, Angelica Cazaly, Gregory Seumois, Serena J Chee, Aiman Alzetani, Emma V King, Catherine C Hedrick, Gareth Thomas, Peter S Friedmann, Christian Hermann Ottensmeier, Pandurangan Vijayanand, Tilman Sanchez-Elsner
Original research: Peptide vaccination directed against IDO1-expressing immune cells elicits CD8⁺ and CD4⁺ T-cell-mediated antitumor immunity and enhanced anti-PD1 responses (20 July, 2020)
Souvik Dey, Erika Sutanto-Ward, Katharina L Kopp, James DuHadaway, Arpita Mondal, Dema Ghaban, Inés Lecoq, Mai-Britt Zocca, Lauren M F Merlo, Laura Mandik-Nayak, Mads Hald Andersen, Ayako Wakatsuki Pedersen, Alexander J Muller
Original research: Interrogating the immune-modulating roles of radiation therapy for a rational combination with immune-checkpoint inhibitors in treating pancreatic cancer (16 July, 2020)
Kenji Fujiwara, May Tun Saung, Hao Jing, Brian Herbst, MacKenzie Zarecki, Stephen Muth, Annie Wu, Elaine Bigelow, Linda Chen, Keyu Li, Neolle Jurcak, Alex B Blair, Ding Ding, Michael Wichroski, Jordan Blum, Nathan Cheadle, Jennifer Koenitzer, Lei Zheng

Case report

Immune-mediated ototoxicity associated with immune checkpoint inhibitors in patients with melanoma (16 December, 2020)
Samuel Rosner, Yuri Agrawal, Daniel Q Sun, Nafi Aygun, Megan D Schollenberger, Evan Lipson, Jarushka Naidoo
Diagnostic approach to the evaluation of myeloid malignancies following CAR T-cell therapy in B-cell acute lymphoblastic leukemia (27 November, 2020)
George Mo, Hao-Wei Wang, Aimee C Talleur, Shilpa A Shahani, Bonnie Yates, Haneen Shalabi, Michael G Douvas, Katherine R Calvo, Jack F Shern, Sridhar Chaganti, Katharine Patrick, Young Song, Terry J Fry, Xiaolin Wu, Brandon M Triplett, Javed Khan, Rebecca A Gardner, Nirali N Shah
Integrated immunological analysis of a successful conversion of locally advanced hepatocellular carcinoma to resectability with neoadjuvant therapy (20 November, 2020)
Won Jin Ho, Gaurav Sharma, Qingfeng Zhu, Genevieve Stein-O'Brien, Jennifer Durham, Robert Anders, Aleksandra Popovic, Guanglan Mo, Ihab Kamel, Matthew Weiss, Elizabeth Jaffee, Elana J Fertig, Mark Yarchoan
Case of Merkel cell carcinoma in a patient with pre-existing ILD (17 November, 2020)
Rohan Maniar, Michaela Anderson, Bret Taback, Shaheer Khan, Diana McDonnell, Anjali Saqi, George W Niedt, Richard Carvajal
Acute interstitial nephritis, a potential predictor of response to immune checkpoint inhibitors in renal cell carcinoma (2 November, 2020)
Viral Patel, Roy Elias, Joseph Formella, William Schwartzman, Alana Christie, Qi Cai, Venkat Malladi, Payal Kapur, Miguel Vazquez, Renee McKay, Ivan Pedrosa, Raquibul Hannan, Hans Hammers, James Brugarolas
Management of a patient with mantle cell lymphoma who developed severe neurotoxicity after chimeric antigen receptor T-cell therapy in ZUMA-2 (16 October, 2020)
Michael Wang, Preetesh Jain, T Linda Chi, Sheree E Chen, Amy Heimberger, Shiao-Pei Weathers, Lianqing Zheng, Arati V Rao, John M Rossi
Immune checkpoint inhibitor associated reactivation of primary membranous nephropathy responsive to rituximab (5 October, 2020)
Jamie S Lin, Daniel Y Wang, Omar Mamlouk, William F Glass, Maen Abdelrahim, Cassian Yee, Ala Abudayyeh
Risk of immunotherapy-related narcolepsy in genetically predisposed patients: a case report of narcolepsy after administration of pembrolizumab (1 October, 2020)
Yutaka Natori, Eisaku Sasaki, Shu Soeda, Shigenori Furukawa, Yusuke Azami, Emi Tokuda, Takashi Kanbayashi, Shigehira Saji
Evolution of cystic airspaces lung lesions on immune checkpoint inhibition in non-small cell lung cancer (1 October, 2020)
Claudia Parisi, Giuseppe Lamberti, Maurizio Zompatori, Francesco Gelsomino, Stefania Salvagni, Francesca Sperandi, Andrea Ardizzoni
Leukemia escape in immune desert: intraocular relapse of pediatric pro-B-ALL during systemic control by CD19-CAR T cells (16 September, 2020)
Semjon Willier, Johannes Raedler, Franziska Blaeschke, Dana Stenger, Montserrat Pazos Escudero, Florian Jurgeleit, Thomas G P Grünewald, Vera Binder, Irene Schmid, Michael H Albert, Armin Wolf, Tobias Feuchtinger
Identification of dual positive CD19+/CD3+ T cells in a leukapheresis product undergoing CAR transduction: a case report (14 September, 2020)
Liora Schultz, Shabnum Patel, Kara Lynn Davis, Sneha Ramakrishna, Bita Sahaf, Neehar Bhatia, Christina Baggott, Courtney Erickson, Robbie G Majzner, Jean Oak, Alice Bertaina, Crystal Mackall, Steven Feldman
Persistent anti-NY-ESO-1-specific T cells and expression of differential biomarkers in a patient with metastatic gastric cancer benefiting from combined radioimmunotherapy treatment: a case report (10 September, 2020)
Maysaloun Merhi, Afsheen Raza, Varghese Philipose Inchakalody, Kodappully S Siveen, Deepak Kumar, Fairooz Sahir, Sarra Mestiri, Shereena Hydrose, Niloofar Allahverdi, Munir Jalis, Allan Relecom, Lobna Al Zaidan, Mohamed Sir Elkhatim Hamid, Mai Mostafa, Abdul Rehman Zar Gul, Shahab Uddin, Mohammed Al Homsi, Said Dermime
Complete response to avelumab and IL-15 superagonist N-803 with Abraxane in Merkel cell carcinoma: a case study (10 September, 2020)
Leylah Drusbosky, Chaitali Nangia, Andrew Nguyen, Christopher Szeto, Yulia Newton, Patricia Spilman, Sandeep Bobby Reddy
Guillain-Barré syndrome after adoptive cell therapy with tumor-infiltrating lymphocytes (26 August, 2020)
Angela Orcurto, Andreas Hottinger, Benita Wolf, Blanca Navarro Rodrigo, Maria Ochoa de Olza, Aymeric Auger, Thierry Kuntzer, Denis Comte, Virginie Zimmer, Philippe Gannon, Lana Kandalaft, Olivier Michielin, Stefan Zimmermann, Alexandre Harari, Lionel Trueb, George Coukos
HITM-SURE: Hepatic immunotherapy for metastases phase Ib anti-CEA CAR-T study utilizing pressure enabled drug delivery (24 August, 2020)
Steven C Katz, Ashley E Moody, Prajna Guha, John C Hardaway, Ethan Prince, Jason LaPorte, Mirela Stancu, Jill E Slansky, Kimberly R Jordan, Richard D Schulick, Robert Knight, Abdul Saied, Vincent Armenio, Richard P Junghans
Outcomes and biomarker analyses among patients with COVID-19 treated with interleukin 6 (IL-6) receptor antagonist sarilumab at a single institution in Italy (11 August, 2020)
Vincenzo Montesarchio, Roberto Parrella, Chiara Iommelli, Antonella Bianco, Elio Manzillo, Fiorentino Fraganza, Cristiana Palumbo, Gaetano Rea, Patrizia Murino, Rosanna De Rosa, Luigi Atripaldi, Maurizio D’Abbraccio, Marcello Curvietto, Domenico Mallardo, Egidio Celentano, Antonio Maria Grimaldi, Marco Palla, Claudia Trojaniello, Maria Grazia Vitale, Samuel Lewis Million-Weaver, Paolo Antonio Ascierto
SARS-CoV-2 infection in immunocompromised patients: humoral versus cell-mediated immunity (29 July, 2020)
Jia Wei, Jianping Zhao, Meifang Han, Fankai Meng, Jianfeng Zhou
Durable benefit from immunotherapy and accompanied lupus erythematosus in pancreatic adenocarcinoma with DNA repair deficiency (6 July, 2020)
Xionghao Pang, Juanjuan Qian, Hua Jin, Lei Zhang, Lin Lin, Yuli Wang, Yi Lei, Zeqiang Zhou, Meixiang Li, Henghui Zhang

Clinical/translational cancer immunotherapy

Original research: KEYNOTE-022 part 3: a randomized, double-blind, phase 2 study of pembrolizumab, dabrafenib, and trametinib in BRAF-mutant melanoma (24 December, 2020)
Pier Francesco Ferrucci, Anna Maria Di Giacomo, Michele Del Vecchio, Victoria Atkinson, Henrik Schmidt, Jacob Schachter, Paola Queirolo, Georgina V Long, Rosalie Stephens, Inge Marie Svane, Michal Lotem, Mahmoud Abu-Amna, Eduard Gasal, Razi Ghori, Scott J Diede, Elizabeth S Croydon, Antoni Ribas, Paolo Antonio Ascierto
Efficacy of pembrolizumab in patients with pituitary carcinoma: report of four cases from a phase II study (22 December, 2020)
Nazanin Majd, Steven G Waguespack, Filip Janku, Siqing Fu, Marta Penas-Prado, Mingxuan Xu, Anas Alshawa, Carlos Kamiya-Matsuoka, Shaan M Raza, Ian E McCutcheon, Aung Naing
Original research: Blood-based kinase activity profiling: a potential predictor of response to immune checkpoint inhibition in metastatic cancer (22 December, 2020)
Daan P Hurkmans, Els M E Verdegaal, Sabrina A Hogan, Rik de Wijn, Lies Hovestad, Dianne M A van den Heuvel, Rob Ruijtenbeek, Marij J P Welters, Mandy van Brakel, Edwin A Basak, Herbert M Pinedo, Cor H J Lamers, Harmen J G van de Werken, John P Groten, Reno Debets, Mitchell P Levesque, Reinhard Dummer, Ellen Kapiteijn, Ron H J Mathijssen, Joachim G J V Aerts, Sjoerd H van der Burg
Original research: Obesity diminishes response to PD-1-based immunotherapies in renal cancer (22 December, 2020)
Shannon K Boi, Rachael M Orlandella, Justin Tyler Gibson, William James Turbitt, Gal Wald, Lewis Thomas, Claire Buchta Rosean, Katlyn E Norris, Megan Bing, Laura Bertrand, Brett P Gross, Amani Makkouk, Dmytro Starenki, Kristine I Farag, Robert E Sorge, James A Brown, Jennifer Gordetsky, Hesham Yasin, Rohan Garje, Lakshminarayanan Nandagopal, George J Weiner, David M Lubaroff, Rebecca C Arend, Peng Li, Yousef Zakharia, Eddy Yang, Aliasger K Salem, Kenneth Nepple, Tatiana T Marquez-Lago, Lyse A Norian
Original research: Domain binding and isotype dictate the activity of anti-human OX40 antibodies (21 December, 2020)
Jordana Griffiths, Khiyam Hussain, Hannah L Smith, Theodore Sanders, Kerry L Cox, Monika Semmrich, Linda Mårtensson, Jinny Kim, Tatyana Inzhelevskaya, Chris A Penfold, Alison L Tutt, C Ian Mockridge, HT Claude Chan, Vikki English, Ruth F French, Ingrid Teige, Aymen Al-Shamkhani, Martin J Glennie, Bjorn L Frendeus, Jane E Willoughby, Mark S Cragg
Original research: Durvalumab and tremelimumab with or without stereotactic body radiation therapy in relapsed small cell lung cancer: a randomized phase II study (21 December, 2020)
Suchita Pakkala, Kristin Higgins, Zhengjia Chen, Gabriel Sica, Conor Steuer, Chao Zhang, Guojing Zhang, Shuhua Wang, Mohammad S Hossain, Bassel Nazha, Tyler Beardslee, Fadlo R Khuri, Walter Curran, Sagar Lonial, Edmund K Waller, Suresh Ramalingam, Taofeek K Owonikoko
Original research: Initiation of immunotherapy with activated natural killer cells and anti-GD2 antibody dinutuximab prior to resection of primary neuroblastoma prolongs survival in mice (18 December, 2020)
Michael John Zobel, Abigail K Zamora, Hong-wei Wu, Jianping Sun, Danny Lascano, Jemily Malvar, Larry Wang, Michael A Sheard, Robert C Seeger, Eugene S Kim
Original research: Antibody profiling of patients with prostate cancer reveals differences in antibody signatures among disease stages (16 December, 2020)
Hemanth K Potluri, Tun Lee Ng, Michael A Newton, Jin Zhang, Christopher A Maher, Peter S Nelson, Douglas G McNeel
Original research: Bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with human papillomavirus-associated malignancies (15 December, 2020)
Julius Strauss, Margaret E Gatti-Mays, Byoung Chul Cho, Andrew Hill, Sébastien Salas, Edward McClay, Jason M Redman, Houssein A Sater, Renee N Donahue, Caroline Jochems, Elizabeth Lamping, Andrea Burmeister, Jennifer L Marté, Lisa M Cordes, Marijo Bilusic, Fatima Karzai, Laureen S Ojalvo, Genevieve Jehl, P Alexander Rolfe, Christian S Hinrichs, Ravi A Madan, Jeffrey Schlom, James L Gulley
Original research: Galectin-9 expression defines exhausted T cells and impaired cytotoxic NK cells in patients with virus-associated solid tumors (12 December, 2020)
Isobel Okoye, Lai Xu, Melika Motamedi, Pallavi Parashar, John W Walker, Shokrollah Elahi
Original research: Increased rates of immunosuppressive treatment and hospitalization after checkpoint inhibitor therapy in cancer patients with autoimmune disease (10 December, 2020)
David Andrew Bender, Samuel P Heilbroner, Tony J C Wang, Catherine A Shu, Brigham Hyde, Catherine Spina, Simon K Cheng
Mobilization of pre-existing polyclonal T cells specific to neoantigens but not self-antigens during treatment of a patient with melanoma with bempegaldesleukin and nivolumab (9 December, 2020)
Joshua R Veatch, Naina Singhi, Brenda Jesernig, Kelly G Paulson, Jonathan Zalevsky, Ernesto Iacucci, Scott S Tykodi, Stanley R Riddell
Original research: Intensified immunosuppressive therapy in patients with immune checkpoint inhibitor-induced myocarditis (8 December, 2020)
Jennifer Cautela, Sarah Zeriouh, Melanie Gaubert, Laurent Bonello, Marc Laine, Michael Peyrol, Franck Paganelli, Nathalie Lalevee, Fabrice Barlesi, Franck Thuny
Original research: Comprehensive analysis of cutaneous and uveal melanoma liver metastases (1 December, 2020)
Esmee P Hoefsmit, Elisa A Rozeman, Trieu My Van, Petros Dimitriadis, Oscar Krijgsman, Jordan W Conway, Ines Pires da Silva, Jacqueline E van der Wal, Steven L C Ketelaars, Kaspar Bresser, Annegien Broeks, Ron M Kerkhoven, Jason W Reeves, Sarah Warren, Pia Kvistborg, Richard A Scolyer, Ellen W Kapiteijn, Daniel S Peeper, Georgina V Long, Ton N M Schumacher, Christian U Blank
Original research: Clinicopathological characteristics and management of colitis with anti-PD1 immunotherapy alone or in combination with ipilimumab (24 November, 2020)
Kazi J Nahar, Robert V Rawson, Tasnia Ahmed, Stephen Tattersall, Neomal Sandanayake, Christopher J Kiely, Serigne Lo, Matteo Carlino, Umaimainthan Palendira, Richard A Scolyer, Georgina V Long, Alexander M Menzies
Original research: Regorafenib combined with PD1 blockade increases CD8 T-cell infiltration by inducing CXCL10 expression in hepatocellular carcinoma (24 November, 2020)
Kohei Shigeta, Aya Matsui, Hiroto Kikuchi, Sebastian Klein, Emilie Mamessier, Ivy X Chen, Shuichi Aoki, Shuji Kitahara, Koetsu Inoue, Ayako Shigeta, Tai Hato, Rakesh R Ramjiawan, Daniel Staiculescu, Dieter Zopf, Lukas Fiebig, Gabriela S Hobbs, Alexander Quaas, Simona Dima, Irinel Popescu, Peigen Huang, Lance L Munn, Mark Cobbold, Lipika Goyal, Andrew X Zhu, Rakesh K Jain, Dan G Duda
Original research: Investigation of the prognostic value of CD4 T cell subsets expanded from tumor-infiltrating lymphocytes of colorectal cancer liver metastases (23 November, 2020)
Marie Kroemer, Celia Turco, Laurie Spehner, Julien Viot, Idir Idirène, Adeline Bouard, Elodie Renaude, Marina Deschamps, Yann Godet, Olivier Adotévi, Samuel Limat, Bruno Heyd, Marine Jary, Romain Loyon, Christophe Borg
Original research: Eftilagimod alpha, a soluble lymphocyte activation gene-3 (LAG-3) protein plus pembrolizumab in patients with metastatic melanoma (20 November, 2020)
Victoria Atkinson, Adnan Khattak, Andrew Haydon, Melissa Eastgate, Amitesh Roy, Prashanth Prithviraj, Christian Mueller, Chrystelle Brignone, Frederic Triebel
Original research: Baseline prognostic nutritional index and changes in pretreatment body mass index associate with immunotherapy response in patients with advanced cancer (20 November, 2020)
Paul Johannet, Amelia Sawyers, Yingzhi Qian, Samuel Kozloff, Nicholas Gulati, Douglas Donnelly, Judy Zhong, Iman Osman
Original research: Efficacy and immune-related adverse event associations in avelumab-treated patients (20 November, 2020)
Karen Kelly, Juliane Manitz, Manish R Patel, Sandra P D’Angelo, Andrea B Apolo, Arun Rajan, Vijay Kasturi, Isabell Speit, Marcis Bajars, John Warth, James L Gulley
Original research: Nivolumab and sunitinib combination in advanced soft tissue sarcomas: a multicenter, single-arm, phase Ib/II trial (17 November, 2020)
Javier Martin-Broto, Nadia Hindi, Giovanni Grignani, Javier Martinez-Trufero, Andres Redondo, Claudia Valverde, Silvia Stacchiotti, Antonio Lopez-Pousa, Lorenzo D'Ambrosio, Antonio Gutierrez, Herminia Perez-Vega, Victor Encinas-Tobajas, Enrique de Alava, Paola Collini, Maria Peña-Chilet, Joaquin Dopazo, Irene Carrasco-Garcia, Maria Lopez-Alvarez, David S Moura, Jose A Lopez-Martin
Original research: Nuclear imaging-guided PD-L1 blockade therapy increases effectiveness of cancer immunotherapy (17 November, 2020)
Hannan Gao, Yue Wu, Jiyun Shi, Xin Zhang, Tianyu Liu, Biao Hu, Bing Jia, Yakun Wan, Zhaofei Liu, Fan Wang
Original research: Body mass index (BMI) and outcome of metastatic melanoma patients receiving targeted therapy and immunotherapy: a multicenter international retrospective study (17 November, 2020)
Piotr Rutkowski, Alice Indini, Matilde De Luca, Barbara Merelli, Anna Mariuk-Jarema, Pawel Teterycz, Pawel Rogala, Iwona Lugowska, Bożena Cybulska-Stopa, Alice Labianca, Lorenza Di Guardo, Michele Del Vecchio, Jacopo Pigozzo, Giovanni Randon, Francesca Corti, Carlo Alberto Tondini, Eliana Rulli, Mario Mandala
Original research: Differential effect on different immune subsets of neoadjuvant chemotherapy in patients with TNBC (16 November, 2020)
Chiara Massa, Thomas Karn, Carsten Denkert, Andreas Schneeweiss, Claus Hanusch, Jens-Uwe Blohmer, Dirk-Michael Zahm, Christian Jackisch, Marion van Mackelenbergh, Jörg Thomalla, Frederik Marme, Jens Huober, Volkmar Müller, Christian Schem, Anja Mueller, Elmar Stickeler, Katharina Biehl, Peter A Fasching, Michael Untch, Sibylle Loibl, Karsten Weber, Barbara Seliger
Original research: Vaccination against RhoC induces long-lasting immune responses in patients with prostate cancer: results from a phase I/II clinical trial (12 November, 2020)
Juliane Schuhmacher, Sonja Heidu, Torben Balchen, Jennifer Rebecca Richardson, Camilla Schmeltz, Jesper Sonne, Jonas Schweiker, Hans-Georg Rammensee, Per Thor Straten, Martin Andreas Røder, Klaus Brasso, Cécile Gouttefangeas
Original research: Long-term survival of patients with stage III colon cancer treated with VRP-CEA(6D), an alphavirus vector that increases the CD8+ effector memory T cell to Treg ratio (11 November, 2020)
Erika J Crosby, Amy C Hobeika, Donna Niedzwiecki, Christel Rushing, David Hsu, Peter Berglund, Jonathan Smith, Takuya Osada, William R Gwin III, Zachary C Hartman, Michael A Morse, Herbert Kim Lyerly
Original research: Prognostic significance and immune correlates of CD73 expression in renal cell carcinoma (11 November, 2020)
Abhishek Tripathi, Edwin Lin, Wanling Xie, Abdallah Flaifel, John A Steinharter, Emily N Stern Gatof, Gabrielle Bouchard, Justin H Fleischer, Nieves Martinez-Chanza, Connor Gray, Charlene Mantia, Linda Thompson, Xiao X Wei, Marios Giannakis, Bradley A McGregor, Toni K Choueiri, Neeraj Agarwal, David F McDermott, Sabina Signoretti, Lauren C Harshman
Original research: Immunogenic cell death pathway polymorphisms for predicting oxaliplatin efficacy in metastatic colorectal cancer (10 November, 2020)
Hiroyuki Arai, Yi Xiao, Fotios Loupakis, Natsuko Kawanishi, Jingyuan Wang, Francesca Battaglin, Shivani Soni, Wu Zhang, Christoph Mancao, Bodour Salhia, Shannon M Mumenthaler, Daniel J Weisenberger, Gangning Liang, Chiara Cremolini, Alfredo Falcone, Joshua Millstein, Heinz-Josef Lenz
Original research: Camrelizumab plus gemcitabine and oxaliplatin (GEMOX) in patients with advanced biliary tract cancer: a single-arm, open-label, phase II trial (10 November, 2020)
Xiaofeng Chen, Xiaofeng Wu, Hao Wu, Yanhong Gu, Yang Shao, Qianwen Shao, Feipeng Zhu, Xiao Li, Xiaofeng Qian, Jun Hu, Fengjiao Zhao, Weidong Mao, Jing Sun, Jian Wang, Gaohua Han, Changxian Li, Yongxiang Xia, Poshita Kumari Seesaha, Dongqin Zhu, Huajun Li, Junling Zhang, Guoqiang Wang, Xuehao Wang, Xiangcheng Li, Yongqian Shu
Original research: Analysis of tumor-infiltrating NK and T cells highlights IL-15 stimulation and TIGIT blockade as a combination immunotherapy strategy for soft tissue sarcomas (6 November, 2020)
Sean J Judge, Morgan A Darrow, Steve W Thorpe, Alicia A Gingrich, Edmond F O'Donnell, Alyssa R Bellini, Ian R Sturgill, Logan V Vick, Cordelia Dunai, Kevin M Stoffel, Yue Lyu, Shuai Chen, May Cho, Robert B Rebhun, Arta M Monjazeb, William J Murphy, Robert J Canter
Original research: SOX2 promotes resistance of melanoma with PD-L1 high expression to T-cell-mediated cytotoxicity that can be reversed by SAHA (6 November, 2020)
Ruiyan Wu, Caiqin Wang, Zhiming Li, Jian Xiao, Chunyan Li, Xuemin Wang, Pengfei Kong, Jianghua Cao, Fuxue Huang, Zhiling Li, Yun Huang, Yuhong Chen, Xuan Li, Dong Yang, Hailiang Zhang, Jia Mai, Gongkan Feng, Rong Deng, Xiaofeng Zhu
Original research: Integrated analysis of concomitant medications and oncological outcomes from PD-1/PD-L1 checkpoint inhibitors in clinical practice (5 November, 2020)
Alessio Cortellini, Marco Tucci, Vincenzo Adamo, Luigia Stefania Stucci, Alessandro Russo, Enrica Teresa Tanda, Francesco Spagnolo, Francesca Rastelli, Renato Bisonni, Daniele Santini, Marco Russano, Cecilia Anesi, Raffaele Giusti, Marco Filetti, Paolo Marchetti, Andrea Botticelli, Alain Gelibter, Mario Alberto Occhipinti, Riccardo Marconcini, Maria Giuseppa Vitale, Linda Nicolardi, Rita Chiari, Claudia Bareggi, Olga Nigro, Alessandro Tuzi, Michele De Tursi, Nicola Petragnani, Laura Pala, Sergio Bracarda, Serena Macrini, Alessandro Inno, Federica Zoratto, Enzo Veltri, Barbara Di Cocco, Domenico Mallardo, Maria Grazia Vitale, David James Pinato, Giampiero Porzio, Corrado Ficorella, Paolo Antonio Ascierto
Original research: RECIST and iRECIST criteria for the evaluation of nivolumab plus ipilimumab in patients with microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer: the GERCOR NIPICOL phase II study (3 November, 2020)
Romain Cohen, Jaafar Bennouna, Aurélia Meurisse, Christophe Tournigand, Christelle De La Fouchardière, David Tougeron, Christophe Borg, Thibault Mazard, Benoist Chibaudel, Marie-Line Garcia-Larnicol, Magali Svrcek, Dewi Vernerey, Yves Menu, Thierry André
Original research: Antitumor efficacy of combined CTLA4/PD-1 blockade without intestinal inflammation is achieved by elimination of FcγR interactions (30 October, 2020)
David Bauché, Smita Mauze, Christina Kochel, Jeff Grein, Anandi Sawant, Yulia Zybina, Wendy Blumenschein, Peng Yang, Lakshmanan Annamalai, Jennifer H Yearley, Juha Punnonen, Edward P Bowman, Alissa Chackerian, Drake Laface
Original research: In pancreatic cancer, chemotherapy increases antitumor responses to tumor-associated antigens and potentiates DNA vaccination (28 October, 2020)
Giorgia Mandili, Claudia Curcio, Sara Bulfamante, Laura Follia, Giulio Ferrero, Emanuela Mazza, Moitza Principe, Francesca Cordero, Maria Antonietta Satolli, Rosella Spadi, Andrea Evangelista, Daniele Giordano, Duy Viet, Paola Cappello, Francesco Novelli
Original research: Synergizing sunitinib and radiofrequency ablation to treat hepatocellular cancer by triggering the antitumor immune response (28 October, 2020)
Xiaoqiang Qi, Ming Yang, Lixin Ma, Madeline Sauer, Diego Avella, Jussuf T Kaifi, Jeffrey Bryan, Kun Cheng, Kevin F Staveley-O’Carroll, Eric T Kimchi, Guangfu Li
Original research: Upfront dose-reduced chemotherapy synergizes with immunotherapy to optimize chemoimmunotherapy in squamous cell lung carcinoma (28 October, 2020)
Xiran He, Yang Du, Zhijie Wang, Xin Wang, Jianchun Duan, Rui Wan, Jiachen Xu, Pei Zhang, Di Wang, Yanhua Tian, Jiefei Han, Kailun Fei, Hua Bai, Jie Tian, Jie Wang
Original research: Checkpoint therapeutic target database (CKTTD): the first comprehensive database for checkpoint targets and their modulators in cancer immunotherapy (27 October, 2020)
Yixiao Zhang, Yuan Yao, Peng Chen, Yu Liu, Hao Zhang, He Liu, Yu Liu, Hong Xu, Xibao Tian, Zichu Wang, Peng Chu, Dongyu Zhao, Hongxu Liu, Chenlei Zhang, Shuyuan Chen, Yuhong Zhao, Caigang Liu, Yongliang Yang
Original research: Novel cytokine–antibody fusion protein, N-820, to enhance the functions of ex vivo expanded natural killer cells against Burkitt lymphoma (27 October, 2020)
Yaya Chu, Gaurav Nayyar, Nang Kham Su, Jeremy M Rosenblum, Patrick Soon-Shiong, John Lee, Jeffrey T Safrit, Matthew Barth, Dean Lee, Mitchell S Cairo
Original research: Low-dose radiation treatment enhances systemic antitumor immune responses by overcoming the inhibitory stroma (26 October, 2020)
Hampartsoum B Barsoumian, Rishab Ramapriyan, Ahmed I Younes, Mauricio S Caetano, Hari Menon, Nathan I Comeaux, Taylor R Cushman, Jonathan E Schoenhals, Alexandra P Cadena, Timothy P Reilly, Dawei Chen, Fatemeh Masrorpour, Ailin Li, David S Hong, Adi Diab, Quynh-Nhu Nguyen, Isabella Glitza, Renata Ferrarotto, Stephen G Chun, Maria Angelica Cortez, James Welsh
Original research: Phase Ib study of anti-CSF-1R antibody emactuzumab in combination with CD40 agonist selicrelumab in advanced solid tumor patients (23 October, 2020)
Jean-Pascal Machiels, Carlos Gomez-Roca, Jean-Marie Michot, Dmitriy Zamarin, Tara Mitchell, Gaetan Catala, Lauriane Eberst, Wolfgang Jacob, Anna-Maria Jegg, Michael A Cannarile, Carl Watson, Galina Babitzki, Konstanty Korski, Irina Klaman, Priscila Teixeira, Sabine Hoves, Carola Ries, Georgina Meneses-Lorente, Francesca Michielin, Randolph Christen, Dominik Rüttinger, Martin Weisser, Jean-Pierre Delord, Philippe Cassier
Original research: Evaluating the psychometric properties of the Immunotherapy module of the MD Anderson Symptom Inventory (23 October, 2020)
Tito Mendoza, Ajay Sheshadri, Mehmet Altan, Kenneth Hess, Goldy George, Bettzy Stephen, Lilibeth Castillo, Enedelia Rodriguez, Jing Gong, Christine Peterson, Jordi Rodon Ahnert, Siqing Fu, Sarina A Piha-Paul, Shubham Pant, Ecaterina Dumbrava, Timonthy A Yap, Filip Janku, Apostolia M Tsimberidou, Vivek Subbiah, Daniel D Karp, Abdulrazzak Zarifa, Lacey M McQuinn, Charles Cleeland, David S Hong, Aung Naing
Original research: Blood-based extracellular matrix biomarkers are correlated with clinical outcome after PD-1 inhibition in patients with metastatic melanoma (22 October, 2020)
Daan P Hurkmans, Christina Jensen, Stijn L W Koolen, Joachim Aerts, Morten Asser Karsdal, Ron H J Mathijssen, Nicholas Willumsen
Original research: Immune checkpoint inhibition therapy for advanced skin cancer in patients with concomitant hematological malignancy: a retrospective multicenter DeCOG study of 84 patients (22 October, 2020)
Ulrike Leiter, Carmen Loquai, Lydia Reinhardt, David Rafei-Shamsabadi, Ralf Gutzmer, Katharina Kaehler, Lucie Heinzerling, Jessica C Hassel, Valerie Glutsch, Judith Sirokay, Nora Schlecht, Albert Rübben, Thilo Gambichler, Kerstin Schatton, Claudia Pfoehler, Cindy Franklin, Patrick Terheyden, Sebastian Haferkamp, Peter Mohr, Lena Bischof, Elisabeth Livingstone, Lisa Zimmer, Michael Weichenthal, Dirk Schadendorf, Andreas Meiwes, Ulrike Keim, Claus Garbe, Jürgen Christian Becker, Selma Ugurel
Original research: Baseline BMI and BMI variation during first line pembrolizumab in NSCLC patients with a PD-L1 expression ≥ 50%: a multicenter study with external validation (19 October, 2020)
Alessio Cortellini, Biagio Ricciuti, Marcello Tiseo, Emilio Bria, Giuseppe L Banna, Joachim GJV Aerts, Fausto Barbieri, Raffaele Giusti, Diego L Cortinovis, Maria R Migliorino, Annamaria Catino, Francesco Passiglia, Mariangela Torniai, Alessandro Morabito, Carlo Genova, Francesca Mazzoni, Vincenzo Di Noia, Diego Signorelli, Alain Gelibter, Mario Alberto Occhipinti, Francesca Rastelli, Rita Chiari, Danilo Rocco, Alessandro Inno, Michele De Tursi, Pietro Di Marino, Giovanni Mansueto, Federica Zoratto, Francesco Grossi, Marco Filetti, Pamela Pizzutilo, Marco Russano, Fabrizio Citarella, Luca Cantini, Giada Targato, Olga Nigro, Miriam G Ferrara, Sebastiano Buti, Simona Scodes, Lorenza Landi, Giorgia Guaitoli, Luigi Della Gravara, Fabrizio Tabbò, Serena Ricciardi, Alessandro De Toma, Alex Friedlaender, Fausto Petrelli, Alfredo Addeo, Giampiero Porzio, Corrado Ficorella
Original research: Clinical advantage of targeted sequencing for unbiased tumor mutational burden estimation in samples with low tumor purity (19 October, 2020)
Tae Hee Hong, Hongui Cha, Joon Ho Shim, Boram Lee, Jongsuk Chung, Chung Lee, Nayoung K D Kim, Yoon-La Choi, Soohyun Hwang, Yoomi Lee, Sehhoon Park, Hyun Ae Jung, Ji-Yeon Kim, Yeon Hee Park, Jong-Mu Sun, Jin Seok Ahn, Myung-Ju Ahn, Keunchil Park, Se-Hoon Lee, Woong-Yang Park
Impact of COVID-19 on patients with rheumatic complications of cancer immunotherapy: results of a registry survey (16 October, 2020)
Nilasha Ghosh, Aidan Tirpack, Karmela K Chan, Anne R Bass
Original research: Axitinib plus avelumab in the treatment of recurrent glioblastoma: a stratified, open-label, single-center phase 2 clinical trial (GliAvAx) (16 October, 2020)
Gil Awada, Laila Ben Salama, Jennifer De Cremer, Julia Katharina Schwarze, Lydia Fischbuch, Laura Seynaeve, Stephanie Du Four, Anne-Marie Vanbinst, Alex Michotte, Hendrik Everaert, Anne Rogiers, Peter Theuns, Johnny Duerinck, Bart Neyns
Original research: HX008, an anti-PD1 antibody, plus irinotecan as second-line treatment for advanced gastric or gastroesophageal junction cancer: a multicenter, single-arm phase II trial (15 October, 2020)
Yan Song, Ning Li, Qun Li, Xinjun Liang, Shu Zhang, Qingxia Fan, Xianli Yin, Zhixiang Zhuang, Yunpeng Liu, Jingdong Zhang, Xiaoge Kou, Haijun Zhong, Xiaofei Wang, Yiwei Dou, Jing Huang
Original research: Impact of COVID-19 outbreak on cancer immunotherapy in Italy: a survey of young oncologists (15 October, 2020)
Margaret Ottaviano, Marcello Curvietto, Pasquale Rescigno, Marianna Tortora, Giovannella Palmieri, Diana Giannarelli, Michele Aieta, Pasquale Assalone, Laura Attademo, Antonio Avallone, Francesco Bloise, Davide Bosso, Valentina Borzillo, Giuseppe Buono, Giuseppe Calderoni, Francesca Caputo, Giacomo Cartenì, Diletta Cavallero, Alessia Cavo, Fortunato Ciardiello, Raffaele Conca, Vincenza Conteduca, Stefano De Falco, Marco De Felice, Michelino De Laurentiis, Pietro De Placido, Sabino De Placido, Irene De Santo, Alfonso De Stefano, Carminia Maria Della Corte, Rossella Di Franco, Vincenzo Di Lauro, Antonietta Fabbrocini, Piera Federico, Lucia Festino, Pasqualina Giordano, Mario Giuliano, Cesare Gridelli, Antonio Maria Grimaldi, Michela Lia, Antonella Lucia Marretta, Valentina Massa, Alessia Mennitto, Sara Merler, Valeria Merz, Carlo Messina, Marco Messina, Monica Milano, Alessandro Marco Minisini, Vincenzo Montesarchio, Alessandro Morabito, Floriana Morgillo, Brigitta Mucci, Lucia Nappi, Fabiana Napolitano, Immacolata Paciolla, Martina Pagliuca, Giuseppe Palmieri, Sara Parola, Stefano Pepe, Angelica Petrillo, Francovito Piantedosi, Luisa Piccin, Fernanda Picozzi, Erica Pietroluongo, Sandro Pignata, Veronica Prati, Vittorio Riccio, Mario Rosanova, Alice Rossi, Anna Russo, Massimiliano Salati, Giuseppe Santabarbara, Andrea Sbrana, Ester Simeone, Antonia Silvestri, Massimiliano Spada, Paolo Tarantino, Paola Taveggia, Federica Tomei, Tortora Vincenzo, Dario Trapani, Claudia Trojanello, Vito Vanella, Sabrina Vari, Jole Ventriglia, Maria Grazia Vitale, Fabiana Vitiello, Caterina Vivaldi, Claudia von Arx, Francesca Zacchi, Ilaria Zampiva, Andrea Zivi, Bruno Daniele, Paolo Antonio Ascierto
Original research: PD1 blockade enhances K⁺ channel activity, Ca²⁺ signaling, and migratory ability in cytotoxic T lymphocytes of patients with head and neck cancer (15 October, 2020)
Hannah S Newton, Vaibhavkumar S Gawali, Ameet A Chimote, Maria A Lehn, Sarah M Palackdharry, Benjamin H Hinrichs, Roman Jandarov, David Hildeman, Edith M Janssen, Trisha M Wise-Draper, Laura Conforti
Original research: Infiltrating pattern and prognostic value of tertiary lymphoid structures in resected non-functional pancreatic neuroendocrine tumors (14 October, 2020)
Wu-Hu Zhang, Wen-Quan Wang, Xuan Han, He-Li Gao, Shuai-Shuai Xu, Shuo Li, Tian-Jiao Li, Hua-Xiang Xu, Hao Li, Long-Yun Ye, Xuan Lin, Chun-Tao Wu, Jiang Long, Xian-Jun Yu, Liang Liu
Original research: p50 suppresses cytotoxic T lymphocyte effector function to regulate tumor immune escape and response to immunotherapy (13 October, 2020)
Chunwan Lu, John D Klement, Alyssa D Smith, Dafeng Yang, Jennifer L Waller, Darren D Browning, David H Munn, Kebin Liu
Original research: Pembrolizumab with or without radiation therapy for metastatic non-small cell lung cancer: a randomized phase I/II trial (13 October, 2020)
James Welsh, Hari Menon, Dawei Chen, Vivek Verma, Chad Tang, Mehmet Altan, Kenneth Hess, Patricia de Groot, Quynh-Nhu Nguyen, Rejani Varghese, Nathan I Comeaux, George Simon, Ferdinandos Skoulidis, Joe Y Chang, Vasiliki Papdimitrakopoulou, Steven H Lin, John V Heymach
Original research: Safety and efficacy of AMG 820, an anti-colony-stimulating factor 1 receptor antibody, in combination with pembrolizumab in adults with advanced solid tumors (12 October, 2020)
Albiruni RA Razak, James M Cleary, Victor Moreno, Michael Boyer, Emiliano Calvo Aller, William Edenfield, Jeanne Tie, R Donald Harvey, Annemie Rutten, Manish A Shah, Anthony J Olszanski, Dirk Jäger, Nehal Lakhani, David P Ryan, Erik Rasmussen, Gloria Juan, Hansen Wong, Neelesh Soman, Marie-Anne Damiette Smit, Dirk Nagorsen, Kyriakos P Papadopoulos
Original research: Avelumab as second-line therapy for metastatic, platinum-treated urothelial carcinoma in the phase Ib JAVELIN Solid Tumor study: 2-year updated efficacy and safety analysis (9 October, 2020)
Andrea B Apolo, John A Ellerton, Jeffrey R Infante, Manish Agrawal, Michael S Gordon, Raid Aljumaily, Theodore Gourdin, Luc Dirix, Keun-Wook Lee, Matthew H Taylor, Patrick Schöffski, Ding Wang, Alain Ravaud, Juliane Manitz, Gregory Pennock, Mary Ruisi, James L Gulley, Manish R Patel
Original research: Diagnostic utility of CT for suspected immune checkpoint inhibitor enterocolitis (8 October, 2020)
Sienna M Durbin, Meghan J Mooradian, Florian Johannes Fintelmann, Leyre Zubiri, Donald F Chute, Avinash Kambadakone, Nisanard Pisuchpen, Kerry L Reynolds, Michael Dougan
Original research: Tumor-draining lymph node is important for a robust abscopal effect stimulated by radiotherapy (7 October, 2020)
Zachary S Buchwald, Tahseen H Nasti, Judong Lee, Christiane S Eberhardt, Andres Wieland, Se Jin Im, David Lawson, Walter Curran, Rafi Ahmed, Mohammad K Khan
Original research: Safety and efficacy of single cycle induction treatment with cisplatin/docetaxel/ durvalumab/tremelimumab in locally advanced HNSCC: first results of CheckRad-CD8 (6 October, 2020)
Markus Hecht, Antoniu Oreste Gostian, Markus Eckstein, Sandra Rutzner, Jens von der Grün, Thomas Illmer, Matthias G Hautmann, Gunther Klautke, Simon Laban, Thomas Brunner, Axel Hinke, Ina Becker, Benjamin Frey, Sabine Semrau, Carol I Geppert, Arndt Hartmann, Panagiotis Balermpas, Wilfried Budach, Udo S Gaipl, Heinrich Iro, Rainer Fietkau
Original research: ⁸⁹Zr-pembrolizumab biodistribution is influenced by PD-1-mediated uptake in lymphoid organs (5 October, 2020)
Elly L van der Veen, Danique Giesen, Linda Pot-de Jong, Annelies Jorritsma-Smit, Elisabeth G E De Vries, Marjolijn N Lub-de Hooge
Original research: Effect of cyclo-oxygenase inhibitor use during checkpoint blockade immunotherapy in patients with metastatic melanoma and non-small cell lung cancer (5 October, 2020)
Shang-Jui Wang, Karishma Khullar, Sinae Kim, Nikhil Yegya-Raman, Jyoti Malhotra, Roman Groisberg, Samuel H Crayton, Ann W Silk, John L Nosher, Michael A Gentile, Janice M Mehnert, Salma K Jabbour
Original research: Phase II study of atezolizumab in combination with bevacizumab in patients with advanced cervical cancer (1 October, 2020)
Claire F Friedman, Alexandra Snyder Charen, Qin Zhou, Michael A Carducci, Alexandre Buckley De Meritens, Bradley R Corr, Siqing Fu, Travis J Hollmann, Alexia Iasonos, Jason A Konner, Panagiotis A Konstantinopoulos, Susan C Modesitt, Elad Sharon, Carol Aghajanian, Dmitriy Zamarin
Original research: CDK4/6 inhibition enhances antitumor efficacy of chemotherapy and immune checkpoint inhibitor combinations in preclinical models and enhances T-cell activation in patients with SCLC receiving chemotherapy (1 October, 2020)
Anne Y Lai, Jessica A Sorrentino, Konstantin H Dragnev, Jared M Weiss, Taofeek K Owonikoko, Julie A Rytlewski, Jill Hood, Zhao Yang, Rajesh K Malik, Jay C Strum, Patrick J Roberts
Original research: Poly-IC enhances the effectiveness of cancer immunotherapy by promoting T cell tumor infiltration (21 September, 2020)
Hussein Sultan, Juan Wu, Valentyna I Fesenkova, Aaron E Fan, Diane Addis, Andres M Salazar, Esteban Celis
Original research: Avelumab for advanced Merkel cell carcinoma in the Netherlands: a real-world cohort (18 September, 2020)
Sonja Levy, Maureen J B Aarts, Ferry A L M Eskens, Kristien B M I Keymeulen, Lukas B Been, Dirk Grünhagen, Alexander van Akkooi, Mathilde Jalving, Margot E T Tesselaar
Original research: Modulating TNFα activity allows transgenic IL15-Expressing CLL-1 CAR T cells to safely eliminate acute myeloid leukemia (16 September, 2020)
Pinar Ataca Atilla, Mary K McKenna, Haruko Tashiro, Madhuwanti Srinivasan, Feiyan Mo, Norihiro Watanabe, Brian Wesley Simons, Alexandra McLean Stevens, Michele S Redell, Helen E Heslop, Maksim Mamonkin, Malcolm K Brenner, Erden Atilla
Original research: Efficacy and safety of first-line avelumab in patients with advanced non-small cell lung cancer: results from a phase Ib cohort of the JAVELIN Solid Tumor study (8 September, 2020)
Claire F Verschraegen, Guy Jerusalem, Edward F McClay, Nicholas Iannotti, Charles H Redfern, Jaafar Bennouna, Franklin L Chen, Karen Kelly, Janice Mehnert, John C Morris, Matthew Taylor, David Spigel, Ding Wang, Hans Juergen Grote, Dongli Zhou, Neru Munshi, Marcis Bajars, James L Gulley
Original research: FcγRIIB engagement drives agonistic activity of Fc-engineered αOX40 antibody to stimulate human tumor-infiltrating T cells (7 September, 2020)
Lucia Campos Carrascosa, Adriaan A van Beek, Valeska de Ruiter, Michail Doukas, Jie Wei, Timothy S Fisher, Keith Ching, Wenjing Yang, Karlijn van Loon, Patrick P C Boor, Yannick S Rakké, Lisanne Noordam, Pascal Doornebosch, Dirk Grünhagen, Kees Verhoef, Wojciech G Polak, Jan N M IJzermans, Irene Ni, Yik Andy Yeung, Shahram Salek-Ardakani, Dave Sprengers, Jaap Kwekkeboom
Original research: Impact of cytokine release syndrome on cardiac function following CD19 CAR-T cell therapy in children and young adults with hematological malignancies (3 September, 2020)
Haneen Shalabi, Vandana Sachdev, Amita Kulshreshtha, Julia W Cohen, Bonnie Yates, Doug R Rosing, Stanislav Sidenko, Cindy Delbrook, Crystal Mackall, Brandon Wiley, Daniel W Lee, Nirali N Shah
Original research: Post-registration experience of nivolumab in advanced hepatocellular carcinoma: an international study (31 August, 2020)
Petros Fessas, Ahmed Kaseb, Yinghong Wang, Anwaar Saeed, David Szafron, Tomi Jun, Sirish Dharmapuri, Abdul Rafeh Naqash, Mahvish Muzaffar, Musharraf Navaid, Uqba Khan, ChiehJu Lee, Anushi Bulumulle, Bo Yu, Sonal Paul, Neil Nimkar, Dominik Bettinger, Francesca Benevento, Hannah Hildebrand, Tiziana Pressiani, Yehia I Abugabal, Nicola Personeni, Yi-Hsiang Huang, Lorenza Rimassa, Celina Ang, Thomas Marron, David J Pinato
Original research: Immune-related pneumonitis associated with immune checkpoint inhibitors in lung cancer: a network meta-analysis (30 August, 2020)
Xinru Chen, Zhonghan Zhang, Xue Hou, Yaxiong Zhang, Ting Zhou, Jiaqing Liu, Zhihuan Lin, Wenfeng Fang, Yunpeng Yang, Yuxiang Ma, Yan Huang, Hongyun Zhao, Li Zhang
Original research: Risk of HBV reactivation in patients with immune checkpoint inhibitor-treated unresectable hepatocellular carcinoma (30 August, 2020)
Pei-Chang Lee, Yee Chao, Ming-Huang Chen, Keng-Hsin Lan, I-Cheng Lee, Ming-Chih Hou, Yi-Hsiang Huang
Original research: Durvalumab activity in previously treated patients who stopped durvalumab without disease progression (26 August, 2020)
Siddharth Sheth, Chen Gao, Nancy Mueller, Natasha Angra, Ashok Gupta, Caroline Germa, Pablo Martinez, Jean-Charles Soria
Original research: Preclinical investigations and a first-in-human phase I trial of M4112, the first dual inhibitor of indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase 2, in patients with advanced solid tumors (24 August, 2020)
Aung Naing, Joseph P Eder, Sarina A Piha-Paul, Claude Gimmi, Elizabeth Hussey, Sen Zhang, Vera Hildebrand, Vinayak Hosagrahara, Christina Habermehl, Jacques Moisan, Kyriakos P Papadopoulos
Original research: Chimeric Ad5.F35 vector evades anti-adenovirus serotype 5 neutralization opposing GUCY2C-targeted antitumor immunity (20 August, 2020)
John C Flickinger Jr, Jagmohan Singh, Robert Carlson, Elinor Leong, Trevor R Baybutt, Joshua Barton, Ellen Caparosa, Amanda Pattison, Jeffrey A Rappaport, Jamin Roh, Tingting Zhan, Babar Bashir, Scott A Waldman, Adam E Snook
Original research: Combination of thermally ablative focused ultrasound with gemcitabine controls breast cancer via adaptive immunity (20 August, 2020)
Natasha D Sheybani, Alexandra R Witter, Eric A Thim, Hideo Yagita, Timothy N J Bullock, Richard J Price
Original research: Dose escalation phase 1 study of radiotherapy in combination with anti-cytotoxic-T-lymphocyte-associated antigen 4 monoclonal antibody ipilimumab in patients with metastatic melanoma (20 August, 2020)
Celine Boutros, Nathalie Chaput-Gras, Emilie Lanoy, Alicia Larive, Christine Mateus, Emilie Routier, Roger Sun, Yun Gan Tao, Christophe Massard, Rastilav Bahleda, Dominique Schwob, Nathalie Ibrahim, Rita Maria Khoury Abboud, Caroline Caramella, Andrea Lancia, Lydie Cassard, Severine Roy, J -C Soria, Caroline Robert, Eric Deutsch
Original research: Novel platform leveraging electronic medical record (EMR) to triage patients admitted with high-grade immune-related adverse events (irAEs) to the immune-toxicity (ITOX) service (18 August, 2020)
Osama Abu-Shawer, Prabhsimranjot Singh, Eric Yenulevich, Amanda Brito, Jian Ni, Raja-Elie E Abdulnour, Shilpa Grover, Michael Manos, Peter Bowling, Nicole R LeBoeuf, Patrick Ott, F Stephen Hodi, Joseph Jacobson, Osama Rahma
Original research: Therapeutic plasma exchange clears circulating soluble PD-L1 and PD-L1-positive extracellular vesicles (17 August, 2020)
Jacob J Orme, Elizabeth Ann L Enninga, Fabrice Lucien-Matteoni, Heather Dale, Edwin Burgstaler, Susan M Harrington, Matthew K Ball, Aaron S Mansfield, Sean S Park, Mathew S Block, Svetomir N Markovic, Yiyi Yan, Haidong Dong, Roxana S Dronca, Jeffrey L Winters
Original research: Intratumoral TIGIT⁺ CD8⁺ T-cell infiltration determines poor prognosis and immune evasion in patients with muscle-invasive bladder cancer (16 August, 2020)
Zhaopei Liu, Quan Zhou, Zewei Wang, Hongyu Zhang, Han Zeng, Qiuren Huang, Yifan Chen, Wenbin Jiang, Zhiyuan Lin, Yang Qu, Ying Xiong, Qi Bai, Yu Xia, Yiwei Wang, Li Liu, Yu Zhu, Le Xu, Bo Dai, Jianming Guo, Jiajun Wang, Yuan Chang, Weijuan Zhang
Original research: Oxazaphosphorines combined with immune checkpoint blockers: dose-dependent tuning between immune and cytotoxic effects (11 August, 2020)
Julia Delahousse, Charles Skarbek, Mélanie Desbois, Jean-Luc Perfettini, Nathalie Chaput, Angelo Paci
Original research: CD163⁺ cytokine-producing cDC2 stimulate intratumoral type 1 T cell responses in HPV16-induced oropharyngeal cancer (7 August, 2020)
Saskia J Santegoets, Chantal L Duurland, Ekaterina J Jordanova, Vanessa J van Ham, Ilina Ehsan, Nikki M Loof, Vipin Narang, Charles A Dutertre, Florent Ginhoux, Sylvia L van Egmond, Marij J P Welters, Sjoerd H van der Burg
Original research: Genetic associations of T cell cancer immune response-related genes with T cell phenotypes and clinical outcomes of early-stage lung cancer (6 August, 2020)
Qinchuan Wang, Jianchun Gu, Linbo Wang, David W Chang, Yuanqing Ye, Maosheng Huang, Jack A Roth, Xifeng Wu
Original research: Rationalized inhibition of mixed lineage kinase 3 and CD70 enhances life span and antitumor efficacy of CD8⁺ T cells (5 August, 2020)
Sandeep Kumar, Sunil Kumar Singh, Navin Viswakarma, Gautam Sondarva, Rakesh Sathish Nair, Periannan Sethupathi, Matthew Dorman, Subhash C Sinha, Kent Hoskins, Gregory Thatcher, Basabi Rana, Ajay Rana
Original research: Tumor infiltrating lymphocytes (TIL) therapy in metastatic melanoma: boosting of neoantigen-specific T cell reactivity and long-term follow-up (4 August, 2020)
Joost H van den Berg, Bianca Heemskerk, Nienke van Rooij, Raquel Gomez-Eerland, Samira Michels, Maaike van Zon, Renate de Boer, Noor A M Bakker, Annelies Jorritsma-Smit, Marit M van Buuren, Pia Kvistborg, Hergen Spits, Remko Schotte, Henk Mallo, Matthias Karger, Joris A van der Hage, Michel W J M Wouters, Loes M Pronk, Marnix H Geukes Foppen, Christian U Blank, Jos H Beijnen, Bastiaan Nuijen, Ton N Schumacher, John B A G Haanen
Original research: An open-label, phase II multicohort study of an oral hypomethylating agent CC-486 and durvalumab in advanced solid tumors (4 August, 2020)
Kirsty Taylor, Helen Loo Yau, Ankur Chakravarthy, Ben Wang, Shu Yi Shen, Ilias Ettayebi, Charles A Ishak, Philippe L Bedard, Albiruni Abdul Razak, Aaron R Hansen, Anna Spreafico, Dave Cescon, Marcus O Butler, Amit M Oza, Stephanie Lheureux, Neda Stjepanovic, Brendan Van As, Sarah Boross-Harmer, Lisa Wang, Trevor J Pugh, Pamela S Ohashi, Lillian L Siu, Daniel D De Carvalho
Original research: Combined lenvatinib and pembrolizumab as salvage therapy in advanced adrenal cortical carcinoma (30 July, 2020)
Sara Bedrose, Kevin Charles Miller, Lina Altameemi, Mohamed S Ali, Sameh Nassar, Naveen Garg, Marilyne Daher, Keith D Eaton, Jeffrey Thomas Yorio, Davey B Daniel, Matthew Campbell, Keith C Bible, Mabel Ryder, Ashish V Chintakuntlawar, Mouhammed Amir Habra
Original research: Human CLEC9A antibodies deliver NY-ESO-1 antigen to CD141⁺ dendritic cells to activate naïve and memory NY-ESO-1-specific CD8⁺ T cells (30 July, 2020)
Kelly-Anne Masterman, Oscar L Haigh, Kirsteen M Tullett, Ingrid M Leal-Rojas, Carina Walpole, Frances E Pearson, Jonathon Cebon, Christopher Schmidt, Liam O'Brien, Nikita Rosendahl, Ghazal Daraj, Irina Caminschi, Eric H Gschweng, Roger P Hollis, Donald B Kohn, Mireille H Lahoud, Kristen J Radford
Original research: Comprehensive analyses of immunodynamics and immunoreactivity in response to treatment in ALK-positive non-small-cell lung cancer (29 July, 2020)
Kyoung-Ho Pyo, Sun Min Lim, Chae-Won Park, Ha-Ni Jo, Jae Hwan Kim, Mi-Ran Yun, Dohee Kim, Chun-Feng Xin, Wongeun Lee, Bianca Gheorghiu, Min Hee Hong, Hye Ryun Kim, Hyo Sup Shim, Mi Jang, Sung Sook Lee, Byoung Chul Cho
Original research: Clinical outcomes of prexasertib monotherapy in recurrent BRCA wild-type high-grade serous ovarian cancer involve innate and adaptive immune responses (23 July, 2020)
Erika J Lampert, Ashley Cimino-Mathews, Joo Sang Lee, Jayakumar Nair, Min-Jung Lee, Akira Yuno, Daniel An, Jane B Trepel, Eytan Ruppin, Jung-Min Lee
Original research: Globo H-KLH vaccine adagloxad simolenin (OBI-822)/OBI-821 in patients with metastatic breast cancer: phase II randomized, placebo-controlled study (22 July, 2020)
Chiun-Sheng Huang, Alice L Yu, Ling-Ming Tseng, Louis W C Chow, Ming-Feng Hou, Sara A Hurvitz, Richard B Schwab, James L Murray, Hsien-Kun Chang, Hong-Tai Chang, Shin-Cheh Chen, Sung-Bae Kim, Jung-Tung Hung, Shir-Hwa Ueng, Su-Hua Lee, Chwen-Cheng Chen, Hope S Rugo
Original research: Dendritic cell vaccination and CD40-agonist combination therapy licenses T cell-dependent antitumor immunity in a pancreatic carcinoma murine model (20 July, 2020)
Sai Ping Lau, Nadine van Montfoort, Priscilla Kinderman, Melanie Lukkes, Larissa Klaase, Menno van Nimwegen, Mandy van Gulijk, Jasper Dumas, Dana A M Mustafa, Sanne L A Lievense, Christianne Groeneveldt, Ralph Stadhouders, Yunlei Li, Andrew Stubbs, Koen A Marijt, Heleen Vroman, Sjoerd H van der Burg, Joachim Aerts, Thorbald van Hall, Floris Dammeijer, Casper H J van Eijck
Original research: In situ vaccination at a peripheral tumor site augments response against melanoma brain metastases (19 July, 2020)
Paul A Clark, Raghava N Sriramaneni, Won Jong Jin, Justin C Jagodinsky, Amber M Bates, Abigail A Jaquish, Bryce R Anderson, Trang Le, Jonathan A Lubin, Ishan Chakravarty, Ian S Arthur, Clinton M Heinze, Emily I Guy, Jasdeep Kler, Kelsey A Klar, Peter M Carlson, Kyung Mann Kim, John S Kuo, Zachary S Morris
Original research: Monocyte-derived APCs are central to the response of PD1 checkpoint blockade and provide a therapeutic target for combination therapy (19 July, 2020)
Sjoerd T T Schetters, Ernesto Rodriguez, Laura J W Kruijssen, Matheus H W Crommentuijn, Louis Boon, Jan Van den Bossche, Joke M M Den Haan, Yvette Van Kooyk
Original research: ACE2 and TMPRSS2 expression by clinical, HLA, immune, and microbial correlates across 34 human cancers and matched normal tissues: implications for SARS-CoV-2 COVID-19 (15 July, 2020)
Riyue Bao, Kyle Hernandez, Lei Huang, Jason John Luke
Original research: Survival outcomes and independent response assessment with nivolumab plus ipilimumab versus sunitinib in patients with advanced renal cell carcinoma: 42-month follow-up of a randomized phase 3 clinical trial (12 July, 2020)
Robert J Motzer, Bernard Escudier, David F McDermott, Osvaldo Arén Frontera, Bohuslav Melichar, Thomas Powles, Frede Donskov, Elizabeth R Plimack, Philippe Barthélémy, Hans J Hammers, Saby George, Viktor Grünwald, Camillo Porta, Victoria Neiman, Alain Ravaud, Toni K Choueiri, Brian I Rini, Pamela Salman, Christian K Kollmannsberger, Scott S Tykodi, Marc-Oliver Grimm, Howard Gurney, Raya Leibowitz-Amit, Poul F Geertsen, Asim Amin, Yoshihiko Tomita, M Brent McHenry, Shruti Shally Saggi, Nizar M Tannir
Original research: Bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in advanced squamous cell carcinoma of the head and neck: results from a phase I cohort (7 July, 2020)
Byoung Chul Cho, Amaury Daste, Alain Ravaud, Sébastien Salas, Nicolas Isambert, Edward McClay, Ahmad Awada, Christian Borel, Laureen S Ojalvo, Christoph Helwig, P Alexander Rolfe, James L Gulley, Nicolas Penel
Original research: Atezolizumab in patients with renal insufficiency and mixed variant histology: analyses from an expanded access program in platinum-treated locally advanced or metastatic urothelial carcinoma (7 July, 2020)
Jean Hoffman-Censits, Sumanta Pal, Constanze Kaiser, Beiying Ding, Joaquim Bellmunt
Original research: Phase I study of the ¹⁷⁷Lu-DOTA⁰-Tyr³-Octreotate (lutathera) in combination with nivolumab in patients with neuroendocrine tumors of the lung (2 July, 2020)
Chul Kim, Stephen V Liu, Deepa S Subramaniam, Tisdrey Torres, Massimo Loda, Giuseppe Esposito, Giuseppe Giaccone
Original research: A phase II single-arm study of pembrolizumab with enzalutamide in men with metastatic castration-resistant prostate cancer progressing on enzalutamide alone (2 July, 2020)
Julie N Graff, Tomasz M Beer, Joshi J Alumkal, Rachel E Slottke, William L Redmond, George V Thomas, Reid F Thompson, Mary A Wood, Yoshinobu Koguchi, Yiyi Chen, Emile Latour, Raymond C Bergan, Charles G Drake, Amy E Moran
Original research: Fibroblast activation protein-targeted-4-1BB ligand agonist amplifies effector functions of intratumoral T cells in human cancer (2 July, 2020)
Marta Trüb, Franziska Uhlenbrock, Christina Claus, Petra Herzig, Martin Thelen, Vaios Karanikas, Marina Bacac, Maria Amann, Rosemarie Albrecht, Claudia Ferrara-Koller, Daniela Thommen, Sacha Rothschield, Spasenija Savic Prince, Kirsten D Mertz, Gieri Cathomas, Robert Rosenberg, Viola Heinzelmann-Schwarz, Mark Wiese, Didier Lardinois, Pablo Umana, Christian Klein, Heinz Laubli, Abhishek S Kashyap, Alfred Zippelius
Original research: Pituitary dysfunction induced by immune checkpoint inhibitors is associated with better overall survival in both malignant melanoma and non-small cell lung carcinoma: a prospective study (30 June, 2020)
Tomoko Kobayashi, Shintaro Iwama, Yoshinori Yasuda, Norio Okada, Takayuki Okuji, Masaaki Ito, Takeshi Onoue, Motomitsu Goto, Mariko Sugiyama, Taku Tsunekawa, Hiroshi Takagi, Daisuke Hagiwara, Yoshihiro Ito, Hidetaka Suga, Ryoichi Banno, Kenji Yokota, Tetsunari Hase, Masahiro Morise, Naozumi Hashimoto, Masahiko Ando, Yasushi Fujimoto, Hideharu Hibi, Michihiko Sone, Yuichi Ando, Masashi Akiyama, Yoshinori Hasegawa, Hiroshi Arima

Commentary

Management of immune checkpoint therapy for patients with cancer in the face of COVID-19 (10 December, 2020)
Chen Shen, Qianru Li, Yongchang Wei, Yuting Li, Jun Li, Juan Tao
Improving the therapeutic index in adoptive cell therapy: key factors that impact efficacy (6 October, 2020)
Ena Wang, Alessandra Cesano, Lisa H Butterfield, Francesco Marincola
Campylobacteriosis following immunosuppression for immune checkpoint inhibitor-related toxicity (5 October, 2020)
Karla A Lee, Heather Shaw, Véronique Bataille, Paul Nathan
Immune-checkpoint inhibitors plus chemotherapy versus chemotherapy as first-line treatment for patients with extensive-stage small cell lung cancer (7 September, 2020)
Fei Zhou, Wencheng Zhao, Xiaomei Gong, Shengxiang Ren, Chunxia Su, Tao Jiang, Caicun Zhou
Tracking the tail (3 September, 2020)
Alex Friedlaender, Stephen V Liu, Alfredo Addeo
Pneumonitis from immune checkpoint inhibitors and COVID-19: current concern in cancer treatment (21 July, 2020)
Ernesto Rossi, Giovanni Schinzari, Giampaolo Tortora
BCG vaccine and COVID-19: implications for infection prophylaxis and cancer immunotherapy (6 July, 2020)
Madhuri Koti, Alvaro Morales, Charles H Graham, David Robert Siemens

Guidelines and Consensus Statements

Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of lymphoma (24 December, 2020)
Sattva S Neelapu, Sherry Adkins, Stephen M Ansell, Joshua Brody, Mitchell S Cairo, Jonathan W Friedberg, Justin P Kline, Ronald Levy, David L Porter, Koen van Besien, Michael Werner, Michael R Bishop
Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immune effector cell-related adverse events (16 December, 2020)
Marcela V Maus, Sara Alexander, Michael R Bishop, Jennifer N Brudno, Colleen Callahan, Marco L Davila, Claudia Diamonte, Jorg Dietrich, Julie C Fitzgerald, Matthew J Frigault, Terry J Fry, Jennifer L Holter-Chakrabarty, Krishna V Komanduri, Daniel W Lee, Frederick L Locke, Shannon L Maude, Philip L McCarthy, Elena Mead, Sattva S Neelapu, Tomas G Neilan, Bianca D Santomasso, Elizabeth J Shpall, David T Teachey, Cameron J Turtle, Tom Whitehead, Stephan A Grupp
Society for Immunotherapy of Cancer clinical and biomarkers data sharing resource document: Volume II—practical challenges (15 December, 2020)
Alessandra Cesano, Michael A Cannarile, Sacha Gnjatic, Bruno Gomes, Justin Guinney, Vaios Karanikas, Mohan Karkada, John M Kirkwood, Beatrix Kotlan, Giuseppe V Masucci, Els Meeusen, Anne Monette, Aung Naing, Vésteinn Thorsson, Nicholas Tschernia, Ena Wang, Daniel K Wells, Timothy L Wyant, Sergio Rutella
Strategies for improving the management of immune-related adverse events (12 December, 2020)
Aung Naing, Joud Hajjar, James L Gulley, Michael B Atkins, Gennaro Ciliberto, Funda Meric-Bernstam, Patrick Hwu
SITC cancer immunotherapy resource document: a compass in the land of biomarker discovery (2 December, 2020)
Siwen Hu-Lieskovan, Srabani Bhaumik, Kavita Dhodapkar, Jean-Charles J B Grivel, Sumati Gupta, Brent A Hanks, Sylvia Janetzki, Thomas O Kleen, Yoshinobu Koguchi, Amanda W Lund, Cristina Maccalli, Yolanda D Mahnke, Ruslan D Novosiadly, Senthamil R Selvan, Tasha Sims, Yingdong Zhao, Holden T Maecker
Society for Immunotherapy of Cancer clinical and biomarkers data sharing resource document: Volume I—conceptual challenges (30 October, 2020)
Sergio Rutella, Michael A Cannarile, Sacha Gnjatic, Bruno Gomes, Justin Guinney, Vaios Karanikas, Mohan Karkada, John M Kirkwood, Beatrix Kotlan, Giuseppe V Masucci, Els Meeusen, Anne Monette, Aung Naing, Vésteinn Thorsson, Nicholas Tschernia, Ena Wang, Daniel K Wells, Timothy L Wyant, Alessandra Cesano
The Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of acute leukemia (19 October, 2020)
Michael M Boyiadzis, Ivan Aksentijevich, Daniel A Arber, John Barrett, Renier J Brentjens, Jill Brufsky, Jorge Cortes, Marcos De Lima, Stephen J Forman, Ephraim J Fuchs, Linda J Fukas, Steven D Gore, Mark R Litzow, Jeffrey S Miller, John M Pagel, Edmund K Waller, Martin S Tallman
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of multiple myeloma (12 July, 2020)
Nina Shah, Jack Aiello, David E Avigan, Jesus G Berdeja, Ivan M Borrello, Ajai Chari, Adam D Cohen, Karthik Ganapathi, Lissa Gray, Damian Green, Amrita Krishnan, Yi Lin, Elisabet Manasanch, Nikhil C Munshi, Ajay K Nooka, Aaron P Rapoport, Eric L Smith, Ravi Vij, Madhav Dhodapkar
Current challenges for assessing the long-term clinical benefit of cancer immunotherapy: a multi-stakeholder perspective (12 July, 2020)
Casey Quinn, Louis P Garrison, Anja K Pownell, Michael B Atkins, Gérard de Pouvourville, Kevin Harrington, Paolo Antonio Ascierto, Phil McEwan, Samuel Wagner, John Borrill, Elise Wu

Hypothesis

Complement controls the immune synapse and tumors control complement (15 December, 2020)
Alan Herbert
Microbiome-derived metabolome as a potential predictor of response to cancer immunotherapy (30 October, 2020)
Agnieszka Beata Malczewski, Severine Navarro, Jermaine IG Coward, Natkunam Ketheesan

Immune cell therapies and immune cell engineering

Original research: In vivo therapeutic effects of affinity-improved-TCR engineered T-cells on HBV-related hepatocellular carcinoma (15 December, 2020)
Qi Liu, Ye Tian, Yanyan Li, Wei Zhang, Wenxuan Cai, Yaju Liu, Yuefei Ren, Zhaoduan Liang, Peipei Zhou, Yajing Zhang, Yifeng Bao, Yi Li
Original research: Systemic and intravesical adoptive cell therapy of tumor-reactive T cells can decrease bladder tumor growth in vivo (10 December, 2020)
Brittany L Bunch, Jennifer Morse, Sarah Asby, Jamie Blauvelt, Ahmet M Aydin, Patrick Innamarato, Ali Hajiran, Matthew Beatty, Michael Poch, Shari Pilon-Thomas
Original research: Diacylglycerol kinase ζ limits IL-2-dependent control of PD-1 expression in tumor-infiltrating T lymphocytes (27 November, 2020)
Javier Arranz-Nicolás, Miguel Martin-Salgado, Cristina Rodríguez-Rodríguez, Rosa Liébana, Maria C Moreno-Ortiz, Judith Leitner, Peter Steinberger, Antonia Ávila-Flores, Isabel Merida
Original research: Transgenic CD8αβ co-receptor rescues endogenous TCR function in TCR-transgenic virus-specific T cells (3 November, 2020)
Gagan Bajwa, Inès Lanz, Mara Cardenas, Malcolm K Brenner, Caroline Arber
Original research: Sensitive manipulation of CAR T cell activity using a chimeric endocytosing receptor (30 October, 2020)
Boning Zhang, John Victor Napoleon, Xin Liu, Qian Luo, Madduri Srinivasarao, Philip S Low
Original research: CAR-T cells and TRUCKs that recognize an EBNA-3C-derived epitope presented on HLA-B*35 control Epstein-Barr virus-associated lymphoproliferation (30 October, 2020)
Anna Christina Dragon, Katharina Zimmermann, Thomas Nerreter, Deborah Sandfort, Julia Lahrberg, Stephan Klöß, Christina Kloth, Caroline Mangare, Agnes Bonifacius, Sabine Tischer-Zimmermann, Rainer Blasczyk, Britta Maecker-Kolhoff, Barbara Uchanska-Ziegler, Hinrich Abken, Axel Schambach, Michael Hudecek, Britta Eiz-Vesper
Original research: Human macrophages engineered to secrete a bispecific T cell engager support antigen-dependent T cell responses to glioblastoma (29 October, 2020)
Jennifer L Gardell, Lisa R Matsumoto, Harrison Chinn, Kole R DeGolier, Shannon A Kreuser, Brooke Prieskorn, Stephanie Balcaitis, Amira Davis, Richard G Ellenbogen, Courtney A Crane
Original research: Genetically engineered macrophages persist in solid tumors and locally deliver therapeutic proteins to activate immune responses (28 October, 2020)
Katherine J Brempelis, Courtney M Cowan, Shannon A Kreuser, Kevin P Labadie, Brooke M Prieskorn, Nicole A P Lieberman, Chibawanye I Ene, Kara W Moyes, Harrison Chinn, Kole R DeGolier, Lisa R Matsumoto, Sara K Daniel, Jason K Yokoyama, Amira D Davis, Virginia J Hoglund, Kimberly S Smythe, Stephanie D Balcaitis, Michael C Jensen, Richard G Ellenbogen, Jean S Campbell, Robert H Pierce, Eric C Holland, Venu G Pillarisetty, Courtney A Crane
Original research: PD-1 inhibitor inducing exosomal miR-34a-5p expression mediates the cross talk between cardiomyocyte and macrophage in immune checkpoint inhibitor–related cardiac dysfunction (28 October, 2020)
Wenzheng Xia, Hanbin Chen, Didi Chen, Yijia Ye, Congying Xie, Meng Hou
Original research: Adherent cell depletion promotes the expansion of renal cell carcinoma infiltrating T cells with optimal characteristics for adoptive transfer (9 October, 2020)
Mitchell W Braun, Haitham Abdelhakim, Meizhang Li, Stephen Hyter, Ziyan Pessetto, Devin C Koestler, Harsh B Pathak, Neil Dunavin, Andrew K Godwin
Original research: Point mutation in CD19 facilitates immune escape of B cell lymphoma from CAR-T cell therapy (6 October, 2020)
Zhen Zhang, Xinfeng Chen, Yonggui Tian, Feng Li, Xuan Zhao, Jinyan Liu, Chang Yao, Yi Zhang
Original research: Adoptive transfer of zoledronate-expanded autologous Vγ9Vδ2 T-cells in patients with treatment-refractory non-small-cell lung cancer: a multicenter, open-label, single-arm, phase 2 study (18 September, 2020)
Kazuhiro Kakimi, Hirokazu Matsushita, Keita Masuzawa, Takahiro Karasaki, Yukari Kobayashi, Koji Nagaoka, Akihiro Hosoi, Shinnosuke Ikemura, Kentaro Kitano, Ichiro Kawada, Tadashi Manabe, Tomohiro Takehara, Toshiaki Ebisudani, Kazuhiro Nagayama, Yukio Nakamura, Ryuji Suzuki, Hiroyuki Yasuda, Masaaki Sato, Kenzo Soejima, Jun Nakajima
Original research: Neoantigen-specific CD4⁺ T-cell response is critical for the therapeutic efficacy of cryo-thermal therapy (16 September, 2020)
Peng Peng, Hongming Hu, Ping Liu, Lisa X Xu
Original research: Cell-based artificial APC resistant to lentiviral transduction for efficient generation of CAR-T cells from various cell sources (7 September, 2020)
Andrea Schmidts, Leah C Marsh, Ambike A Srivastava, Amanda A Bouffard, Angela C Boroughs, Irene Scarfò, Rebecca C Larson, Felipe Bedoya, Bryan D Choi, Matthew J Frigault, Stefanie R Bailey, Mark B Leick, Sonika Vatsa, Michael C Kann, Michelle S Prew, Benjamin P Kleinstiver, J Keith Joung, Marcela V Maus
Original research: Bone marrow MSC from pediatric patients with B-ALL highly immunosuppress T-cell responses but do not compromise CD19-CAR T-cell activity (31 August, 2020)
Samanta Romina Zanetti, Paola Alejandra Romecin, Meritxell Vinyoles, Manel Juan, José Luis Fuster, Mireia Cámos, Sergi Querol, Mario Delgado, Pablo Menendez
Original research: Rapid tumor vaccine using Toll-like receptor-activated ovarian cancer ascites monocytes (16 August, 2020)
Sarah F Adams, Alizée J Grimm, Cheryl L-L Chiang, Ananda Mookerjee, Dallas Flies, Stephanie Jean, Georgia A McCann, Justine Michaux, HuiSong Pak, Florian Huber, Christopher Neal, Denarda Dangaj, Michal Bassani-Sternberg, Sylvie Rusakiewicz, Andrea Facciabene, George Coukos, Phyllis A Gimotty, Lana E Kandalaft
Original research: Safety and efficacy of CAR-T cell targeting BCMA in patients with multiple myeloma coinfected with chronic hepatitis B virus (13 August, 2020)
Lu Han, Jian Zhou, Keshu Zhou, Xinghu Zhu, Lingdi Zhao, Baijun Fang, Qingsong Yin, Xudong Wei, Hu Zhou, Linlin Li, Bengling Xu, Jishuai Zhang, Yongping Song, Quanli Gao
Original research: Efficient elimination of primary B-ALL cells in vitro and in vivo using a novel 4-1BB-based CAR targeting a membrane-distal CD22 epitope (11 August, 2020)
Talia Velasco-Hernandez, Samanta Romina Zanetti, Heleia Roca-Ho, Francisco Gutierrez-Aguera, Paolo Petazzi, Diego Sánchez-Martínez, Oscar Molina, Matteo Libero Baroni, Jose Luis Fuster, Paola Ballerini, Clara Bueno, Narcis Fernandez-Fuentes, Pablo Engel, Pablo Menendez
Original research: Local injection of CCL19-expressing mesenchymal stem cells augments the therapeutic efficacy of anti-PD-L1 antibody by promoting infiltration of immune cells (16 July, 2020)
Yuichi Iida, Rintaro Yoshikawa, Akihiko Murata, Hitoshi Kotani, Yasuhiro Kazuki, Mitsuo Oshimura, Yumi Matsuzaki, Mamoru Harada

Immunotherapy biomarkers

Original research: Serum CD73 is a prognostic factor in patients with metastatic melanoma and is associated with response to anti-PD-1 therapy (23 December, 2020)
Roberta Turiello, Mariaelena Capone, Diana Giannarelli, Elva Morretta, Maria Chiara Monti, Gabriele Madonna, Domenico Mallardo, Lucia Festino, Rosa Azzaro, Mitchell P Levesque, Laurence Imhof, Benjamin Weide, Teresa Amaral, Marc Chevrier, Antje Sucker, Piotr Rutkowski, Dirk Schadendorf, Celeste Lebbe, Jason John Luke, Kilian Wistuba-Hamprecht, Reinhard Dummer, Aldo Pinto, Silvana Morello, Paolo A Ascierto
Original research: Glucose-6-phosphate dehydrogenase correlates with tumor immune activity and programmed death ligand-1 expression in Merkel cell carcinoma (23 December, 2020)
Motoki Nakamura, Kotaro Nagase, Maki Yoshimitsu, Tetsuya Magara, Yuka Nojiri, Hiroshi Kato, Tadahiro Kobayashi, Yukiko Teramoto, Masahito Yasuda, Hidefumi Wada, Toshiyuki Ozawa, Yukie Umemori, Dai Ogata, Akimichi Morita
Original research: EPHA mutation as a predictor of immunotherapeutic efficacy in lung adenocarcinoma (10 December, 2020)
Hua Bai, Jianchun Duan, Chengcheng Li, Wenzhuan Xie, Wenfeng Fang, Yu Xu, Guoqiang Wang, Rui Wan, Jing Sun, Jiachen Xu, Xin Wang, Kailun Fei, Zhengyi Zhao, Shangli Cai, Li Zhang, Jie Wang, Zhijie Wang
Original research: Mitochondrial Lon-induced mtDNA leakage contributes to PD-L1–mediated immunoescape via STING-IFN signaling and extracellular vesicles (2 December, 2020)
An Ning Cheng, Li-Chun Cheng, Cheng-Liang Kuo, Yu Kang Lo, Han-Yu Chou, Chung-Hsing Chen, Yi-Hao Wang, Tsung-Hsien Chuang, Shih-Jung Cheng, Alan Yueh-Luen Lee
Original research: PODO447: a novel antibody to a tumor-restricted epitope on the cancer antigen podocalyxin (26 November, 2020)
Diana Canals Hernaez, Michael R Hughes, Pamela Dean, Peter Bergqvist, Ismael Samudio, Ola Blixt, Katharina Wiedemeyer, Yicong Li, Chris Bond, Eric Cruz, Martin Köbel, Blake Gilks, Calvin D Roskelley, Kelly M McNagny
Comparison of PD-L1 protein expression between primary tumors and metastatic lesions in triple negative breast cancers (25 November, 2020)
Mariya Rozenblit, Richard Huang, Natalie Danziger, Priti Hegde, Brian Alexander, Shakti Ramkissoon, Kim Blenman, Jeffrey S Ross, David L Rimm, Lajos Pusztai
Original research: Prognostic value of HLA-I homozygosity in patients with non-small cell lung cancer treated with single agent immunotherapy (23 November, 2020)
Afaf Abed, Leslie Calapre, Johnny Lo, Suzana Correia, Samantha Bowyer, Abha Chopra, Mark Watson, Muhammad Adnan Khattak, Michael Millward, Elin Solomonovna Gray
Original research: Early changes in immune cell subsets with corticosteroids in patients with solid tumors: implications for COVID-19 management (20 November, 2020)
Jennifer L Marté, Nicole J Toney, Lisa Cordes, Jeffrey Schlom, Renee N Donahue, James L Gulley
Original research: Immune profiling of uveal melanoma identifies a potential signature associated with response to immunotherapy (17 November, 2020)
Yong Qin, Kathryn Bollin, Mariana Petaccia de Macedo, Fernando Carapeto, Kevin B Kim, Jason Roszik, Khalida M Wani, Alexandre Reuben, Sujan T Reddy, Michelle D Williams, Michael T Tetzlaff, Wei-Lien Wang, Dan S Gombos, Bita Esmaeli, Alexander J Lazar, Patrick Hwu, Sapna P Patel
Original research: PD-1 and TIGIT coexpression identifies a circulating CD8 T cell subset predictive of response to anti-PD-1 therapy (13 November, 2020)
Sylvain Simon, Valentin Voillet, Virginie Vignard, Zhong Wu, Camille Dabrowski, Nicolas Jouand, Tiffany Beauvais, Amir Khammari, Cécile Braudeau, Régis Josien, Olivier Adotevi, Caroline Laheurte, François Aubin, Charles Nardin, Samuel Rulli, Raphael Gottardo, Nirasha Ramchurren, Martin Cheever, Steven P Fling, Candice D Church, Paul Nghiem, Brigitte Dreno, Stanley R Riddell, Nathalie Labarriere
Original research: Radiomics to predict outcomes and abscopal response of patients with cancer treated with immunotherapy combined with radiotherapy using a validated signature of CD8 cells (13 November, 2020)
Roger Sun, Nora Sundahl, Markus Hecht, Florian Putz, Andrea Lancia, Angela Rouyar, Marina Milic, Alexandre Carré, Enzo Battistella, Emilie Alvarez Andres, Stéphane Niyoteka, Edouard Romano, Guillaume Louvel, Jérôme Durand-Labrunie, Sophie Bockel, Rastilav Bahleda, Charlotte Robert, Celine Boutros, Maria Vakalopoulou, Nikos Paragios, Benjamin Frey, Jean-Charles Soria, Christophe Massard, Charles Ferté, Rainer Fietkau, Piet Ost, Udo Gaipl, Eric Deutsch
Original research: Plasma-based microsatellite instability detection strategy to guide immune checkpoint blockade treatment (10 November, 2020)
Zhenghang Wang, Xiaochen Zhao, Chan Gao, Jifang Gong, Xicheng Wang, Jing Gao, Zhongwu Li, Jie Wang, Bo Yang, Lei Wang, Bei Zhang, Yifan Zhou, Dalei Wang, Xiaofang Li, Yuezong Bai, Jian Li, Lin Shen
Original research: Intratumoral injection reduces toxicity and antibody-mediated neutralization of immunocytokine in a mouse melanoma model (28 October, 2020)
Claire C Baniel, Elizabeth G Sumiec, Jacquelyn A Hank, Amber M Bates, Amy K Erbe, Alexander A Pieper, Anna G Hoefges, Ravi B Patel, Alexander L Rakhmilevich, Zachary S Morris, Paul M Sondel
Original research: Galectin-9-based immune risk score model helps to predict relapse in stage I–III small cell lung cancer (20 October, 2020)
Peixin Chen, Liping Zhang, Wei Zhang, Chenglong Sun, Chunyan Wu, Yayi He, Caicun Zhou
Original research: Clinical, FDG-PET and molecular markers of immune checkpoint inhibitor response in patients with metastatic Merkel cell carcinoma (15 October, 2020)
Alison M Weppler, Andrew Pattison, Prachi Bhave, Paolo De Ieso, Jeanette Raleigh, Athena Hatzimihalis, Anthony J Gill, Shiva Balachander, Jason Callahan, Margaret Chua, George Au-Yeung, Grant A McArthur, Rodney J Hicks, Richard W Tothill, Shahneen Sandhu
Original research: Novel, non-invasive imaging approach to identify patients with advanced non-small cell lung cancer at risk of hyperprogressive disease with immune checkpoint blockade (13 October, 2020)
Pranjal Vaidya, Kaustav Bera, Pradnya D Patil, Amit Gupta, Prantesh Jain, Mehdi Alilou, Mohammadhadi Khorrami, Vamsidhar Velcheti, Anant Madabhushi
Original research: KALRN mutations promote antitumor immunity and immunotherapy response in cancer (9 October, 2020)
Mengyuan Li, Yuxiang Ma, You Zhong, Qian Liu, Canping Chen, Lei Qiang, Xiaosheng Wang
Original research: Gene signature of antigen processing and presentation machinery predicts response to checkpoint blockade in non-small cell lung cancer (NSCLC) and melanoma (7 October, 2020)
Jeffrey C Thompson, Christiana Davis, Charuhas Deshpande, Wei-Ting Hwang, Seth Jeffries, Alexander Huang, Tara C Mitchell, Corey J Langer, Steven M Albelda
Original research: Plasma IL-6 changes correlate to PD-1 inhibitor responses in NSCLC (5 October, 2020)
Alissa Keegan, Biagio Ricciuti, Padric Garden, Limor Cohen, Reiko Nishihara, Anika Adeni, Cloud Paweletz, Julianna Supplee, Pasi A Jänne, Mariano Severgnini, Mark M Awad, David R Walt
Original research: Expression and clinical significance of PD-L1, B7-H3, B7-H4 and VISTA in craniopharyngioma (21 September, 2020)
Yuelong Wang, Jiaojiao Deng, Lin Wang, Tingyue Zhou, Jinlong Yang, Zerong Tian, Jinhao Yang, Hongxu Chen, Xin Tang, Shasha Zhao, Liangxue Zhou, Aiping Tong, Jianguo Xu
Original research: CyTOF mass cytometry reveals phenotypically distinct human blood neutrophil populations differentially correlated with melanoma stage (9 September, 2020)
Yanfang Peipei Zhu, Tobias Eggert, Daniel J Araujo, Pandurangan Vijayanand, Christian Hermann Ottensmeier, Catherine C Hedrick
Original research: Differential expansion of circulating human MDSC subsets in patients with cancer, infection and inflammation (8 September, 2020)
Luca Cassetta, Kirsten Bruderek, Joanna Skrzeczynska-Moncznik, Oktawia Osiecka, Xiaoying Hu, Ida Marie Rundgren, Ang Lin, Kim Santegoets, Utku Horzum, Ana Godinho-Santos, Gennadiy Zelinskyy, Thalia Garcia-Tellez, Sunčica Bjelica, Bartłomiej Taciak, Astrid Olsnes Kittang, Benedikt Höing, Stephan Lang, Michael Dixon, Verena Müller, Jochen Sven Utikal, Derya Karakoç, Kerim Bora Yilmaz, Emilia Górka, Lubomir Bodnar, Olympia Evdoxia Anastasiou, Christine Bourgeois, Robert Badura, Monika Kapinska-Mrowiecka, Mirjana Gotic, Mark ter Laan, Esther Kers-Rebel, Magdalena Król, Juan Francisco Santibañez, Michaela Müller-Trutwin, Ulf Dittmer, Ana Espada de Sousa, Güneş Esendağlı, Gosse Adema, Karin Loré, Elisabeth Ersvær, Viktor Umansky, Jeffrey W Pollard, Joanna Cichy, Sven Brandau
Original research: Combination therapy with T cell engager and PD-L1 blockade enhances the antitumor potency of T cells as predicted by a QSP model (27 August, 2020)
Huilin Ma, Hanwen Wang, Richard J Sové, Jun Wang, Craig Giragossian, Aleksander S Popel
Original research: Brain metastasis PD-L1 and CD8 expression is dependent on primary tumor type and its PD-L1 and CD8 status (27 August, 2020)
Florian Camy, Georgia Karpathiou, Jean Marc Dumollard, Nicolas Magne, Jean Luc Perrot, Francois Vassal, Tiphanie Picot, Mousa Mobarki, Fabien Forest, Francois Casteillo, Sirine Hathroubi, Marios Froudarakis, Michel Peoc'h
Original research: M2-like macrophages dictate clinically relevant immunosuppression in metastatic ovarian cancer (20 August, 2020)
Michal Hensler, Lenka Kasikova, Karel Fiser, Jana Rakova, Petr Skapa, Jan Laco, Tereza Lanickova, Ladislav Pecen, Iva Truxova, Sarka Vosahlikova, Irena Moserova, Ivan Praznovec, Vit Drochytek, Martina Rehackova, Tomas Brtnicky, Lukas Rob, Vladimir Benes, Jelena Pistolic, Ludek Sojka, Ales Ryska, Catherine Sautes-Fridman, Wolf Herve Fridman, Lorenzo Galluzzi, Radek Spisek, Jitka Fucikova
Original research: Tumor copy-number alterations predict response to immune-checkpoint-blockade in gastrointestinal cancer (13 August, 2020)
Zhihao Lu, Huan Chen, Shuang Li, Jifang Gong, Jian Li, Jianling Zou, Lihong Wu, Jianing Yu, Wenbo Han, Huaibo Sun, Xi Jiao, Xiaotian Zhang, Zhi Peng, Ming Lu, Zhenghang Wang, Henghui Zhang, Lin Shen
Original research: Discovery and validation of surface N-glycoproteins in MM cell lines and patient samples uncovers immunotherapy targets (7 August, 2020)
Robyn A A Oldham, Mary L Faber, Theodore R Keppel, Amanda R Buchberger, Matthew Waas, Parameswaran Hari, Rebekah L Gundry, Jeffrey A Medin
Original research: Impact of body composition on outcomes from anti-PD1 +/− anti-CTLA-4 treatment in melanoma (2 August, 2020)
Arissa C Young, Henry T Quach, Haocan Song, Elizabeth J Davis, Javid J Moslehi, Fei Ye, Grant R Williams, Douglas B Johnson
Original research: Prognostic value of novel immune-related genomic biomarkers identified in head and neck squamous cell carcinoma (27 July, 2020)
Yao Yao, Zhongyi Yan, Senlin Lian, Liangnian Wei, Chao Zhou, Dongju Feng, Yuan Zhang, Jianrong Yang, Ming Li, Yun Chen
Original research: Baseline metabolic tumor volume as a strong predictive and prognostic biomarker in patients with non-small cell lung cancer treated with PD1 inhibitors: a prospective study (23 July, 2020)
David Chardin, Marie Paquet, Renaud Schiappa, Jacques Darcourt, Caroline Bailleux, Michel Poudenx, Aurélie Sciazza, Marius Ilie, Jonathan Benzaquen, Nicolas Martin, Josiane Otto, Olivier Humbert
Original research: Prognostic value of immune score in nasopharyngeal carcinoma using digital pathology (19 July, 2020)
Ya-Qin Wang, Lei Chen, Yan-Ping Mao, Ying-Qing Li, Wei Jiang, Shuo-Yu Xu, Yu Zhang, Yu-Pei Chen, Xiao-Min Li, Qing-Mei He, Shi-Wei He, Xiao-Jing Yang, Yuan Lei, Yin Zhao, Jing-Ping Yun, Na Liu, Yingqin Li, Jun Ma
Original research: Correlates of clinical benefit from immunotherapy and targeted therapy in metastatic renal cell carcinoma: comprehensive genomic and transcriptomic analysis (12 July, 2020)
Nazli Dizman, Yung Lyou, Nicholas Salgia, Paulo Gustavo Bergerot, JoAnn Hsu, Daniel Enriquez, Tyler Izatt, Jeffrey M Trent, Sara Byron, Sumanta Pal
Original research: Predicting response to immunotherapy in advanced non-small-cell lung cancer using tumor mutational burden radiomic biomarker (6 July, 2020)
Bingxi He, Di Dong, Yunlang She, Caicun Zhou, Mengjie Fang, Yongbei Zhu, Henghui Zhang, Zhipei Huang, Tao Jiang, Jie Tian, Chang Chen
Original research: Identification of FABP5 as an immunometabolic marker in human hepatocellular carcinoma (1 July, 2020)
Fangming Liu, Weiren Liu, Shuang Zhou, Chunhui Yang, Mengxin Tian, Guangshuai Jia, Han Wang, Bijun Zhu, Mingxiang Feng, Yan Lu, Tiankui Qiao, Xinxin Wang, Wei Cao, Xiangdong Wang, Yinghong Shi, Duojiao Wu

Meeting report

The Great Debate at ‘Immunotherapy Bridge’, Naples, December 5, 2019 (24 August, 2020)
Paolo A Ascierto, Carlo Bifulco, Jerome Galon, Claus Garbe, Samir N Khleif, Jennifer McQuade, Kunle Odunsi, Hideho Okada, Chrystal M Paulos, Sergio A Quezada, Hussein A Tawbi, John Timmerman, Giorgio Trinchieri, Lisa H Butterfield, Igor Puzanov

Oncolytic and local immunotherapy

Original research: Safety of immune checkpoint inhibitor rechallenge after discontinuation for grade ≥2 immune-related adverse events in patients with cancer (21 December, 2020)
Marion Allouchery, Thomas Lombard, Mickael Martin, Franck Rouby, Marion Sassier, Celia Bertin, Marina Atzenhoffer, Ghada Miremont-Salame, Marie-Christine Perault-Pochat, Mathieu Puyade
Original research: Neospora caninum: a new class of biopharmaceuticals in the therapeutic arsenal against cancer (30 November, 2020)
Louis Lantier, Agathe Poupée-Beaugé, Anne di Tommaso, Céline Ducournau, Mathieu Epardaud, Zineb Lakhrif, Stéphanie Germon, Françoise Debierre-Grockiego, Marie-Noëlle Mévélec, Arthur Battistoni, Loïs Coënon, Nora Deluce-Kakwata-Nkor, Florence Velge-Roussel, Céline Beauvillain, Thomas Baranek, Gordon Scott Lee, Thibault Kervarrec, Antoine Touzé, Nathalie Moiré, Isabelle Dimier-Poisson
Original research: Oncolytic vaccinia virus reinvigorates peritoneal immunity and cooperates with immune checkpoint inhibitor to suppress peritoneal carcinomatosis in colon cancer (16 November, 2020)
Yu Seong Lee, Won Suk Lee, Chang Woo Kim, Seung Joon Lee, Hannah Yang, So Jung Kong, John Ning, Kyung-Mee Yang, Beodeul Kang, Woo Ram Kim, Hong Jae Chon, Chan Kim
Original research: Preconditioning of the tumor microenvironment with oncolytic reovirus converts CD3-bispecific antibody treatment into effective immunotherapy (20 October, 2020)
Christianne Groeneveldt, Priscilla Kinderman, Diana J M van den Wollenberg, Ruben L van den Oever, Jim Middelburg, Dana A M Mustafa, Rob C Hoeben, Sjoerd H van der Burg, Thorbald van Hall, Nadine van Montfoort
Original research: In situ immunization of a TLR9 agonist virus-like particle enhances anti-PD1 therapy (15 October, 2020)
Yinwen Cheng, Caitlin D Lemke-Miltner, Wattawan Wongpattaraworakul, Zhaoming Wang, Carlos H F Chan, Aliasger K Salem, George J Weiner, Andrean L Simons
Original research: Safety and clinical activity of intratumoral MEDI9197 alone and in combination with durvalumab and/or palliative radiation therapy in patients with advanced solid tumors (9 October, 2020)
Lillian Siu, Joshua Brody, Shilpa Gupta, Aurélien Marabelle, Antonio Jimeno, Pamela Munster, Juneko Grilley-Olson, Alain H Rook, Antoine Hollebecque, Rebecca K S Wong, James W Welsh, Yuling Wu, Christopher Morehouse, Oday Hamid, Farzana Walcott, Zachary A Cooper, Rakesh Kumar, Charles Ferté, David S Hong
Original research: Nanoemulsion adjuvantation strategy of tumor-associated antigen therapy rephrases mucosal and immunotherapeutic signatures following intranasal vaccination (9 October, 2020)
Chung-Hsiung Huang, Chiung-Yi Huang, Hui-Min Ho, Ching-Hung Lee, Pang-Ti Lai, Suh-Chin Wu, Shih-Jen Liu, Ming-Hsi Huang
Original research: Therapeutic efficacy and safety of a human fusion construct targeting the TWEAK receptor Fn14 and containing a modified granzyme B (21 September, 2020)
Ana Alvarez de Cienfuegos, Lawrence H Cheung, Khalid A Mohamedali, Timothy G Whitsett, Jeffrey A Winkles, Walter N Hittelman, Michael G Rosenblum
Original research: Combining BRAF inhibition with oncolytic herpes simplex virus enhances the immune-mediated antitumor therapy of BRAF-mutant thyroid cancer (5 August, 2020)
Eva Crespo-Rodriguez, Katharina Bergerhoff, Galabina Bozhanova, Shane Foo, Emmanuel C Patin, Harriet Whittock, Richard Buus, Syed Haider, Gareth Muirhead, Khin Thway, Kate Newbold, Robert S Coffin, Richard G Vile, Dae Kim, Martin McLaughlin, Alan A Melcher, Kevin J Harrington, Malin Pedersen
Original research: A recombinant oncolytic Newcastle virus expressing MIP-3α promotes systemic antitumor immunity (5 August, 2020)
Feng-Ying Huang, Jin-Yan Wang, Shu-Zhen Dai, Ying-Ying Lin, Yan Sun, Liming Zhang, Zhuoxuan Lu, Rong Cao, Guang-Hong Tan
Original research: Relaxin-expressing oncolytic adenovirus induces remodeling of physical and immunological aspects of cold tumor to potentiate PD-1 blockade (4 August, 2020)
Bo-Kyeong Jung, Hae Young Ko, Hyunji Kang, JinWoo Hong, Hyo Min Ahn, Youjin Na, Hyeongi Kim, Jin Su Kim, Chae-Ok Yun
Original research: A heat-shocked melanoma cell lysate vaccine enhances tumor infiltration by prototypic effector T cells inhibiting tumor growth (20 July, 2020)
María Alejandra Gleisner, Cristián Pereda, Andrés Tittarelli, Mariela Navarrete, Camila Fuentes, Ignacio Ávalos, Fabian Tempio, Juan Pablo Araya, María Inés Becker, Fermín Eduardo González, Mercedes Natalia López, Flavio Salazar-Onfray

Review

Landscape of natural killer cell activity in head and neck squamous cell carcinoma (21 December, 2020)
Andrew J Charap, Tomohiro Enokida, Rachel Brody, John Sfakianos, Brett Miles, Nina Bhardwaj, Amir Horowitz
Phagocytic function of tumor-associated macrophages as a key determinant of tumor progression control: a review (17 December, 2020)
Marc Lecoultre, Valérie Dutoit, Paul R Walker
Role of immunotherapy in Ewing sarcoma (8 December, 2020)
Erin Morales, Michael Olson, Fiorella Iglesias, Saurabh Dahiya, Tim Luetkens, Djordje Atanackovic
Interleukin-15 and cancer: some solved and many unsolved questions (17 November, 2020)
Piera Filomena Fiore, Sabina Di Matteo, Nicola Tumino, Francesca Romana Mariotti, Gabriella Pietra, Selene Ottonello, Simone Negrini, Barbara Bottazzi, Lorenzo Moretta, Erwan Mortier, Bruno Azzarone
Defining best practices for tissue procurement in immuno-oncology clinical trials: consensus statement from the Society for Immunotherapy of Cancer Surgery Committee (16 November, 2020)
Brian Gastman, Piyush K Agarwal, Adam Berger, Genevieve Boland, Stephen Broderick, Lisa H Butterfield, David Byrd, Peter E Fecci, Robert L Ferris, Yuman Fong, Stephanie L Goff, Matthew M Grabowski, Fumito Ito, Michael Lim, Michael T Lotze, Haider Mahdi, Mokenge Malafa, Carol D Morris, Pranav Murthy, Rogerio I Neves, Adekunle Odunsi, Sara I Pai, Sangeetha Prabhakaran, Steven A Rosenberg, Ragheed Saoud, Jyothi Sethuraman, Joseph Skitzki, Craig L Slingluff, Vernon K Sondak, John B Sunwoo, Simon Turcotte, Cecilia CS Yeung, Howard L Kaufman
When steroids are not enough in immune-related hepatitis: current clinical challenges discussed on the basis of a case report (2 November, 2020)
Dimitrios C Ziogas, Aikaterini Gkoufa, Evangelos Cholongitas, Panagiotis Diamantopoulos, Amalia Anastasopoulou, Paolo Antonio Ascierto, Helen Gogas
Reconsidering the management of patients with cancer with viral hepatitis in the era of immunotherapy (16 October, 2020)
Dimitrios C Ziogas, Frosso Kostantinou, Evangelos Cholongitas, Amalia Anastasopoulou, Panagiotis Diamantopoulos, John Haanen, Helen Gogas
Role of myeloid-derived suppressor cells in the promotion and immunotherapy of colitis-associated cancer (13 October, 2020)
Yungang Wang, Yanxia Ding, Yijun Deng, Yu Zheng, Shengjun Wang
Clinical landscape of oncolytic virus research in 2020 (12 October, 2020)
Nicholas Macedo, David M Miller, Rizwan Haq, Howard L Kaufman
Evolving impact of long-term survival results on metastatic melanoma treatment (9 October, 2020)
Olivier Michielin, Michael B Atkins, Henry B Koon, Reinhard Dummer, Paolo Antonio Ascierto
Tumor-associated carbohydrates and immunomodulatory lectins as targets for cancer immunotherapy (5 October, 2020)
Natalia Rodrigues Mantuano, Marina Natoli, Alfred Zippelius, Heinz Läubli
Impact of anatomic site on antigen-presenting cells in cancer (5 October, 2020)
Maria Zagorulya, Ellen Duong, Stefani Spranger
T-cell agonists in cancer immunotherapy (5 October, 2020)
Yeonjoo Choi, Yaoyao Shi, Cara L Haymaker, Aung Naing, Gennaro Ciliberto, Joud Hajjar
LAG-3: from molecular functions to clinical applications (13 September, 2020)
Takumi Maruhashi, Daisuke Sugiura, Il-mi Okazaki, Taku Okazaki
TIGIT in cancer immunotherapy (7 September, 2020)
Joe-Marc Chauvin, Hassane M Zarour
Antigen processing and presentation in cancer immunotherapy (27 August, 2020)
Maxwell Y Lee, Jun W Jeon, Cem Sievers, Clint T Allen
Mirage or long-awaited oasis: reinvigorating T-cell responses in pancreatic cancer (25 August, 2020)
Michael Brandon Ware, Bassel F El-Rayes, Gregory B Lesinski
Rationalizing the pathway to personalized neoadjuvant immunotherapy: the Lombard Street Approach (24 August, 2020)
Judith M Versluis, Daniela S Thommen, Christian U Blank
Neuropilin-1: a checkpoint target with unique implications for cancer immunology and immunotherapy (15 July, 2020)
Christopher A Chuckran, Chang Liu, Tullia C Bruno, Creg J Workman, Dario AA Vignali
Molecular mechanisms of human herpes viruses inferring with host immune surveillance (2 July, 2020)
Simon Jasinski-Bergner, Ofer Mandelboim, Barbara Seliger
On the use of immune checkpoint inhibitors in patients with viral infections including COVID-19 (1 July, 2020)
Thilo Gambichler, Judith Reuther, Christina H Scheel, Jürgen Christian Becker

Short report

Impact of age on the toxicity of immune checkpoint inhibition (8 October, 2020)
Amit Samani, Shuai Zhang, Laura Spiers, Ali Abdulnabi Mohamed, Sophie Merrick, Zayd Tippu, Miranda Payne, Guy Faust, Sophie Papa, Paul Fields, Mieke Van Hemelrijck, Debra H Josephs
Impact of corticosteroid therapy on the outcomes of hepatocellular carcinoma treated with immune checkpoint inhibitor therapy (7 October, 2020)
David J Pinato, Ahmed Kaseb, Yinghong Wang, Anwaar Saeed, David Szafron, Tomi Jun, Sirish Dharmapuri, Abdul Rafeh Naqash, Mahvish Muzaffar, Musharraf Navaid, Uqba Khan, ChiehJu Lee, Anushi Bulumulle, Bo Yu, Sonal Paul, Petros Fessas, Neil Nimkar, Dominik Bettinger, Hannah Hildebrand, Tiziana Pressiani, Yehia I Abugabal, Nicola Personeni, Yi-Hsiang Huang, Jingky Lozano-Kuehne, Lorenza Rimassa, Celina Ang, Thomas U Marron
Neoadjuvant nivolumab plus ipilimumab in resectable non-small cell lung cancer (13 September, 2020)
Joshua E Reuss, Valsamo Anagnostou, Tricia R Cottrell, Kellie N Smith, Franco Verde, Marianna Zahurak, Mara Lanis, Joseph C Murray, Hok Yee Chan, Caroline McCarthy, Daphne Wang, James R White, Stephen Yang, Richard Battafarano, Stephen Broderick, Errol Bush, Malcolm Brock, Jinny Ha, David Jones, Taha Merghoub, Janis Taube, Victor E Velculescu, Gary Rosner, Peter Illei, Drew M Pardoll, Suzanne Topalian, Jarushka Naidoo, Ben Levy, Matthew D Hellmann, Julie R Brahmer, Jamie E Chaft, Patrick M Forde
Short report: Somatic POLE exonuclease domain mutations elicit enhanced intratumoral immune responses in stage II colorectal cancer (27 August, 2020)
Shaobo Mo, Xiaoji Ma, Yaqi Li, Long Zhang, Ting Hou, Han Han-Zhang, Juanjuan Qian, Sanjun Cai, Dan Huang, Junjie Peng
Short report: Genetic ablation of adipocyte PD-L1 reduces tumor growth but accentuates obesity-associated inflammation (17 August, 2020)
Bogang Wu, Huai-Chin Chiang, Xiujie Sun, Bin Yuan, Payal Mitra, Yanfen Hu, Tyler J Curiel, Rong Li
Short report: Enhanced immunotherapeutic profile of oncolytic virus-based cancer vaccination using cyclophosphamide preconditioning (13 August, 2020)
Jonathan G Pol, Matthew J Atherton, Kyle B Stephenson, Byram W Bridle, Samuel T Workenhe, Natasha Kazdhan, AJ Robert McGray, Yonghong Wan, Guido Kroemer, Brian D Lichty
Short report: Prediction of immune checkpoint inhibition with immune oncology-related gene expression in gastrointestinal cancer using a machine learning classifier (13 August, 2020)
Zhihao Lu, Huan Chen, Xi Jiao, Wei Zhou, Wenbo Han, Shuang Li, Chang Liu, Jifang Gong, Jian Li, Xiaotian Zhang, Xicheng Wang, Zhi Peng, Changsong Qi, Zhenghang Wang, Yanyan Li, Jie Li, Yan Li, Malcolm Brock, Henghui Zhang, Lin Shen
Short report: Subtype and grade-dependent spatial heterogeneity of T-cell infiltration in pediatric glioma (11 August, 2020)
M Hope Robinson, Juan Vasquez, Akhilesh Kaushal, Tobey J MacDonald, José E Velázquez Vega, Matthew Schniederjan, Kavita Dhodapkar
Short report: Clinical activity of pembrolizumab in metastatic prostate cancer with microsatellite instability high (MSI-H) detected by circulating tumor DNA (11 August, 2020)
Pedro Barata, Neeraj Agarwal, Roberto Nussenzveig, Benjamin Gerendash, Ellen Jaeger, Whitley Hatton, Elisa Ledet, Brian Lewis, Jodi Layton, Hani Babiker, Alan Bryce, Rohan Garje, Cy Stein, Lesli Kiedrowski, Philip Saylor, Oliver Sartor
Short report: Efficacy of immunotherapy in lung cancer with co-occurring mutations in NOTCH and homologous repair genes (5 August, 2020)
Marco Mazzotta, Marco Filetti, Mario Occhipinti, Daniele Marinelli, Stefano Scalera, Irene Terrenato, Francesca Sperati, Matteo Pallocca, Francesco Rizzo, Alain Gelibter, Andrea Botticelli, Giorgia Scafetta, Arianna Di Napoli, Eriseld Krasniqi, Laura Pizzuti, Maddalena Barba, Silvia Carpano, Patrizia Vici, Maurizio Fanciulli, Francesca De Nicola, Ludovica Ciuffreda, Frauke Goeman, Ruggero De Maria, Andrea Vecchione, Raffaele Giusti, Gennaro Ciliberto, Paolo Marchetti, Marcello Maugeri-Saccà
Short report: Outcomes to first-line pembrolizumab in patients with PD-L1-high (≥50%) non–small cell lung cancer and a poor performance status (4 August, 2020)
Joao V Alessi, Biagio Ricciuti, Elizabeth Jiménez-Aguilar, Fangxin Hong, Zihan Wei, Mizuki Nishino, Andrew J Plodkowski, Peter Sawan, Jia Luo, Hira Rizvi, Brett W Carter, John V Heymach, Mehmet Altan, Matthew Hellmann, Mark Awad
Short report: Is there a link between very early changes of primary and secondary lymphoid organs in ¹⁸F-FDG-PET/MRI and treatment response to checkpoint inhibitor therapy? (4 August, 2020)
Ferdinand Seith, Andrea Forschner, Benjamin Weide, Brigitte Gückel, Martin Schwartz, Johannes Schwenck, Ahmed E Othman, Matthias Fenchel, Claus Garbe, Konstantin Nikolaou, Nina Schwenzer, Christian la Fougère, Christina Pfannenberg
Short report: Reintroduction of immune-checkpoint inhibitors after immune-related meningitis: a case series of melanoma patients (2 August, 2020)
Stefania Cuzzubbo, Pauline Tetu, Sarah Guegan, Renata Ursu, Catherine Belin, Lila Sirven Villaros, Julie Mazoyer, Coralie Lheure, Celeste Lebbe, Barouyr Baroudjian, Antoine F Carpentier
Short report: Future role for adoptive T-cell therapy in checkpoint inhibitor-resistant metastatic melanoma (2 August, 2020)
Troels Holz Borch, Rikke Andersen, Eva Ellebaek, Özcan Met, Marco Donia, Inge Marie Svane
Short report: Checkpoint inhibitor-related renal vasculitis and use of rituximab (22 July, 2020)
Omar Mamlouk, Jamie S Lin, Maen Abdelrahim, Amanda S Tchakarov, William F Glass, Umut Selamet, Maryam Buni, Noha Abdel-Wahab, Ala Abudayyeh
Short report: Immunization associated with primary tumor growth leads to rejection of commonly used syngeneic tumors upon tumor rechallenge (15 July, 2020)
Bruno Alicke, Klara Totpal, Jill M Schartner, Amy M Berkley, Sophie M Lehar, Aude-Hélène Capietto, Rafael A Cubas, Stephen E Gould
Short report: Hematopoietic lineage-converted T cells carrying tumor-associated antigen-recognizing TCRs effectively kill tumor cells (14 July, 2020)
Fangxiao Hu, Dehao Huang, Yuxuan Luo, Peiqing Zhou, Cui Lv, Kaitao Wang, Qitong Weng, Xiaofei Liu, Yuxian Guan, Yang Geng, Juan Du, Jiekai Chen, Jinyong Wang, Hongling Wu

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Table of contents

December 2020 - Volume 8 - 2

Basic tumor immunology

Case report

Clinical/translational cancer immunotherapy

Commentary

Guidelines and Consensus Statements

Hypothesis

Immune cell therapies and immune cell engineering

Immunotherapy biomarkers

Meeting report

Oncolytic and local immunotherapy

Review

Short report

Correction

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Table of contents

December 2020 - Volume 8 - 2

Basic tumor immunology

Case report

Clinical/translational cancer immunotherapy

Commentary

Guidelines and Consensus Statements

Hypothesis

Immune cell therapies and immune cell engineering

Immunotherapy biomarkers

Meeting report

Oncolytic and local immunotherapy

Review

Short report

Correction