195 Avelumab internalization and lysosomal degradation by circulating immune cells in human is mediated by both Fc gamma Receptor (FcgR) and PD-L1 binding

Hulin Jin; Vittorio D’Urso; Berend Neuteboom; Sean McKenna; Rene Schweickhardt; Alec Gross; Yves Fomekong Nanfack; Lars Toleikis; Markus Fluck; Juergen Scheuenpflug; Ti Cai

doi:10.1136/jitc-2020-SITC2020.0195

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Regular and young investigator award abstracts

Checkpoint blockade therapy

195 Avelumab internalization and lysosomal degradation by circulating immune cells in human is mediated by both Fc gamma Receptor (FcgR) and PD-L1 binding

Authors

Hulin Jin Merck KGaA, Darmstadt, Germany, Darmstadt, Germany PubMed articles Google scholar articles
Vittorio D’Urso Merck KGaA, Darmstadt, Germany, Darmstadt, Germany PubMed articles Google scholar articles
Berend Neuteboom EMD Serono Research and Development Institute, Inc., Billerica, MA, USA; a business of Merck KGaA, Darmstadt, Germany, Billerica, MA, USA PubMed articles Google scholar articles
Sean McKenna EMD Serono Research and Development Institute, Inc., Billerica, MA, USA; a business of Merck KGaA, Darmstadt, Germany, Billerica, MA, USA PubMed articles Google scholar articles
Rene Schweickhardt EMD Serono Research and Development Institute, Inc., Billerica, MA, USA; a business of Merck KGaA, Darmstadt, Germany, Billerica, MA, USA PubMed articles Google scholar articles
Alec Gross EMD Serono Research and Development Institute, Inc., Billerica, MA, USA; a business of Merck KGaA, Darmstadt, Germany, Billerica, MA, USA PubMed articles Google scholar articles
Yves Fomekong Nanfack EMD Serono Research and Development Institute, Inc., Billerica, MA, USA; a business of Merck KGaA, Darmstadt, Germany, Billerica, MA, USA PubMed articles Google scholar articles
Lars Toleikis Merck KGaA, Darmstadt, Germany, Darmstadt, Germany PubMed articles Google scholar articles
Markus Fluck Merck KGaA, Darmstadt, Germany, Darmstadt, Germany PubMed articles Google scholar articles
Juergen Scheuenpflug Merck KGaA, Darmstadt, Germany, Darmstadt, Germany PubMed articles Google scholar articles
Ti Cai EMD Serono Research and Development Institute, Inc., Billerica, MA, USA; a business of Merck KGaA, Darmstadt, Germany, Billerica, MA, USA PubMed articles Google scholar articles

Citation

Jin H, D’Urso V, Neuteboom B, et al

195 Avelumab internalization and lysosomal degradation by circulating immune cells in human is mediated by both Fc gamma Receptor (FcgR) and PD-L1 binding

Journal for ImmunoTherapy of Cancer 2020;8:doi: 10.1136/jitc-2020-SITC2020.0195

Publication history

First published November 9, 2020.

Online issue publication

December 12, 2020

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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